Effect of acute hyperglycemia on visual cortical activation as measured by functional MRI.

Abstract:

:To determine whether acute hyperglycemia changes the hyperemic response to functional activation of brain, the area and magnitude of the activation were measured in healthy volunteers maintained at euglycemia and then at hyperglycemia using the hyperglycemic clamp technique. Activation of the visual cortex (8-16 Hz) was assessed by functional MRI with blood oxygenation level dependent (BOLD) contrast using a 4 Tesla magnet and a multi-slice echo-planar imaging sequence (TE = 30 msec, TR = 1.5 sec). At euglycemia (4.8 +/- 0.2 mM, mean +/- SEM, n = 6), the number of activated pixels in the occipital lobe was 79 +/- 10 and the intensity of activation was 4.5 +/- 0.5%. During hyperglycemia (plasma glucose 300% of control), the number of activated pixels was 90 +/- 20% of control and the BOLD activation was 3.5 +/- 0.3%, respectively. The change in BOLD signal was below 0.2%/mM plasma glucose. This study demonstrates that acute hyperglycemia is without substantial effect on the size and intensity of activation of the occipital cortex. The results further suggest that fluctuations in blood glucose within the physiologic range are without effect on the functional activation of the cerebral cortex measured by BOLD fMRI.

journal_name

J Neurosci Res

authors

Gruetter R,Uğurbil K,Seaquist ER

doi

10.1002/1097-4547(20001015)62:2<279::AID-JNR12>3.0

keywords:

subject

Has Abstract

pub_date

2000-10-15 00:00:00

pages

279-85

issue

2

eissn

0360-4012

issn

1097-4547

pii

10.1002/1097-4547(20001015)62:2<279::AID-JNR12>3.0

journal_volume

62

pub_type

杂志文章
  • Regional distribution of heme oxygenase, HSP70, and glutathione in brain: relevance for endogenous oxidant/antioxidant balance and stress tolerance.

    abstract::It is generally recognized that lipid peroxides play an important role in the pathogenesis of several diseases and that sulfhydryl groups are critically involved in cellular defense against endogenous or exogenous oxidants. Recent evidence indicates that lipid peroxides directly participate in induction of cytoprotect...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.10177

    authors: Calabrese V,Scapagnini G,Ravagna A,Fariello RG,Giuffrida Stella AM,Abraham NG

    更新日期:2002-04-01 00:00:00

  • Dopamine receptors mediate differential morphological effects on cerebral cortical neurons in vitro.

    abstract::A morphogenic role of neurotransmitters during cellular differentiation in vitro has been demonstrated in recent years. Using in situ hybridization, we confirm the presence of the D1 receptor at E16 and show additionally that the transcript is relatively widespread and present in both proliferative and differentiating...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19960215)43:4<439::AID-JNR

    authors: Reinoso BS,Undie AS,Levitt P

    更新日期:1996-02-15 00:00:00

  • Intracellular Zn(2+) signaling in cognition.

    abstract::Brain zinc homeostasis is strictly controlled under healthy conditions, indicating the importance of zinc for physiological function in the brain. A part of zinc in the brain exists in the synaptic vesicles, is released from a subclass of glutamatergic neurons (i.e., zincergic neurons), and serves as a signal factor (...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.23385

    authors: Takeda A,Fujii H,Minamino T,Tamano H

    更新日期:2014-07-01 00:00:00

  • Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression.

    abstract::Accumulating evidence indicates an immunosuppressive role for CD4(+)CD25(+) regulatory T cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with relapsing-remitting multiple sclerosis (RR-MS) has been reported recently, no information is available so far about Treg function in the pro...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20852

    authors: Venken K,Hellings N,Hensen K,Rummens JL,Medaer R,D'hooghe MB,Dubois B,Raus J,Stinissen P

    更新日期:2006-06-01 00:00:00

  • Structure, expression, and function of Ng-CAM, a member of the immunoglobulin superfamily involved in neuron-neuron and neuron-glia adhesion.

    abstract::The neuron-glia cell adhesion molecule (Ng-CAM) mediates neuron-neuron adhesion by a homophilic mechanism and neuron-astrocyte adhesion by a heterophilic mechanism. The protein is expressed on neurons and Schwann cells but not on astrocytes. It is most prevalent during development on cell bodies of migrating neurons a...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.490310102

    authors: Grumet M

    更新日期:1992-01-01 00:00:00

  • Role of central nervous system microvascular pericytes in activation of antigen-primed splenic T-lymphocytes.

