Sex differences in neuroinflammation and neuroprotection in ischemic stroke.

Abstract:

:Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke-related disability. Stroke has dropped to the fifth leading cause of death in men, but remains the third in women. This review discusses sex differences in common stroke risk factors, the efficacy of stroke prevention therapies, acute treatment responses, and post-stroke recovery in clinical populations. Women have an increased lifetime risk of stroke compared to men, largely due to a steep increase in stroke incidence in older postmenopausal women, yet most basic science studies continue to only evaluate young male animals. Women also have an increased lifetime prevalence of many common stroke risk factors, including hypertension and atrial fibrillation, as well as abdominal obesity and metabolic syndrome. None of these age-related risk factors have been well modeled in the laboratory. Evidence from the bench has implicated genetic and epigenetic factors, differential activation of cell-death programs, cell-cell signaling pathways, and systemic immune responses as contributors to sex differences in ischemic stroke. The most recent basic scientific findings have been summarized in this review, with an emphasis on factors that differ between males and females that are pertinent to stroke outcomes. Identification and understanding of the underlying biological factors that contribute to sex differences will be critical to the development of translational targets to improve the treatment of women after stroke. © 2016 Wiley Periodicals, Inc.

journal_name

J Neurosci Res

authors

Spychala MS,Honarpisheh P,McCullough LD

doi

10.1002/jnr.23962

subject

Has Abstract

pub_date

2017-01-02 00:00:00

pages

462-471

issue

1-2

eissn

0360-4012

issn

1097-4547

journal_volume

95

pub_type

杂志文章,评审
  • Characterization of synaptic vesicles and related neuronal features in nerve growth factor and ras oncogene differentiated PC12 cells.

    abstract::PC12 cells can differentiate into neuron-like cells after treatment with either nerve growth factor (NGF) or transduction with a retrovirus which expresses the K-ras oncogene. The concomitant treatment of NGF plus ras differentiates PC12 cells further than either agent alone with respect to neurite outgrowth, acetylch...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490420306

    authors: Tao-Cheng JH,Dosemeci A,Bressler JP,Brightman MW,Simpson DL

    更新日期:1995-10-15 00:00:00

  • Maternal dietary restriction causes myelin and lipid deficits in the brain of offspring.

    abstract::The relationship between brain myelination and nutritional insufficiency in suckling rats whose dams had a restricted dietary intake was studied. The undernourished pups were characterized by body weight and brain weight that were 40-70% and 82-88% that of controls throughout the suckling period. Myelin concentrations...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490190311

    authors: Yeh YY

    更新日期:1988-03-01 00:00:00

  • Detection of choline-acetyltransferase activity in lymphocytes.

    abstract::The cholinergic system takes part in the immune-neuroendocrine integration. Lymphocytes have been found to express muscarinic and nicotinic cholinergic receptors, as well as acetylcholine-esterase on their surface, and cholinergic agents modulate immune functions in vitro and in vivo. In the present study we provide e...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490350209

    authors: Rinner I,Schauenstein K

    更新日期:1993-06-01 00:00:00

  • Personality traits affect the influences of intensity perception and emotional responses on hedonic rating and preference rank toward basic taste solutions.

    abstract::This study aimed at determining, based on independent predictors of taste intensity and emotional response, whether individual personality traits could affect prediction models of overall liking and preference rank toward basic taste solutions. Sixty-seven participants rated taste intensities (TI) of four basic-taste ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.24321

    authors: Samant SS,Seo HS

    更新日期:2019-03-01 00:00:00

  • Tenascin-C in brain injuries and edema after subarachnoid hemorrhage: Findings from basic and clinical studies.

    abstract::Subarachnoid hemorrhage (SAH) by a rupture of cerebral aneurysms remains the most devastating cerebrovascular disease. Early brain injury (EBI) is increasingly recognized to be the primary determinant for poor outcomes, and also considered to cause delayed cerebral ischemia (DCI) after SAH. Both clinical and experimen...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.24330

    authors: Suzuki H,Fujimoto M,Kawakita F,Liu L,Nakatsuka Y,Nakano F,Nishikawa H,Okada T,Kanamaru H,Imanaka-Yoshida K,Yoshida T,Shiba M

    更新日期:2020-01-01 00:00:00

  • Calcium modulates dopamine potentiation of N-methyl-D-aspartate responses: electrophysiological and imaging evidence.

