Abstract:
:Using a solution-hybridization assay and specific oligonucleotidic probes, we have studied IGF-I and insulin receptor mRNAs in the rat central nervous system during development. The expression of mRNAs was maximal at embryonic day 15 and 20 for IGF-I receptors, and at embryonic day 20 and the day of birth for insulin receptors. After birth, the expression of both receptor transcripts decreased and reached minimal levels in the adult. At the time at which these transcripts were maximally expressed (embryonic day 20), the regional analysis indicated that IGF-I receptor transcripts were widely distributed in the brain. In contrast, insulin receptor transcripts were restricted to certain areas in which they were coexpressed with the IGF-I receptor transcripts. We next analyzed which cells at embryonic day 20 expressed those receptor transcripts. Late embryonic neurons, astrocytes, and neonatal progenitors of oligodendrocytes synthesized both IGF-I and insulin receptor mRNAs after a short time in culture. However, astrocytes expressed preferentially IGF-I receptor transcripts, while young progenitors for oligodendrocytes expressed high levels of insulin receptor transcripts. As a whole, our data indicate that during rat CNS development expression of IGF-I and insulin receptors appears to be stage- and cell-specific. The differences observed between the expression of both receptors might point to a specific, but coordinative role of IGF-I and insulin and their receptors during that time.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Baron-Van Evercooren A,Olichon-Berthe C,Kowalski A,Visciano G,Van Obberghen Edoi
10.1002/jnr.490280212subject
Has Abstractpub_date
1991-02-01 00:00:00pages
244-53issue
2eissn
0360-4012issn
1097-4547journal_volume
28pub_type
杂志文章abstract::The neonatal lesion with 6-hydroxydopamine (6-OHDA) in rodents induces juvenile hyperactivity and paradoxical hypolocomotor response to psychostimulants, in striking contrast to what is observed when similar lesions are carried out in adults. The early disruption of central dopaminergic pathways is followed by increas...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20245
更新日期:2004-10-15 00:00:00
abstract::Although they likely involve activation of N-methyl-D-aspartate (NMDA) receptors, the mechanisms giving rise to perinatal hypoxic-ischemic-induced damages remained unclear. The purpose of the present study was to investigate in vivo the mechanisms regulating the glutamate-induced release of toxic hydroxyl radicals (.O...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/1097-4547(20001001)62:1<84::AID-JNR9>3.0.C
更新日期:2000-10-01 00:00:00
abstract::We have developed a transgenic mouse expressing the Cre recombinase under control of a tetracycline-responsive promoter. Using a CamKIIalpha-driven tTA transgenic strain and a lacZ reporter mouse, we obtained the expected neuronal pattern of recombination in the olfactory lobe, cortex, striatum, hippocampus and Purkin...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10213
更新日期:2002-04-15 00:00:00
abstract::The amino acid glutamate plays a key role in brain function. One of the major roles of glutamate is to mediate fast excitatory neurotransmission via activation of ionotropic glutamate receptors (iGluRs). More recently, however, it has become clear that glutamate also serves a regulatory function through activation of ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-4547(19961015)46:2<131::AID-JNR
更新日期:1996-10-15 00:00:00
abstract::Factor Xa (FXa) plays a critical role in the coagulation cascade by generation of thrombin. During focal ischemia thrombin levels increase in the brain tissue and cause neural damage. This study examined the hypothesis that administration of the FXa inhibitor, apixaban, following focal ischemic stroke may have therape...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24253
更新日期:2018-08-01 00:00:00
abstract::Retinal microglia play an important role as resident immunocompetent and phagocytic cells in the event of injury and disease. Retinal microglia and microglia precursor transplantation show a rescue effect in ischemic retina and retinal degeneration. However, studies of retinal microglia have been hampered by the diffi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23337
更新日期:2014-04-01 00:00:00
abstract::We previously demonstrated that a synthetic retinoic acid receptor agonist, Am80, attenuated intracerebral hemorrhage (ICH)-induced neuropathological changes and neurological dysfunction. Because inflammatory events are among the prominent features of ICH pathology that are affected by Am80, this study investigated th...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23379
更新日期:2014-08-01 00:00:00
