Endothelial cell heterogeneity of blood-brain barrier gene expression along the cerebral microvasculature.

abstract：:Mounting evidence has demonstrated that the microenvironment of stem/progenitor cells plays an important role in their proliferation and commitment to their fate. However, it remains unclear how all elements, such as astrocytes, microglia, extracellular matrix molecules, soluble factors, and their cross-talk interacti...

journal_title：Journal of neuroscience research

authors： Liao H,Huang W,Niu R,Sun L,Zhang L

更新日期：2008-01-01 00:00:00

abstract：:Identification of behavioral loci through complex trait mapping remains a widely employed approach but suffers from poor gene localization and low replicability. Genome-tagged mice (GTMs) are overlapping sets of congenic strains spanning the whole genome and offer the possibilities of superior mapping power and reprod...

journal_title：Journal of neuroscience research

authors： Liu D,Singh RP,Khan AH,Bhavsar K,Lusis AJ,Davis RC,Smith DJ

更新日期：2003-11-15 00:00:00

abstract：:In the embryonic and postnatal rat retina a cell surface antigen that is detected by monoclonal antibody JONES is distributed in a dorsoventral gradient. Biochemical analysis has determined that the antigen is a modified ganglioside, 9-O-acetyl GD3. In the present study, the distributions of 9-O-acetyl GD3 and its pos...

journal_title：Journal of neuroscience research

authors： Sparrow JR,Barnstable CJ

更新日期：1988-10-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) regulates the proliferation and migration of olfactory bulb (OB) interneuron progenitors derived from the subventricular zone (SVZ), but the role of GABA in the differentiation of these progenitors has been largely unexplored. This study examines the role of GABA in the differentiation o...

journal_title：Journal of neuroscience research

authors： Akiba Y,Sasaki H,Huerta PT,Estevez AG,Baker H,Cave JW

更新日期：2009-08-01 00:00:00

abstract：:Metallothionein (MT) belongs to a family of metal-binding cysteine-rich proteins comprising several structurally related proteins implicated in tissue protection and regeneration after injuries and functioning as antiapoptotic antioxidants in neurological disorders. This has been demonstrated in animals receiving MT t...

journal_title：Journal of neuroscience research

authors： Asmussen JW,Von Sperling ML,Penkowa M

更新日期：2009-10-01 00:00:00

abstract：:The contribution of glucose carbon to the biosynthesis of cholesterol and phospholipids in distinct brain regions was studied quantitatively in the adult male rat. Rates of flow of glucose carbon into the lipids in vivo were calculated from two measurements: the curve representing the decrease in plasma 14C-glucose wi...

journal_title：Journal of neuroscience research

authors： Barkai AI

更新日期：1981-01-01 00:00:00

abstract：:The expression of gangliosides of the lactosylceramide (LC) and of the gangliotetraosylceramide (GTC) series on the surface of cells from rat embryonic cerebellar tissue was investigated by double-color indirect immunofluorescence. GD3 was assumed to be representative of LC and was detected using a specific monoclonal...

journal_title：Journal of neuroscience research

authors： Gravotta D,Ferreira A,Busciglio J,Caceres A,Landa CA,Maccioni HJ

更新日期：1990-02-01 00:00:00

abstract：:The amygdala contributes to the generation and propagation of epileptiform activity in temporal lobe epilepsy (TLE). Ictal symptoms such as fear, dreamy states (déjà vu, memory flashbacks, experiential hallucinations), epigastric auras, or sympathetic outflow with cardiovascular changes are often linked to a seizure f...

journal_title：Journal of neuroscience research

authors： Yilmazer-Hanke D,O'Loughlin E,McDermott K

更新日期：2016-06-01 00:00:00

abstract：:Several recently discovered lines of evidence support the involvement of myelin basic protein (BP)-specific T cells in multiple sclerosis (MS). To identify potentially relevant immunodominant T cell epitopes, human BP (Hu-BP)-reactive T cell lines were selected from MS and normal donors and tested for reactivity to cl...

journal_title：Journal of neuroscience research

authors： Chou YK,Henderikx P,Vainiene M,Whitham R,Bourdette D,Chou CH,Hashim G,Offner H,Vandenbark AA

更新日期：1991-02-01 00:00:00

abstract：:The induction of an inflammatory response and release of cytokines such as TNF may be involved in the age-related etiology of Alzheimer disease (AD). In the brain, microglia have been shown to produce a wide variety of immune mediators, including the pro-inflammatory cytokine tumor necrosis factor (TNF). We hypothesiz...

