Abstract:
:Four major discoveries on the function of the pedunculopontine nucleus (PPN) have significantly advanced our understanding of the role of arousal in neurodegenerative disorders. The first was the finding that stimulation of the PPN-induced controlled locomotion on a treadmill in decerebrate animals, the second was the revelation of electrical coupling in the PPN and other arousal and sleep-wake control regions, the third was the determination of intrinsic gamma band oscillations in PPN neurons, and the last was the discovery of gene transcription resulting from the manifestation of gamma activity in the PPN. These discoveries have led to novel therapies such as PPN deep brain stimulation (DBS) for Parkinson's disease (PD), identified the mechanism of action of the stimulant modafinil, determined the presence of separate mechanisms underlying gamma activity during waking versus REM sleep, and revealed the presence of gene transcription during the manifestation of gamma band oscillations. These discoveries set the stage for additional major advances in the treatment of a number of disorders.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Garcia-Rill Edoi
10.1002/jnr.24417subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1515-1520issue
12eissn
0360-4012issn
1097-4547journal_volume
97pub_type
杂志文章,评审abstract::The location of glyoxylate-complex molecules has been investigated in several areas of the rat cerebral cortex using the immunohistochemical peroxidase-antiperoxidase (PAP) method. Antibodies against glyoxylate-complex molecules have been developed in the rabbit after immunization with a glyoxylate-bovine serum albumi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980115)51:2<268::AID-JNR
更新日期:1998-01-15 00:00:00
abstract::In this study we used as glial cell models, early and late passage C-6 glial cells, 2B clone, and advanced passages of glial cells derived from aged mouse cerebral hemispheres (MACH) to examine responsiveness to opioids. We have previously reported that early passage C-6 glial cells, 2B clone, are bipotential and can ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490360509
更新日期:1993-12-01 00:00:00
abstract::Sensory axons do not regenerate into or within the spinal cord because of the presence of the axon regeneration inhibitor chondroitin sulfate proteoglycan (CSPG) on activated astrocytes. In the peripheral nervous system, CSPG associated with denervated Schwann cells retards axon regeneration, but regeneration occurs b...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22132
更新日期:2009-10-01 00:00:00
abstract::In cultured Schwann cells, single-channel and whole-cell K+ currents can be activated by depolarizing the membrane to values more negative than -50 mV. In elevated extracellular K+ concentration ([K+]o), however, single-channel activity and whole-cell currents could be recorded at more negative potentials. Thus, the t...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490280208
更新日期:1991-02-01 00:00:00
abstract::Increase of intracellular [Ca(2+)] evoked by action potentials in a cell can induce long-term synaptic plasticity even without concomitant presynaptic stimulation. We used optical recording of the fluorescence of a Ca(2+)-indicator Oregon Green to investigate whether differences in results obtained with modifications ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20104
更新日期:2004-05-15 00:00:00
abstract::Heat shock proteins (HSPs) are stress-responsive proteins that serve as important molecules contributing to cellular "protein triage." We and others have reported an increase of selected HSPs in multiple sclerosis (MS) lesions. However, the exact expression pattern of HSP family genes in MS is not known. The aim of ou...
journal_title:Journal of neuroscience research
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doi:10.1002/jnr.23079
更新日期:2012-10-01 00:00:00
abstract::Protein zero (P0) glycoprotein is the major integral membrane protein of the peripheral nervous system myelin in higher vertebrates. Previous findings indicate the formation of tetrameric assemblies from studies on isolated P0. To determine whether in intact myelin the P0 exists as oligomers, we isolated myelin from s...
journal_title:Journal of neuroscience research
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doi:10.1002/jnr.10167
更新日期:2002-03-15 00:00:00
abstract::We have shown previously that in oligodendrocytes, the transcription factor cyclic AMP response element binding protein (CREB) is maximally expressed immediately prior to the most rapid period of myelination in rat brain. We have begun to investigate the role of this protein during myelination by downregulating CREB s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19961001)46:1<98::AID-JNR1
更新日期:1996-10-01 00:00:00
abstract::The effect of the potent soluble guanylyl cyclase (sGC) inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) on neurite outgrowth and retraction was investigated in PC12 cells and SH-SY5Y human neuroblastoma cells. ODQ inhibited neurite outgrowth and triggered neurite retraction in the cells stimulated with ner...
