Abnormalities in 5-HT2A receptor mRNA expression in frontal cortex of chronic elderly schizophrenics with varying histories of neuroleptic treatment.

abstract：:Human fetal brain is a potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative diseases. We explored whether NSCs isolated from cortex and striatum of human fetuses, aged 6-9 weeks post-conception, maintain their regional identity and differentiate into specific neuron types in c...

journal_title：Journal of neuroscience research

authors： Kallur T,Darsalia V,Lindvall O,Kokaia Z

更新日期：2006-12-01 00:00:00

abstract：:We investigated whether a learning impairment after a controlled cortical impact (CCI) injury was associated with alterations in molecules involved in synaptic plasticity and learning and memory. Adult male rats with moderate CCI to the left parietal cortex, tested in a Morris water maze (MWM) beginning at postinjury ...

journal_title：Journal of neuroscience research

authors： Griesbach GS,Sutton RL,Hovda DA,Ying Z,Gomez-Pinilla F

更新日期：2009-02-15 00:00:00

abstract：:We studied the postischemic alterations of second messenger and receptor systems focusing on the strionigral pathway in order to clarify the mechanism of the delayed neuronal changes in remote areas of the rat brain after transient focal ischemia. Chronological changes of [3H]forskolin and [3H]SCH 23390 binding sites ...

journal_title：Journal of neuroscience research

authors： Nagasawa H,Araki T,Kogure K

更新日期：1992-11-01 00:00:00

abstract：:The molecular mechanisms by which extracellular guidance cues regulate axonal morphology are not fully understood. Recent findings suggest that increased activity of the protein kinase Akt promotes dendritic branching and elongation in hippocampal neurons. We tested whether expression of constitutively active Akt (CA-...

journal_title：Journal of neuroscience research

authors： Grider MH,Park D,Spencer DM,Shine HD

更新日期：2009-11-01 00:00:00

abstract：:The expression of many myelin-specific molecules in Schwann cells is profoundly decreased following denervation. This study examines the early reexpression of myelin protein genes associated with reinnervation. Following sciatic nerve crush, the distal, regenerated nerve was divided into appropriate (2.5 or 5 mm) cons...

journal_title：Journal of neuroscience research

authors： Mitchell LS,Griffiths IR,Morrison S,Barrie JA,Kirkham D,McPhilemy K

更新日期：1990-10-01 00:00:00

abstract：:Increased serum level of homocysteine, a sulfur-containing amino acid, is considered a risk factor in vascular disorders and in dementias. The effect of homocysteine and metabolically related compounds on brain production of kynurenic acid (KYNA), an endogenous antagonist of glutamate ionotropic receptors, was studied...

journal_title：Journal of neuroscience research

authors： Luchowska E,Luchowski P,Paczek R,Ziembowicz A,Kocki T,Turski WA,Wielosz M,Lazarewicz J,Urbanska EM

更新日期：2005-02-01 00:00:00

abstract：:Oligodendrocytes (OLs) and the myelin produced by them are enriched in two glycosphingolipids, galactosylceramide (GalC) and its sulfated form, cerebroside sulfate (CBS). We showed earlier that these two glycolipids in opposed liposomal membranes or in methanol solution can adhere to each other. Here we have examined ...

journal_title：Journal of neuroscience research

authors： Boggs JM,Wang H

更新日期：2001-10-15 00:00:00

abstract：:The possibility that neuron-astrocyte communication may be responsible for glutamate (Glu)-stimulated cGMP formation even in relatively homogeneous primary cultures of mouse cerebellar granule cells (7 days in vitro) was investigated. Pharmacological analysis using selective excitatory amino acid (EAA) receptor antago...

journal_title：Journal of neuroscience research

authors： Malcolm C,Grieve A,Ritchie L,Schousboe A,Griffiths R

更新日期：1996-07-15 00:00:00

abstract：:Neuron-glia interactions at paranodal junctions play important roles in action potential propagation. Among their many functions, they contribute to the passive electrical properties of myelinated nerve fibers and actively regulate the polarized distribution of ion channels along axons. Despite their importance, relat...

journal_title：Journal of neuroscience research

authors： Ogawa Y,Rasband MN

更新日期：2009-11-15 00:00:00

abstract：:Isatin (indole-2,3-dione) is an endogenous indole that has a distinct and discontinuous distribution in the brain and in other mammalian tissues and body fluids. Its output is increased under conditions of stress and anxiety. Its biological targets remain poorly characterized, although [(3)H]isatin binding sites have ...

