Expression of myelin protein gene transcripts by Schwann cells of regenerating nerve.

abstract：:Chloride efflux is known to be involved in the progression of apoptosis in various cell types. We have recently shown that the volume-sensitive outwardly rectifying (VSOR) anion channel serves as the pathway for apoptotic chloride efflux in some cells. In the present study, we tested the neuroprotective effects of dru...

journal_title：Journal of neuroscience research

authors： Inoue H,Ohtaki H,Nakamachi T,Shioda S,Okada Y

更新日期：2007-05-15 00:00:00

abstract：:Tauopathies, including Alzheimer's disease (AD), are a group of neurodegenerative disorders characterized by the presence of intraneuronal filamentous inclusions of abnormally phosphorylated tau protein. In AD brains, it has been shown that the level of abnormally phosphorylated tau is higher than in age-matched contr...

journal_title：Journal of neuroscience research

authors： Blard O,Frébourg T,Campion D,Lecourtois M

更新日期：2006-10-01 00:00:00

abstract：:Acetylcholinesterase (AChE) molecular forms were studied in normal (NM) and in dystrophic (DM) 129B6F1/J mouse muscle. Successive extractions of the tissue with saline and saline-Triton X-100 buffers yielded two soluble fractions, S1 and S2. Forty percent of the AChE in NM was measured in S1 and 60% in S2, and 65% and...

journal_title：Journal of neuroscience research

authors： Cabezas-Herrera J,Campoy FJ,Vidal CJ

更新日期：1994-08-01 00:00:00

abstract：:Precursor cells of the adult mouse subventricular zone (SVZ) are mobilized and recruited by a lysolecithin (LPC)-induced demyelination of the corpus callosum. Because age decreases the proliferation of the SVZ neural precursors as well as the potential for myelin repair of the adult central nervous system, we have com...

journal_title：Journal of neuroscience research

authors： Decker L,Picard-Riera N,Lachapelle F,Baron-Van Evercooren A

更新日期：2002-09-15 00:00:00

abstract：:Fractionation of muscle microsomes rich in sarcoplasmic reticulum (SR) by isopicnic centrifugation yielded three types of membranes. Heavy (HM), intermediate (IM), and light membranes (LM), with isopicnic points of 38, 33, and 25% w/w sucrose, were rich in terminal cisternae/triads, longitudinal SR, and T-tubules, res...

journal_title：Journal of neuroscience research

authors： Campoy FJ,Cabezas-Herrera J,Vidal CJ

更新日期：1992-12-01 00:00:00

abstract：:Previous animal studies have linked white matter damage to certain schizophrenia-like behaviors in cuprizone (CPZ)-exposed mouse. Mitochondrial dysfunction, oxidative stress, neuroinflammation, and oligodendrocyte loss coexist in the brain of such mice. The aim of this study was to examine effects of the antioxidant N...

journal_title：Journal of neuroscience research

authors： Zhang L,Xu S,Huang Q,Xu H

更新日期：2018-05-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) coactivates a number of transcription factors critical for mitochondrial biogenesis. Previously, we found that the expression of PGC-1alpha is governed by neuronal activity, but the signaling mechanism is poorly understood. The present st...

journal_title：Journal of neuroscience research

authors： Liang HL,Dhar SS,Wong-Riley MT

更新日期：2010-02-15 00:00:00

abstract：:Amyloid beta-peptide (A beta) likely causes functional alterations in neurons well prior to their death. Nuclear factor-kappaB (NF-kappaB), a transcription factor that is known to play important roles in cell survival and apoptosis, has been shown to be modulated by A beta in neurons and glia, but the mechanism is unk...

journal_title：Journal of neuroscience research

authors： Kawamoto EM,Lepsch LB,Boaventura MF,Munhoz CD,Lima LS,Yshii LM,Avellar MC,Curi R,Mattson MP,Scavone C

更新日期：2008-03-01 00:00:00

abstract：:Although serotonin regulates synthesis of the neurotrophic factor S-100 beta by astrocytes, its ability to affect nerve growth factor (NGF) synthesis has never been examined. We report here that there is a correlation between the effect of serotonin on cyclic adenosine monophosphate (cAMP) content and on NGF content i...

journal_title：Journal of neuroscience research

authors： Krzan M,Wu VW,Schwartz JP

更新日期：2001-05-01 00:00:00

abstract：:Astroglial cells play an important role in maintaining neuronal function in the adult and in the developing nervous system. Ethanol exposure induces profound alterations in the astrogliogenesis process, affecting important cell functions, including intracellular protein trafficking. Because the actin cytoskeleton play...

