Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death.

abstract：:The cutaneous electroreceptor "tuberous organs" of the lateral line system of Eigenmannia virescens were studied at light and electron microscopic levels with immunohistochemical and autoradiographic techniques after sectioning of the posterior branch of the lateral line nerve. After deafferentation total degeneration...

journal_title：Journal of neuroscience research

authors： Bensouilah M,Denizot JP

更新日期：1994-12-01 00:00:00

abstract：:Drebrins are developmentally regulated actin-binding proteins. In this study, we analyzed subcellular distribution of drebrin E in neuroblastoma cells (SH-SY5Y) in culture, especially in terms of its relationship to actin filaments. In undifferentiated cells, drebrin E was scattered as flocculus small dots along the s...

journal_title：Journal of neuroscience research

authors： Asada H,Uyemura K,Shirao T

更新日期：1994-06-01 00:00:00

abstract：:Nerve growth factor (NGF)-specific signal transduction leads to changes in protein methylation during neuronal differentiation of PC12 cells (Cimato et al. [1997] J. Cell Biol. 138:1089-1103). In the present work, we demonstrate that, among NGF-regulated proteins, arginine methylation is more prevalent than carboxylme...

journal_title：Journal of neuroscience research

authors： Cimato TR,Tang J,Xu Y,Guarnaccia C,Herschman HR,Pongor S,Aletta JM

更新日期：2002-02-15 00:00:00

abstract：:It was previously reported that a monoclonal antibody to beta-amyloid precursor protein (mab22C11; Boehringer Mannheim, Indianapolis, IN) labels an intermediate filament-associated protein (beta APP-IFAP) in cultured human skin fibroblasts (Dooley et al.: J Neurosci Res 33:60-67, 1992). The time course of its expressi...

journal_title：Journal of neuroscience research

authors： Durham HD,Minotti S,Dooley NP,Nalbantoglu J

更新日期：1994-08-15 00:00:00

abstract：:Traumatic brain injury (TBI) is the major cause of physical disability and emotional vulnerability. Treatment of TBI is lacking due to its multimechanistic etiology, including derailed mitochondrial and cellular energy metabolism. Previous studies from our laboratory show that an endogenous nitric oxide (NO) metabolit...

journal_title：Journal of neuroscience research

authors： Khan M,Shunmugavel A,Dhammu TS,Khan H,Singh I,Singh AK

更新日期：2018-12-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) glycoprotein gp120 causes neuronal cell death; however, the molecular mechanisms of the neurotoxic effect remain largely unresolved. It has been suggested that gp120 evokes cell death by inducing the release of neurotoxins, including glutamate. The objective of this work...

journal_title：Journal of neuroscience research

authors： Bachis A,Mocchetti I

更新日期：2004-01-01 00:00:00

abstract：:The present experiments tested the hypothesis that one of the critical mechanisms underlying genetically defined aggressiveness involves brain serotonin 5-HT1A receptors. 5-HT1A receptor density, the receptor mRNA expression in brain structures, and functional correlates for 5-HT1A receptors identified as 8-OH-DPAT-in...

journal_title：Journal of neuroscience research

authors： Popova NK,Naumenko VS,Plyusnina IZ,Kulikov AV

更新日期：2005-04-15 00:00:00

abstract：:It is believed that the impact of stress on interleukin-1β (IL-1β) depends on the ontogenetic age. This study examines the influence of acute or chronic exposure to forced-swim (FS) stress or high-light open-field (HL-OF) stimulation on the expression of IL-1β. Double immunofluorescence staining was used to reveal the...

journal_title：Journal of neuroscience research

authors： Badowska-Szalewska E,Ludkiewicz B,Spodnik JH,Moryś J

更新日期：2014-11-01 00:00:00

abstract：:A link between aluminum (Al) exposure and age-related neurological disorders has long been proposed. Although the exact mechanism by which the metal may influence disease processes is unknown, there is evidence that exposure to Al causes an increase in both oxidative stress and inflammatory events. These processes hav...

journal_title：Journal of neuroscience research

authors： Campbell A,Becaria A,Lahiri DK,Sharman K,Bondy SC

更新日期：2004-02-15 00:00:00

abstract：:Heme oxygenase-1 (HO-1) is a stress protein induced in response to a variety of oxidative challenges. After treatment of the hybrid septal cells SN 56 with beta-amyloid peptide (beta-AP1-40) or hydrogen peroxide (H2O2), we detected high levels of reactive oxygen species, accompanied by a significant elevation in HO-1 ...

