Abstract：
:The influence of a concentrated extract of soluble substances from the sciatic nerve upon the acetylcholine receptor (AChR) content in the soleus muscle of adult rats was examined by in vivo infusions. Internal and membrane-inserted AChR were quantitated by the specific binding of 125I-alpha-bungarotoxin (a-BuTX). Interestingly, the nerve extract had no apparent effect unless the soleus muscle was also denervated at the start of the infusion. Then, after 66 hr, substantially less (60-80%) binding of 125I-a-BuTX to AChR was observed compared to denervated solei that did not receive an infusion of nerve extract. However, the concentration of protein in the nerve extract had to exceed 5 mg/ml before this effect was evident. Infusions of phosphate-buffered saline, bovine serum albumin, rat liver extract, or human transferrin had no striking effect upon AChR. The prevention of the characteristic denervation-induced increase in non-junctional AChR by an active component in the nerve extract may be due to a trophic signal for decreased synthesis of AChR, but it is also possible that the degradation of AChR was increased.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Sayers ST,Yeoh HC,McLane JA,Held IRdoi
10.1002/jnr.490160307subject
Has Abstractpub_date
1986-01-01 00:00:00pages
517-25issue
3eissn
0360-4012issn
1097-4547journal_volume
16pub_type
杂志文章abstract：:To scale up human neural stem/progenitor cell (NSPC) cultures for clinical use, we need to know how long these cells can live ex vivo without losing their ability to proliferate and differentiate; thus, a convenient method is needed to estimate the proliferative activity of human NSPCs grown in neurosphere cultures, a...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10377
更新日期：2002-09-15 00:00:00
abstract：:In this study we used as glial cell models, early and late passage C-6 glial cells, 2B clone, and advanced passages of glial cells derived from aged mouse cerebral hemispheres (MACH) to examine responsiveness to opioids. We have previously reported that early passage C-6 glial cells, 2B clone, are bipotential and can ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490360509
更新日期：1993-12-01 00:00:00
abstract：:In situ cDNA:mRNA hybridization is a technique that has been developed for the visualization of cDNA:mRNA hybrids in individual cells. To use this technique to answer questions of regulation in heterogeneous populations of cells in the brain, it must be combined with other procedures allowing for the identification of...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490160109
更新日期：1986-01-01 00:00:00
abstract：:The thrombospondin (TSP) family of extracellular matrix glycoproteins are widely expressed in the developing and adult central nervous system although their function remains poorly defined. We have used cell culture techniques to analyse the expression and function of TSPs in glial cells derived from myelinated region...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19971015)50:2<202::AID-JNR
更新日期：1997-10-15 00:00:00
abstract：:Chronic alcohol consumption has adverse effects on the central nervous system, affecting some hippocampal and hypothalamic functions. In this study we tempted to demonstrate that some of these modifications could involve impairment of neurotrophic factors. Three experimental groups of male Sprague Dawley rats were stu...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/1097-4547(20010115)63:2<200::AID-JNR1012>3
更新日期：2001-01-15 00:00:00
abstract：:Axonal injury is often characterized by axonal transport defects and abnormal accumulation of intra-axonal components. Nitric oxide (NO) has a key role in mediating inflammatory axonopathy in many neurodegenerative diseases, but little is known about how nitrosative/oxidative stress affects axonal transport or whether...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23556
更新日期：2015-06-01 00:00:00
abstract：:The effects of KCl-treatment on the survival and proliferation of NE-4C self-renewing neural progenitor cells were investigated during early phases of in vitro induced neurogenesis. NE-4C cells, derived from the anterior brain vesicles of embryonic mouse (E9), divided continuously under non-inducing conditions, but ac...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10155
更新日期：2002-03-01 00:00:00
abstract：:Heat shock proteins (HSPs) are stress-responsive proteins that serve as important molecules contributing to cellular "protein triage." We and others have reported an increase of selected HSPs in multiple sclerosis (MS) lesions. However, the exact expression pattern of HSP family genes in MS is not known. The aim of ou...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23079
更新日期：2012-10-01 00:00:00
abstract：:Nerve growth factor (NGF)-specific signal transduction leads to changes in protein methylation during neuronal differentiation of PC12 cells (Cimato et al. [1997] J. Cell Biol. 138:1089-1103). In the present work, we demonstrate that, among NGF-regulated proteins, arginine methylation is more prevalent than carboxylme...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10123
更新日期：2002-02-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490140208
更新日期：1985-01-01 00:00:00
abstract：:The p53 tumor suppressor gene, which is considered the guardian of the genome, encodes a phosphoprotein, which is a sequence-specific transcriptional activator or repressor of target genes. The role of p53 in developmental processes has not been studied extensively, although its expression appears to undergo temporal ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19990515)56:4<427::AID-JNR
更新日期：1999-05-15 00:00:00
abstract：:The neonatal lesion with 6-hydroxydopamine (6-OHDA) in rodents induces juvenile hyperactivity and paradoxical hypolocomotor response to psychostimulants, in striking contrast to what is observed when similar lesions are carried out in adults. The early disruption of central dopaminergic pathways is followed by increas...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20245
更新日期：2004-10-15 00:00:00
abstract：:Although increased neurogenesis has been described in rodent models of focal traumatic brain injury (TBI), the neurogenic response occurring after diffuse TBI uncomplicated by focal injury has not been examined to date, despite the pervasiveness of this distinct type of brain injury in the TBI patient population. Here...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22635
更新日期：2011-07-01 00:00:00