journal_title：Journal of neuroscience research

authors： Guasch RM,Tomas M,Miñambres R,Valles S,Renau-Piqueras J,Guerri C

更新日期：2003-05-15 00:00:00

abstract：:New neurons are continuously generated throughout life in the subgranular zone in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles. With the aid of new methodologies, significant progress has been made in the characterization of endogenous stem cells (ependymal ce...

journal_title：Journal of neuroscience research

authors： Qin Y,Zhang W,Yang P

更新日期：2015-03-01 00:00:00

abstract：:Persephin (PSP) is the most recently discovered member of the GDNF family of neurotrophic factors. We have used an RT-PCR approach to start addressing the putative functional significance of PSP by determining sites of its synthesis in the neonatal rat brain. Generally, two transcripts were found. Sequence analysis of...

journal_title：Journal of neuroscience research

authors： Jaszai J,Farkas L,Galter D,Reuss B,Strelau J,Unsicker K,Krieglstein K

更新日期：1998-08-15 00:00:00

abstract：:In cultured Schwann cells, single-channel and whole-cell K+ currents can be activated by depolarizing the membrane to values more negative than -50 mV. In elevated extracellular K+ concentration ([K+]o), however, single-channel activity and whole-cell currents could be recorded at more negative potentials. Thus, the t...

journal_title：Journal of neuroscience research

authors： Verkhratsky A,Hoppe D,Kettenmann H

更新日期：1991-02-01 00:00:00

abstract：:Nonmotor symptoms of cognitive and affective nature are present in premotor and motor stages of Parkinson's disease (PD). Neurogenesis, the generation of new neurons, persists throughout the mammalian life span in the hippocampal dentate gyrus. Adult hippocampal neurogenesis may be severely affected in the course of P...

journal_title：Journal of neuroscience research

authors： Schlachetzki JC,Grimm T,Schlachetzki Z,Ben Abdallah NM,Ettle B,Vöhringer P,Ferger B,Winner B,Nuber S,Winkler J

更新日期：2016-01-01 00:00:00

abstract：:Changes in gene expression were examined in the brain of mice treated with a drug of abuse, 3,4-methylenedioxymethamphetamine (MDMA, also called Ecstasy). Frontal cortex and midbrain mRNA, analyzed by differential display polymerase chain reaction (DD-PCR) method, showed an altered expression of several cDNAs, 11 of w...

journal_title：Journal of neuroscience research

authors： Peng W,Simantov R

更新日期：2003-04-15 00:00:00

abstract：:A number of cytokines and growth factors may affect astrocyte proliferation and functions. Transforming growth factor-beta 1 (TGF-beta 1) is a pleiotropic cytokine which exerts multiple effects on growth and differentiation of different cell types. TGF-beta 1 is present in low amounts in the normal brain. TGF-beta 1 g...

journal_title：Journal of neuroscience research

authors： Vergeli M,mazzanti B,Ballerini C,Gran B,Amaducci L,Massacesi L

更新日期：1995-01-01 00:00:00

abstract：:Traumatic Brain Injury (TBI) is the most frequent cause of death and disability in young adults and children in the developed world, occurring in over 1.7 million persons and resulting in 50,000 deaths in the United States alone. The Centers for Disease Control and Prevention estimate that between 3.2 and 5.3 million ...

journal_title：Journal of neuroscience research

authors： Sulhan S,Lyon KA,Shapiro LA,Huang JH

更新日期：2020-01-01 00:00:00

abstract：:Two clones encoding human glial fibrillary acidic protein (GFAP) were isolated from a human astrocytoma cDNA library. The clones pHGFAP1 and pHGFAP2 were selected by the combined use of differential colony hybridization and hybridization-selection technique with polyclonal anti GFAP antiserum. The longer one, pHGFAP1,...

journal_title：Journal of neuroscience research

authors： Rataboul P,Faucon Biguet N,Vernier P,De Vitry F,Boularand S,Privat A,Mallet J

更新日期：1988-01-01 00:00:00

abstract：:Individuals who regularly shift their sleep timing, like night and/or shift-workers suffer from circadian desynchrony and are at risk of developing cardiometabolic diseases and cancer. Also, shift-work is are suggested to be a risk factor for the development of mood disorders such as the burn out syndrome, anxiety, an...

journal_title：Journal of neuroscience research

authors： Guerrero-Vargas NN,Zárate-Mozo C,Guzmán-Ruiz MA,Cárdenas-Rivera A,Escobar C

更新日期：2021-02-01 00:00:00

abstract：:Disturbances in neuronal calcium homeostasis have been implicated in a variety of neuropathological conditions, including cerebral ischemia, hypoglycemia, and epilepsy, and possibly constitute part of the cell death process associated with chronic neurodegenerative disorders. We investigated if endoplasmic reticulum (...

