Roles of glial p75NTR in axonal regeneration.

abstract：:Ca(2+) influx through L-type Ca(2+) channels regulates several different cellular processes in developing Purkinje neurons, including activation of transcription factors and expression of cellular proteins. In the current studies, we examined the age dependence of these actions of Ca(2+) during the early developmental...

journal_title：Journal of neuroscience research

authors： Gruol DL,Quina LA,Netzeband JG,Nguyen D,Gullette CE

更新日期：2006-06-01 00:00:00

abstract：:The G protein-coupled muscarinic acetylcholine receptor (mAChR) isoforms have been identified in neural stem/progenitor (or precursor) cells. In previous studies, activation of these receptors induced elevations in intracellular Ca(2+) signals and mitogen-activated protein (MAP) kinase activity that led to enhanced DN...

journal_title：Journal of neuroscience research

authors： Zhao WQ,Alkon DL,Ma W

更新日期：2003-05-01 00:00:00

abstract：:Our previous results support the idea that CREB (cyclic AMP-response element binding protein) may be a mediator of neuroligand and growth factor signals that, coupled to different signal transduction pathways, play different roles at specific stages of oligodendrocyte development. In the early stages, when cells are i...

journal_title：Journal of neuroscience research

authors： Afshari FS,Chu AK,Sato-Bigbee C

更新日期：2001-10-01 00:00:00

abstract：:Deletion of the tumor suppressor gene p53 has been shown to improve the outcome in experimental models of focal cerebral ischemia and kainate-induced seizures. To evaluate the potential role of p53 in traumatic brain injury, genetically modified mice lacking a functional p53 gene (p53(-/-), n = 9) and their wild-type ...

journal_title：Journal of neuroscience research

authors： Tomasevic G,Raghupathi R,Scherbel U,Wieloch T,McIntosh TK

更新日期：2010-11-15 00:00:00

abstract：:The present study examined the effects of high-altitude exposure on the pineal gland, the main source of production of melatonin. It was surmised that hypoxia experienced at high altitude, caused by decreased oxygen tension in the ambient air, might lead to some structural alterations in the pineal gland and, hence, a...

journal_title：Journal of neuroscience research

authors： Kaur C,Srinivasan KN,Singh J,Peng CM,Ling EA

更新日期：2002-02-15 00:00:00

abstract：:In contrast to mammals, teleost fish are able to regrow severed long-range projection axons in the central nervous system (CNS), leading to recovery of function. The optic projection in teleost fish is used to study neuron-intrinsic and environmental molecular factors that determine successful axon regrowth and naviga...

journal_title：Journal of neuroscience research

authors： Becker CG,Becker T

更新日期：2007-09-01 00:00:00

abstract：:HAND2 (also known as dHAND) is a basic helix-loop-helix (bHLH) transcription factor essential for development of the heart, limbs, and neural crest-derived lineages. HAND2 expression is observed in a number of tissues derived from the neural crest, including components of the peripheral nervous system, where it has be...

journal_title：Journal of neuroscience research

authors： Dai YS,Hao J,Bonin C,Morikawa Y,Cserjesi P

更新日期：2004-06-01 00:00:00

abstract：:Cortical or total brain cultures of microglia are commonly used as a model to study the inflammatory processes in Parkinson's disease. Here we characterize microglia cultures from rat ventral midbrain and evaluate their response to zymosan A. We used specific markers of microglia and evaluated the morphology, the phag...

journal_title：Journal of neuroscience research

authors： Cristóvão AC,Saavedra A,Fonseca CP,Campos F,Duarte EP,Baltazar G

更新日期：2010-02-15 00:00:00

abstract：:To study the influence of cell surface-associated molecules on intercellular communication, C6 glioma cells were cultured both on plastic and on substrata of paraformaldehyde-fixed B104 neuroblastoma cells. By then comparing the phenotypic expression of these "cocultured" C6 cells with cells cultured on tissue culture...

journal_title：Journal of neuroscience research

authors： Ciment G,de Vellis J

更新日期：1982-01-01 00:00:00

abstract：:Using a canine model of classical late-infantile neuronal ceroid lipofuscinosis (CLN2 disease), a study was conducted to evaluate the potential pharmacological activity of recombinant human tripeptidyl peptidase-1 (rhTPP1) enzyme replacement therapy administered directly to the cerebrospinal fluid (CSF). CLN2 disease ...

journal_title：Journal of neuroscience research

authors： Katz ML,Coates JR,Sibigtroth CM,Taylor JD,Carpentier M,Young WM,Wininger FA,Kennedy D,Vuillemenot BR,O'Neill CA