journal_title：Journal of neuroscience research

authors： Le WD,Xie WJ,Appel SH

更新日期：1999-06-15 00:00:00

abstract：:Neuron-glia interactions at paranodal junctions play important roles in action potential propagation. Among their many functions, they contribute to the passive electrical properties of myelinated nerve fibers and actively regulate the polarized distribution of ion channels along axons. Despite their importance, relat...

journal_title：Journal of neuroscience research

authors： Ogawa Y,Rasband MN

更新日期：2009-11-15 00:00:00

abstract：:Hippocalcin is a Ca2+-binding protein that is expressed mainly in pyramidal nerve cells of the hippocampus. However, its functions and mechanism in the brain remain unclear. To elucidate the role of hippocalcin, we used a conditionally immortalized hippocampal cell line (H19-7) and showed that bFGF treatment increased...

journal_title：Journal of neuroscience research

authors： Oh DY,Cho JH,Park SY,Kim YS,Yoon YJ,Yoon SH,Chung KC,Lee KS,Han JS

更新日期：2008-05-15 00:00:00

abstract：:Microglia, central nervous system (CNS) resident phagocytic cells, persistently police the integrity of CNS tissue and respond to any kind of damage or pathophysiological changes. These cells sense and rapidly respond to danger and inflammatory signals by changing their cell morphology; by release of cytokines, chemok...

journal_title：Journal of neuroscience research

authors： Färber K,Cheung G,Mitchell D,Wallis R,Weihe E,Schwaeble W,Kettenmann H

更新日期：2009-02-15 00:00:00

abstract：:Soluble amyloid beta protein (Abeta) oligomers have been considered recently to be responsible for the cognitive dysfunction that sets in prior to senile plaque formation in the Alzheimer's disease (AD) brain. By using the newly prepared antibody against oligomer Abeta, rather than fibrillar or monomer Abeta, we obser...

journal_title：Journal of neuroscience research

authors： Ishibashi K,Tomiyama T,Nishitsuji K,Hara M,Mori H

更新日期：2006-08-15 00:00:00

abstract：:Motoneuron number and expression of cytoplasmic RNA and ribosomal RNA (rRNA) gene transcription activity in the facial nucleus were examined quantitatively and chronologically for up to 4 weeks in rats after facial nerve axotomy and avulsion in order to elucidate interrelationships in axonal changes. The right facial ...

journal_title：Journal of neuroscience research

authors： Nagasao J,Hayashi Y,Kawazoe Y,Kawakami E,Watabe K,Oyanagi K

更新日期：2008-02-01 00:00:00

abstract：:Bovine cerebrum, including the corpus callosum, and a human oligodendroglioma were investigated by an immunohistochemical technique to determine the distribution of 2':3'-cyclic nucleotide 3'-phosphodiesterase (CNP). Also, three human oligodendrogliomas (ODG) were characterized by an immunoblot procedure to identify a...

journal_title：Journal of neuroscience research

authors： Sheedlo HJ,Yaghmai F,Wolfe L 3rd,Sprinkle TJ

更新日期：1985-01-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) cause a wide spectrum of toxic effects in the brain through undefined mechanisms. Exposure to the PCB mixture Aroclor-1254 (A1254) increases the repressor element-1 silencing transcription factor (REST) expression, leading to neuronal death. This study sought to understand the sequence...

journal_title：Journal of neuroscience research

authors： Formisano L,Guida N,Laudati G,Boscia F,Esposito A,Secondo A,Di Renzo G,Canzoniero LM

更新日期：2015-01-01 00:00:00

abstract：:Primary fibroblasts initiated from skin biopsies of Wistar rats were transfected with a plasmid that encodes the human growth hormone and the neomycin resistance genes. Cell clones selected for G418 resistance and expressing high levels of human growth hormone were propagated in vitro and subsequently transplanted int...

journal_title：Journal of neuroscience research

authors： Doering LC,Chang PL

更新日期：1991-07-01 00:00:00

abstract：:Heat shock protein 60 (HSP60) and HSP10 are mitochondrial chaperonin proteins and are responsible for the folding of newly imported proteins and 13 polypeptides encoded by mitochondrial DNA. The expressions of HSP60 and HSP10 are regulated simultaneously because these genes are localized head to head on chromosome, se...

journal_title：Journal of neuroscience research

authors： Kim SW,Lee JK

更新日期：2007-05-01 00:00:00

abstract：:Brain zinc homeostasis is strictly controlled under healthy conditions, indicating the importance of zinc for physiological function in the brain. A part of zinc in the brain exists in the synaptic vesicles, is released from a subclass of glutamatergic neurons (i.e., zincergic neurons), and serves as a signal factor (...