    abstract::In the striatum, dopamine (DA) exerts a major modulatory influence on voltage- and ligand-gated currents. Previously we have shown that DA modulates glutamatergic neurotransmission and that the direction of this modulation depends on, among other factors, the glutamate and DA receptor subtypes activated. These effects...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20079

    authors: Liu JC,DeFazio RA,Espinosa-Jeffrey A,Cepeda C,de Vellis J,Levine MS

    更新日期:2004-05-01 00:00:00

  • Isolation and characterization of Bsk, a growth factor receptor-like tyrosine kinase associated with the limbic system.

    abstract::Neuronal degeneration has been shown to be involved in various neurological disorders. Growth/trophic factors and their receptors are known to be important for the regeneration and survival of neurons. We report here the molecular cloning of a receptor-like protein tyrosine kinase, bsk, (for brain specific kinase). Bs...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490370117

    authors: Zhou R,Copeland TD,Kromer LF,Schulz NT

    更新日期:1994-01-01 00:00:00

  • Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons.

    abstract::The ligand-activated transcription factor peroxisome proliferator-activated receptor beta (PPARbeta) is present in the brain and is implicated in the regulation of genes with potential roles in neurotoxicity. We sought to examine the role of PPARbeta in neuronal cell death by using the PPARbeta ligand GW0742. Primary ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20153

    authors: Smith SA,Monteith GR,Robinson JA,Venkata NG,May FJ,Roberts-Thomson SJ

    更新日期:2004-07-15 00:00:00

  • Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis.

    abstract::The presence of the apolipoprotein E (apoE) allele epsilon4 is a major risk factor for the development of Alzheimer's disease (AD); however, the molecular mechanism underlying the acceleration of AD development in individuals with epsilon4 remains to be determined. To investigate the isoform-specific effects of apoE o...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19981001)54:1<58::AID-JNR7

    authors: Michikawa M,Yanagisawa K

    更新日期:1998-10-01 00:00:00

  • Transplantation of human adult astrocytes: efficiency and safety requirements for an autologous gene therapy.

    abstract::Ex vivo gene therapy is emerging as a promising approach for the treatment of neurodegenerative diseases and central nervous system (CNS) trauma. We have shown previously that human adult astrocytes can be expanded in vitro and can express various therapeutic transgenes (Ridet et al. [1999] Hum. Gene Ther. 10:271-280;...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.10617

    authors: Ridet JL,Sarkis C,Serguera C,Zennou V,Charneau P,Mallet J

    更新日期:2003-06-15 00:00:00

  • Novel astrocytic protein in multiple sclerosis plaques.

    abstract::Monoclonal antibody J1-31 (MAb J1-31, isotype IgG 2b) was raised against crude homogenate of brain tissue from a multiple sclerosis (MS) patient (autopsy sample; Malhotra et al.: Microbios Letters 26:151-157, 1984). In human brain, MAb J1-31 recognizes an intracellular protein antigen (J1-31 antigen), which bands at a...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490220106

    authors: Malhotra SK,Predy R,Johnson ES,Singh R,Leeuw K

    更新日期:1989-01-01 00:00:00

  • mRNA expression of ephrins and Eph receptor tyrosine kinases in the neonatal and adult mouse central nervous system.

    abstract::Ephrins and Eph receptors are a family of molecules that have been implicated in axonal pathfinding. A unique feature of B-class ephrins and Eph receptors is their ability to transmit bidirectional signals in both ephrin- and Eph receptor-expressing cells upon cell-cell contact. These signals can lead to cytoskeletal ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.10457

    authors: Liebl DJ,Morris CJ,Henkemeyer M,Parada LF

    更新日期:2003-01-01 00:00:00

  • In vitro studies of primary explosive blast loading on neurons.

    abstract::In a military setting, traumatic brain injury (TBI) is frequently caused by blast waves that can trigger a series of neuronal biochemical changes. Although many animal models have been used to study the effects of primary blast waves, elucidating the mechanisms of damage in a whole-animal model is extremely complex. I...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.23594

    authors: Zander NE,Piehler T,Boggs ME,Banton R,Benjamin R

    更新日期:2015-09-01 00:00:00

  • The effect of trimethadione on brain energy metabolism and EEG activity of the conscious rat exposed to HPO.