abstract：:The presence of the apolipoprotein E (apoE) allele epsilon4 is a major risk factor for the development of Alzheimer's disease (AD); however, the molecular mechanism underlying the acceleration of AD development in individuals with epsilon4 remains to be determined. To investigate the isoform-specific effects of apoE o...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19981001)54:1<58::AID-JNR7
更新日期：1998-10-01 00:00:00
abstract：:Cultures of chicken day 8 embryo retinal cells, essentially free of contaminating non-neuronal elements, were used to examine the neurotoxicity of various excitatory amino acid transmitter receptor agonists. At 7 days in vitro, N-methyl-D-aspartate (NMDA), following 24 hr exposure to 0.1-1.0 mM, destroyed 60-70% of th...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490270210
更新日期：1990-10-01 00:00:00
abstract：:Disturbances in neuronal calcium homeostasis have been implicated in a variety of neuropathological conditions, including cerebral ischemia, hypoglycemia, and epilepsy, and possibly constitute part of the cell death process associated with chronic neurodegenerative disorders. We investigated if endoplasmic reticulum (...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20631
更新日期：2005-10-15 00:00:00
abstract：:The incubation of murine thymocytes for 24 hr in the presence of cholinergic agonists induces selective proliferation of PNA- cells as measured by thymidine incorporation. The response of PNA- cells is mediated by the activation of nicotinic receptors. This conclusion is suggested by the inability of the muscarinic ag...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490240305
更新日期：1989-11-01 00:00:00
abstract：:The effect of the potent soluble guanylyl cyclase (sGC) inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) on neurite outgrowth and retraction was investigated in PC12 cells and SH-SY5Y human neuroblastoma cells. ODQ inhibited neurite outgrowth and triggered neurite retraction in the cells stimulated with ner...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21838
更新日期：2009-01-01 00:00:00
abstract：:Our previous results support the idea that CREB (cyclic AMP-response element binding protein) may be a mediator of neuroligand and growth factor signals that, coupled to different signal transduction pathways, play different roles at specific stages of oligodendrocyte development. In the early stages, when cells are i...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.1195
更新日期：2001-10-01 00:00:00
abstract：:Cell death in outer hair cells of the mammalian inner ear induced by aminoglycoside antibiotics is mediated by reactive oxygen species (ROS) and can be prevented by antioxidants. The current study investigates the role of the nuclear factor (NF)-kappaB pathway in cell death or survival in adult CBA mice. Kanamycin (70...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20392
更新日期：2005-03-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/(sici)1097-4547(20000101)59:1<11::aid-jnr2
更新日期：2000-01-01 00:00:00
abstract：:The expression of many myelin-specific molecules in Schwann cells is profoundly decreased following denervation. This study examines the early reexpression of myelin protein genes associated with reinnervation. Following sciatic nerve crush, the distal, regenerated nerve was divided into appropriate (2.5 or 5 mm) cons...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490270202
更新日期：1990-10-01 00:00:00
abstract：:In order to identify the relative number of benzodiazepine (BZ) receptors in Purkinje and granule cells, the Purkinje cell degeneration (pcd) mutant mouse was used at different ages. In these mice, Purkinje cells have degenerated almost completely by 45-50 days of age. Granule cell loss occurs only later, and is most ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490090308
更新日期：1983-01-01 00:00:00
abstract：:The male preponderance in autism prevalence has brought together the disparate topics of sex/gender and autism research. Two directions of neuroimaging studies on the relationships between sex/gender and autism may inform male-specific risk mechanisms and female-specific protective mechanisms of autism. First, we revi...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.23948
更新日期：2017-01-02 00:00:00
abstract：:The multifactorial nature of traumatic brain injury (TBI), especially the complex secondary tissue injury involving intertwined networks of molecular pathways that mediate cellular behavior, has confounded attempts to elucidate the pathology underlying the progression of TBI. Here, systems biology strategies are explo...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23503
更新日期：2015-02-01 00:00:00
abstract：:Previous animal studies have linked white matter damage to certain schizophrenia-like behaviors in cuprizone (CPZ)-exposed mouse. Mitochondrial dysfunction, oxidative stress, neuroinflammation, and oligodendrocyte loss coexist in the brain of such mice. The aim of this study was to examine effects of the antioxidant N...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24189
更新日期：2018-05-01 00:00:00
abstract：:An immortalized dorsal root ganglion cell line F-11 exhibits many properties of spinal cord neurons and undergoes apoptosis in response to growth factor withdrawal and the exogenous addition of inhibitors of phosphatidylinositol-3-kinase (PI3K). To elucidate the mechanism of apoptosis we generated F-11 clones which ov...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：
更新日期：1999-09-15 00:00:00
abstract：:Cortical or total brain cultures of microglia are commonly used as a model to study the inflammatory processes in Parkinson's disease. Here we characterize microglia cultures from rat ventral midbrain and evaluate their response to zymosan A. We used specific markers of microglia and evaluated the morphology, the phag...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22219
更新日期：2010-02-15 00:00:00
abstract：:Cytoskeletal structures under the cell membrane carry out pivotal roles in the maintenance and remodeling of the cell structures. Reforming of the cytoskeletal networks after partial extraction of membrane components could be a good clue to identify molecular components pertaining the interaction of cytoskeleton with ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20555
更新日期：2005-07-15 00:00:00
abstract：:Both IgCAMs and the actin cytoskeleton play critical roles in neuronal growth cone motility and guidance. However, it is unclear how IgCAM receptors transduce signals from the plasma membrane to induce actin remodeling. Previous studies have shown that local clustering and immobilization of apCAM, the Aplysia homolog ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21937
更新日期：2009-04-01 00:00:00