journal_title：Journal of neuroscience research

authors： Crumeyrolle-Arias M,Buneeva O,Zgoda V,Kopylov A,Cardona A,Tournaire MC,Pozdnev V,Glover V,Medvedev A

更新日期：2009-09-01 00:00:00

abstract：:We reported previously that stem cell factor (SCF) is produced mainly by neurons and that its receptor (c-kitR), encoded by the protooncogene c-kit, is expressed in microglia, suggesting that SCF/c-kitR signaling may be involved in neuron-microglia interactions. We now report that SCF supports microglial survival in c...

journal_title：Journal of neuroscience research

authors： Zhang SC,Fedoroff S

更新日期：1998-07-01 00:00:00

abstract：:The number of older people who are suffering from memory impairment is increasing among populations throughout the world. Alzheimer's disease (AD) affects about 5% of people over 65 years old. The hippocampus, a brain area critical for learning and memory, is especially vulnerable to damage in the early stages of AD. ...

journal_title：Journal of neuroscience research

authors： Esfandiary E,Karimipour M,Mardani M,Alaei H,Ghannadian M,Kazemi M,Mohammadnejad D,Hosseini N,Esmaeili A

更新日期：2014-04-01 00:00:00

abstract：:Apolipoprotein E (ApoE) is the major brain lipoprotein and plays an important role in lipid transport. ApoE-deficient mice whose apoE gene has been knocked out have distinct cognitive and neurochemical deficits, and their recovery from brain injury is impaired. In the present study we examined the possibility that the...

journal_title：Journal of neuroscience research

authors： Lomnitski L,Oron L,Sklan D,Michaelson DM

更新日期：1999-11-15 00:00:00

abstract：:There is supporting evidence of alcohol negative effects on the brain: neuroimaging and psychophysiological studies finding anatomical and functional connectivity (FC) changes associated with the dependence process. Thus, the aim of this work was to evaluate brain FC and network characteristics of alcohol-dependent in...

journal_title：Journal of neuroscience research

authors： Sion A,Bruña Fernández R,Martínez Maldonado A,Domínguez Centeno I,Torrado-Carvajal A,Rubio G,Pereda E,Jurado-Barba R

更新日期：2020-10-01 00:00:00

abstract：:Previous histochemical studies of iron in the brain demonstrated iron enrichment in oligodendrocytes, but the iron-enriched oligodendrocytes had a spatially restricted distribution that excluded major white matter tracts. In this study we used techniques designed to permeabilize tissue, combined with iron histochemist...

journal_title：Journal of neuroscience research

authors： LeVine SM,Macklin WB

更新日期：1990-08-01 00:00:00

abstract：:Integrins comprise a large family of cell adhesion molecules that mediate interactions between the extracellular environment and the cytoplasm. During the last decade, analysis of the expression and function of these molecules has revealed that integrins regulate many aspects of cell behavior including cell death, pro...

journal_title：Journal of neuroscience research

authors： Milner R,Campbell IL

更新日期：2002-08-01 00:00:00

abstract：:Four major discoveries on the function of the pedunculopontine nucleus (PPN) have significantly advanced our understanding of the role of arousal in neurodegenerative disorders. The first was the finding that stimulation of the PPN-induced controlled locomotion on a treadmill in decerebrate animals, the second was the...

journal_title：Journal of neuroscience research

authors： Garcia-Rill E

更新日期：2019-12-01 00:00:00

abstract：:Electrical activity shapes development of the nervous system, presumably in part by regulating gene expression. A set of regulatory genes, immediate early genes (IEGs), which are responsive to a number of extrinsic cellular stimuli have been proposed to play a role in coupling such activity to gene expression. Using a...

journal_title：Journal of neuroscience research

authors： Sheng HZ,Fields RD,Nelson PG

更新日期：1993-08-01 00:00:00

abstract：:Transplanting neural stem cells (NSC) to the damaged brain has been regarded as a potential treatment for neurodegenerative diseases such as Alzheimer's disease (AD), a condition characterized by memory loss. We hypothesized that transplantation of NSC into the hippocampal regions of APP + PS1 transgenic (Tg) mice, a ...

journal_title：Journal of neuroscience research

authors： Zhang W,Wang GM,Wang PJ,Zhang Q,Sha SH

更新日期：2014-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis is an age-related neurological disease, characterized by neurofilament (NF) accumulation in primary axons followed by degeneration of motor neurons. To elucidate age-related factors that might lead to pathological NF accumulation, NFs were compared between young and aged rats. Electron mi...