    abstract::The cellular constituents of the blood-brain barrier (BBB) must make finely tuned, regulatory responses to maintain microvascular homeostasis. The mechanisms by which this task is accomplished are largely unknown. However, it is thought they involve a series of cross-talk mechanisms among endothelial cells (EC), peric...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19990301)55:5<578::AID-JNR

    authors: Balabanov R,Beaumont T,Dore-Duffy P

    更新日期:1999-03-01 00:00:00

  • Nerve growth factor protein level increases in the adult rat hippocampus after a specific cholinergic lesion.

    abstract::Nerve growth factor (NGF) is the best-characterized neurotrophic substance and has recently been shown to influence cholinergic neurons in the basal forebrain. Hippocampus and neocortex, the primary targets for these central neurons, have further been found to contain high levels of NGF. Using enzyme immunoassay and a...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490180404

    authors: Lärkfors L,Strömberg I,Ebendal T,Olson L

    更新日期:1987-01-01 00:00:00

  • Cell lines expressing an acetylcholine release mechanism; correction of a release-deficient cell by mediatophore transfection.

    abstract::Several neuronal and non-neuronal cell lines express a Ca(2+)-dependent mechanism of transmitter release that can be demonstrated after loading the cells with acetylcholine during culture. In contrast, a particular cell line, the neuroblastoma N18TG-2, was found to be deficient for release. We transfected N18TG-2 cell...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19960801)45:3<195::AID-JNR

    authors: Falk-Vairant J,Meunier FM,Lesbats B,Corrèges P,Eder-Colli L,Salem N,Synguelakis M,Dunant Y,Israël M

    更新日期:1996-08-01 00:00:00

  • Neurofilament protein in cerebrospinal fluid: a marker of white matter changes.

    abstract::The objective of this study was to compare cerebrospinal fluid (CSF) levels of the light subtype of the neurofilament proteins (NFL), tau, and beta-amyloid42 (Abeta42) in individuals with moderate or severe white matter changes (WMC) and in those with mild or no WMC. Twenty-two patients with Alzheimer's disease (AD), ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.1242

    authors: Sjögren M,Blomberg M,Jonsson M,Wahlund LO,Edman A,Lind K,Rosengren L,Blennow K,Wallin A

    更新日期:2001-11-01 00:00:00

  • Deletion of the p53 tumor suppressor gene improves neuromotor function but does not attenuate regional neuronal cell loss following experimental brain trauma in mice.

    abstract::Deletion of the tumor suppressor gene p53 has been shown to improve the outcome in experimental models of focal cerebral ischemia and kainate-induced seizures. To evaluate the potential role of p53 in traumatic brain injury, genetically modified mice lacking a functional p53 gene (p53(-/-), n = 9) and their wild-type ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22491

    authors: Tomasevic G,Raghupathi R,Scherbel U,Wieloch T,McIntosh TK

    更新日期:2010-11-15 00:00:00

  • Co-activation of insulin-like growth factor-I receptors and protein kinase C results in parasympathetic neuronal survival.

    abstract::We have studied the interaction between several growth factors to promote parasympathetic neuronal survival. Neither insulin nor insulin-like growth factor-I (IGF-I) had any effect on the survival of embryonic day 8 chick ciliary neurons in culture. Similarly, the protein kinase C activator phorbol dibutyrate (PdBu) h...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490280112

    authors: Crouch MF,Hendry IA

    更新日期:1991-01-01 00:00:00

  • Manipulation of proliferation and differentiation of human bone marrow-derived neural stem cells in vitro and in vivo.

    abstract::Recent evidence has demonstrated that neural stem cells (NSC) can be expanded from a variety of sources, including embryos, fetuses, and adult bone marrow and brain tissue. We have previously reported the generation of adult rat bone marrow-derived cellular spheres that are morphologically and phenotypically similar t...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21131

    authors: Zeng Z,Yuan X,Liu G,Zeng X,Zeng X,Ng H,Chen H,Jiang T,Akasaki Y,Kessey K,Black KL,Yu JS

    更新日期:2007-02-01 00:00:00

  • Alteration of carnosine expression in olfactory system of mouse after unilateral naris closure and partial bulbectomy.

    abstract::To investigate the function of the dipeptide carnosine in the olfactory system, alterations of carnosine in the primary olfactory nerve after unilateral naris closure or olfactory bulb semilesion were studied by means of immunocytochemistry. After unilateral naris closure, carnosine staining showed no alteration, but ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490340608

    authors: Sakai M,Nagatsu I

    更新日期:1993-04-15 00:00:00

  • Comparison of nerve growth factor receptor binding models using heterodimeric muteins.

