Abstract:
:A series of major and minor ganglioside species were isolated from a single human adult brain and analyzed for their lipophilic composition. Hematosides, GM3 and GD3, each showing double bands on thin-layer chromatograms, were separated into the upper band and lower band fractions to be analyzed for the heterogeneity of their ceramide moieties. The upper band fractions of GM3 and GD3 were found to contain relatively high amounts of longer-chain fatty acids (C20-C26), whereas the lower band fractions contained high amounts of shorter-chain fatty acids (C16-C18). Compared to other gangliosides which contain hexosamine, the two hematosides contained a smaller proportion of stearic acid. The proportion of 4-eicosasphingenine was found to increase with increasing sialic acid content in gangliosides. These findings suggest that, in the biosynthesis of various gangliosides, N-acetylhexosamine is preferentially transferred to hematosides rich in stearic acid, and sialic acid residues are preferentially transferred to 4-eicosasphingenine-containing species.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Ando S,Yu RKdoi
10.1002/jnr.490120208subject
Has Abstractpub_date
1984-01-01 00:00:00pages
205-11issue
2-3eissn
0360-4012issn
1097-4547journal_volume
12pub_type
杂志文章abstract::The amygdala contributes to the generation and propagation of epileptiform activity in temporal lobe epilepsy (TLE). Ictal symptoms such as fear, dreamy states (déjà vu, memory flashbacks, experiential hallucinations), epigastric auras, or sympathetic outflow with cardiovascular changes are often linked to a seizure f...
journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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更新日期:1995-06-15 00:00:00
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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更新日期:2001-07-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490270406
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490210231
更新日期:1988-10-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:1994-12-01 00:00:00
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journal_title:Journal of neuroscience research
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doi:10.1002/jnr.22714
更新日期:2011-11-01 00:00:00
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journal_title:Journal of neuroscience research
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doi:10.1002/jnr.23080
更新日期:2012-10-01 00:00:00
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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更新日期:2009-02-01 00:00:00
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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更新日期:2009-08-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
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