Respiration in rat cerebral astrocytes from primary culture.

abstract：:The BM89 antigen, first identified in porcine brain by means of a monoclonal antibody, is a neuron-specific molecule widely distributed in the mammalian central and peripheral nervous system (Merkouri and Matsas: Neuroscience 50:53-68, 1992). Here we describe the purification of BM89 antigen from porcine and mouse bra...

journal_title：Journal of neuroscience research

authors： Gaitanou M,Mamalaki A,Merkouri E,Matsas R

更新日期：1997-06-15 00:00:00

abstract：:Traumatic brain injury (TBI) is the major cause of physical disability and emotional vulnerability. Treatment of TBI is lacking due to its multimechanistic etiology, including derailed mitochondrial and cellular energy metabolism. Previous studies from our laboratory show that an endogenous nitric oxide (NO) metabolit...

journal_title：Journal of neuroscience research

authors： Khan M,Shunmugavel A,Dhammu TS,Khan H,Singh I,Singh AK

更新日期：2018-12-01 00:00:00

abstract：:The inherited deficiency of galactosylceramide beta-galactosidase (E.C. 3.2.1.46: galactocerebrosidase) activity results in globoid cell leukodystrophy in humans (Krabbe disease) and in mice (twitcher mutant). To determine whether Krabbe patients' cells complement twitcher cells to produce, in hybrid combination, grea...

journal_title：Journal of neuroscience research

authors： Skiba MC,Lyerla TA,Konola JT,Raghavan S

更新日期：1990-12-01 00:00:00

abstract：:This Review describes some in vitro approaches used to investigate the mechanisms involved in Krabbe's disease, with particular regard to the cellular systems employed to study processes of inflammation, apoptosis, and angiogenesis. The aim was to update the knowledge on the results obtained from in vitro models of th...

journal_title：Journal of neuroscience research

authors： Avola R,Graziano AC,Pannuzzo G,Alvares E,Cardile V

更新日期：2016-11-01 00:00:00

abstract：:The analysis of proteins in damaged myelin is crucial to clarify the mechanisms of dysmyelination and demyelination. In the present study, proteomic analysis of myelin using a modified two-dimensional electrophoresis (2-DE) method was carried out to obtain a better understanding of myelin biology. Although standard 2-...

journal_title：Journal of neuroscience research

authors： Yamaguchi Y,Miyagi Y,Baba H

更新日期：2008-03-01 00:00:00

abstract：:Previously, we showed that in rat cortical neurons, chronic donepezil treatment (10 microM, 4 days) up-regulates nicotinic receptors (nAChR) and makes neurons more sensitive to the neuroprotective effect of donepezil. Here we examined the mechanism of donepezil-induced neuroprotection in neurons chronically treated wi...

journal_title：Journal of neuroscience research

authors： Takada-Takatori Y,Kume T,Ohgi Y,Izumi Y,Niidome T,Fujii T,Sugimoto H,Akaike A

更新日期：2008-12-01 00:00:00

abstract：:We previously demonstrated that a synthetic retinoic acid receptor agonist, Am80, attenuated intracerebral hemorrhage (ICH)-induced neuropathological changes and neurological dysfunction. Because inflammatory events are among the prominent features of ICH pathology that are affected by Am80, this study investigated th...

journal_title：Journal of neuroscience research

authors： Matsushita H,Hijioka M,Ishibashi H,Anan J,Kurauchi Y,Hisatsune A,Seki T,Shudo K,Katsuki H

更新日期：2014-08-01 00:00:00

abstract：:Noradrenalin (NA) regulates the expression of arginine-vasopressin (AVP) and oxytocin (OT) by magnocellular neurons in the supraoptic nucleus (SON) of the hypothamalus. Nitric oxide (NO) may be one of the factors involved in the NA signaling pathway regulating AVP and OT expression. To test this possibility, we used a...

journal_title：Journal of neuroscience research

authors： Maolood N,Grange-Messent V,Raison D,Hardin-Pouzet H

更新日期：2007-10-01 00:00:00

abstract：:L-deprenyl protects neurons in a number of in vivo and in vitro models and it has been postulated that it ameliorates some neurodegenerative disorders. Superoxide dismutase (SOD) is one of the enzymes responsible for the inactivation of oxygen free radicals, and one of the mechanisms of the effect of L-deprenyl is tho...

journal_title：Journal of neuroscience research

authors： Li XM,Juorio AV,Qi J,Boulton AA

更新日期：1998-07-15 00:00:00

abstract：:Ischemic stroke is a leading cause of death and disability in the United States. It is known that males and females respond differently to stroke. Depending on age, the incidence, prevalence, mortality rate, and disability outcome of stroke differ between the sexes. Females generally have strokes at older ages than ma...

