Identification of Gas6, a putative ligand for Sky and Axl receptor tyrosine kinases, as a novel neurotrophic factor for hippocampal neurons.

abstract：:The postmortem stability of brain RNA was measured in rat and human samples for up to 48 hr. Whole rat brains, cooled at a rate approximating that of human brains awaiting autopsy, were collected at intervals from 0 to 48 hr after death and frozen. These samples were compared with freshly obtained, unfrozen rat brains...

journal_title：Journal of neuroscience research

authors： Johnson SA,Morgan DG,Finch CE

更新日期：1986-01-01 00:00:00

abstract：:The expression of GABAB receptors in cultured mouse cerebellar granule cells was investigated in binding experiments using [3H](S,R)-baclofen as well as in functional assessment of the ability of (R)-baclofen to interact with depolarization (15-40 mM KCl) coupled changes in intracellular Ca2+ homeostasis and neurotran...

journal_title：Journal of neuroscience research

authors： Kardos J,Elster L,Damgaard I,Krogsgaard-Larsen P,Schousboe A

更新日期：1994-12-15 00:00:00

abstract：:Multi-unit activity was recorded from the diencephalon of unanesthetized, immobilized female rats. Less than 50% of the recording sites in the hypothalamus showed changes in the level of multi-unit activity to changes in the level of glucose utilization induced by injection of 2-deoxy-D-glucose (2-DG). It was also not...

journal_title：Journal of neuroscience research

authors： Rabin BM,Miller DS

更新日期：1980-01-01 00:00:00

abstract：:Extracts of bovine heart, rat heart, and rat skeletal muscle were chromatographically separated and the fractions tested for their ability to maintain the survival of dissociated sympathetic, parasympathetic, and sensory neurones. Bovine heart contained at least five, rat heart at least six, and rat skeletal muscle at...

journal_title：Journal of neuroscience research

authors： Bonyhady RE,Hendry IA,Hill CE,Watters DJ

更新日期：1985-01-01 00:00:00

abstract：:Myelin-associated glycoprotein (MAG) is a potent inhibitor of axonal regeneration and also, depending on the age and type of neuron, can promote axonal growth. In addition, MAG influences stability of both myelin and the axon in the intact, mature nervous system. The identity of the neuron/axonal MAG-binding receptor ...

journal_title：Journal of neuroscience research

authors： De Bellard ME,Filbin MT

更新日期：1999-04-15 00:00:00

abstract：:The neonatal lesion with 6-hydroxydopamine (6-OHDA) in rodents induces juvenile hyperactivity and paradoxical hypolocomotor response to psychostimulants, in striking contrast to what is observed when similar lesions are carried out in adults. The early disruption of central dopaminergic pathways is followed by increas...

journal_title：Journal of neuroscience research

authors： Avale ME,Nemirovsky SI,Raisman-Vozari R,Rubinstein M

更新日期：2004-10-15 00:00:00

abstract：:The olfactory ensheathing cell (OEC) is a unique glial cell able to support neurite outgrowth in the CNS throughout life. The OEC has been described as having both Schwann cell-like and astrocyte-like characteristics. The purpose of this study was to compare gap junctional communication and connexin (Cx) expression in...

journal_title：Journal of neuroscience research

authors： Barnett SC,Thompson RJ,Lakatos A,Pitts J

更新日期：2001-09-15 00:00:00

abstract：:Cultured Schwann cells treated with heregulin growth factor require costimulation with a cyclic adenosine monophosphate-elevating agent to produce maximal cell proliferation. Gene chip expression analysis was used to identify genes that are induced or repressed when Schwann cells are treated with heregulin and/or fors...

journal_title：Journal of neuroscience research

authors： Schworer CM,Masker KK,Wood GC,Carey DJ

更新日期：2003-08-15 00:00:00

abstract：:Culturing sympathetic ganglion neurons in vitro may modify phenotypic expression of some neurotransmitters. For dorsal root ganglia (DRG), contradictory results have been reported; most studies have used immature material. We have therefore performed a detailed immunocytochemical analysis of the transmitter content of...

journal_title：Journal of neuroscience research

authors： Schoenen J,Delree P,Leprince P,Moonen G

更新日期：1989-04-01 00:00:00

abstract：:Charcot-Marie-Tooth neuropathy type 1A (CMT 1 A) is the most common inherited neuropathy in humans and is mostly caused by a 1.5-Mb tandem duplication of chromosome 17 comprising the gene for the peripheral myelin protein 22-kDa (PMP 22). Although there are numerous studies on the functional role of PMP 22, the mechan...

journal_title：Journal of neuroscience research

authors： Kobsar I,Hasenpusch-Theil K,Wessig C,Müller HW,Martini R

更新日期：2005-09-15 00:00:00

abstract：:Nerve growth factor (NGF) is a protein essential for the survival and normal function of sympathetic neurons. Two-site immunoassays have been developed over the past decade in several laboratories and used to estimate its endogenous concentrations in a variety of effector tissues. However, levels appear restricted to ...