journal_title：Journal of neuroscience research

authors： Viel JJ,McManus DQ,Smith SS,Brewer GJ

更新日期：2001-06-01 00:00:00

abstract：:Previous studies have shown that treating rat cortical neurons in primary culture with apolipoprotein E (apoE) peptide increased cytoplasmic Ca2+ by 2 mechanisms: 1) an influx of extracellular Ca2+ resulting from the activation of a cell surface Ca2+ channel; and 2) release of Ca2+ from internal Ca2+ stores via a G-pr...

journal_title：Journal of neuroscience research

authors： Wang X,Luebbe P,Gruenstein E,Zemlan F

更新日期：1998-03-01 00:00:00

abstract：:Organotypic slices are used frequently in studies of central nervous system development and function because they provide excellent experimental access with significant preservation of cellular context and relationships. Within a slice, however, a variety of factors may cause individual classes of neurons to respond d...

journal_title：Journal of neuroscience research

authors： Niblock MM,Brunso-Bechtold JK,Riddle DR

更新日期：2001-09-01 00:00:00

abstract：:We used the Plp1-overexpressing transgenic mouse model to investigate whether progressive demyelination of axons results in adaptive changes involving mitochondria within the axons. These models have myelinated axons from birth but gradually lose myelin and develop axonal loss associated with progressive neurological ...

journal_title：Journal of neuroscience research

authors： Hogan V,White K,Edgar J,McGill A,Karim S,McLaughlin M,Griffiths I,Turnbull D,Nichols P

更新日期：2009-02-01 00:00:00

abstract：:We recently reported that a new monoclonal antibody, 4F2, which labels oligodendroglial lineage cells, recognizes a DEAD-box RNA helicase Ddx54 and that Ddx54 binds to myelin basic protein (MBP) in brain and cultured oligodendrocytes. To elucidate the biological function of Ddx54, we generated a recombinant adenovirus...

journal_title：Journal of neuroscience research

authors： Zhan R,Yamamoto M,Ueki T,Yoshioka N,Tanaka K,Morisaki H,Seiwa C,Yamamoto Y,Kawano H,Tsuruo Y,Watanabe K,Asou H,Aiso S

更新日期：2013-03-01 00:00:00

abstract：:Recent evidence has demonstrated that neural stem cells (NSC) can be expanded from a variety of sources, including embryos, fetuses, and adult bone marrow and brain tissue. We have previously reported the generation of adult rat bone marrow-derived cellular spheres that are morphologically and phenotypically similar t...

journal_title：Journal of neuroscience research

authors： Zeng Z,Yuan X,Liu G,Zeng X,Zeng X,Ng H,Chen H,Jiang T,Akasaki Y,Kessey K,Black KL,Yu JS

更新日期：2007-02-01 00:00:00

abstract：:We have demonstrated recently that atypical antipsychotics possess neuroprotective actions in H2O2-mediated and serum-withdrawal models of cell death. In the present study, we compared the ability of atypical and typical antipsychotics to protect against an insult mediated by Abeta(25-35), an apoptogenic fragment of t...

journal_title：Journal of neuroscience research

authors： Wei Z,Mousseau DD,Richardson JS,Dyck LE,Li XM

更新日期：2003-12-15 00:00:00

abstract：:Extracts of bovine heart, rat heart, and rat skeletal muscle were chromatographically separated and the fractions tested for their ability to maintain the survival of dissociated sympathetic, parasympathetic, and sensory neurones. Bovine heart contained at least five, rat heart at least six, and rat skeletal muscle at...

journal_title：Journal of neuroscience research

authors： Bonyhady RE,Hendry IA,Hill CE,Watters DJ

更新日期：1985-01-01 00:00:00

abstract：:Target ablation by olfactory bulbectomy synchronizes the degenerative cell death of olfactory receptor neurons (ORNs), infiltration of macrophages, and proliferation of progenitor cells, leading to neurogenesis, ORN replacement, and regeneration of the sensory epithelium. Although macrophages participate in the degene...

journal_title：Journal of neuroscience research

authors： Getchell TV,Subhedar NK,Shah DS,Hackley G,Partin JV,Sen G,Getchell ML

更新日期：2002-12-15 00:00:00

abstract：:The neurotrophin receptor p75 (p75NTR) is expressed by both neurons and glia. Nerve injury triggers up-regulation of p75NTR in Schwann cells (SC) but not in central glia. In contrast to neuronal p75NTR, which mediates negative signals from myelin-associated proteins resulting in neurite collapse, glial p75NTR may play...

journal_title：Journal of neuroscience research

authors： Zhou XF,Li HY

更新日期：2007-06-01 00:00:00

abstract：:The BM89 antigen, first identified in porcine brain by means of a monoclonal antibody, is a neuron-specific molecule widely distributed in the mammalian central and peripheral nervous system (Merkouri and Matsas: Neuroscience 50:53-68, 1992). Here we describe the purification of BM89 antigen from porcine and mouse bra...

