Inhibition of N-cadherin and beta-catenin function reduces axon-induced Schwann cell proliferation.

abstract：:Transforming growth factor-β1 (TGF-β1) is an important member of multifunctional growth factor superfamily. It has been implicated in pain signaling, but little is known about the underlying mechanisms. Herein, we report that TGF-β1 can exert a sustained enhancing effect on the functional activity of acid-sensing ion ...

journal_title：Journal of neuroscience research

authors： Qiu CY,Liu TT,Wei S,Zhou YM,Wu L,Jin Y,Hu WP

更新日期：2019-10-01 00:00:00

abstract：:Although proteins belonging to the sHSP superfamily are diverse in sequence and size, most share characteristic features, including 1) a small molecular mass of 12-43 kDa, 2) a conserved alpha-crystallin domain of 80-100 residues, 3) formation of large oligomers, 4) a dynamic quaternary structure, and 5) induction by ...

journal_title：Journal of neuroscience research

authors： Hu Z,Yang B,Lu W,Zhou W,Zeng L,Li T,Wang X

更新日期：2008-08-01 00:00:00

abstract：:Neuron-glia interactions at paranodal junctions play important roles in action potential propagation. Among their many functions, they contribute to the passive electrical properties of myelinated nerve fibers and actively regulate the polarized distribution of ion channels along axons. Despite their importance, relat...

journal_title：Journal of neuroscience research

authors： Ogawa Y,Rasband MN

更新日期：2009-11-15 00:00:00

abstract：:Mitochondrial dysfunction has been implicated in cell death in many neurodegenerative diseases. Diminished activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), a key and arguably rate-limiting enzyme of the Krebs cycle, occurs in these disorders and may underlie decreased brain metabolism. The present st...

journal_title：Journal of neuroscience research

authors： Huang HM,Ou HC,Xu H,Chen HL,Fowler C,Gibson GE

更新日期：2003-10-15 00:00:00

abstract：:Contrary to widely held beliefs, the gene encoding proteolipid protein (PLP), the major structural protein of central nervous system myelin, is expressed in Schwann cells and their tumors. Proteolipid mRNA was identified in human acoustic neuromas and in rat and rabbit sciatic nerves using a human PLP cDNA as a probe....

journal_title：Journal of neuroscience research

authors： Puckett C,Hudson L,Ono K,Friedrich V,Benecke J,Dubois-Dalcq M,Lazzarini RA

更新日期：1987-01-01 00:00:00

abstract：:The activity levels of pyruvate dehydrogenase, enzymes of the citric acid cycle, aspartate and alanine aminotransferases, and NADP+-isocitrate dehydrogenase were determined in the cerebral cortex, cerebellum, brain stem, corpus striatum, hippocampus, and midbrain regions of normal rats and rats injected with acute and...

journal_title：Journal of neuroscience research

authors： Ratnakumari L,Subbalakshmi GY,Murthy CR

更新日期：1985-01-01 00:00:00

abstract：:Macrophages play critical roles in both degenerative and regenerative processes following peripheral nerve injury. These include phagocytosis of debris, stimulation of Schwann cell dedifferentiation and proliferation, and salvage of myelin lipids for reutilization during regeneration. To better define the role of macr...

journal_title：Journal of neuroscience research

authors： Venezie RD,Toews AD,Morell P

更新日期：1995-01-01 00:00:00

abstract：:To identify and characterize the lineage potential of rat neural retina progenitor cells (NRPCs) in vitro and engrafted into rats with retinal degeneration, NRPCs were isolated from neural retinas of embryonic day 17 Long Evans rats and cultured in serum-free or serum-containing media with fibroblast growth factor 2 a...

journal_title：Journal of neuroscience research

authors： Yang P,Seiler MJ,Aramant RB,Whittemore SR

更新日期：2002-08-15 00:00:00

abstract：:Acute intoxication with large ammonia doses leads to activation of NMDA receptors in the brain, resulting in oxidative stress and disturbance of mitochondrial function. Altered mitochondrial function is a crucial step in some mechanisms of cellular apoptosis. This study assesses whether ammonia intoxication in vivo le...

journal_title：Journal of neuroscience research

authors： Kosenko E,Kaminsky Y,Solomadin I,Marov N,Venediktova N,Felipo V,Montoliu C

更新日期：2007-08-15 00:00:00

abstract：:The transport kinetics of the excitatory sulphur-containing amino acid (SAA) transmitter candidates, L-cysteine sulphinate (L-CSA), L-cysteate (L-CA), L-homocysteine sulphinate (L-HCSA), and L-homocysteate (L-HCA), together with their plasma membrane carrier specificity, was studied in cerebrocortical synaptosome frac...