journal_title：Journal of neuroscience research

authors： Zettler C,Bridges DC,Zhou XF,Rush RA

更新日期：1996-12-01 00:00:00

abstract：:In situ cDNA:mRNA hybridization is a technique that has been developed for the visualization of cDNA:mRNA hybrids in individual cells. To use this technique to answer questions of regulation in heterogeneous populations of cells in the brain, it must be combined with other procedures allowing for the identification of...

journal_title：Journal of neuroscience research

authors： Wilcox JN,Roberts JL,Chronwall BM,Bishop JF,O'Donohue T

更新日期：1986-01-01 00:00:00

abstract：:Intact synaptosomes prepared from 28-day-old rat brains were incubated with CMP-N-acetyl-(14C) neuraminic acid in Krebs-Henseleit buffer in an atmosphere of 95% O2: 5% CO2, at 37 degrees C. The activity of CMP-NANA:ganglioside sialosyltransferase using endogenous acceptors was 0.84 pmoles NANA transferred/mg synaptoso...

journal_title：Journal of neuroscience research

authors： Durrie R,Saito M,Rosenberg A

更新日期：1987-01-01 00:00:00

abstract：:Dissociated embryonic rat ventral mesencephalon containing the developing A8-A10 dopamine (DA) neurons was cultured alone or in the presence of a 10 mm segment of adult rat sciatic nerve that had been explanted and maintained in separate culture for 72 hours prior to introduction to mesencephalic cultures. Nerve segme...

journal_title：Journal of neuroscience research

authors： Collier TJ,Sladek CD,Gallagher MJ,Gereau RW 4th,Springer JE

更新日期：1990-11-01 00:00:00

abstract：:Transferrin is the second most abundant plasma protein and functions to transport iron. It is an essential constituent in culture media for virtually all cells. In a recent study, we reported that transferrin (Tf) is specifically located in oligodendrocytes in the rat nervous system. This investigation examines immuno...

journal_title：Journal of neuroscience research

authors： Connor JR,Fine RE

更新日期：1987-01-01 00:00:00

abstract：:The role of intracellular proteases (e.g., calpains and caspases) in the pathophysiology of neuronal cell death has been extensively investigated. More recently, accumulating data have suggested that extracellular proteolysis also plays a critical role. The two major systems that modify the extracellular matrix in bra...

journal_title：Journal of neuroscience research

authors： Lo EH,Wang X,Cuzner ML

更新日期：2002-07-01 00:00:00

abstract：:Noradrenalin (NA) regulates the expression of arginine-vasopressin (AVP) and oxytocin (OT) by magnocellular neurons in the supraoptic nucleus (SON) of the hypothamalus. Nitric oxide (NO) may be one of the factors involved in the NA signaling pathway regulating AVP and OT expression. To test this possibility, we used a...

journal_title：Journal of neuroscience research

authors： Maolood N,Grange-Messent V,Raison D,Hardin-Pouzet H

更新日期：2007-10-01 00:00:00

abstract：:The mast cell, an immunocompetent cell that contributes to neurogenic inflammation in a variety of tissues, including synovium, is found in close proximity to peripheral terminals of unmyelinated primary afferents and sympathetic postganglionic nerve terminals. In this study we evaluated the hypothesis that the densit...

journal_title：Journal of neuroscience research

authors： Levine JD,Coderre TJ,Covinsky K,Basbaum AI

更新日期：1990-07-01 00:00:00

abstract：:Cognitive decline in Parkinson's disease (PD) is a common sequela of the disorder that has a large impact on patient well-being. Its physiological etiology, however, remains elusive. Our study used graph theory analysis to investigate the large-scale topological patterns of the extrastriatal dopamine D2 receptor netwo...

journal_title：Journal of neuroscience research

authors： Mihaescu AS,Kim J,Masellis M,Graff-Guerrero A,Cho SS,Christopher L,Valli M,Díez-Cirarda M,Koshimori Y,Strafella AP

更新日期：2020-12-03 00:00:00

abstract：:Calcium-activated neutral proteinase (CANP) activity was determined in cytosolic and membranous subcellular fractions of transformed Schwann cells (tSc). The muM and mM Ca(2+)-sensitive (mu- and mCANP) forms of CANP were separated by DEAE and phenyl Sepharose column chromatography, the latter step enabling removal of ...

journal_title：Journal of neuroscience research

authors： Banik NL,DeVries GH,Neuberger T,Russell T,Chakrabarti AK,Hogan EL

更新日期：1991-07-01 00:00:00

abstract：:Withdrawal of serum from cell cultures constitutes a useful model for the study of mechanisms involved in the regulation of Akt function in vitro. However, there have been several reports of changes in Akt activity that are not fully explained by the current model of phosphatidylinositol 3'-kinase (PI3K)/Akt signaling...

