Neuroinflammation and blood-brain barrier disruption following traumatic brain injury: Pathophysiology and potential therapeutic targets.

Abstract:

:Traumatic Brain Injury (TBI) is the most frequent cause of death and disability in young adults and children in the developed world, occurring in over 1.7 million persons and resulting in 50,000 deaths in the United States alone. The Centers for Disease Control and Prevention estimate that between 3.2 and 5.3 million persons in the United States live with a TBI-related disability, including several neurocognitive disorders and functional limitations. Following the primary mechanical injury in TBI, literature suggests the presence of a delayed secondary injury involving a variety of neuroinflammatory changes. In the hours to days following a TBI, several signaling molecules and metabolic derangements result in disruption of the blood-brain barrier, leading to an extravasation of immune cells and cerebral edema. The primary, sudden injury in TBI occurs as a direct result of impact and therefore cannot be treated, but the timeline and pathophysiology of the delayed, secondary injury allows for a window of possible therapeutic options. The goal of this review is to discuss the pathophysiology of the primary and delayed injury in TBI as well as present several preclinical studies that identify molecular targets in the potential treatment of TBI. Additionally, certain recent clinical trials are briefly discussed to demonstrate the current state of TBI investigation.

journal_name

J Neurosci Res

authors

Sulhan S,Lyon KA,Shapiro LA,Huang JH

doi

10.1002/jnr.24331

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

19-28

issue

1

eissn

0360-4012

issn

1097-4547

journal_volume

98

pub_type

杂志文章,评审
  • The involvement of thrombin in the pathogenesis of glioblastoma.

    abstract::Prothrombin and its active derivative thrombin are key members of the coagulation system. The only site of extra-hepatic thrombin expression is the central nervous system (CNS), where it is involved in brain development, protection, and regeneration. Thrombin affects various degenerative and ischemic CNS diseases like...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.24049

    authors: Krenzlin H,Lorenz V,Alessandri B

    更新日期:2017-10-01 00:00:00

  • I(h) "run-up" in rat neocortical neurons and transiently rat or human HCN1-expressing HEK293 cells.

    abstract::Hyperpolarization-activated cyclic nucleotide-gated ion channels (HCN) are key determinants of CNS functions. Here we describe an increase in hyperpolarization-activated current (I(h)) at the beginning of whole-cell recordings in rat layer 5 cortical neurons. For a closer investigation of this I(h) increase, we overex...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22475

    authors: Battefeld A,Bierwirth C,Li YC,Barthel L,Velmans T,Strauss U

    更新日期:2010-11-01 00:00:00

  • Liquid diet induces memory impairment accompanied by a decreased number of hippocampal neurons in mice.

    abstract::It is suggested that masticatory dysfunction affects the central nervous system; however, the underlying mechanism remains unknown. Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are known to play important roles in memory and learning. In this study, we examined the effects of mastication on memory,...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.23383

    authors: Okihara H,Ito J,Kokai S,Ishida T,Hiranuma M,Kato C,Yabushita T,Ishida K,Ono T,Michikawa M

    更新日期:2014-08-01 00:00:00

  • Characterization of the neuroimmune protein F5: localization to the dendrites and perikarya of mature neurons and the basal aspect of choroid plexus epithelial cells.

    abstract::F5 was identified originally as an interleukin-2-regulated gene in L2 cells, a murine helper T-lymphocyte clone. In adult mouse, F5 mRNA was expressed at a modest level in lymphoid tissues, at a high level in mature neurons in the nervous system, but not in other tissues. Although the F5 sequence is highly conserved o...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490360308

    authors: Arai M,Cohen JA

    更新日期:1993-10-15 00:00:00

  • Microglia and Alzheimer's disease pathogenesis.

    abstract::The most visible and, until very recently, the only hypothesis regarding the involvement of microglial cells in Alzheimer's disease (AD) pathogenesis is centered around the notion that activated microglia are neurotoxin-producing immune effector cells actively involved in causing the neurodegeneration that is the caus...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.20093

    authors: Streit WJ

    更新日期:2004-07-01 00:00:00

  • Specificity of human T cell clones reactive to immunodominant epitopes of myelin basic protein.

    abstract::Several recently discovered lines of evidence support the involvement of myelin basic protein (BP)-specific T cells in multiple sclerosis (MS). To identify potentially relevant immunodominant T cell epitopes, human BP (Hu-BP)-reactive T cell lines were selected from MS and normal donors and tested for reactivity to cl...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490280215

    authors: Chou YK,Henderikx P,Vainiene M,Whitham R,Bourdette D,Chou CH,Hashim G,Offner H,Vandenbark AA

