Ethanol alters the concentration of Met-enkephalin in brain by affecting peptide transport system-1 independent of preproenkephalin mRNA.

abstract：:In the rat brain, a heteromeric association between adenosine A(1) and purinergic P2Y(1) receptors has been demonstrated. It is suggested that this association plays an important role in the control of purine-mediated responses during pathophysiological conditions. Recently, we have demonstrated that these receptors c...

journal_title：Journal of neuroscience research

authors： Tonazzini I,Trincavelli ML,Montali M,Martini C

更新日期：2008-10-01 00:00:00

abstract：:In a number of pathological states of the brain, the activation of the inducible nitric oxide synthase (iNOS) plays a major role. Interleukin (IL)-1beta is believed to be an essential factor in the induction of iNOS. However, little is known about the cascade of events culminating in iNOS expression in vivo. To identi...

journal_title：Journal of neuroscience research

authors： Hartlage-Rübsamen M,Lemke R,Schliebs R

更新日期：1999-08-01 00:00:00

abstract：:Traumatic Brain Injury (TBI) is the most frequent cause of death and disability in young adults and children in the developed world, occurring in over 1.7 million persons and resulting in 50,000 deaths in the United States alone. The Centers for Disease Control and Prevention estimate that between 3.2 and 5.3 million ...

journal_title：Journal of neuroscience research

authors： Sulhan S,Lyon KA,Shapiro LA,Huang JH

更新日期：2020-01-01 00:00:00

abstract：:The postmortem stability of brain RNA was measured in rat and human samples for up to 48 hr. Whole rat brains, cooled at a rate approximating that of human brains awaiting autopsy, were collected at intervals from 0 to 48 hr after death and frozen. These samples were compared with freshly obtained, unfrozen rat brains...

journal_title：Journal of neuroscience research

authors： Johnson SA,Morgan DG,Finch CE

更新日期：1986-01-01 00:00:00

abstract：:Lead is putatively regarded as an environmental neurotoxicant. Long-term low-level lead exposure causes cognitive deficits, but the mechanism remains to be elucidated. In the present study, the excitatory effects of low-level lead exposure on action potential (AP) firing of pyramidal neurons in CA1 region of rat hippo...

journal_title：Journal of neuroscience research

authors： Yan D,Xiao C,Ma FL,Wang L,Luo YY,Liu J,Wang HL,Chen JT,Ruan DY

更新日期：2008-12-01 00:00:00

abstract：:Ferritin is the major iron storage protein and accounts for the majority of the iron in the brain. Thus, ferritin is a key component in protecting the brain from iron induced oxidative damage. The high lipid content, high rate of oxidative metabolism, and high iron content combine to make the brain the organ most susc...

journal_title：Journal of neuroscience research

authors： Connor JR,Boeshore KL,Benkovic SA,Menzies SL

更新日期：1994-03-01 00:00:00

abstract：:In the embryonic and postnatal rat retina a cell surface antigen that is detected by monoclonal antibody JONES is distributed in a dorsoventral gradient. Biochemical analysis has determined that the antigen is a modified ganglioside, 9-O-acetyl GD3. In the present study, the distributions of 9-O-acetyl GD3 and its pos...

journal_title：Journal of neuroscience research

authors： Sparrow JR,Barnstable CJ

更新日期：1988-10-01 00:00:00

abstract：:Grafting fetal ventral mesencephalon has been utilized to alleviate the symptoms of Parkinson's disease. One obstacle in using this approach is the limited outgrowth from the transplanted dopamine neurons. Thus, it is important to evaluate factors that promote outgrowth from fetal dopamine neurons. Proteoglycans (PGs)...

journal_title：Journal of neuroscience research

authors： Berglöf E,Plantman S,Johansson S,Strömberg I

更新日期：2008-01-01 00:00:00

abstract：:The expression of gangliosides of the lactosylceramide (LC) and of the gangliotetraosylceramide (GTC) series on the surface of cells from rat embryonic cerebellar tissue was investigated by double-color indirect immunofluorescence. GD3 was assumed to be representative of LC and was detected using a specific monoclonal...

journal_title：Journal of neuroscience research

authors： Gravotta D,Ferreira A,Busciglio J,Caceres A,Landa CA,Maccioni HJ

更新日期：1990-02-01 00:00:00

abstract：:Neuron expression of the cytokine tumor necrosis factor-alpha (TNF), and the regulation of the levels of TNF by alpha(2)-adrenergic receptor activation were investigated. Adult rat hippocampal neurons and phorbol ester (PMA)-differentiated SH-SY5Y cells were examined. Intracellular levels of TNF mRNA accumulation, as ...