journal_title：Journal of neuroscience research

authors： Grieve A,Butcher SP,Griffiths R

更新日期：1992-05-01 00:00:00

abstract：:In the embryonic and postnatal rat retina a cell surface antigen that is detected by monoclonal antibody JONES is distributed in a dorsoventral gradient. Biochemical analysis has determined that the antigen is a modified ganglioside, 9-O-acetyl GD3. In the present study, the distributions of 9-O-acetyl GD3 and its pos...

journal_title：Journal of neuroscience research

authors： Sparrow JR,Barnstable CJ

更新日期：1988-10-01 00:00:00

abstract：:The effects of hyposmotic conditions on taurine uptake and release were studied in mice cultured cerebellar granule cells. The effect of DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonate) and of the divalent cations Mg++ and Mn++ on the hyposmolarity-induced changes in these parameters was investigated. Mg++ (20 mM...

journal_title：Journal of neuroscience research

authors： Schousboe A,Sánchez Olea R,Morán J,Pasantes-Morales H

更新日期：1991-12-01 00:00:00

abstract：:We used intracellular recording to investigate the functional interaction between protein kinase C (PKC) and protein kinase A (PKA) signal transduction cascades in the control of transmitter release in the neuromuscular synapses from adult rats. Our results indicate that: 1) PKA and PKC are independently involved in a...

journal_title：Journal of neuroscience research

authors： Santafé MM,Garcia N,Lanuza MA,Tomàs M,Tomàs J

更新日期：2009-02-15 00:00:00

abstract：:It is believed that the impact of stress on interleukin-1β (IL-1β) depends on the ontogenetic age. This study examines the influence of acute or chronic exposure to forced-swim (FS) stress or high-light open-field (HL-OF) stimulation on the expression of IL-1β. Double immunofluorescence staining was used to reveal the...

journal_title：Journal of neuroscience research

authors： Badowska-Szalewska E,Ludkiewicz B,Spodnik JH,Moryś J

更新日期：2014-11-01 00:00:00

abstract：:Time-to-contact (TTC) perception refers to the ability of an observer to estimate the remaining time before an object reaches a point in the environment, and is of crucial importance in daily life. Noninvasive correlational approaches have identified several brain areas sensitive to TTC information. Here we report the...

journal_title：Journal of neuroscience research

authors： Baurès R,Fourteau M,Thébault S,Gazard C,Pasquio L,Meneghini G,Perrin J,Rosito M,Durand JB,Roux FE

更新日期：2021-02-01 00:00:00

abstract：:Accumulating evidence points to roles for oxidative stress, amyloid beta (Aβ), and mitochondrial dysfunction in the pathogenesis of Alzheimer's disease (AD). In neurons, the base excision repair pathway is the predominant DNA repair (BER) pathway for repairing oxidized base lesions. Apurinic/apyrimidinic endonuclease ...

journal_title：Journal of neuroscience research

authors： Kaur N,Dhiman M,Perez-Polo JR,Mantha AK

更新日期：2015-06-01 00:00:00

abstract：:This investigation explores the central nervous system protein-synthetic responses to hemisection of the spinal cord. Adult male rats hemisected at mid T2 were given intravenous injections of 14C-leucine at 0.7, 30, or 70 days postoperative. Four hours later the T1, T2, T3, and C6 segments of the spinal cord and right...

journal_title：Journal of neuroscience research

authors： Luttge WG,Mannis MJ,Bernstein JJ

更新日期：1975-01-01 00:00:00

abstract：:Precursor cells of the adult mouse subventricular zone (SVZ) are mobilized and recruited by a lysolecithin (LPC)-induced demyelination of the corpus callosum. Because age decreases the proliferation of the SVZ neural precursors as well as the potential for myelin repair of the adult central nervous system, we have com...

journal_title：Journal of neuroscience research

authors： Decker L,Picard-Riera N,Lachapelle F,Baron-Van Evercooren A

更新日期：2002-09-15 00:00:00

abstract：:Cytoskeletal structures under the cell membrane carry out pivotal roles in the maintenance and remodeling of the cell structures. Reforming of the cytoskeletal networks after partial extraction of membrane components could be a good clue to identify molecular components pertaining the interaction of cytoskeleton with ...

journal_title：Journal of neuroscience research

authors： Taguchi K,Yoshinaka K,Yoshino K,Yonezawa K,Maekawa S

更新日期：2005-07-15 00:00:00

abstract：:During late postnatal development, mice with the autosomal recessive wobbler mutation (wr/wr) develop motoneuron degeneration associated with astrogliosis in the spinal cord. In vitro, primary wobbler astrocytes are also affected, exhibiting abnormal cell-cell contacts. To characterize further the wobbler disease, we ...