abstract::A growing body of evidence suggests that neurotrophins (NTs) play a critical role in synaptic plasticity and other activity dependent processes in the CNS. Release of these growth factors by neurons and neuroendocrine cells was recently shown to occur via the regulated secretory pathway, representing a possible mechan...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980215)51:4<463::AID-JNR
更新日期:1998-02-15 00:00:00
abstract::The combination of nerve growth factor (NGF) and phorbol 12-myristate 13-acetate (PMA) rapidly induced the locomotion of PC12 cells by sequentially stimulating lamellar spreading, ruffling with pinocytosis, and polarization by retraction from the substratum. During migration, cells acquired long processes as a result ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960515)44:4<308::AID-JNR
更新日期:1996-05-15 00:00:00
abstract::NG2 chondroitin sulfate proteoglycan is a surface marker of oligodendroglial progenitor cells (OPCs) in various species. In contrast to well-studied rat OPCs, however, we found that purified mouse NG2 surface positive cells (NG2(+) cells) require additional activation of cyclic AMP (cAMP) signaling for survival in a m...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22262
更新日期:2010-04-01 00:00:00
abstract::Damselfish neurofibromatosis is a naturally occurring disease of a tropical marine fish species. Affected fish exhibit peripheral nerve sheath tumors which contain morphologically abnormal Schwann cells (SC), similar to tumors encountered in the human disease neurofibromatosis type 1. Unitary A-type K channels in cell...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1997-05-15 00:00:00
abstract::To further our understanding of the functions of the major myelin proteins, myelin basic protein (MBP) and proteolipid protein (PLP), and other myelin proteins, such as 2'3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and myelin-associated glycoprotein (MAG), bovine brain myelin was extracted with Triton X-100, and p...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10383
更新日期:2002-10-01 00:00:00
abstract::During surgical intervention in medically refractory temporal lobe epilepsy (TLE) patients, diagnosed with either mesial temporal lobe sclerosis (MTS)- or tumor (T)-associated TLE, biopsies were taken from the anterior temporal neocortex and the hippocampal region. Synaptosomes, isolated from these biopsies were used ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000601)60:5<686::AID-JNR
更新日期:2000-06-01 00:00:00
abstract::Transplanting neural stem cells (NSC) to the damaged brain has been regarded as a potential treatment for neurodegenerative diseases such as Alzheimer's disease (AD), a condition characterized by memory loss. We hypothesized that transplantation of NSC into the hippocampal regions of APP + PS1 transgenic (Tg) mice, a ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23299
更新日期:2014-02-01 00:00:00
abstract::Maternal stress exerts long-lasting psychiatric and somatic on offspring, which persist into adulthood. However, the effect of maternal stress on the postnatal growth of pups has not been widely reported. In this study, we found that maternal immobilization stress (IS) during lactation resulted in low body weight of m...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22550
更新日期:2011-03-01 00:00:00
abstract::Neuronal progenitors in the adult hippocampus continually proliferate and differentiate to the neuronal lineage, and ischemic insult promotes hippocampal neurogenesis. However, newborn neurons show a progressive reduction in numbers during the initial few weeks, therefore, enhanced survival of newborn neurons seems to...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21036
更新日期:2006-11-01 00:00:00
abstract::Most cases of early-onset torsion dystonia are caused by deletion of GAG in the coding region of the DYT1 gene encoding torsinA. This autosomal dominant neurologic disorder is characterized by abnormal movements, believed to originate from neuronal dysfunction in the basal ganglia of the human brain. The torsins (tors...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10567
更新日期:2003-04-15 00:00:00
abstract::Most previous studies on spinal cord injury (SCI) have used rodent models. Direct extrapolation of the results obtained in rodents to clinical cases is difficult, however, because of neurofunctional and anatomic differences between rodents and primates. In the present study, the development of histopathologic changes ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20435
更新日期:2005-04-15 00:00:00
