Abstract：
:Ferritin is the major iron storage protein and accounts for the majority of the iron in the brain. Thus, ferritin is a key component in protecting the brain from iron induced oxidative damage. The high lipid content, high rate of oxidative metabolism, and high iron content combine to make the brain the organ most susceptible to oxidative stress. The role of oxidative damage and disruption of brain iron homeostasis is considered clinically important to normal aging and a potential pathogenic component of a number of neurologic disorders including Alzheimer's disease and Parkinson's disease. Little is known, however, of the mechanism by which the brain maintains iron homeostasis at either the whole organ or cellular level. In this study we report the cellular distribution of the two isoforms of ferritin in the brain of adult subhuman primates. A subset of neurons immunolabel specifically for the H-chain ferritin protein, whereas cells resembling microglia are immunolabeled only after exposure to the L-chain ferritin antibody. Only one cell type immunostains for both H- and L-chain ferritin; these cells are morphologically similar and have the same distribution pattern as oligodendrocytes. Neither ferritin isoform is usually detected in astrocytes. These data indicate considerable differences in iron sequestration and use between neurons and glia and among neuronal and glial subtypes. This information will be essential in determining the role of each of these cells in maintaining general brain iron homeostasis and the relative abilities of these cells to withstand oxidative stress.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Connor JR,Boeshore KL,Benkovic SA,Menzies SLdoi
10.1002/jnr.490370405subject
Has Abstractpub_date
1994-03-01 00:00:00pages
461-5issue
4eissn
0360-4012issn
1097-4547journal_volume
37pub_type
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journal_title：Journal of neuroscience research
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
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更新日期：1990-07-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19990215)55:4<504::AID-JNR
更新日期：1999-02-15 00:00:00
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journal_title：Journal of neuroscience research
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更新日期：1995-04-15 00:00:00
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journal_title：Journal of neuroscience research
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journal_title：Journal of neuroscience research
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22591
更新日期：2011-05-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24493
更新日期：2019-12-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
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更新日期：1990-04-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(20000301)59:5<624::AID-JNR
更新日期：2000-03-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19990301)55:5<578::AID-JNR
更新日期：1999-03-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/1097-4547(20001201)62:5<717::AID-JNR11>3.0
更新日期：2000-12-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24275
更新日期：2018-10-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10009
更新日期：2001-11-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22803
更新日期：2012-04-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490410609
更新日期：1995-08-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490380605
更新日期：1994-08-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10156
更新日期：2002-03-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490200411
更新日期：1988-08-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
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更新日期：2002-01-15 00:00:00
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pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19960601)44:5<490::AID-JNR
更新日期：1996-06-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490360308
更新日期：1993-10-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.23853
更新日期：2017-01-02 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490330409
更新日期：1992-12-01 00:00:00
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更新日期：2001-12-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10512
更新日期：2003-03-01 00:00:00
abstract：:Apoptosis is a form of cell death historically defined by morphological and biochemical changes that occur in the cell body and nucleus. However, in contrast to nonneuronal cells in which apoptosis has been most intensively studied, neurons exhibit elaborate morphologies with synaptic connections often located at site...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-01 00:00:00