    更新日期:1991-02-01 00:00:00

  • Divergent role for MMP-2 in myelin breakdown and oligodendrocyte death following transient global ischemia.

    abstract::Transient global ischemia causes delayed white matter injury to the brain with oligodendrocyte (OLG) death and myelin breakdown. There is increasing evidence that hypoxia may be involved in several diseases of the white matter, including multiple sclerosis, vascular dementia, and ischemia. Matrix metalloproteinases (M...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22257

    authors: Walker EJ,Rosenberg GA

    更新日期:2010-03-01 00:00:00

  • Rab7 may be a novel therapeutic target for neurologic diseases as a key regulator in autophagy.

    abstract::Macroautophagy is an evolutionally conserved membrane trafficking pathway that delivers intracellular materials to lysosomes for degradation and recycling. Rab7, as a member of the Rab GTPase superfamily, has a unique role in the regulation of macroautophagy, especially in modulating autophagy flux. The functional sta...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.24034

    authors: Wen H,Zhan L,Chen S,Long L,Xu E

    更新日期:2017-10-01 00:00:00

  • SNAP-25 requirement for dendritic growth of hippocampal neurons.

    abstract::Structure and dimension of the dendritic arbor are important determinants of information processing by the nerve cell, but mechanisms and molecules involved in dendritic growth are essentially unknown. We investigated early mechanisms of dendritic growth using mouse fetal hippocampal neurons in primary culture, which ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19990601)56:5<539::AID-JNR

    authors: Grosse G,Grosse J,Tapp R,Kuchinke J,Gorsleben M,Fetter I,Höhne-Zell B,Gratzl M,Bergmann M

    更新日期:1999-06-01 00:00:00

  • Delayed leptin administration after stroke induces neurogenesis and angiogenesis.

    abstract::Leptin is a potent AMP kinase (AMPK) inhibitor that induces neuroprotection, neurogenesis, and angiogenesis when administered immediately after stroke. To dissociate these effects, we explored the effects of delayed administration of leptin, at 10 days after stroke onset, on neurogenesis and angiogenesis after stroke....

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.23147

    authors: Avraham Y,Dayan M,Lassri V,Vorobiev L,Davidi N,Chernoguz D,Berry E,Leker RR

    更新日期:2013-02-01 00:00:00

  • Statistical morphological analysis of hippocampal principal neurons indicates cell-specific repulsion of dendrites from their own cell.

    abstract::Traditionally, the sources of guidance cues for dendritic outgrowth are mainly associated with external bodies (A) rather than with the same neuron from which dendrites originate (B). To quantify the relationship between factors A and B as determinants of the adult dendritic shape, the morphology of 83 intracellularly...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.10475

    authors: Samsonovich AV,Ascoli GA

    更新日期:2003-01-15 00:00:00

  • Hyperosmotic mannitol induces Src kinase-dependent phosphorylation of beta-catenin in cerebral endothelial cells.

    abstract::Mannitol, which is a cell-impermeable and nontoxic polyalcohol, has been shown to be a useful tool for reversible opening of the blood-brain barrier (BBB). Despite successful clinical trials, the molecular mechanism of the mannitol-induced changes in cerebral endothelial cells (CECs) are poorly understood. For our exp...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20521

    authors: Farkas A,Szatmári E,Orbók A,Wilhelm I,Wejksza K,Nagyoszi P,Hutamekalin P,Bauer H,Bauer HC,Traweger A,Krizbai IA

    更新日期:2005-06-15 00:00:00

  • Advanced glycation end products induce in vitro cross-linking of alpha-synuclein and accelerate the process of intracellular inclusion body formation.

    abstract::Cross-linking of alpha-synuclein and Lewy body formation have been implicated in the dopaminergic neuronal cell death observed in Parkinson's disease (PD); the mechanisms responsible, however, are not clear. Reactive oxygen species and advanced glycation end products (AGEs) have been found in the intracellular, alpha-...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21644

    authors: Shaikh S,Nicholson LF

    更新日期:2008-07-01 00:00:00

  • Differential lineage restriction of rat retinal progenitor cells in vitro and in vivo.

    abstract::To identify and characterize the lineage potential of rat neural retina progenitor cells (NRPCs) in vitro and engrafted into rats with retinal degeneration, NRPCs were isolated from neural retinas of embryonic day 17 Long Evans rats and cultured in serum-free or serum-containing media with fibroblast growth factor 2 a...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.10320

    authors: Yang P,Seiler MJ,Aramant RB,Whittemore SR

    更新日期:2002-08-15 00:00:00

  • Neural precursor cell susceptibility to human cytomegalovirus diverges along glial or neuronal differentiation pathways.

