Abstract:
:Multi-unit activity was recorded from the diencephalon of unanesthetized, immobilized female rats. Less than 50% of the recording sites in the hypothalamus showed changes in the level of multi-unit activity to changes in the level of glucose utilization induced by injection of 2-deoxy-D-glucose (2-DG). It was also not possible to specificy an area within the hypothalamus in which there was a concentration of recording sites which consistently responded to 2-DG. Relatively large amplitude, long duration changes in multi-unit activity levels were also observed in the optic tract, suggesting that 2-DG induced a widespread cellular metabolic response to glucoprivation which may not have been related to the regulation of feeding.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Rabin BM,Miller DSdoi
10.1002/jnr.490050308subject
Has Abstractpub_date
1980-01-01 00:00:00pages
233-9issue
3eissn
0360-4012issn
1097-4547journal_volume
5pub_type
杂志文章abstract::Electrical activity shapes development of the nervous system, presumably in part by regulating gene expression. A set of regulatory genes, immediate early genes (IEGs), which are responsive to a number of extrinsic cellular stimuli have been proposed to play a role in coupling such activity to gene expression. Using a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490350502
更新日期:1993-08-01 00:00:00
abstract::Scar formation after injury of the brain or spinal cord is a common event. While glial scar formation by astrocytes has been extensively studied, much less is known about the fibrotic scar, in particular after stroke. Platelet-derived growth factor receptor ß-expressing (PDGFRß+ ) pericytes have been suggested as a so...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24557
更新日期:2020-05-01 00:00:00
abstract::Previous observations have demonstrated decreased in vivo and in vitro protein synthesis by brain ribosomal systems following long-term ethanol ingestion. For further investigation of the properties of brain ribosomes, the 40S and 60S ribosomal subunits were successfully isolated from control and chronic 10% ethanol-d...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490030509
更新日期:1978-01-01 00:00:00
abstract::Dorsal root ganglia (DRG) neurons connect the spinal cord and uterine cervix, and are activated at parturition with subsequent stimulation of secondary neurons in the spinal dorsal horn and autonomic areas. Neuropeptide neurotransmitters and receptors have been studied in these areas, but amino acid transmitters, e.g....
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21225
更新日期:2007-05-01 00:00:00
abstract::The types of cells contacted by growth cones were examined in chick-quail and vice versa chimeras. Simultaneously, the presence of nonspecific cholinesterase (nChE) was monitored in developing peripheral nerves of these embryos. In all the chimeras studied, the growth cones were in contact with both Schwann cell proge...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490310211
更新日期:1992-02-01 00:00:00
abstract::Glial cell-line derived neurotrophic factor (GDNF) is the most potent trophic factor for motoneuron survival and neuromuscular junction formation. GDNF is upregulated in injured or denervated skeletal muscle and returns to normal levels following reinnervation. However, the mechanism by which GDNF is regulated in dene...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23512
更新日期:2015-03-01 00:00:00
abstract::Nerve growth factor (NGF) is the best-characterized neurotrophic substance and has recently been shown to influence cholinergic neurons in the basal forebrain. Hippocampus and neocortex, the primary targets for these central neurons, have further been found to contain high levels of NGF. Using enzyme immunoassay and a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180404
更新日期:1987-01-01 00:00:00
abstract::Apolipoprotein E (apo-E), a protein involved in lipid metabolism and cholesterol transport, has been found to be up-regulated in CNS injury and is associated with Alzheimer's disease in humans. In this study, we show that apo-E is also up-regulated after complete spinal cord transection in the C57BL/6 mouse. In the un...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10482
更新日期:2003-02-01 00:00:00
abstract::The close homologue of L1 (CHL1) is a member of the L1 family of cell recognition molecules. The protein is expressed by a variety of nerve cell types and subpopulations of glial cells in vivo and promotes elongation of neurites and survival of nerve cells in vitro. Here we demonstrate that glial cells up-regulate exp...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10533
更新日期:2003-03-15 00:00:00
abstract::The iron transport protein, transferrin, and the iron storage protein ferritin were examined immunohistochemically along with iron in a number of brain regions from normal and aged humans. Two age groups were examined: a middle-aged group (28-49 years), and an older group (60-90 years). Transferrin, ferritin, and iron...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490270421
更新日期:1990-12-01 00:00:00
abstract::Retinal microglia play an important role as resident immunocompetent and phagocytic cells in the event of injury and disease. Retinal microglia and microglia precursor transplantation show a rescue effect in ischemic retina and retinal degeneration. However, studies of retinal microglia have been hampered by the diffi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23337
更新日期:2014-04-01 00:00:00
abstract::Four major discoveries on the function of the pedunculopontine nucleus (PPN) have significantly advanced our understanding of the role of arousal in neurodegenerative disorders. The first was the finding that stimulation of the PPN-induced controlled locomotion on a treadmill in decerebrate animals, the second was the...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24417
更新日期:2019-12-01 00:00:00
abstract::Traumatic injury to the adult central nervous system (CNS) results in a rapid response from resident astrocytes, a process often referred to as reactive astrogliosis or glial scarring. The robust formation of the glial scar and its associated extracellular matrix (ECM) molecules have been suggested to interfere with a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/1097-4547(20010115)63:2<109::AID-JNR1002>3
更新日期:2001-01-15 00:00:00
abstract::The expression of many myelin-specific molecules in Schwann cells is profoundly decreased following denervation. This study examines the early reexpression of myelin protein genes associated with reinnervation. Following sciatic nerve crush, the distal, regenerated nerve was divided into appropriate (2.5 or 5 mm) cons...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490270202