journal_title：Journal of neuroscience research

authors： Renauld AE,Spengler RN

更新日期：2002-01-15 00:00:00

abstract：:Thirty-day readmission rates has been increasingly used by clinicians, hospital administrators, and policy makers as a metric for the quality of care. However, the 30-day readmission rates may be affected by other factors intrinsic to the patient and may not be a good measure of the quality of care provided by the hos...

journal_title：Journal of neuroscience research

authors： Ng I,Du R

更新日期：2020-01-01 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-exposed cats develop severe Parkinsonism that spontaneously resolves in 4-6 weeks. The present study examined the extent to which compensatory changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) gene and protein expression may underlie this behaviora...

journal_title：Journal of neuroscience research

authors： Rothblat DS,Schroeder JA,Schneider JS

更新日期：2001-08-01 00:00:00

abstract：:Programmed cell death involving gene regulation and de novo protein synthesis is a major component of both normal development and a number of disease conditions. Hence, knowledge of its mechanisms, especially transcription factors, that regulate expression of the genes involved in neurodegenerative disorders is of gre...

journal_title：Journal of neuroscience research

authors： Mioduszewska B,Jaworski J,Szklarczyk AW,Klejman A,Kaczmarek L

更新日期：2008-01-01 00:00:00

abstract：:We investigated whether a learning impairment after a controlled cortical impact (CCI) injury was associated with alterations in molecules involved in synaptic plasticity and learning and memory. Adult male rats with moderate CCI to the left parietal cortex, tested in a Morris water maze (MWM) beginning at postinjury ...

journal_title：Journal of neuroscience research

authors： Griesbach GS,Sutton RL,Hovda DA,Ying Z,Gomez-Pinilla F

更新日期：2009-02-15 00:00:00

abstract：:We review three principally different forms of injury-induced synaptic alterations. (1) Displacement of presynaptic terminals from perikarya and dendrites of axotomized neurons, (2) central changes in primary afferent terminals of peripherally axotomized sensory ganglion cells, and (3) anterograde Wallerian-type degen...

journal_title：Journal of neuroscience research

authors： Aldskogius H,Liu L,Svensson M

更新日期：1999-10-01 00:00:00

abstract：:The pathogenic processing of the amyloid precursor protein (APP) into beta-amyloid peptides, which give rise to beta-amyloid plaques in the brains of Alzheimer's disease patients, requires the enzymatic activity of the beta-site APP-cleaving enzyme 1 (BACE1). We report the cloning and sequence of a 1.5-kb DNA fragment...

journal_title：Journal of neuroscience research

authors： Lange-Dohna C,Zeitschel U,Gaunitz F,Perez-Polo JR,Bigl V,Rossner S

更新日期：2003-07-01 00:00:00

abstract：:Previous observations have demonstrated decreased in vivo and in vitro protein synthesis by brain ribosomal systems following long-term ethanol ingestion. For further investigation of the properties of brain ribosomes, the 40S and 60S ribosomal subunits were successfully isolated from control and chronic 10% ethanol-d...

journal_title：Journal of neuroscience research

authors： Tewari S,Murray S,Noble EP

更新日期：1978-01-01 00:00:00

abstract：:By using two different approaches, ubiquitin C-terminal hydrolase 1 (UCHL1) was identified as a potential cerebrospinal fluid (CSF) biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage (ASAH) and presumably other CNS damage and disease states. Appropriate antibodies and a sensitive ELISA were generated, an...

journal_title：Journal of neuroscience research

authors： Lewis SB,Wolper R,Chi YY,Miralia L,Wang Y,Yang C,Shaw G

更新日期：2010-05-15 00:00:00

abstract：:High levels of the proto-oncogene product, pp60c-src, have been found in developing and adult neural tissues as well as in certain fully mature cells of the hematopoietic lineage, e.g., platelets and myelomonocytes. Adrenal medullary chromaffin cells exhibit characteristics of both types of cells, i.e., they are deriv...

journal_title：Journal of neuroscience research

authors： Oddie KM,Litz JS,Balserak JC,Payne DM,Creutz CE,Parsons SJ

更新日期：1989-09-01 00:00:00

abstract：:Contacts between horizontal and bipolar cells are described in the retina of the teleost Eugerres plumieri. A single, long expansion observed in the external cone horizontal cells makes contact by means of a terminal button with the cell body of a bipolar. It represents the only contact between this class of horizonta...