    abstract::Nerve growth factor (NGF) is a homodimer that binds to two distinct receptor types, TrkA and p75, to support survival and differentiation of neurons. The high-affinity binding on the cell surface is believed to involve a heteroreceptor complex, but its exact nature is unclear. We developed a heterodimer (heteromutein)...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.23116

    authors: Mehta HM,Woo SB,Neet KE

    更新日期:2012-12-01 00:00:00

  • Targeting of mRNAs within the glial cell cytoplasm: how to hide the message along the journey.

    abstract::The subcellular targeting of mRNAs encoding myelin proteins to the oligodendrocyte processes is an accepted fact in myelin formation. How these messengers are kept silent during their movement to the subcellular domain where they are turned on remains a mystery. This review focuses on aspects of mRNA targeting and spe...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/1097-4547(20001115)62:4<473::AID-JNR1>3.0.

    authors: Boccaccio GL

    更新日期:2000-11-15 00:00:00

  • Gender-specific regulation of tyrosine hydroxylase in thymocyte differentiation antigen-1 knockout mice.

    abstract::Thymocyte differentiation antigen-1 (Thy-1) is a cell surface glycoprotein found on T cells and neurons and is involved in cell-to-cell interactions. In addition, Thy-1 knockouts (KO) are a potential mouse model of restless legs syndrome (RLS) based on clinical observations and the role of dopamine in the disease. In ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.23046

    authors: Carkaci-Salli N,Battula S,Wang X,Connor JR,Vrana KE

    更新日期:2012-08-01 00:00:00

  • Dephosphorylation of Akt in C6 cells grown in serum-free conditions corresponds with redistribution of p85/PI3K to the nucleus.

    abstract::Withdrawal of serum from cell cultures constitutes a useful model for the study of mechanisms involved in the regulation of Akt function in vitro. However, there have been several reports of changes in Akt activity that are not fully explained by the current model of phosphatidylinositol 3'-kinase (PI3K)/Akt signaling...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21516

    authors: Sephton CF,Mousseau DD

    更新日期:2008-02-15 00:00:00

  • Amyloid β accelerates phosphorylation of tau and neurofibrillary tangle formation in an amyloid precursor protein and tau double-transgenic mouse model.

    abstract::In Alzheimer's disease, Aβ deposits are considered the initial cardinal events that induce tauopathy secondarily. However, the relationship between Aβ amyloidosis and tauopathy has not been determined in detail. We produced double transgenic mice, 2×TgTau(+/-) APP(+/-) , by mating Tg2576 mice that exhibit Aβ amyloidos...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22516

    authors: Seino Y,Kawarabayashi T,Wakasaya Y,Watanabe M,Takamura A,Yamamoto-Watanabe Y,Kurata T,Abe K,Ikeda M,Westaway D,Murakami T,Hyslop PS,Matsubara E,Shoji M

    更新日期:2010-12-01 00:00:00

  • Specificity of human T cell clones reactive to immunodominant epitopes of myelin basic protein.

    abstract::Several recently discovered lines of evidence support the involvement of myelin basic protein (BP)-specific T cells in multiple sclerosis (MS). To identify potentially relevant immunodominant T cell epitopes, human BP (Hu-BP)-reactive T cell lines were selected from MS and normal donors and tested for reactivity to cl...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490280215

    authors: Chou YK,Henderikx P,Vainiene M,Whitham R,Bourdette D,Chou CH,Hashim G,Offner H,Vandenbark AA

    更新日期:1991-02-01 00:00:00

  • Localization of NGF receptors in normal and Alzheimer's basal forebrain with monoclonal antibodies against the truncated form of the receptor.

    abstract::Four new monoclonal antibodies to the extracellular domain of the nerve growth factor receptor (NGFR) have been evaluated for their specificity to NGFR and their utility in localizing NGFR in human brain. All four antibodies, as well as Me20.4, show similar cellular localization and patterns of immunoreactivity in bas...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490270426

    authors: Loy R,Heyer D,Clagett-Dame M,DiStefano PS

    更新日期:1990-12-01 00:00:00

  • Expression of the receptor tyrosine kinase c-kit in oligodendrocyte progenitor cells.

    abstract::The growth and differentiation of neural precursor cells in the central nervous system (CNS) are regulated by their response to polypeptide growth factors which interact with specific transmembrane receptor tyrosine kinases (RTKs). We demonstrate that rat oligodendrocyte-type 2 astrocyte (O-2A) glial progenitor cells,...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490360512

    authors: Ida JA Jr,Dubois-Dalcq M,McKinnon RD

    更新日期:1993-12-01 00:00:00

  • Platelet-derived growth factor and basic fibroblast growth factor regulate cell proliferation and the expression of notch-1 receptor in a new oligodendrocyte cell line.