journal_title：Journal of neuroscience research

authors： Takeda A,Fujii H,Minamino T,Tamano H

更新日期：2014-07-01 00:00:00

abstract：:The inward-rectifier K(+) channel Kir4.1 is responsible for maintaining cochlear homeostasis and restoring neural excitability. The large-conductance calcium-activated K(+) channel (BK(Ca)) plays a key role in phase locking signals in the mammalian inner ear. To evaluate the influence of mitochondrial dysfunction on t...

journal_title：Journal of neuroscience research

authors： Zou J,Zhang Y,Yin S,Wu H,Pyykkö I

更新日期：2009-01-01 00:00:00

abstract：:Nerve growth factor (NGF) has a modulating effect on immune function, which may occur as a consequence of binding to the NGF receptor (NGF-R). To determine if mRNA for the gene coding for p75NGFR (low affinity NGF-R) is present in lymphocytes, Northern blot analysis of mRNA from human peripheral blood lymphocytes (PBL...

journal_title：Journal of neuroscience research

authors： Kittur SD,Song L,Endo H,Adler WH

更新日期：1992-07-01 00:00:00

abstract：:Experiments were conducted with the aid of intracellular microelectrodes to study physiological properties of neuropile glial cells in the central nervous system of the medicinal leech. The results showed significant contributions of both K+ and Cl- ions to the membrane potential. The transmitter substance 5-hydroxytr...

journal_title：Journal of neuroscience research

authors： Walz W

更新日期：1982-01-01 00:00:00

abstract：:In a nominally calcium-free medium, a toxic phospholipase A2, paradoxin, PDX (1-200nM) was able to significantly decrease glutamate uptake by rat hippocampal mini-slices. Under the same experimental conditions, PDX could also inhibit the reuptake of choline and dopamine, suggesting a nonselective action. Furthermore, ...

journal_title：Journal of neuroscience research

authors： Dorandeu F,Antier D,Pernot-Marino I,Lapeyre P,Lallement G

更新日期：1998-02-01 00:00:00

abstract：:Membrane compaction and adhesion at the major dense line (cytoplasmic apposition) of myelin, particularly in the central nervous system (CNS), is typically attributed to myelin basic protein (MBP). To explore the role of MBP in myelin membrane adhesion, we attempted to reconstitute the major dense line of myelin from ...

journal_title：Journal of neuroscience research

authors： Riccio P,Fasano A,Borenshtein N,Bleve-Zacheo T,Kirschner DA

更新日期：2000-02-15 00:00:00

abstract：:In this study, the responses of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) activities were quantitatively analyzed at different times in both ipsilateral and contralateral sides of trigeminal nuclei, after unilateral trigeminal muscle nerve transection, i...

journal_title：Journal of neuroscience research

authors： Varathan V,Shigenaga Y,Takemura M

更新日期：2001-11-01 00:00:00

abstract：:The incidence of dementia and obstructive sleep apnea (OSA) increases with age. Late-onset Alzheimer's disease (AD) is an irreversible neurodegenerative disease of the elderly characterized by amyloid β (Aβ) plaques and neurofibrillary tangles. The disease involves widespread synaptic loss in the neocortex and the hip...

journal_title：Journal of neuroscience research

authors： Daulatzai MA

更新日期：2015-12-01 00:00:00

abstract：:An immortalized dorsal root ganglion cell line F-11 exhibits many properties of spinal cord neurons and undergoes apoptosis in response to growth factor withdrawal and the exogenous addition of inhibitors of phosphatidylinositol-3-kinase (PI3K). To elucidate the mechanism of apoptosis we generated F-11 clones which ov...

journal_title：Journal of neuroscience research

authors： Goswami R,Kilkus J,Dawson SA,Dawson G

更新日期：1999-09-15 00:00:00

abstract：:The transforming growth factors beta (TGF-beta), a family of regulatory polypeptides, are involved in numerous vital processes including inflammation and wound healing. Since repair of a peripheral nerve lesion includes a series of well-defined steps of cellular actions possibly controlled by TGF-beta s, and since TGF...

journal_title：Journal of neuroscience research

authors： Rufer M,Flanders K,Unsicker K

更新日期：1994-11-01 00:00:00

abstract：:Brain cathepsin D, purified by affinity chromatography on Sepharose pepstatin columns, was incubated with synthetic peptides corresponding to the susceptible regions of the myelin basic protein encompassing the two Phe-Phe bonds. One peptide, Leu-Gly-Arg-Phe-Phe-Gly-Gly, was cleaved by cathepsin D at the Phe-Phe bond ...

journal_title：Journal of neuroscience research

authors： Marks N,Benuck M,Hashim G

更新日期：1980-01-01 00:00:00