更新日期：2014-11-01 00:00:00

abstract：:Lentiviral vectors are used widely to direct efficient gene transfer in vivo. We examined cell-specific expression in adult murine white matter after stereotaxic microinjection of four lentiviral constructs. We synthesized vesicular stomatitis virus glycoprotein (VSV-G) pseudotyped lentiviruses with combinations of tw...

journal_title：Journal of neuroscience research

authors： McIver SR,Lee CS,Lee JM,Green SH,Sands MS,Snider BJ,Goldberg MP

更新日期：2005-11-01 00:00:00

abstract：:Noise exposure is one of the most common causes of hearing loss. Recent studies found that noise exposure-induced cochlear damage may change the excitability and tonotopic organization of the central auditory system (CAS). This plasticity was suspected to be related to tinnitus and hyperacusis. However, how cochlear d...

journal_title：Journal of neuroscience research

authors： Niu Y,Kumaraguru A,Wang R,Sun W

更新日期：2013-02-01 00:00:00

abstract：:Neurotrophins may have a neuroprotective role and are probably involved in the control of axonal sprouting and synaptic plasticity. An antibody raised against a pro-sequence of nerve growth factor (NGF) was tested. In control undisturbed rats, a strong immunoreactivity was detected in scattered cells in and around the...

journal_title：Journal of neuroscience research

authors： Humpel C,Ebendal T,Cao Y,Olson L

更新日期：1993-07-01 00:00:00

abstract：:The inner ear of humans and experimental animals demonstrate an abundance of glucocorticoid receptors (GR). Glucocorticoids (GC) are widely used to treat different hearing disorders; yet the mechanisms of GC action on the inner ear are unknown. We demonstrate how GR can directly modulate hearing sensitivity in respons...

journal_title：Journal of neuroscience research

authors： Tahera Y,Meltser I,Johansson P,Bian Z,Stierna P,Hansson AC,Canlon B

更新日期：2006-05-01 00:00:00

abstract：:Molecular and behavioral timekeeping is regulated by the circadian system which includes the brain's suprachiasmatic nucleus (SCN) that translates environmental light information into neuronal and endocrine signals aligning peripheral tissue rhythms to the time of day. Despite the critical role of circadian rhythms in...

journal_title：Journal of neuroscience research

authors： Yaw AM,Duong TV,Nguyen D,Hoffmann HM

更新日期：2021-01-01 00:00:00

abstract：:Given the ubiquitous nature of opioids in the treatment of pain, it is an interesting paradox that this class of medications also represents one of the least understood components of clinical pain medicine. For many years, there has been intense interest in the mechanisms of opioid activity, but this has not resulted ...

journal_title：Journal of neuroscience research

authors： Montgomery LS

更新日期：2020-08-07 00:00:00

abstract：:T cell receptor (TCR) transgenic mice have been used extensively to study T cell development in vivo. Such studies have demonstrated high levels of expression of the TCR transgenes. Although a number of human T cell receptors appear to play a role in the development of autoimmune diseases, in vitro studies have proven...

journal_title：Journal of neuroscience research

authors： Baker AM,Wang Y,Richert JR

更新日期：1996-08-15 00:00:00

abstract：:Cognitive decline in Parkinson's disease (PD) is a common sequela of the disorder that has a large impact on patient well-being. Its physiological etiology, however, remains elusive. Our study used graph theory analysis to investigate the large-scale topological patterns of the extrastriatal dopamine D2 receptor netwo...

journal_title：Journal of neuroscience research

authors： Mihaescu AS,Kim J,Masellis M,Graff-Guerrero A,Cho SS,Christopher L,Valli M,Díez-Cirarda M,Koshimori Y,Strafella AP

更新日期：2020-12-03 00:00:00

abstract：:The rate and direction of neurite growth have been shown in a number of studies to be determined by the distribution of adhesive sites on the growth cone. Recent evidence showing that the application of extrinsic electric fields can redistribute membrane molecules and alter both the rate and direction of neurite growt...

journal_title：Journal of neuroscience research

authors： Freeman JA,Manis PB,Snipes GJ,Mayes BN,Samson PC,Wikswo JP Jr,Freeman DB

更新日期：1985-01-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is well known to play a critical role in cognition. Its role in mood disorders, including post stroke depression (PSD), is also recognized with more evidence surfacing. In patients with PSD, their serum BNDF level is lower than in those without depression. Furthermore, antidepr...