    abstract::We generated a new cell line, N38, by conditionally immortalizing mouse oligodendrocytes (OLs) at early stages of maturation. The morphology and marker expression pattern suggest N38 cells are similar to immature OLs. N38 cells were sensitive to changes in serum concentrations, and forcing the cells to differentiate i...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/1097-4547(20001101)62:3<319::AID-JNR1>3.0.

    authors: Bongarzone ER,Byravan S,Givogri MI,Schonmann V,Campagnoni AT

    更新日期:2000-11-01 00:00:00

  • EEG discrimination of perceptually similar tastes.

    abstract::Perceptually similar stimuli, despite not being consciously distinguishable, may result in distinct cortical brain activations. Hypothesizing that perceptually similar tastes are discriminable by electroencephalography (EEG), we recorded 22 human participants' response to equally intense sweet-tasting stimuli: caloric...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.24281

    authors: Andersen CA,Kring ML,Andersen RH,Larsen ON,Kjaer TW,Kidmose U,Møller S,Kidmose P

    更新日期:2019-03-01 00:00:00

  • Characteristics of the trigeminal depressor response in cats.

    abstract::We studied the effects of electrical stimulation of the inferior alveolar nerve (IAN) on cardiovascular responses in cats. There was statistical correlation between cardiovascular response and prestimulus mean arterial blood pressure (MABP) and heart rate (HR). A trigeminal depressor response (TDR) was induced when th...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20131

    authors: Ohshita N,Nakajo N,Takemura M

    更新日期:2004-06-15 00:00:00

  • Growth and pathfinding of regenerating axons in the optic projection of adult fish.

    abstract::In contrast to mammals, teleost fish are able to regrow severed long-range projection axons in the central nervous system (CNS), leading to recovery of function. The optic projection in teleost fish is used to study neuron-intrinsic and environmental molecular factors that determine successful axon regrowth and naviga...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.21121

    authors: Becker CG,Becker T

    更新日期:2007-09-01 00:00:00

  • The function of NOD-like receptors in central nervous system diseases.

    abstract::NOD-like receptors (NLRs) are critical cytoplasmic pattern-recognition receptors (PRRs) that play an important role in the host innate immune response and immunity homeostasis. There is a growing body of evidence that NLRs are involved in a wide range of inflammatory diseases, including cancer, metabolic diseases, and...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.24004

    authors: Kong X,Yuan Z,Cheng J

    更新日期:2017-08-01 00:00:00

  • Nerve growth factor-mediated increases in protein methylation occur predominantly at type I arginine methylation sites and involve protein arginine methyltransferase 1.

    abstract::Nerve growth factor (NGF)-specific signal transduction leads to changes in protein methylation during neuronal differentiation of PC12 cells (Cimato et al. [1997] J. Cell Biol. 138:1089-1103). In the present work, we demonstrate that, among NGF-regulated proteins, arginine methylation is more prevalent than carboxylme...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.10123

    authors: Cimato TR,Tang J,Xu Y,Guarnaccia C,Herschman HR,Pongor S,Aletta JM

    更新日期:2002-02-15 00:00:00

  • Pentylenetetrazol seizures increase pro-nerve growth factor-like immunoreactivity in the reticular thalamic nucleus and nerve growth factor mRNA in the dentate gyrus.

    abstract::Neurotrophins may have a neuroprotective role and are probably involved in the control of axonal sprouting and synaptic plasticity. An antibody raised against a pro-sequence of nerve growth factor (NGF) was tested. In control undisturbed rats, a strong immunoreactivity was detected in scattered cells in and around the...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490350409

    authors: Humpel C,Ebendal T,Cao Y,Olson L

    更新日期:1993-07-01 00:00:00

  • GDNF-related factor persephin is widely distributed throughout the nervous system.

    abstract::Persephin (PSP) is the most recently discovered member of the GDNF family of neurotrophic factors. We have used an RT-PCR approach to start addressing the putative functional significance of PSP by determining sites of its synthesis in the neonatal rat brain. Generally, two transcripts were found. Sequence analysis of...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19980815)53:4<494::AID-JNR

    authors: Jaszai J,Farkas L,Galter D,Reuss B,Strelau J,Unsicker K,Krieglstein K

    更新日期:1998-08-15 00:00:00

  • Expression of heat shock genes (hsp70) in the mammalian brain: distinguishing constitutively expressed and hyperthermia-inducible mRNA species.

    abstract::The mammalian genome contains both constitutively expressed and heat-shock-inducible members of the hsp70 gene family. Riboprobes derived from members of these two classes of heat shock genes were utilized in Northern blot studies to analyze brain mRNA isolated from control rabbits and rats and from animals subjected ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490250103

    authors: Brown IR,Rush SJ

    更新日期:1990-01-01 00:00:00