    abstract::Cytomegalovirus (CMV) is a major cause of congenital brain disease, and its neuropathogenesis may be related to viral infection of rapidly dividing, susceptible neural precursor cells (NPCs). In the present study, we evaluated the susceptibility of human fetal brain-derived NPCs (nestin(+), A2B5(+), CD133(+)) to infec...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20682

    authors: Cheeran MC,Hu S,Ni HT,Sheng W,Palmquist JM,Peterson PK,Lokensgard JR

    更新日期:2005-12-15 00:00:00

  • Distribution of mitochondria along small-diameter myelinated central nervous system axons.

    abstract::Small-diameter myelinated CNS axons are preferentially affected in multiple sclerosis (MS) and in the hereditary spastic paraplegias (HSP), in which the distal axon degenerates. Mitochondrial dysfunction has been implicated in the pathogenesis of these and other disorders involving axonal degeneration. The aim of this...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21672

    authors: Edgar JM,McCulloch MC,Thomson CE,Griffiths IR

    更新日期:2008-08-01 00:00:00

  • Expression of TNF alpha in central neurons of Lewis rat spinal cord after EAE induction.

    abstract::Experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), is a demyelinating autoimmune disease of the central nervous system (CNS). The proinflammatory cytokine TNF alpha, as an endogenous mediator of inflammation, plays an important role in the pathogenesis of EAE disease. In this s...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19970901)49:5<592::AID-JNR

    authors: Villarroya H,Marie Y,Ouallet JC,Le Saux F,Tchélingérian JL,Baumann N

    更新日期:1997-09-01 00:00:00

  • Early-stage development of human induced pluripotent stem cell-derived neurons.

    abstract::Recent advances in human induced pluripotent stem cells (hiPSCs) offer new possibilities for biomedical research and clinical applications. Differentiated neurons from hiPSCs are expected to be useful for developing novel methods of treatment for various neurological diseases. However, the detailed process of function...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.23666

    authors: Ohara Y,Koganezawa N,Yamazaki H,Roppongi RT,Sato K,Sekino Y,Shirao T

    更新日期:2015-12-01 00:00:00

  • Calcium-sensing receptor stimulates secretion of an interferon-gamma-induced monokine (CXCL10) and monocyte chemoattractant protein-3 in immortalized GnRH neurons.

    abstract::Biology of GnRH neurons is critically dependent on extracellular Ca(2+) (Ca(2+) (o)). We evaluated differences in gene expression patterns with low and high Ca(2+) (o) in an immortalized GnRH neuron line, GT1-7 cells. Mouse global oligonucleotide microarray was used to evaluate transcriptional differences among the ge...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21177

    authors: Bandyopadhyay S,Jeong KH,Hansen JT,Vassilev PM,Brown EM,Chattopadhyay N

    更新日期:2007-03-01 00:00:00

  • Lentiviral transduction of murine oligodendrocytes in vivo.

    abstract::Lentiviral vectors are used widely to direct efficient gene transfer in vivo. We examined cell-specific expression in adult murine white matter after stereotaxic microinjection of four lentiviral constructs. We synthesized vesicular stomatitis virus glycoprotein (VSV-G) pseudotyped lentiviruses with combinations of tw...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20626

    authors: McIver SR,Lee CS,Lee JM,Green SH,Sands MS,Snider BJ,Goldberg MP

    更新日期:2005-11-01 00:00:00

  • Inflammation-regulatory microRNAs: Valuable targets for intracranial atherosclerosis.

    abstract::Intracranial atherosclerosis (ICAS) is the most common etiology of ischemic stroke with the highest rate of stroke recurrence. Little is currently known of the association of circulating inflammation-regulatory microRNAs (miRNAs) with ICAS. In this review, we briefly discuss that ICAS is characterized as a dynamic and...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.24487

    authors: Li J,Li K,Chen X

    更新日期:2019-10-01 00:00:00

  • Chronic phencyclidine induces behavioral sensitization and apoptotic cell death in the olfactory and piriform cortex.

    abstract::In this study, we tested the hypothesis that chronic administration of phencyclidine (PCP), an N-methyl-D-aspartate (NMDA) receptor antagonist, would cause a long-lasting behavioral sensitization associated with neuronal toxicity. Female Sprague-Dawley rats were administered PCP (20 mg/kg, i.p.) once a day for 5 days,...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19980615)52:6<709::AID-JNR

    authors: Johnson KM,Phillips M,Wang C,Kevetter GA

    更新日期:1998-06-15 00:00:00

  • Formation of new sensory cells in deafferented tuberous organs of the gymnotid fish Eigenmannia virescens.