journal_title：Journal of neuroscience research

authors： Sephton CF,Mousseau DD

更新日期：2008-02-15 00:00:00

abstract：:We have recently demonstrated that brain plastic events significantly modify synaptic protein synthesis measured by the incorporation of [(35)S]methionine in brain synaptosomal proteins. Notably, in rats learning a two-way active avoidance task, the local synthesis of two synaptic proteins was selectively enhanced. Be...

journal_title：Journal of neuroscience research

authors： Ferrara E,Cefaliello C,Eyman M,De Stefano R,Giuditta A,Crispino M

更新日期：2009-07-01 00:00:00

abstract：:People showing symptoms of attention deficit hyperactivity disorder (ADHD) often present an impairment of reaction time and response inhibition. These executive functions are influenced by nicotinergic acetylcholine receptors (nAchr) as mediators of cholinergic signaling, and show differences between both sexes. We ex...

journal_title：Journal of neuroscience research

authors： Schote AB,A L Sayk C,Pabst K,Meier JK,Frings C,Meyer J

更新日期：2019-02-01 00:00:00

abstract：:Our previous study demonstrated that 2-phenylethynyl-butyltellurium (PEBT), an organotellurium compound, enhances memory in mice. In this study, the effects of PEBT on cognitive impairment induced by Aβ25-35 were assessed by Morris water maze and step-down inhibitory avoidance tasks. Mice received a single intracerebr...

journal_title：Journal of neuroscience research

authors： Souza AC,Sari MH,Pinton S,Luchese C,Neto JS,Nogueira CW

更新日期：2013-06-01 00:00:00

abstract：:BACE1 initiates processing of the amyloid precursor protein (APP) in the production of amyloid beta (Abeta) peptide. After beta-cleavage by BACE1, the C-terminal stub of the APP fragment is further processed by the gamma-secretase complex to produce Abeta. Because APP, Abeta, the gamma-secretase complex, and BACE1 are...

journal_title：Journal of neuroscience research

authors： Ebina M,Futai E,Tanabe C,Sasagawa N,Kiso Y,Ishiura S

更新日期：2009-02-01 00:00:00

abstract：:Gap junctions (GJs) are widely distributed in brains across the animal kingdom. To visualize the GJ- coupled networks of two major mechanosensory neurons in the ganglia of medicinal leeches, we injected these cells with the GJ-permeable tracer Neurobiotin. When diffusion time was limited to only 30 min, tracer couplin...

journal_title：Journal of neuroscience research

authors： Segura OM,Abdulnoor L,Hua VV,Solano MJ,Macagno ER,Baker MW

更新日期：2020-06-01 00:00:00

abstract：:In the striatum, dopamine (DA) exerts a major modulatory influence on voltage- and ligand-gated currents. Previously we have shown that DA modulates glutamatergic neurotransmission and that the direction of this modulation depends on, among other factors, the glutamate and DA receptor subtypes activated. These effects...

journal_title：Journal of neuroscience research

authors： Liu JC,DeFazio RA,Espinosa-Jeffrey A,Cepeda C,de Vellis J,Levine MS

更新日期：2004-05-01 00:00:00

abstract：:Catecholamine-producing cell types are generated from specified neuronal lineages during vertebrate development. The catecholaminergic phenotype is also expressed transiently in some cell types in non-catecholaminergic tissues, including the sensory ganglia, enteric ganglia, and ventral portions of the neural tube dur...

journal_title：Journal of neuroscience research

authors： Matsushita N,Kobayashi K,Miyazaki J,Kobayashi K

更新日期：2004-10-01 00:00:00

abstract：:Butyrate produced a biphasic modulation of the thyroid hormone receptor in neuroblastoma N2A cells increasing receptor number by 20-35% at concentrations 0.25-0.75 mM and decreasing receptor levels by 30-55% at 2-4 mM. The half-life of the receptor, as assessed by its disappearance after incubation with 18 microM cycl...

journal_title：Journal of neuroscience research

authors： Yusta B,Ortiz-Caro J,Bedo G,Pascual A,Aranda A

更新日期：1990-09-01 00:00:00

abstract：:As it displays progressive hair-cell loss and degeneration of spiral ganglion neurons (SGNs) characterized by early-onset progressive hearing loss (ePHL), DBA/2J is an inbred mouse strain widely used in hearing research. Mouse nerve growth factor (mNGF), as a common exogenous nerve growth factor (NGF), has been studie...

journal_title：Journal of neuroscience research

authors： Wang Q,Zhao H,Zheng T,Wang W,Zhang X,Wang A,Li B,Wang Y,Zheng Q

更新日期：2017-10-01 00:00:00