Executive function deficits and glutamatergic protein alterations in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

abstract：:Pyruvate dehydrogenase complex (PDH) is a brain mitochondrial matrix enzyme. PDH impairment after stroke is particularly devastating given PDH's critical role in the link between anaerobic and aerobic metabolism. This study evaluates the restoration of oxidative metabolism and energy regulation with a therapeutic comb...

journal_title：Journal of neuroscience research

authors： Cai L,Thibodeau A,Peng C,Ji X,Rastogi R,Xin R,Singh S,Geng X,Rafols JA,Ding Y

更新日期：2016-08-01 00:00:00

abstract：:The amino acid glutamate plays a key role in brain function. One of the major roles of glutamate is to mediate fast excitatory neurotransmission via activation of ionotropic glutamate receptors (iGluRs). More recently, however, it has become clear that glutamate also serves a regulatory function through activation of ...

journal_title：Journal of neuroscience research

authors： Winder DG,Conn PJ

更新日期：1996-10-15 00:00:00

abstract：:In our in vitro model, rasagiline a selective irreversible monoamine oxidase-B (MAO-B) inhibitor, protected nerve growth factor (NGF)-differentiated PC12 cells from cell death under oxygen and glucose deprivation (OGD). The severity of the OGD insult, as expressed by cell death, was time-dependent. Exposure of the cel...

journal_title：Journal of neuroscience research

authors： Abu-Raya S,Blaugrund E,Trembovler V,Shilderman-Bloch E,Shohami E,Lazarovici P

更新日期：1999-11-01 00:00:00

abstract：:It has been postulated that cellular glutamate is released into the extracellular fluid when the energy supply of the brain is compromised (i.e., anoxia or oxygen/glucose deprivation), and there the amino acid triggers the so-called excitotoxic cascade, causing neuronal death. Several mechanisms for this release have ...

journal_title：Journal of neuroscience research

authors： Martín ME,Muñoz FM,Dickinson DA,Forman HJ,Martín del Río R,Salinas M,Fando JL

更新日期：2005-10-01 00:00:00

abstract：:We have developed a silicone nerve regeneration chamber that is partitioned into two compartments by a strip of nitrocellulose paper. The modified two-compartment chamber allows the investigation of the effects on rat sciatic nerve regeneration of trophic or growth factors that are initially bound to the nitrocellulos...

journal_title：Journal of neuroscience research

authors： Danielsen N,Pettmann B,Vahlsing HL,Manthorpe M,Varon S

更新日期：1988-07-01 00:00:00

abstract：:The ligand-activated transcription factor peroxisome proliferator-activated receptor beta (PPARbeta) is present in the brain and is implicated in the regulation of genes with potential roles in neurotoxicity. We sought to examine the role of PPARbeta in neuronal cell death by using the PPARbeta ligand GW0742. Primary ...

journal_title：Journal of neuroscience research

authors： Smith SA,Monteith GR,Robinson JA,Venkata NG,May FJ,Roberts-Thomson SJ

更新日期：2004-07-15 00:00:00

abstract：:Fetal low brain oxygenation may be an outcome of maternal complications during pregnancy and is associated with increased risk of cerebral palsy and periventricular leukomalacia in newborns. One treatment used for prevention of fetal brain damage is maternal treatment with MgSO(4). Although this treatment is indicated...

journal_title：Journal of neuroscience research

authors： Golan H,Kashtuzki I,Hallak M,Sorokin Y,Huleihel M

更新日期：2004-11-01 00:00:00

abstract：:DBA/2J mice are one of several animal strains used for experimental models of both intraocular hypertension and glaucoma. This study investigates the relationship between endoplasmic reticulum (ER) stress and optic nerve degeneration in DBA/2J mice. Intraocular pressure (IOP) was measured in DBA/2J mice between the ag...

journal_title：Journal of neuroscience research

authors： Ojino K,Shimazawa M,Izawa H,Nakano Y,Tsuruma K,Hara H

更新日期：2015-11-01 00:00:00

abstract：:The activation of cellular inflammatory response is tightly linked to induced production of reactive oxygen species (ROS) and nitric oxide (NO), which in turn have been identified as important regulators of cellular iron metabolism. In the present study, we have used the microglia cell line BV-2 and the neuroblastoma ...

journal_title：Journal of neuroscience research

authors： Reis K,Hälldin J,Fernaeus S,Pettersson C,Land T

更新日期：2006-10-01 00:00:00

abstract：:An elevated expression of c-fos nuclear protooncogene (immediate early gene) has been shown repeatedly to correlate with long-term neuronal responses. This paper reviews recent data suggesting that neuronal plasticity, including learning and memory formation, may involve c-fos expression as well. On the basis of biolo...