journal_title：Journal of neuroscience research

authors： Parthe V

更新日期：1981-01-01 00:00:00

abstract：:Essential to understanding the roles proteins and structural elements play at the synapse is to understand the development, remodeling and reinnervation of peripheral neuromuscular junctions. It has, however, been a challenging task to label and visualize neuromuscular junctions. In this paper we demonstrate how adeno...

journal_title：Journal of neuroscience research

authors： Jacob JM,Zhou Q,Liu Y

更新日期：2000-07-01 00:00:00

abstract：:We have examined the expression and distribution of the extracellular matrix molecule tenascin-C in and around lesions of the thoracic dorsal columns in adult rats 3 days to 8 weeks after injury, using in situ hybridization, immunofluorescence, electron microscopy and immunoelectron microscopy. Numerous tenascin-C mRN...

journal_title：Journal of neuroscience research

authors： Zhang Y,Winterbottom JK,Schachner M,Lieberman AR,Anderson PN

更新日期：1997-08-15 00:00:00

abstract：:The transforming growth factors beta (TGF-beta), a family of regulatory polypeptides, are involved in numerous vital processes including inflammation and wound healing. Since repair of a peripheral nerve lesion includes a series of well-defined steps of cellular actions possibly controlled by TGF-beta s, and since TGF...

journal_title：Journal of neuroscience research

authors： Rufer M,Flanders K,Unsicker K

更新日期：1994-11-01 00:00:00

abstract：:Individuals who regularly shift their sleep timing, like night and/or shift-workers suffer from circadian desynchrony and are at risk of developing cardiometabolic diseases and cancer. Also, shift-work is are suggested to be a risk factor for the development of mood disorders such as the burn out syndrome, anxiety, an...

journal_title：Journal of neuroscience research

authors： Guerrero-Vargas NN,Zárate-Mozo C,Guzmán-Ruiz MA,Cárdenas-Rivera A,Escobar C

更新日期：2021-02-01 00:00:00

abstract：:Neuronal ceroid lipofuscinoses (NCLs) are a group of hereditary childhood diseases characterized mainly by lipopigment accumulation and a multisystemic pattern of symptoms including mental retardation, seizures, motor impairment, and blindness. The mnd mouse, carrying a mutation in the Cln8 gene, has been proposed as ...

journal_title：Journal of neuroscience research

authors： Bigini P,Milanese M,Gardoni F,Longhi A,Bonifacino T,Barbera S,Fumagalli E,Di Luca M,Mennini T,Bonanno G

更新日期：2012-06-01 00:00:00

abstract：:The response of cells localized in the brain subventricular zone (SVZ) to growth factor stimulation has been largely described for development and adult life, whereas no information on their behavior during aging is available. To address the question of whether the cells in the SVZ of old mice respond to the intracere...

journal_title：Journal of neuroscience research

authors： Tirassa P,Triaca V,Amendola T,Fiore M,Aloe L

更新日期：2003-06-01 00:00:00

abstract：:Prothrombin and its active derivative thrombin are key members of the coagulation system. The only site of extra-hepatic thrombin expression is the central nervous system (CNS), where it is involved in brain development, protection, and regeneration. Thrombin affects various degenerative and ischemic CNS diseases like...

journal_title：Journal of neuroscience research

authors： Krenzlin H,Lorenz V,Alessandri B

更新日期：2017-10-01 00:00:00

abstract：:Intracranial atherosclerosis (ICAS) is the most common etiology of ischemic stroke with the highest rate of stroke recurrence. Little is currently known of the association of circulating inflammation-regulatory microRNAs (miRNAs) with ICAS. In this review, we briefly discuss that ICAS is characterized as a dynamic and...

journal_title：Journal of neuroscience research

authors： Li J,Li K,Chen X

更新日期：2019-10-01 00:00:00

abstract：:Cross-linking of alpha-synuclein and Lewy body formation have been implicated in the dopaminergic neuronal cell death observed in Parkinson's disease (PD); the mechanisms responsible, however, are not clear. Reactive oxygen species and advanced glycation end products (AGEs) have been found in the intracellular, alpha-...

journal_title：Journal of neuroscience research

authors： Shaikh S,Nicholson LF

更新日期：2008-07-01 00:00:00

abstract：:Traumatic injury to the adult central nervous system (CNS) results in a rapid response from resident astrocytes, a process often referred to as reactive astrogliosis or glial scarring. The robust formation of the glial scar and its associated extracellular matrix (ECM) molecules have been suggested to interfere with a...

journal_title：Journal of neuroscience research

authors： McGraw J,Hiebert GW,Steeves JD

更新日期：2001-01-15 00:00:00