    abstract::The cutaneous electroreceptor "tuberous organs" of the lateral line system of Eigenmannia virescens were studied at light and electron microscopic levels with immunohistochemical and autoradiographic techniques after sectioning of the posterior branch of the lateral line nerve. After deafferentation total degeneration...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490390506

    authors: Bensouilah M,Denizot JP

    更新日期:1994-12-01 00:00:00

  • C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation.

    abstract::Microglia, central nervous system (CNS) resident phagocytic cells, persistently police the integrity of CNS tissue and respond to any kind of damage or pathophysiological changes. These cells sense and rapidly respond to danger and inflammatory signals by changing their cell morphology; by release of cytokines, chemok...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21875

    authors: Färber K,Cheung G,Mitchell D,Wallis R,Weihe E,Schwaeble W,Kettenmann H

    更新日期:2009-02-15 00:00:00

  • Characterization of astrocytes derived from human NTera-2/D1 embryonal carcinoma cells.

    abstract::Astrocytes are the predominant cell type in the vicinity of glutamatergic synapses, where they monitor and maintain low levels of glutamate. Synaptic homeostasis of glutamate involves its removal from the synaptic cleft via high-affinity glutamate transporters, glutamate transporter-1 (GLT-1)/excitatory amino acid tra...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.10236

    authors: Sandhu JK,Sikorska M,Walker PR

    更新日期:2002-06-01 00:00:00

  • Reduction in 5-HT1A receptor density, 5-HT1A mRNA expression, and functional correlates for 5-HT1A receptors in genetically defined aggressive rats.

    abstract::The present experiments tested the hypothesis that one of the critical mechanisms underlying genetically defined aggressiveness involves brain serotonin 5-HT1A receptors. 5-HT1A receptor density, the receptor mRNA expression in brain structures, and functional correlates for 5-HT1A receptors identified as 8-OH-DPAT-in...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20456

    authors: Popova NK,Naumenko VS,Plyusnina IZ,Kulikov AV

    更新日期:2005-04-15 00:00:00

  • Differential vulnerability of cortical and cerebellar neurons in primary culture to oxygen glucose deprivation followed by reoxygenation.

    abstract::The effects of glucose and O2 deprivation (OGD) on the survival of cortical and cerebellar neurons were examined to characterize the biochemical mechanisms involved in OGD and OGD followed by reoxygenation. To this aim, neurons were kept for different time periods in a hypoxic chamber with a controlled atmosphere of 9...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/1097-4547(20010101)63:1<20::AID-JNR3>3.0.C

    authors: Scorziello A,Pellegrini C,Forte L,Tortiglione A,Gioielli A,Iossa S,Amoroso S,Tufano R,Di Renzo G,Annunziato L

    更新日期:2001-01-01 00:00:00

  • Inhibition of proteoglycan synthesis affects neuronal outgrowth and astrocytic migration in organotypic cultures of fetal ventral mesencephalon.

    abstract::Grafting fetal ventral mesencephalon has been utilized to alleviate the symptoms of Parkinson's disease. One obstacle in using this approach is the limited outgrowth from the transplanted dopamine neurons. Thus, it is important to evaluate factors that promote outgrowth from fetal dopamine neurons. Proteoglycans (PGs)...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21465

    authors: Berglöf E,Plantman S,Johansson S,Strömberg I

    更新日期:2008-01-01 00:00:00

  • Diversity of immune cell types in multiple sclerosis and its animal model: Pathological and therapeutic implications.

    abstract::Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system with an autoimmune attack on the components of the myelin sheath and axons. The etiology of the disease remains largely unknown, but it is commonly acknowledged that the development of MS probably results from the interacti...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.24023

    authors: Cheng Y,Sun L,Xie Z,Fan X,Cao Q,Han J,Zhu J,Jin T

    更新日期:2017-10-01 00:00:00

  • Effect of acute hyperglycemia on visual cortical activation as measured by functional MRI.

    abstract::To determine whether acute hyperglycemia changes the hyperemic response to functional activation of brain, the area and magnitude of the activation were measured in healthy volunteers maintained at euglycemia and then at hyperglycemia using the hyperglycemic clamp technique. Activation of the visual cortex (8-16 Hz) w...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/1097-4547(20001015)62:2<279::AID-JNR12>3.0

    authors: Gruetter R,Uğurbil K,Seaquist ER

    更新日期:2000-10-15 00:00:00