Immortalization of bipotential glial progenitors and generation of permanent "blue" cell lines.

abstract：:The effects of the environmental contaminants methylmercury (MeHg) and inorganic mercury (HgCl(2)) on cell viability, intracellular calcium concentration ([Ca(2+)](i)), and reactive oxygen species (ROS) generation were studied in rat cerebellar granule neuron cultures using fluorescent methods. MeHg exhibited an LC(50...

journal_title：Journal of neuroscience research

authors： Gassó S,Cristòfol RM,Selema G,Rosa R,Rodríguez-Farré E,Sanfeliu C

更新日期：2001-10-01 00:00:00

abstract：:In this study we used as glial cell models, early and late passage C-6 glial cells, 2B clone, and advanced passages of glial cells derived from aged mouse cerebral hemispheres (MACH) to examine responsiveness to opioids. We have previously reported that early passage C-6 glial cells, 2B clone, are bipotential and can ...

journal_title：Journal of neuroscience research

authors： Kozlova M,Kentroti S,Vernadakis A

更新日期：1993-12-01 00:00:00

abstract：:Increased serum level of homocysteine, a sulfur-containing amino acid, is considered a risk factor in vascular disorders and in dementias. The effect of homocysteine and metabolically related compounds on brain production of kynurenic acid (KYNA), an endogenous antagonist of glutamate ionotropic receptors, was studied...

journal_title：Journal of neuroscience research

authors： Luchowska E,Luchowski P,Paczek R,Ziembowicz A,Kocki T,Turski WA,Wielosz M,Lazarewicz J,Urbanska EM

更新日期：2005-02-01 00:00:00

abstract：:To determine whether acute hyperglycemia changes the hyperemic response to functional activation of brain, the area and magnitude of the activation were measured in healthy volunteers maintained at euglycemia and then at hyperglycemia using the hyperglycemic clamp technique. Activation of the visual cortex (8-16 Hz) w...

journal_title：Journal of neuroscience research

authors： Gruetter R,Uğurbil K,Seaquist ER

更新日期：2000-10-15 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease with similarities to multiple sclerosis that requires the activation of auto reactive T cells that infiltrate the central nervous system. In previous studies we have shown that intraperitoneal administration of synaptosomal antige...

journal_title：Journal of neuroscience research

authors： Scerbo MJ,Rupil LL,Bibolini MJ,Roth GA,Monferran CG

更新日期：2009-08-01 00:00:00

abstract：:Spinal cord injury (SCI) triggers chronic intraspinal inflammation consisting of activated resident and infiltrating immune cells (especially microglia/macrophages). The environmental factors contributing to this protracted inflammation are not well understood; however, myelin lipid debris is a hallmark of SCI. Myelin...

journal_title：Journal of neuroscience research

authors： Kopper TJ,Gensel JC

更新日期：2018-06-01 00:00:00

abstract：:N-cadherin and beta-catenin are involved in cell adhesion and cell cycle in tumor cells and neural crest. Both are expressed at key stages of Schwann cell (SC) development, but little is known about their function in the SC lineage. We studied the role of these molecules in adult rat derived SC-embryonic dorsal root g...

journal_title：Journal of neuroscience research

authors： Gess B,Halfter H,Kleffner I,Monje P,Athauda G,Wood PM,Young P,Wanner IB

更新日期：2008-03-01 00:00:00

abstract：:Ionotropic N-methyl-D-aspartate (NMDA) receptor agonists, L-aspartic acid (L-Asp) and NMDA, have been shown to inhibit histamine-stimulated acid secretion, but their effect on gastric mucosal blood flow (GMBF) is largely unknown. The aim of this study was to investigate whether L-Asp and NMDA inhibit histamine-stimula...

journal_title：Journal of neuroscience research

authors： Tsai LH,Lee YJ,Wu JY

更新日期：2004-09-01 00:00:00

abstract：:The expression of GABAB receptors in cultured mouse cerebellar granule cells was investigated in binding experiments using [3H](S,R)-baclofen as well as in functional assessment of the ability of (R)-baclofen to interact with depolarization (15-40 mM KCl) coupled changes in intracellular Ca2+ homeostasis and neurotran...

journal_title：Journal of neuroscience research

authors： Kardos J,Elster L,Damgaard I,Krogsgaard-Larsen P,Schousboe A

更新日期：1994-12-15 00:00:00

abstract：:Monoclonal 2C3 specific to β-amyloid (Aβ) oligomers (AβOs) enabled us to test our hypothesis that the alteration of lipoprotein-Aβ interaction in the central nervous system (CNS) initiates and/or accelerates the cascade favoring Aβ assembly. Immunoprecipitation of frontal cortex employing 2C3 unequivocally detected so...

journal_title：Journal of neuroscience research

authors： Takamura A,Kawarabayashi T,Yokoseki T,Shibata M,Morishima-Kawashima M,Saito Y,Murayama S,Ihara Y,Abe K,Shoji M,Michikawa M,Matsubara E