    abstract::The use of trimethadione (TMO) as a protector in hyperbaric oxygen toxicity in the conscious rat has been examined in detail. The oxidation-reduction state of pyridine nucleotides was measured simultaneously with the EEG activity from the surface of the brain cortex. From the data obtained, a few parameters were calcu...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490010205

    authors: Mayevsky A

    更新日期:1975-01-01 00:00:00

  • Cultured astrocytes from heme oxygenase-1 knockout mice are more vulnerable to heme-mediated oxidative injury.

    abstract::Hemin, the oxidized form of heme, is released from hemoglobin after CNS hemorrhage and may contribute to injury to surrounding tissue. The heme oxygenase (HO) enzymes catalyze the breakdown of hemin to biliverdin, carbon monoxide, and ferric iron. Although HO-2, the isoform expressed predominantly in neurons, accelera...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20681

    authors: Chen-Roetling J,Benvenisti-Zarom L,Regan RF

    更新日期:2005-12-15 00:00:00

  • Zonisamide promotes survival of human-induced pluripotent stem cell-derived dopaminergic neurons in the striatum of female rats.

    abstract::The transplantation of dopaminergic (DA) progenitors derived from pluripotent stem cells improves the behavior of Parkinson's disease model animals. However, the survival of DA progenitors is low, and the final yield of DA neurons is only approximately 0.3%-2% the number of transplanted cells. Zonisamide (ZNS) increas...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.24668

    authors: Miyawaki Y,Samata B,Kikuchi T,Nishimura K,Takahashi J

    更新日期:2020-08-01 00:00:00

  • GM1 ganglioside protects nucleus basalis from excitotoxin damage: reduced cortical cholinergic losses and animal mortality.

    abstract::Ten days after bilateral injections of ibotenic acid into the nucleus basalis, rats injected daily (i.m.) with ganglioside GM1 were protected from anterograde degeneration of cholinergic projections to the fronto-lateral cortex. This protection was reflected by reduced losses (associated with ibotenic acid lesions) of...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490200411

    authors: Mahadik SP,Vilim F,Korenovsky A,Karpiak SE

    更新日期:1988-08-01 00:00:00

  • Xenopus oocytes as immunological vectors to produce monoclonal antibodies to rat brain antigens.

    abstract::A novel approach was developed to raise a panel of monoclonal antibodies (mAb) against brain antigens using Xenopus oocytes as immunological vectors. Xenopus oocytes were injected to express proteins encoded by brain-derived mRNA extracted from rat cerebral cortex. A crude membrane preparation from mRNA-injected oocyt...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490290109

    authors: Matute C,Tigyi GJ,Miledi R

    更新日期:1991-05-01 00:00:00

  • Calcium-induced activation of the mitochondrial permeability transition in hippocampal neurons.

    abstract::The mitochondrial permeability transition (mPT) has been implicated in both excitotoxic and apoptotic neuronal cell death, despite the fact that it has not been previously identified in neurons. To study the mPT in hippocampal neurons, cultures were loaded with the mitochondrial dye JC-1 and observed with confocal and...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19980915)53:6<728::AID-JNR

    authors: Dubinsky JM,Levi Y

    更新日期:1998-09-15 00:00:00

  • Induction of connexin43 and gap junctional communication in PC12 cells overexpressing the carboxy terminal region of amyloid precursor protein.

    abstract::Previous studies have shown that PC12 cells overexpressing beta/A4 amyloid peptide display altered morphology characterized by pronounced membrane ruffling and extensive intercellular appositions. Having observed other cell types in which these features accompany increased connexin43 (Cx43) production and gap junction...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19960415)44:2<124::AID-JNR

    authors: Nagy JI,Hossain MZ,Hertzberg EL,Marotta CA

    更新日期:1996-04-15 00:00:00

  • Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells.

    abstract::Neuronal pathology of the brain with Alzheimer's disease (AD) is characterized by numerous depositions of amyloid-beta peptides (Abeta). Abeta binding to the 75-kDa neurotrophin receptor (p75NTR) causes neuronal cell death. Here we report that Abeta causes cell death in neuronal hybrid cells transfected with p75NTR, b...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.10703

    authors: Tsukamoto E,Hashimoto Y,Kanekura K,Niikura T,Aiso S,Nishimoto I

    更新日期:2003-09-01 00:00:00

  • C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation.