journal_title：Journal of neuroscience research

authors： Zhang E,Liao P

更新日期：2020-03-01 00:00:00

abstract：:Respiration was measured polarographically in astrocytes from dissociated neonatal rat cerebra grown in primary culture. Cells grown in a modified Eagle's minimal essential medium containing 20% fetal calf serum for 14 to 21 days respired at a rate of 34.23 n at. equiv 0 mg protein-1 min-1. Cells which were grown in t...

journal_title：Journal of neuroscience research

authors： Olson JE,Holtzman D

更新日期：1980-01-01 00:00:00

abstract：:Several neurological diseases involve focal injury of specific brain structures. Poisons of the electron transport chain complexes (ETCC) can also produce selective injury of brain structures when given systemically and have been implicated in the development of neurological disease. Why ETCC poisons damage particular...

journal_title：Journal of neuroscience research

authors： Fern R

更新日期：2003-03-15 00:00:00

abstract：:SH-SY5Y cells differentiate into neuronal-like cells and express marker proteins like growth-associated protein (GAP-43) and neuropeptide tyrosine when treated with a low concentration (16 nM) of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in the presence of growth factors or serum. Both control and d...

journal_title：Journal of neuroscience research

authors： Parrow V,Fagerström S,Meyerson G,Nånberg E,Påhlman S

更新日期：1995-08-15 00:00:00

abstract：:Music has a long history of healing or mitigating physical and mental illness in the clinical setting. We aimed to test changes in behavioral cognition and serum proteomics in rats undergoing music intervention (MI). The Morris water maze (MWM) was used to evaluate spatial learning and memory in rats. Serum protein ex...

journal_title：Journal of neuroscience research

authors： Xiong X,Han L,Liu S,Miao J,Luo M,Xue M,Wang X,Ni L,Yang J,Huang C

更新日期：2018-10-01 00:00:00

abstract：:Growing evidence suggests that decreased brain-derived neurotrophic factor (BDNF) levels are associated with Alzheimer's disease (AD) pathogenesis. Therefore, BDNF gene therapy is considered to be a promising therapeutic strategy for treating AD. Sendai virus (SeV) is a type I parainfluenza virus that does not interac...

journal_title：Journal of neuroscience research

authors： Iwasaki Y,Negishi T,Inoue M,Tashiro T,Tabira T,Kimura N

更新日期：2012-05-01 00:00:00

abstract：:Here we show that rabbit Müller cell differentiation from radial glial progenitor cells is accompanied by a decreasing capability to respond to specific stimuli (depolarization and extracellular adenosine 5'-triphosphate [ATP]) with an elevation of intracellular calcium. Intracellular free calcium was recorded in reti...

journal_title：Journal of neuroscience research

authors： Uckermann O,Grosche J,Reichenbach A,Bringmann A

更新日期：2002-10-15 00:00:00

abstract：:A morphogenic role of neurotransmitters during cellular differentiation in vitro has been demonstrated in recent years. Using in situ hybridization, we confirm the presence of the D1 receptor at E16 and show additionally that the transcript is relatively widespread and present in both proliferative and differentiating...

journal_title：Journal of neuroscience research

authors： Reinoso BS,Undie AS,Levitt P

更新日期：1996-02-15 00:00:00

abstract：:Adhesion responses triggered by integrin-class matrix receptors have been implicated in the synaptic reorganization events necessary for certain types of neuronal plasticity. Hippocampal slice cultures were used to test whether the related structural transformations elicited by NMDA receptor stimulation are regulated ...

journal_title：Journal of neuroscience research

authors： Bahr BA

更新日期：2000-03-15 00:00:00

abstract：:Monitoring pathology/regeneration in experimental models of de-/remyelination requires an accurate measure not only of functional changes but also of the amount of myelin. We tested whether X-ray diffraction (XRD), which measures periodicity in unfixed myelin, can assess the structural integrity of myelin in fixed tis...

journal_title：Journal of neuroscience research

authors： Kirschner DA,Avila RL,Gamez Sazo RE,Luoma A,Enzmann GU,Agrawal D,Inouye H,Bunge MB,Kocsis J,Peters A,Whittemore SR

更新日期：2010-03-01 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating condition characterized by disruption of axonal connections, failure of axonal regeneration, and loss of motor and sensory function. The therapeutic promise of neural stem cells has been focused on cell replacement, but many obstacles remain in obtaining neuronal integration f...

journal_title：Journal of neuroscience research

authors： Bonner JF,Blesch A,Neuhuber B,Fischer I

更新日期：2010-05-01 00:00:00