Abstract：
:Although increased neurogenesis has been described in rodent models of focal traumatic brain injury (TBI), the neurogenic response occurring after diffuse TBI uncomplicated by focal injury has not been examined to date, despite the pervasiveness of this distinct type of brain injury in the TBI patient population. Here we characterize multiple stages of neurogenesis following a traumatic axonal injury (TAI) model of diffuse TBI as well as the proliferative response of glial cells. TAI was induced in adult rats using an impact-acceleration model, and 5-bromo-2'-deoxyuridine (BrdU) was administered on days 1-4 posttrauma or sham operation to label mitotic cells. Using immunohistochemistry for BrdU combined with phenotype-specific markers, we found that proliferation was increased following TAI in the subventricular zone of the lateral ventricles and in the hippocampal subgranular zone, although the ultimate production of new dentate granule neurons at 8 weeks was not significantly enhanced. Also, abundant proliferating and reactive astrocytes, microglia, and polydendrocytes were detected throughout the brain following TAI, indicating that a robust glial response occurs in this model, although very few new cells in the nonneurogenic brain regions became mature neurons. We conclude that diffuse brain injury stimulates early stages of a neurogenic response similar to that described for models of focal TBI.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Bye N,Carron S,Han X,Agyapomaa D,Ng SY,Yan E,Rosenfeld JV,Morganti-Kossmann MCdoi
10.1002/jnr.22635subject
Has Abstractpub_date
2011-07-01 00:00:00pages
986-1000issue
7eissn
0360-4012issn
1097-4547journal_volume
89pub_type
杂志文章abstract：:Respiration was measured polarographically in astrocytes from dissociated neonatal rat cerebra grown in primary culture. Cells grown in a modified Eagle's minimal essential medium containing 20% fetal calf serum for 14 to 21 days respired at a rate of 34.23 n at. equiv 0 mg protein-1 min-1. Cells which were grown in t...
journal_title：Journal of neuroscience research
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journal_title：Journal of neuroscience research
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doi：10.1002/jnr.490170304
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pub_type： 杂志文章
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
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更新日期：1992-01-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20626
更新日期：2005-11-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21925
更新日期：2009-04-01 00:00:00
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journal_title：Journal of neuroscience research
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doi：
更新日期：2000-01-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10667
更新日期：2003-08-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23573
更新日期：2015-08-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10567
更新日期：2003-04-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
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更新日期：2007-10-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23337
更新日期：2014-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2002-11-01 00:00:00
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journal_title：Journal of neuroscience research
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pub_type： 杂志文章
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更新日期：1995-12-01 00:00:00
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journal_title：Journal of neuroscience research
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更新日期：1997-08-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/1097-4547(20001015)62:2<169::AID-JNR2>3.0.
更新日期：2000-10-15 00:00:00
abstract：:Pinealocytes of various mammalian species contain abundant synaptic-like microvesicles (SLMVs) which are considered the endocrine equivalent of neuronal synaptic vesicles. Although the pinealocytes may thus be a suitable cellular model for experimental in vitro studies of SLMVs, nothing is known about the presence of ...
journal_title：Journal of neuroscience research
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更新日期：1997-03-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
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abstract：:Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that also possesses neurotrophic and antiapoptotic properties. G-CSF has been reported to decrease amyloid burden significantly, promote hippocampal neurogenesis, and improve spatial learning in a mouse model of Alzheimer's disease. To understan...
journal_title：Journal of neuroscience research
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更新日期：2014-08-01 00:00:00