    abstract::Microglia, central nervous system (CNS) resident phagocytic cells, persistently police the integrity of CNS tissue and respond to any kind of damage or pathophysiological changes. These cells sense and rapidly respond to danger and inflammatory signals by changing their cell morphology; by release of cytokines, chemok...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21875

    authors: Färber K,Cheung G,Mitchell D,Wallis R,Weihe E,Schwaeble W,Kettenmann H

    更新日期:2009-02-15 00:00:00

  • Cardiotrophin-1 requires LIFRbeta to promote survival of mouse motoneurons purified by a novel technique.

    abstract::The cytokines ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) signal through a receptor complex formed between two transmembrane proteins, gp130 and LIFRbeta. In addition, CNTF also uses a ligand-binding component which is anchored to the cell membrane. In the case of cardiotrophin-1 (CT-1), LI...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19990101)55:1<119::AID-JNR

    authors: Arce V,Garces A,de Bovis B,Filippi P,Henderson C,Pettmann B,deLapeyrière O

    更新日期:1999-01-01 00:00:00

  • Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants.

    abstract::The higher prevalence and risk for Alzheimer's disease in women relative to men has been partially attributed to the precipitous decline in gonadal hormone levels that occurs in women following the menopause. Although considerable attention has been focused on the consequence of estrogen loss, and thus estrogen's neur...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21370

    authors: Kaur P,Jodhka PK,Underwood WA,Bowles CA,de Fiebre NC,de Fiebre CM,Singh M

    更新日期:2007-08-15 00:00:00

  • Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell death.

    abstract::Pigment epithelium-derived factor (PEDF) is a neurotrophic protein synthesized and secreted by retinal pigment epithelial (RPE) cells in early embryogenesis and has been shown to be present in the extracellular matrix between the RPE cells and the neural retina. It induces neuronal differentiation and promotes surviva...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:

    authors: Cao W,Tombran-Tink J,Chen W,Mrazek D,Elias R,McGinnis JF

    更新日期:1999-09-15 00:00:00

  • Pathogenesis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage: putative mechanisms and novel approaches.

    abstract::Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of cerebral vasospasm remain poorl...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.21823

    authors: Kolias AG,Sen J,Belli A

    更新日期:2009-01-01 00:00:00

  • Pentoxifylline and propentofylline prevent proliferation and activation of the mammalian target of rapamycin and mitogen activated protein kinase in cultured spinal astrocytes.

    abstract::Astrocyte activation is an important feature in many disorders of the central nervous system, including chronic pain conditions. Activation of astrocytes is characterized by a change in morphology, including hypertrophy and increased size of processes, proliferation, and an increased production of proinflammatory medi...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.23144

    authors: Norsted Gregory E,Delaney A,Abdelmoaty S,Bas DB,Codeluppi S,Wigerblad G,Svensson CI

    更新日期:2013-02-01 00:00:00

  • Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus.

    abstract::Two fundamental questions about neuron cell culture were addressed. Can one serum-free medium that was developed for optimum growth of hippocampal neurons support the growth of neurons from other regions of the brain? Is the region specific state of differentiation maintained in culture? To answer these questions, we ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490420510

    authors: Brewer GJ

    更新日期:1995-12-01 00:00:00

  • Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments.

    abstract::Glial cell line-derived neurotrophic factor (GDNF) has been shown to be a preferentially selective neurotrophic factor for dopamine (DA) neurons. In the present study, we have examined the distribution of GDNF mRNA expression in several major DA-containing cell body and terminal areas and the regulation of GDNF mRNA e...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19980901)53:5<593::AID-JNR

    authors: Tang YP,Ma YL,Chao CC,Chen KY,Lee EH

    更新日期:1998-09-01 00:00:00

  • Inhibition of the synthesis of glycosphingolipids affects the translocation of proteolipid protein to the myelin membrane.

    abstract::Brain slices obtained from young rats were incubated with different radioactive precursors, in the presence and absence of L-cycloserine (an inhibitor of the synthesis of sphingosine) in order to explore the possibility that transport of proteolipids--and specifically of the major myelin proteolipid PLP--to the myelin...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490220309

    authors: Pasquini JM,Guarna MM,Besio-Moreno MA,Iturregui MT,Oteiza PI,Soto EF

    更新日期:1989-03-01 00:00:00