更新日期：2011-06-01 00:00:00

abstract：:Monoclonal antibody J1-31 (MAb J1-31, isotype IgG 2b) was raised against crude homogenate of brain tissue from a multiple sclerosis (MS) patient (autopsy sample; Malhotra et al.: Microbios Letters 26:151-157, 1984). In human brain, MAb J1-31 recognizes an intracellular protein antigen (J1-31 antigen), which bands at a...

journal_title：Journal of neuroscience research

authors： Malhotra SK,Predy R,Johnson ES,Singh R,Leeuw K

更新日期：1989-01-01 00:00:00

abstract：:Both IgCAMs and the actin cytoskeleton play critical roles in neuronal growth cone motility and guidance. However, it is unclear how IgCAM receptors transduce signals from the plasma membrane to induce actin remodeling. Previous studies have shown that local clustering and immobilization of apCAM, the Aplysia homolog ...

journal_title：Journal of neuroscience research

authors： Decourt B,Munnamalai V,Lee AC,Sanchez L,Suter DM

更新日期：2009-04-01 00:00:00

abstract：:To determine whether one or more opioid receptor types might be preferentially involved in gliogenesis, primary mixed glial cultures derived from mouse cerebra were continuously treated with varying concentrations of opioid agonists selective for mu (mu), i.e., DAGO ([D-Ala2, MePhe4, Gly(ol)5]enkephalin), delta (delta...

journal_title：Journal of neuroscience research

authors： Stiene-Martin A,Hauser KF

更新日期：1991-08-01 00:00:00

abstract：:Quercetin, a strong free radical scavenger, is investigated for neuroprotective effects in a Neuro 2a cell line conditionally transfected with 16Q huntingtin (Htt) and 150Q Htt, which express the protein upon stimulation. Cells were protected from death by a 20-µM dose of quercetin on the second day of Htt induction, ...

journal_title：Journal of neuroscience research

authors： Chakraborty J,Rajamma U,Jana N,Mohanakumar KP

更新日期：2015-10-01 00:00:00

abstract：:The purpose of this study was to determine if calpain-induced proteolysis was associated with retinal degeneration or dysfunction in the rat acute ocular hypertensive model. Acute glaucoma was produced by elevation of IOP to 120 mm Hg for 1 hr. Retinal degeneration was evaluated by H&E staining and apoptosis was deter...

journal_title：Journal of neuroscience research

authors： Oka T,Tamada Y,Nakajima E,Shearer TR,Azuma M

更新日期：2006-05-15 00:00:00

abstract：:Gangliosides, sialic acid-containing glycosphingolipids, are ubiquitously expressed in all eukaryotic cells and are localized primarily in the plasma membrane. For a rat pheochromocytoma cell line, PC12, which has been used frequently as a model for investigating events leading to neuronal differentiation, it is gener...

journal_title：Journal of neuroscience research

authors： Yanagisawa M,Ariga T,Yu RK

更新日期：2006-11-01 00:00:00

abstract：:Neuroadaptations in the nucleus accumbens (NAc) are associated with the development of drug addiction. Plasticity in synaptic strength and intrinsic excitability of NAc medium spiny neurons (MSNs) play critical roles in addiction induced by different classes of abused drugs. However, it is unknown whether morphine exp...

journal_title：Journal of neuroscience research

authors： Wu X,Shi M,Wei C,Yang M,Liu Y,Liu Z,Zhang X,Ren W

更新日期：2012-06-01 00:00:00

abstract：:The effect of the potent soluble guanylyl cyclase (sGC) inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) on neurite outgrowth and retraction was investigated in PC12 cells and SH-SY5Y human neuroblastoma cells. ODQ inhibited neurite outgrowth and triggered neurite retraction in the cells stimulated with ner...

journal_title：Journal of neuroscience research

authors： Lee HG,Kim SY,Kim du S,Seo SR,Lee SI,Shin DM,De Smet P,Seo JT

更新日期：2009-01-01 00:00:00

abstract：:Recombinant adeno-associated viral (AAV)-mediated therapeutic gene transfer to dorsal root ganglia (DRG) is an effective and safe tool for treating chronic pain. However, AAV with various constitutively active promoters leads to transgene expression predominantly to neurons, while glial cells are refractory to AAV tra...

journal_title：Journal of neuroscience research

authors： Xiang H,Xu H,Fan F,Shin SM,Hogan QH,Yu H

更新日期：2018-03-01 00:00:00

abstract：:Protein kinase C (PKC) and its potential role in myelin gene expression were investigated in primary cultured rat oligodendrocytes. The major myelin genes were expressed in a developmentally coordinated manner in cultured oligodendrocytes. PKC activity in these cells was similarly regulated with differential expressio...

