Effects of 2-deoxy-D-glucose on multi-unit activity of the hypothalamus in rats.

Abstract:

:Multi-unit activity was recorded from the diencephalon of unanesthetized, immobilized female rats. Less than 50% of the recording sites in the hypothalamus showed changes in the level of multi-unit activity to changes in the level of glucose utilization induced by injection of 2-deoxy-D-glucose (2-DG). It was also not possible to specificy an area within the hypothalamus in which there was a concentration of recording sites which consistently responded to 2-DG. Relatively large amplitude, long duration changes in multi-unit activity levels were also observed in the optic tract, suggesting that 2-DG induced a widespread cellular metabolic response to glucoprivation which may not have been related to the regulation of feeding.

journal_name

J Neurosci Res

authors

Rabin BM,Miller DS

doi

10.1002/jnr.490050308

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

233-9

issue

3

eissn

0360-4012

issn

1097-4547

journal_volume

5

pub_type

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