journal_title：Journal of neuroscience research

authors： Hernández-Fonseca K,Massieu L

更新日期：2005-10-15 00:00:00

abstract：:An immortalized dorsal root ganglion cell line F-11 exhibits many properties of spinal cord neurons and undergoes apoptosis in response to growth factor withdrawal and the exogenous addition of inhibitors of phosphatidylinositol-3-kinase (PI3K). To elucidate the mechanism of apoptosis we generated F-11 clones which ov...

journal_title：Journal of neuroscience research

authors： Goswami R,Kilkus J,Dawson SA,Dawson G

更新日期：1999-09-15 00:00:00

abstract：:The effect of two different potassium channel blockers, 4-aminopyridine (4-AP) and quinine, on the alpha 2-adrenoceptor mediated modulation of norepinephrine (NE) release was investigated. Pairs of mouse vasa deferentia were loaded with 3H-norepinephrine (3H-NE), superfused continuously, and stimulated electrically. 4...

journal_title：Journal of neuroscience research

authors： Zimanyi I,Folly G,Vizi ES

更新日期：1988-05-01 00:00:00

abstract：:The presence of acetylcholinesterase has been detected in the thymus of several species both biochemically and histochemically. In this study we have investigated the molecular forms and the level of this enzyme in separate compartments of the murine thymus and in different thymocyte subpopulations. Similar levels of ...

journal_title：Journal of neuroscience research

authors： Rossi A,Vicini E,Scarsella G,Biagioni S

更新日期：1991-06-01 00:00:00

abstract：:The purpose of this study was to determine if calpain-induced proteolysis was associated with retinal degeneration or dysfunction in the rat acute ocular hypertensive model. Acute glaucoma was produced by elevation of IOP to 120 mm Hg for 1 hr. Retinal degeneration was evaluated by H&E staining and apoptosis was deter...

journal_title：Journal of neuroscience research

authors： Oka T,Tamada Y,Nakajima E,Shearer TR,Azuma M

更新日期：2006-05-15 00:00:00

abstract：:Retinal microglia play an important role as resident immunocompetent and phagocytic cells in the event of injury and disease. Retinal microglia and microglia precursor transplantation show a rescue effect in ischemic retina and retinal degeneration. However, studies of retinal microglia have been hampered by the diffi...

journal_title：Journal of neuroscience research

authors： Jiang XS,Ni YQ,Liu TJ,Zhang M,Jiang R,Xu GZ

更新日期：2014-04-01 00:00:00

abstract：:α-Synuclein (α-syn) is the major component of pathological inclusions characteristic of several neurodegenerative disorders, such as Parkinson's disease. The major posttranslational modification of α-syn is phosphorylation at S129, and previous studies estimate that approximately 90% of α-syn in proteinaceous, patholo...

journal_title：Journal of neuroscience research

authors： Waxman EA,Giasson BI

更新日期：2011-02-01 00:00:00

abstract：:Alcohol-related events have been proposed to be under neurochemical control. For example, the concentration of methionine enkephalin (Met-enkephalin) in brain has been inversely correlated with ethanol consumption in alcohol-preferring and alcohol-nonpreferring mice. The concentrations of Met-enkephalin are controlled...

journal_title：Journal of neuroscience research

authors： Plotkin SR,Banks WA,Waguespack PJ,Kastin AJ

更新日期：1997-05-01 00:00:00

abstract：:Cultured purified oligodendroglia and astroglia exposed to heat stress (45 degrees C, 10 or 20 min) synthesized a 68-kDa heat-stress protein, which migrates on two-dimensional gel electrophoresis and reacts with a specific monoclonal antibody suggesting it is similar to a major 72-kDa heat-shock protein previously rep...

journal_title：Journal of neuroscience research

authors： Nishimura RN,Dwyer BE,Welch W,Cole R,de Vellis J,Liotta K

更新日期：1988-05-01 00:00:00

abstract：:The p53 tumor suppressor gene, which is considered the guardian of the genome, encodes a phosphoprotein, which is a sequence-specific transcriptional activator or repressor of target genes. The role of p53 in developmental processes has not been studied extensively, although its expression appears to undergo temporal ...

journal_title：Journal of neuroscience research

authors： Poulaki V,Benekou A,Bozas E,Bolaris S,Stylianopoulou F

更新日期：1999-05-15 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) has attracted the greatest attention as a major factor in experimental autoimmune encephalomyelitis (EAE) pathogenesis. We compared rats undergoing EAE with manipulated but healthy animals by examining TNF-alpha gene expression in cells recovered from the brain. We used reverse ...

journal_title：Journal of neuroscience research

authors： Sun D,Hu X,Shah R,Zhang L,Coleclough C

更新日期：1996-08-15 00:00:00