journal_title：Journal of neuroscience research

authors： Gaitanou M,Mamalaki A,Merkouri E,Matsas R

更新日期：1997-06-15 00:00:00

abstract：:Despite the accumulating data on the molecular and cell biological characteristics of neural stem/progenitor cells, their electrophysiological properties are not well understood. In the present work, changes in the membrane properties and current profiles were investigated in the course of in vitro-induced neuron form...

journal_title：Journal of neuroscience research

authors： Jelitai M,Anderová M,Chvátal A,Madarász E

更新日期：2007-06-01 00:00:00

abstract：:It has been postulated that the pathogenesis of Parkinson's disease (PD) is associated with mitochondrial dysfunction. Rotenone, an inhibitor of mitochondrial complex I, provides models of PD both in vivo and in vitro. We investigated the neuroprotective effect of D-beta-hydroxybutyrate (bHB), a ketone body, against r...

journal_title：Journal of neuroscience research

authors： Imamura K,Takeshima T,Kashiwaya Y,Nakaso K,Nakashima K

更新日期：2006-11-01 00:00:00

abstract：:The role of intracellular proteases (e.g., calpains and caspases) in the pathophysiology of neuronal cell death has been extensively investigated. More recently, accumulating data have suggested that extracellular proteolysis also plays a critical role. The two major systems that modify the extracellular matrix in bra...

journal_title：Journal of neuroscience research

authors： Lo EH,Wang X,Cuzner ML

更新日期：2002-07-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) are known to act on glial cells in vitro. At the present time, their involvement in the remyelinating process of the adult central nervous system (CNS) is still unknown. In the present study, using immunohistochemistry (IHC), we investigated the evolution in time and space of acidic FG...

journal_title：Journal of neuroscience research

authors： Tourbah A,Baron-Van Evercooren A,Oliver L,Raulais D,Jeanny JC,Gumpel M

更新日期：1992-09-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, has been implicated in the pathogenesis of several disorders and injuries in the central nervous system (CNS). Unlike IGF-I, which promotes CNS growth, TNF-alpha causes brain growth retardation and neural damage. Recently TNF-alpha has been shown to ...

journal_title：Journal of neuroscience research

authors： Ye P,Price W,Kassiotis G,Kollias G,D'Ercole AJ

更新日期：2003-03-01 00:00:00

abstract：:Glutamine synthetase (GS) activity was used as a marker to examine differences in astrocyte development in mice selectively bred for ethanol sensitivity: long sleep (LS), short sleep (SS), mild ethanol withdrawal (MEW), severe ethanol withdrawal (SEW) and control ethanol withdrawal (CEW). We found that 1) GS activity ...

journal_title：Journal of neuroscience research

authors： Sakellaridis N,Mangoura D,Masserrano JM,Detsis V,Leoni CJ,Deitrich R,Vernadakis A

更新日期：1989-11-01 00:00:00

abstract：:Electrical activity shapes development of the nervous system, presumably in part by regulating gene expression. A set of regulatory genes, immediate early genes (IEGs), which are responsive to a number of extrinsic cellular stimuli have been proposed to play a role in coupling such activity to gene expression. Using a...

journal_title：Journal of neuroscience research

authors： Sheng HZ,Fields RD,Nelson PG

更新日期：1993-08-01 00:00:00

abstract：:The osteoinductive capacity of biological noncellular material has been widely recognized. Studies using bone morphogenetic proteins and acellular bone matrix demonstrate that host mesenchymal cells can be readily transformed into osteoprogenitor cells. The current study sought to determine whether another biological ...

journal_title：Journal of neuroscience research

authors： Carpenter EM,Llamas C,Buck BE,Malinin TI

更新日期：2015-03-01 00:00:00

abstract：:Recent experiments have shown that Arg, Lys, and Leu can be incorporated posttranslationally into proteins of regenerating sciatic nerves of rats. The present experiments investigate a mixture of 15 radioactive amino acids to determine if additional amino acids can be conjugated posttranslationally to proteins of rege...

journal_title：Journal of neuroscience research

authors： Chakraborty G,Yu M,Luo D,Sturman JA,Ingoglia NA

更新日期：1990-04-01 00:00:00

abstract：:To determine whether acute hyperglycemia changes the hyperemic response to functional activation of brain, the area and magnitude of the activation were measured in healthy volunteers maintained at euglycemia and then at hyperglycemia using the hyperglycemic clamp technique. Activation of the visual cortex (8-16 Hz) w...

journal_title：Journal of neuroscience research

authors： Gruetter R,Uğurbil K,Seaquist ER

更新日期：2000-10-15 00:00:00