Abstract:
:This study demonstrates the ability of proteasome inhibitors (lactacystin, MG 115, MG 132) adenosine diphosphate to induce a time- and dose-dependent increase in poly-ADP-ribosylation (PAR) in the neural PC6 cell line, a subclone of PC12 cells. Elevated levels of PAR contribute to the toxicity associated with impaired proteasome activity, based on the ability of PAR inhibitors to ameliorate the toxicity associated with the application of lactacystin, MG 115, and MG 132. Proteasome inhibitors induced the accumulation of PAR and neuron death in primary hippocampal neuron cultures, which were both ameliorated by treatment with PAR inhibitors. Together, these data indicate a role for increased PAR in the toxicity associated with proteasome inhibition, and suggest that inhibitors of PAR may provide neuroprotection in conditions where proteasome inhibition occurs.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Keller JN,Markesbery WRdoi
10.1002/1097-4547(20000815)61:4<436::AID-JNR10>3.0keywords:
subject
Has Abstractpub_date
2000-08-15 00:00:00pages
436-42issue
4eissn
0360-4012issn
1097-4547pii
10.1002/1097-4547(20000815)61:4<436::AID-JNR10>3.0journal_volume
61pub_type
杂志文章abstract::CD9 is a tetra-membrane-spanning glycoprotein involved in cell adhesion, migration, and proliferation in both the immune and the immature nervous system. In this study, CD9 expression was detected in myelin of mouse brain, starting at postnatal day 16. The amount of CD9 protein continuously increased with age and pers...
journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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