Abstract:
:The neurotrophins are important for their long-term effects on the survival and differentiation of many types of neurons during development. They also appear to protect mature neurons from injury caused by nutrient or oxygen deprivation. More recently, the neurotrophins have been implicated in such short-term processes as synaptic plasticity. A great deal of evidence suggests that intracellular calcium levels play a key role in neuronal survival during normal development, in neuronal injury following nutrient or oxygen deprivation, and in synaptic plasticity as well. Maintaining appropriate intracellular levels of calcium is important for proper biological function and it has been shown that one of the actions of the neurotrophins is to modulate intracellular calcium levels in a number of in vivo and in vitro systems. Some information about the mechanism(s) by which this is accomplished is now available. Understanding the mechanisms of neurotrophin action should provide insights into the processes by which the brain functions and, further, provide therapeutic tools for the treatment of neuronal injury and neurodegenerative diseases.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Jiang H,Guroff Gdoi
10.1002/(SICI)1097-4547(19971101)50:3<355::AID-JNRsubject
Has Abstractpub_date
1997-11-01 00:00:00pages
355-60issue
3eissn
0360-4012issn
1097-4547pii
10.1002/(SICI)1097-4547(19971101)50:3<355::AID-JNRjournal_volume
50pub_type
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