journal_title:Journal of neuroscience research
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doi:10.1002/jnr.21838
更新日期:2009-01-01 00:00:00
abstract::Abdominal muscle electromyograms were monitored in response to graded mechanical loads added to either inspiration or expiration in anesthetized cats. The surgical preparation, the apparatus, and the levels of loads applied (resistive, tracheal occlusion, and continuous positive pressure) were matched with those emplo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490130413
更新日期:1985-01-01 00:00:00
abstract::Cultures of rat C6 rat glioma cells exhibit a diminished response to isoproterenol and forskolin after being treated with phorbol 12,13-dibutyrate (PDbU). An IC50 for PDbU of 38 +/- 5 nM and 62 +/- 8 nM was observed in the isoproterenol and forskolin response, respectively. Similarly, C6 cultures exhibited a diminishe...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250110
更新日期:1990-01-01 00:00:00
abstract::The remarkable quantities of myelin membrane produced by oligodendrocytes has led us to examine the mechanisms involved in the sorting and transport of proteins and lipids during myelinogenesis. Noting that it has been proposed that proteins destined for the apical surface of polarized epithelial cells co-cluster with...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490420316
更新日期:1995-10-15 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) infection in its human host often results in progressive dementia and encephalopathy in adults and children, respectively. The mechanisms underlying virus-induced neurocognitive dysfunction are not fully understood. However, several studies strongly suggest that secretory vi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20745
更新日期:2006-02-15 00:00:00
abstract::We recently reported that a new monoclonal antibody, 4F2, which labels oligodendroglial lineage cells, recognizes a DEAD-box RNA helicase Ddx54 and that Ddx54 binds to myelin basic protein (MBP) in brain and cultured oligodendrocytes. To elucidate the biological function of Ddx54, we generated a recombinant adenovirus...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23162
更新日期:2013-03-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960901)45:5<549::AID-JNR
更新日期:1996-09-01 00:00:00
abstract::Glial fibrillary acidic protein (GFAP) is the major constituent of glial filaments and is restricted within the CNS to astrocytes. As with other classes of intermediate filament proteins, the regulation of GFAP expression is poorly understood. Utilizing highly purified cultures of astrocytes and a chemically defined (...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490140202
更新日期:1985-01-01 00:00:00
abstract::Studies using Aplysia californica have demonstrated that transcription after nerve injury occurs during a rapid, transient first phase and a delayed, prolonged second phase. Although the second phase is especially important for regeneration, the mRNAs produced during this phase have not been identified. We characteriz...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20645
更新日期:2005-11-15 00:00:00
abstract::This study demonstrates the ability of proteasome inhibitors (lactacystin, MG 115, MG 132) adenosine diphosphate to induce a time- and dose-dependent increase in poly-ADP-ribosylation (PAR) in the neural PC6 cell line, a subclone of PC12 cells. Elevated levels of PAR contribute to the toxicity associated with impaired...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/1097-4547(20000815)61:4<436::AID-JNR10>3.0
更新日期:2000-08-15 00:00:00
abstract::Mouse sciatic nerves were transected and 3 hr to 16 days later proximal segments were removed and homogenized. Supernatants of these segments or of normal sciatic nerves were added to Schwann cells maintained in Dulbecco's modified Eagle's medium (DMEM) + 15% fetal calf serum (FCS). After 6 days, Schwann cells were so...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490370508
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:2010-05-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490170108
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abstract::Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system with an autoimmune attack on the components of the myelin sheath and axons. The etiology of the disease remains largely unknown, but it is commonly acknowledged that the development of MS probably results from the interacti...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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更新日期:2017-10-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990115)55:2<178::AID-JNR
更新日期:1999-01-15 00:00:00
abstract::Microglia, the resident macrophages of the central nervous system, are the primary cells to respond to injury in the brain, both in inflammation, e.g., in multiple sclerosis, and trauma. Chemokines are potential mediators of microglial cell recruitment to sites of injury; thus, the ability of microglia to migrate in r...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990101)55:1<17::AID-JNR3
更新日期:1999-01-01 00:00:00
abstract::The limited availability and potential to culture primary human brain cells means that there is still a need for cell lines that reliably model human neurons and glial cells. The human-derived NTera2/D1 (NT2) cell line is a promising tool from which both neuronal (NT2N) and astrocytic (NT2A) cells can be derived in vi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22692
更新日期:2011-10-01 00:00:00
abstract::The role of the plasmin-generating system, a serum component, in the development of dissociated embryonic chick spinal cord cells in culture was studied. Studies were performed in a defined system where the cells were maintained in a serum-free medium. Under these conditions the cells produce plasminogen activator. It...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490080237
更新日期:1982-01-01 00:00:00
abstract::Leptin is a potent AMP kinase (AMPK) inhibitor that induces neuroprotection, neurogenesis, and angiogenesis when administered immediately after stroke. To dissociate these effects, we explored the effects of delayed administration of leptin, at 10 days after stroke onset, on neurogenesis and angiogenesis after stroke....
journal_title:Journal of neuroscience research
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doi:10.1002/jnr.23147
更新日期:2013-02-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10832
更新日期:2003-12-15 00:00:00
abstract::Calcium/calmodulin-dependent serine kinase (CASK), a causative gene in X-linked mental retardation, carries out multiple functions in neurons, including vesicle trafficking of ion channels, synapse formation, and gene transcription. From a yeast two-hybrid screen, Krüppel-like zinc finger protein B cell lymphoma/COUP-...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22407
更新日期:2010-08-15 00:00:00