更新日期:1990-10-01 00:00:00
abstract::Treatment of chromaffin cells with nitric oxide (NO) donors (SNP and SNAP) and peroxynitrite produces a time- and dose-dependent necrotic and apoptotic cell death. Necrotic cell death was characterized by both an increase in lactate dehydrogenase and ATP release and changes in nuclei and cell morphology (as seen with ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20853
更新日期:2006-07-01 00:00:00
abstract::The periglomerular cells (PG) of the olfactory bulb (OB) are involved in the primary processing and the refinement of sensory information from the olfactory epithelium. The neurochemical composition of these neurons has been studied in depth in many species, and over the last decades such studies have focused mainly o...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22521
更新日期:2011-01-01 00:00:00
abstract::Intrinsic mechanisms that guide damaged axons to regenerate following spinal cord injury remain poorly understood. Manipulation of posttranslational modifications of key proteins in mature neurons could reinvigorate growth machinery after injury. One such modification is acetylation, a reversible process controlled by...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23573
更新日期:2015-08-01 00:00:00
abstract::Here we assess the potential functional role of increased aquaporin 9 (APQ9) in astrocytes. Increased AQP9 expression was achieved in primary astrocyte cultures by transfection of a plasmid-containing green fluorescent protein fused to either wild-type or mutated human AQP9. Increased AQP9 expression and phosphorylati...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24061
更新日期:2018-02-01 00:00:00
abstract::We have studied the effect of induced glial fibrillary acidic protein (GFAP) on motility, cell morphology, and proliferation of two originally GFAP-negative human glioma cell lines. Glioma cell lines U-1242 MG and U-251 MG sp subclone 3A were transfected with a vector system that allows for an inducible GFAP expressio...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000415)60:2<245::AID-JNR
更新日期:2000-04-15 00:00:00
abstract::Data from a study in which 12 chronic mental patients and 12 control subject were given D-[3-14C] glucose intravenously in our arterio-venous technique for determining cerebral metabolism in vivo were reexamined. Previously unpublished whole-blood lactate determinations in these experiments indicated a cerebral produc...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490060209
更新日期:1981-01-01 00:00:00
abstract::Activation of proteolytic enzymes, including the caspase family of proteinases, is a feature characteristic of the apoptotic program. In the present study, we examined a potential role of intracellular proteinases in the death of neuronal PC12 and primary cultured rat microglial cells induced by 6-hydroxydopamine (6-O...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19981015)54:2<214::AID-JNR
更新日期:1998-10-15 00:00:00
abstract::Parallel corticostriatonigral circuits have been proposed that separately process motor, cognitive, and emotional-motivational information. Functional integration requires that interactions exist between neurons participating in these circuits. This makes it imperative to study the complex anatomical substrate underly...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24242
更新日期:2018-09-01 00:00:00
abstract::Although proteins belonging to the sHSP superfamily are diverse in sequence and size, most share characteristic features, including 1) a small molecular mass of 12-43 kDa, 2) a conserved alpha-crystallin domain of 80-100 residues, 3) formation of large oligomers, 4) a dynamic quaternary structure, and 5) induction by ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.21682
更新日期:2008-08-01 00:00:00
abstract::The role of insulin-like growth factor-1 (IGF-1) in amyotrophic lateral sclerosis (ALS) and its mechanism of action are important from both pathogenic and therapeutic points of view. The present study investigated the changes of IGF-1Rbeta and the key intracellular downstream protein insulin receptor substrate-1 (IRS-...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20668
更新日期:2005-11-15 00:00:00
abstract::Neurodevelopmental disorders (NDDs) such as intellectual disability and autism spectrum disorder consistently show a male bias in prevalence, but it remains unclear why males and females are affected with different frequency. While many behavioral studies of transgenic NDD models have focused only on males, the requir...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24577
更新日期:2021-01-01 00:00:00
abstract::The induction of heat-shock protein 70 (hsp70) mRNA in the hyperthermic rabbit brain has been examined previously by using Northern blotting and in situ hybridization procedures that measure steady-state levels of mRNA, which may be influenced by transcript stability and transcription rate. In the present investigatio...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980601)52:5<538::AID-JNR
更新日期:1998-06-01 00:00:00
abstract::Restless Legs Syndrome (RLS) is a disorder of sensation with a prevalence of around 2-5% of the population. Relevant to understanding the possible pathophysiological mechanism is the fact that RLS is extremely responsive to dopaminergic agents. A second issue is that iron deficiency states may precipitate RLS in as mu...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/1097-4547(20001201)62:5<623::AID-JNR1>3.0.
更新日期:2000-12-01 00:00:00
abstract::Uptake of 2-deoxy-D-glucose (2-DG) has been studied in synaptosomes from the Long-Evans rat. Although there are some differences, the results are generally similar to those reported for Sprague--Dawley rats. Both D-glucose and 2-DG are taken up by the same carrier, since D-glucose was found to inhibit uptake of 2-DG. ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490040207
更新日期:1979-01-01 00:00:00
abstract::Zinc is an endogenous N-methyl-D-aspartate (NMDA) receptor blocker. It is possible that zinc-mediated modification of hippocampal CA1 long-term potentiation (LTP) is linked to the expression of NMDA receptor subunits, which varies with postnatal development. In the present study, the effect of ZnCl(2) and CaEDTA, a me...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22787
更新日期:2012-03-01 00:00:00
abstract::The neurotrophin receptor p75 (p75NTR) is expressed by both neurons and glia. Nerve injury triggers up-regulation of p75NTR in Schwann cells (SC) but not in central glia. In contrast to neuronal p75NTR, which mediates negative signals from myelin-associated proteins resulting in neurite collapse, glial p75NTR may play...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.21220
更新日期:2007-06-01 00:00:00