abstract::The neuroblastoma, N1E-115, was grown for 9 days after subcultivation. The development of acetylcholinestrase (AChE), choline acetyltransferase (CAT), QNB-binding, choline uptake, and acetylcholine release was measured on days 1, 3, 6, and 9. In parallel experiments the irreversible AChE inhibitor soman was added to n...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490270115
更新日期:1990-09-01 00:00:00
abstract::Human fetal brain is a potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative diseases. We explored whether NSCs isolated from cortex and striatum of human fetuses, aged 6-9 weeks post-conception, maintain their regional identity and differentiate into specific neuron types in c...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21066
更新日期:2006-12-01 00:00:00
abstract::The effect of the potent soluble guanylyl cyclase (sGC) inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) on neurite outgrowth and retraction was investigated in PC12 cells and SH-SY5Y human neuroblastoma cells. ODQ inhibited neurite outgrowth and triggered neurite retraction in the cells stimulated with ner...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21838
更新日期:2009-01-01 00:00:00
abstract::The 14-3-3 proteins exist predominantly in the brain and may play regulatory roles in cellular processes of growth, differentiation, survival, and apoptosis. The biological functions, however, of the various 14-3-3 isoforms (beta, epsilon, eta, gamma, and zeta) in the brain remain unclear. We have reported previously ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20323
更新日期:2005-01-01 00:00:00
abstract::High-affinity uptake, potassium-stimulated release and receptor binding of gamma-aminobutyric acid (GABA) and taurine were studied in retinas of rats treated with monosodium glutamate (MSG) or iodoacetate-malate (IAM). Such treatments produce a selective damage of the inner retinal layers (MSG) or of the photoreceptor...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490080407
更新日期:1982-01-01 00:00:00
abstract::The purpose of this study was to determine how oligodendrocytes die following Fas receptor activation. An immortalized human oligodendrocyte hybrid line (MO3.13) was challenged with Fas ligand (FasL), and cell death was assessed by flow cytometry and DNA gel electrophoresis. Caspase activation was determined by either...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10285
更新日期:2002-07-15 00:00:00
abstract::Alterations in the 5-HT2A receptor gene expression in the prefrontal cortex have been suggested to play a role in the pathophysiology and pharmacotherapy of schizophrenia. This study measured mRNA encoding 5-HT2A receptor in the left superior frontal gyrus from chronic elderly schizophrenics (n = 21) with varying neur...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:2000-01-15 00:00:00
abstract::Ca(2+) influx through L-type Ca(2+) channels regulates several different cellular processes in developing Purkinje neurons, including activation of transcription factors and expression of cellular proteins. In the current studies, we examined the age dependence of these actions of Ca(2+) during the early developmental...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20844
更新日期:2006-06-01 00:00:00
abstract::The cerebral neocortex is known to modulate asymmetrically certain components of the immune system. It was previously shown that large ablation of the left cortex reduces B and T cell-mediated responses, whereas symmetrical right lesions enhance these responses. We have studied the immunomodulatory role of the brain c...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220212
更新日期:1989-02-01 00:00:00
abstract::Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system with an autoimmune attack on the components of the myelin sheath and axons. The etiology of the disease remains largely unknown, but it is commonly acknowledged that the development of MS probably results from the interacti...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24023
更新日期:2017-10-01 00:00:00
abstract::Pathogenesis of Parkinson's disease and related catecholaminergic neurological disorders is closely associated with changes in the levels of tyrosine hydroxylase (TH). Therefore, investigation of the regulation of the TH gene system should assist in understanding the pathomechanisms involved in these neurological diso...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23085
更新日期:2012-10-01 00:00:00
abstract::Taurine, 2-aminoethanesulfonic acid, is present at high concentrations in many invertebrate and vertebrate systems and has several biological functions. In addition, it has been related to a neuroprotective role against several diseases such as epilepsy. In the present work, we treated mice with taurine and examined i...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22192
更新日期:2010-01-01 00:00:00