journal_title：Journal of neuroscience research

authors： Uchida A,Yorifuji H,Lee VM,Kishimoto T,Hisanaga S

更新日期：1999-10-15 00:00:00

abstract：:In a nominally calcium-free medium, a toxic phospholipase A2, paradoxin, PDX (1-200nM) was able to significantly decrease glutamate uptake by rat hippocampal mini-slices. Under the same experimental conditions, PDX could also inhibit the reuptake of choline and dopamine, suggesting a nonselective action. Furthermore, ...

journal_title：Journal of neuroscience research

authors： Dorandeu F,Antier D,Pernot-Marino I,Lapeyre P,Lallement G

更新日期：1998-02-01 00:00:00

abstract：:Dissociated embryonic rat ventral mesencephalon containing the developing A8-A10 dopamine (DA) neurons was cultured alone or in the presence of a 10 mm segment of adult rat sciatic nerve that had been explanted and maintained in separate culture for 72 hours prior to introduction to mesencephalic cultures. Nerve segme...

journal_title：Journal of neuroscience research

authors： Collier TJ,Sladek CD,Gallagher MJ,Gereau RW 4th,Springer JE

更新日期：1990-11-01 00:00:00

abstract：:Oligodendrocytes (OLs) show heterogeneous properties that depend on their location in the central nervous system (CNS). In this regard, the investigation of oligodendrocyte precursor cells (OPCs) derived from human pluripotent stem cells (hPSCs) should be reconsidered, particularly in cases of brain-predominant disord...

journal_title：Journal of neuroscience research

authors： Hermanto Y,Maki T,Takagi Y,Miyamoto S,Takahashi J

更新日期：2019-07-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) acutely modulates the efficacy of central glutamatergic synapses via activation of the receptor tyrosine kinase TrkB. On a longer time scale, recent evidence suggests an additional role of TrkB signaling in the formation of excitatory synaptic connections. Here, we have overexp...

journal_title：Journal of neuroscience research

authors： Klau M,Hartmann M,Erdmann KS,Heumann R,Lessmann V

更新日期：2001-11-01 00:00:00

abstract：:CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor-like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues. To date, more than 130 differen...

journal_title：Journal of neuroscience research

authors： Ungaro C,Mazzei R,Conforti FL,Sprovieri T,Servillo P,Liguori M,Citrigno L,Gabriele AL,Magariello A,Patitucci A,Muglia M,Quattrone A

更新日期：2009-04-01 00:00:00

abstract：:In contrast to mammals, teleost fish are able to regrow severed long-range projection axons in the central nervous system (CNS), leading to recovery of function. The optic projection in teleost fish is used to study neuron-intrinsic and environmental molecular factors that determine successful axon regrowth and naviga...

journal_title：Journal of neuroscience research

authors： Becker CG,Becker T

更新日期：2007-09-01 00:00:00

abstract：:In this study we used as glial cell models, early and late passage C-6 glial cells, 2B clone, and advanced passages of glial cells derived from aged mouse cerebral hemispheres (MACH) to examine responsiveness to opioids. We have previously reported that early passage C-6 glial cells, 2B clone, are bipotential and can ...

journal_title：Journal of neuroscience research

authors： Kozlova M,Kentroti S,Vernadakis A

更新日期：1993-12-01 00:00:00

abstract：:In a military setting, traumatic brain injury (TBI) is frequently caused by blast waves that can trigger a series of neuronal biochemical changes. Although many animal models have been used to study the effects of primary blast waves, elucidating the mechanisms of damage in a whole-animal model is extremely complex. I...

journal_title：Journal of neuroscience research

authors： Zander NE,Piehler T,Boggs ME,Banton R,Benjamin R

更新日期：2015-09-01 00:00:00

abstract：:Substance P (SP) acts as an immunoregulator by binding to specific functional cell surface receptors on a subpopulation of human T-helper lymphocytes. Receptors with similar properties have also been characterized on the human IM-9 B-lymphoblast cell line. Four distinct proteins of molecular weight (MW) 33,000, 58,000...

journal_title：Journal of neuroscience research

authors： McGillis JP,Organist ML,Scriven KH,Payan DG

更新日期：1987-01-01 00:00:00

abstract：:Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke-related disability. Stroke has dropped to the fifth leading cause of death in men,...

journal_title：Journal of neuroscience research

authors： Spychala MS,Honarpisheh P,McCullough LD

更新日期：2017-01-02 00:00:00