journal_title：Journal of neuroscience research

authors： Aït-Ikhlef A,Hantaz-Ambroise D,Henderson CE,Rieger F

更新日期：2000-01-01 00:00:00

abstract：:Recent advances in human induced pluripotent stem cells (hiPSCs) offer new possibilities for biomedical research and clinical applications. Differentiated neurons from hiPSCs are expected to be useful for developing novel methods of treatment for various neurological diseases. However, the detailed process of function...

journal_title：Journal of neuroscience research

authors： Ohara Y,Koganezawa N,Yamazaki H,Roppongi RT,Sato K,Sekino Y,Shirao T

更新日期：2015-12-01 00:00:00

abstract：:The neurotrophin receptor p75 (p75NTR) is expressed by both neurons and glia. Nerve injury triggers up-regulation of p75NTR in Schwann cells (SC) but not in central glia. In contrast to neuronal p75NTR, which mediates negative signals from myelin-associated proteins resulting in neurite collapse, glial p75NTR may play...

journal_title：Journal of neuroscience research

authors： Zhou XF,Li HY

更新日期：2007-06-01 00:00:00

abstract：:Calpains and cathepsins are two families of proteases that play an important role in ischemic cell death. In this study, we investigated the effect of E64d, a mu-calpain and cathepsin B inhibitor, in the prevention of neuronal and endothelial apoptotic cell death after focal cerebral ischemia in rats. Rats underwent 2...

journal_title：Journal of neuroscience research

authors： Tsubokawa T,Yamaguchi-Okada M,Calvert JW,Solaroglu I,Shimamura N,Yata K,Zhang JH

更新日期：2006-09-01 00:00:00

abstract：:Using a solution-hybridization assay and specific oligonucleotidic probes, we have studied IGF-I and insulin receptor mRNAs in the rat central nervous system during development. The expression of mRNAs was maximal at embryonic day 15 and 20 for IGF-I receptors, and at embryonic day 20 and the day of birth for insulin ...

journal_title：Journal of neuroscience research

authors： Baron-Van Evercooren A,Olichon-Berthe C,Kowalski A,Visciano G,Van Obberghen E

更新日期：1991-02-01 00:00:00

abstract：:Recent experiments have shown that Arg, Lys, and Leu can be incorporated posttranslationally into proteins of regenerating sciatic nerves of rats. The present experiments investigate a mixture of 15 radioactive amino acids to determine if additional amino acids can be conjugated posttranslationally to proteins of rege...

journal_title：Journal of neuroscience research

authors： Chakraborty G,Yu M,Luo D,Sturman JA,Ingoglia NA

更新日期：1990-04-01 00:00:00

abstract：:Changes in executive function are at the root of most cognitive problems associated with Parkinson's disease. Because dopaminergic treatment does not necessarily alleviate deficits in executive function, it has been hypothesized that dysfunction of neurotransmitters/systems other than dopamine (DA) may be associated w...

journal_title：Journal of neuroscience research

authors： Pflibsen L,Stang KA,Sconce MD,Wilson VB,Hood RL,Meshul CK,Mitchell SH

更新日期：2015-12-01 00:00:00

abstract：:Tissue culture media with serum generally cause excessive astrocyte proliferation in neonatal brain cultures, and often fail to support neonatal neurons. Published serum-free media for brain cultures contain sodium pyruvate, which interferes with lactate dehydrogenase (LDH) assays for cell death. We wanted to use neon...

journal_title：Journal of neuroscience research

authors： Martin FC,Wiley CA

更新日期：1995-06-01 00:00:00

abstract：:The midbrain central gray (periaqueductal gray; PAG) mediates defensive behaviors and is implicated in the rewarding effects of opiate drugs. Projections from the PAG to the ventral tegmental area (VTA) suggest that this region might also regulate behaviors involving motivation and cognition. However, studies have not...

journal_title：Journal of neuroscience research

authors： Omelchenko N,Sesack SR

更新日期：2010-04-01 00:00:00

abstract：:Nonmotor symptoms of cognitive and affective nature are present in premotor and motor stages of Parkinson's disease (PD). Neurogenesis, the generation of new neurons, persists throughout the mammalian life span in the hippocampal dentate gyrus. Adult hippocampal neurogenesis may be severely affected in the course of P...

journal_title：Journal of neuroscience research

authors： Schlachetzki JC,Grimm T,Schlachetzki Z,Ben Abdallah NM,Ettle B,Vöhringer P,Ferger B,Winner B,Nuber S,Winkler J

更新日期：2016-01-01 00:00:00

abstract：:Pathological processes affecting presynaptic terminals may contribute to morbidity following traumatic brain injury (TBI). Posttraumatic widespread neuronal depolarization and elevated extracellular potassium and glutamate are predicted to alter the transduction of action potentials in terminals into reliable synaptic...

journal_title：Journal of neuroscience research

authors： Reeves TM,Kao CQ,Phillips LL,Bullock MR,Povlishock JT

更新日期：2000-05-01 00:00:00