journal_title：Journal of neuroscience research

authors： Kaczmarek L

更新日期：1993-03-01 00:00:00

abstract：:Damselfish neurofibromatosis is a naturally occurring disease of a tropical marine fish species. Affected fish exhibit peripheral nerve sheath tumors which contain morphologically abnormal Schwann cells (SC), similar to tumors encountered in the human disease neurofibromatosis type 1. Unitary A-type K channels in cell...

journal_title：Journal of neuroscience research

authors： Fieber LA

更新日期：1997-05-15 00:00:00

abstract：:In the present study, following previous experience with electrolytic lesion of the rat brain, and subsequent reduction of reactive gliosis with 7 beta-hydroxycholesterol derivatives (Bochelen et al.: Neuroscience 51:827-834, 1992), we have performed a hemisection of the spinal cord in adult rats and investigated the ...

journal_title：Journal of neuroscience research

authors： Giménez y Ribotta M,Rajaofetra N,Morin-Richaud C,Alonso G,Bochelen D,Sandillon F,Legrand A,Mersel M,Privat A

更新日期：1995-05-01 00:00:00

abstract：:Molecular cloning has introduced an unexpected, large diversity of neurotransmitter hetero- oligomeric receptors. Extensive research on the molecular structure of the γ-aminobutyric acid receptor (GABAR) has been of great significance for understanding how the nervous system works in both vertebrates and invertebrates...

journal_title：Journal of neuroscience research

authors： Jiménez-Vázquez EN,Díaz-Velásquez CE,Uribe RM,Arias JM,García U

更新日期：2016-02-01 00:00:00

abstract：:Four new monoclonal antibodies to the extracellular domain of the nerve growth factor receptor (NGFR) have been evaluated for their specificity to NGFR and their utility in localizing NGFR in human brain. All four antibodies, as well as Me20.4, show similar cellular localization and patterns of immunoreactivity in bas...

journal_title：Journal of neuroscience research

authors： Loy R,Heyer D,Clagett-Dame M,DiStefano PS

更新日期：1990-12-01 00:00:00

abstract：:The effects of fetal asphyxia on cerebral function and development, involve the transition from fetal to neonatal life. Changes in cerebral glucose metabolism may be an early postnatal indicator of fetal asphyxia. The objective is to develop an experimental lamb model involving the transition from fetal to neonatal li...

journal_title：Journal of neuroscience research

authors： Thorngren-Jerneck K,Ley D,Hellström-Westas L,Hernandez-Andrade E,Lingman G,Ohlsson T,Oskarsson G,Pesonen E,Sandell A,Strand SE,Werner O,Marsal K

更新日期：2001-12-01 00:00:00

abstract：:Pigment epithelium-derived factor (PEDF) is a neurotrophic protein synthesized and secreted by retinal pigment epithelial (RPE) cells in early embryogenesis and has been shown to be present in the extracellular matrix between the RPE cells and the neural retina. It induces neuronal differentiation and promotes surviva...

journal_title：Journal of neuroscience research

authors： Cao W,Tombran-Tink J,Chen W,Mrazek D,Elias R,McGinnis JF

更新日期：1999-09-15 00:00:00

abstract：:The blood-brain barrier (BBB) refers to the network of microvessels that selectively restricts the passage of substances between the circulation and the central nervous system (CNS). This microvascular network is comprised of arterioles, capillaries and venules, yet the respective contribution of each of these to the ...

journal_title：Journal of neuroscience research

authors： Macdonald JA,Murugesan N,Pachter JS

更新日期：2010-05-15 00:00:00

abstract：:Time-to-contact (TTC) perception refers to the ability of an observer to estimate the remaining time before an object reaches a point in the environment, and is of crucial importance in daily life. Noninvasive correlational approaches have identified several brain areas sensitive to TTC information. Here we report the...

journal_title：Journal of neuroscience research

authors： Baurès R,Fourteau M,Thébault S,Gazard C,Pasquio L,Meneghini G,Perrin J,Rosito M,Durand JB,Roux FE

更新日期：2021-02-01 00:00:00

abstract：:The cutaneous electroreceptor "tuberous organs" of the lateral line system of Eigenmannia virescens were studied at light and electron microscopic levels with immunohistochemical and autoradiographic techniques after sectioning of the posterior branch of the lateral line nerve. After deafferentation total degeneration...

journal_title：Journal of neuroscience research

authors： Bensouilah M,Denizot JP

更新日期：1994-12-01 00:00:00

abstract：:Gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter of CNS, has been consistently implicated in the pathophysiology of schizophrenia. GABA is synthesized from glutamate by the enzyme glutamic acid decarboxylase (GAD). Two isoforms of GAD have been identified and have been named GAD65 and GAD67 ba...