journal_title：Journal of neuroscience research

authors： Asotra K,Macklin WB

更新日期：1993-04-01 00:00:00

abstract：:High-affinity uptake, potassium-stimulated release and receptor binding of gamma-aminobutyric acid (GABA) and taurine were studied in retinas of rats treated with monosodium glutamate (MSG) or iodoacetate-malate (IAM). Such treatments produce a selective damage of the inner retinal layers (MSG) or of the photoreceptor...

journal_title：Journal of neuroscience research

authors： Salceda R,Pasantes-Morales H

更新日期：1982-01-01 00:00:00

abstract：:In the embryonic and postnatal rat retina a cell surface antigen that is detected by monoclonal antibody JONES is distributed in a dorsoventral gradient. Biochemical analysis has determined that the antigen is a modified ganglioside, 9-O-acetyl GD3. In the present study, the distributions of 9-O-acetyl GD3 and its pos...

journal_title：Journal of neuroscience research

authors： Sparrow JR,Barnstable CJ

更新日期：1988-10-01 00:00:00

abstract：:Motor neurons (MNs) are designated as alpha/gamma and fast/slow based on their target sites and the types of muscle fibers innervated; however, few molecular markers that distinguish between these subtypes are available. Here we report that osteopontin (OPN) is a selective marker of alpha MNs in the mouse spinal cord....

journal_title：Journal of neuroscience research

authors： Misawa H,Hara M,Tanabe S,Niikura M,Moriwaki Y,Okuda T

更新日期：2012-04-01 00:00:00

abstract：:Low density dissociated cultures of embryonic rat hippocampal cells were used to study the effects of neurotrophin-3 (NT-3) on neuronal morphogenesis. The results obtained indicate that NT-3 enhances neurite outgrowth and branching; this is a dose-dependent effect, detected in approximately 50% of the neurons, and pre...

journal_title：Journal of neuroscience research

authors： Morfini G,DiTella MC,Feiguin F,Carri N,Cáceres A

更新日期：1994-10-01 00:00:00

abstract：:Long-duration exposure to weightlessness results in bone demineralization, muscle atrophy, cardiovascular deconditioning, altered sensory-motor control, and central nervous system reorganizations. Exercise countermeasures and body loading methods so far employed have failed to prevent these changes. A human mission to...

journal_title：Journal of neuroscience research

authors： Lackner JR,DiZio P

更新日期：2000-10-15 00:00:00

abstract：:Subarachnoid hemorrhage (SAH) by a rupture of cerebral aneurysms remains the most devastating cerebrovascular disease. Early brain injury (EBI) is increasingly recognized to be the primary determinant for poor outcomes, and also considered to cause delayed cerebral ischemia (DCI) after SAH. Both clinical and experimen...

journal_title：Journal of neuroscience research

authors： Suzuki H,Fujimoto M,Kawakita F,Liu L,Nakatsuka Y,Nakano F,Nishikawa H,Okada T,Kanamaru H,Imanaka-Yoshida K,Yoshida T,Shiba M

更新日期：2020-01-01 00:00:00

abstract：:The present study analyzed the in vitro effects induced by sodium L-lactate on human astrocytes and the SH-SY5Y cell line, when added at concentrations of 5, 10, and 25 mmol/liter. Expression of brain-derived neurotrophic factor (BDNF), inducible nitric oxide synthase (iNOS), and heat shock protein 70 kDa (HSP70) was ...

journal_title：Journal of neuroscience research

authors： Coco M,Caggia S,Musumeci G,Perciavalle V,Graziano AC,Pannuzzo G,Cardile V

更新日期：2013-02-01 00:00:00

abstract：:Alpha2-adrenergic receptors control norepinephrine (NE) release and tumor necrosis factor-alpha (TNF) production from neurons. TNF regulates NE release, depending on alpha2-adrenergic receptor functioning. The relationship between TNF production in the brain and alpha2-adrenergic receptor activation could have profoun...

journal_title：Journal of neuroscience research

authors： Reynolds JL,Ignatowski TA,Spengler RN

更新日期：2005-03-15 00:00:00

abstract：:It is known that expression of glial fibrillary acidic protein (GFAP) as an astrocyte-specific marker can be regulated by levels of circulating gonadal steroids during postnatal development. In addition, astrocytes play an important role in the physiology of the hippocampus, a brain region considered sexually dimorphi...

journal_title：Journal of neuroscience research

authors： Conejo NM,González-Pardo H,Cimadevilla JM,Argüelles JA,Díaz F,Vallejo-Seco G,Arias JL

更新日期：2005-02-15 00:00:00

abstract：:The rate and direction of neurite growth have been shown in a number of studies to be determined by the distribution of adhesive sites on the growth cone. Recent evidence showing that the application of extrinsic electric fields can redistribute membrane molecules and alter both the rate and direction of neurite growt...

journal_title：Journal of neuroscience research

authors： Freeman JA,Manis PB,Snipes GJ,Mayes BN,Samson PC,Wikswo JP Jr,Freeman DB

更新日期：1985-01-01 00:00:00