journal_title：Journal of neuroscience research

authors： Dracheva S,Elhakem SL,McGurk SR,Davis KL,Haroutunian V

更新日期：2004-05-15 00:00:00

abstract：:The limited availability and potential to culture primary human brain cells means that there is still a need for cell lines that reliably model human neurons and glial cells. The human-derived NTera2/D1 (NT2) cell line is a promising tool from which both neuronal (NT2N) and astrocytic (NT2A) cells can be derived in vi...

journal_title：Journal of neuroscience research

authors： Goodfellow CE,Graham SE,Dragunow M,Glass M

更新日期：2011-10-01 00:00:00

abstract：:Astroglial cells play an important role in maintaining neuronal function in the adult and in the developing nervous system. Ethanol exposure induces profound alterations in the astrogliogenesis process, affecting important cell functions, including intracellular protein trafficking. Because the actin cytoskeleton play...

journal_title：Journal of neuroscience research

authors： Guasch RM,Tomas M,Miñambres R,Valles S,Renau-Piqueras J,Guerri C

更新日期：2003-05-15 00:00:00

abstract：:Astroglial participation in the regional differences of vulnerability to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-induced neurodegeneration was investigated in the rat hippocampus and medial septum using L-alpha-aminoadipate (alpha-AA) as a specific astroglial toxin. alpha-AA was microinjected i...

journal_title：Journal of neuroscience research

authors： Rodríguez MJ,Martínez-Sánchez M,Bernal F,Mahy N

更新日期：2004-08-01 00:00:00

abstract：:Zinc ion elevation contributes to acute excitotoxic brain injury and correlates with the severity of dementia in chronic neurodegenerative diseases. Downstream control of zinc-triggered signals is believed to be an efficient countermeasure. In the current study, we examined whether the flavonoid luteolin (Lu) could pr...

journal_title：Journal of neuroscience research

authors： Zhou F,Qu L,Lv K,Chen H,Liu J,Liu X,Li Y,Sun X

更新日期：2011-11-01 00:00:00

abstract：:We studied the effects of oxygen-derived free radicals on the ultrastructure of brain cortical slices and the release of fatty acids from phospholipids of crude synaptosomes. Xanthine oxidase, hypoxanthine, and ADP-Fe3+, a free-radical-generating system, caused swelling of cellular processes and mitochondria. The oxyg...

journal_title：Journal of neuroscience research

authors： Chan PH,Fishman RA,Schmidley JW,Chen SF

更新日期：1984-01-01 00:00:00

abstract：:This study tested the hypothesis that sensitivity to the Ca(2+) -induced loss of mitochondrial membrane potential (ΔΨ(m)) and the sensitivity of the loss of ΔΨ to mitochondrial permeability transition pore (PTP) inhibitors are different for neurons and astrocytes. Primary cultures of rat cortical neurons and astrocyte...

journal_title：Journal of neuroscience research

authors： Kahraman S,Bambrick LL,Fiskum G

更新日期：2011-12-01 00:00:00

abstract：:Tauopathies, including Alzheimer's disease (AD), are a group of neurodegenerative disorders characterized by the presence of intraneuronal filamentous inclusions of abnormally phosphorylated tau protein. In AD brains, it has been shown that the level of abnormally phosphorylated tau is higher than in age-matched contr...

journal_title：Journal of neuroscience research

authors： Blard O,Frébourg T,Campion D,Lecourtois M

更新日期：2006-10-01 00:00:00

abstract：:Programmed cell death involving gene regulation and de novo protein synthesis is a major component of both normal development and a number of disease conditions. Hence, knowledge of its mechanisms, especially transcription factors, that regulate expression of the genes involved in neurodegenerative disorders is of gre...

journal_title：Journal of neuroscience research

authors： Mioduszewska B,Jaworski J,Szklarczyk AW,Klejman A,Kaczmarek L

更新日期：2008-01-01 00:00:00

abstract：:The properties of neuronal plasma membranes are highly specialized, since they include the receptors by which many hormones, neurotransmitters, drugs, and toxins initiate their actions, as well as the components necessary for receiving synaptic input from a variety of sources and for generating the appropriate pattern...

journal_title：Journal of neuroscience research

authors： Poduslo SE,Chechik T,Filbin MT,Rosenfeld J

更新日期：1986-01-01 00:00:00

abstract：:Brain injury and neuroinflammation are pathophysiologic contributors to acute and chronic neurologic disorders, which are progressive diseases not fully understood. Mammalian metallothioneins I and II (MT-I&II) have significant neuroprotective functions, but the precise mechanisms underlying these effects are still un...

journal_title：Journal of neuroscience research

authors： Penkowa M,Tio L,Giralt M,Quintana A,Molinero A,Atrian S,Vasák M,Hidalgo J

更新日期：2006-05-01 00:00:00