journal_title：Journal of neuroscience research

authors： Dotson AL,Offner H

更新日期：2017-01-02 00:00:00

abstract：:The twitcher mouse is well known as a naturally occurring authentic mouse model of human globoid cell leukodystrophy (GLD; Krabbe disease) due to genetic deficiency of lysosomal galactosylceramidase. The twitcher mice used most commonly are on the C57BL/6J background. We generated twitcher mice that were on the mixed ...

journal_title：Journal of neuroscience research

authors： Tominaga K,Matsuda J,Kido M,Naito E,Yokota I,Toida K,Ishimura K,Suzuki K,Kuroda Y

更新日期：2004-08-15 00:00:00

abstract：:Apoptosis and neuronal atrophy are commonly seen in patients infected with the human immunodeficiency virus type 1 (HIV-1) in the late phase of infection. The HIV-1 envelope glycoprotein gp120 has been suggested to be a causal agent of neuronal loss. Therefore, blocking gp120 neurotoxicity may be an effective way to r...

journal_title：Journal of neuroscience research

authors： Bachis A,Mocchetti I

更新日期：2006-04-01 00:00:00

abstract：:Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis...

journal_title：Journal of neuroscience research

authors： Kane DJ,Ord T,Anton R,Bredesen DE

更新日期：1995-02-01 00:00:00

abstract：:The Rho GTPases are important regulators of neurite outgrowth and pathfinding. We have recently reported that a Rho-family guanine nucleotide exchange factor, GEFT, modulates dendrite spine morphology and basal neurite outgrowth in primary hippocampal neurons and Neuro2A cells, respectively. Here we demonstrate that G...

journal_title：Journal of neuroscience research

authors： Bryan BA,Cai Y,Liu M

更新日期：2006-05-15 00:00:00

abstract：:Monoclonal antibody J1-31 (MAb J1-31, isotype IgG 2b) was raised against crude homogenate of brain tissue from a multiple sclerosis (MS) patient (autopsy sample; Malhotra et al.: Microbios Letters 26:151-157, 1984). In human brain, MAb J1-31 recognizes an intracellular protein antigen (J1-31 antigen), which bands at a...

journal_title：Journal of neuroscience research

authors： Malhotra SK,Predy R,Johnson ES,Singh R,Leeuw K

更新日期：1989-01-01 00:00:00

abstract：:Noise exposure is one of the most common causes of hearing loss. Recent studies found that noise exposure-induced cochlear damage may change the excitability and tonotopic organization of the central auditory system (CAS). This plasticity was suspected to be related to tinnitus and hyperacusis. However, how cochlear d...

journal_title：Journal of neuroscience research

authors： Niu Y,Kumaraguru A,Wang R,Sun W

更新日期：2013-02-01 00:00:00

abstract：:The multifactorial nature of traumatic brain injury (TBI), especially the complex secondary tissue injury involving intertwined networks of molecular pathways that mediate cellular behavior, has confounded attempts to elucidate the pathology underlying the progression of TBI. Here, systems biology strategies are explo...

journal_title：Journal of neuroscience research

authors： Yu C,Boutté A,Yu X,Dutta B,Feala JD,Schmid K,Dave J,Tawa GJ,Wallqvist A,Reifman J

更新日期：2015-02-01 00:00:00

abstract：:Plexiform layer synaptic and photoreceptor cell components were investigated in retinas of Royal College of Surgeons (RCS) dystrophic rats transplanted with normal retinal pigment epithelial (RPE) cells by immunocytochemistry using previously characterized monoclonal antibodies. In retinas of normal adult rats and RPE...

journal_title：Journal of neuroscience research

authors： Sheedlo HJ,Li L,Barnstable CJ,Turner JE

更新日期：1993-11-01 00:00:00

abstract：:In many regions of the rat central nervous system, oligodendrocytes develop from migratory A2B5+ precursor cells. In the rat spinal cord, during early embryonic development the capacity for oligodendrogenesis appears to be restricted to ventral regions of the spinal cord, while cultures of postnatal rat spinal cord co...

journal_title：Journal of neuroscience research

authors： Fok-Seang J,Miller RH

更新日期：1994-02-01 00:00:00

abstract：:NG2 chondroitin sulfate proteoglycan is a surface marker of oligodendroglial progenitor cells (OPCs) in various species. In contrast to well-studied rat OPCs, however, we found that purified mouse NG2 surface positive cells (NG2(+) cells) require additional activation of cyclic AMP (cAMP) signaling for survival in a m...

journal_title：Journal of neuroscience research

authors： Horiuchi M,Lindsten T,Pleasure D,Itoh T

更新日期：2010-04-01 00:00:00

abstract：:The effects of exogenous GM1 and GD1a on S20Y murine neuroblastoma cells were assessed by monitoring morphology, tumorigenicity, mitotic index, and plating efficiency. S20Y cells were seeded at a density equivalent to 5 X 10(4) cells per 35-mm tissue culture dish; 38-42 hr after seeding (preconfluent stage) the cells ...

journal_title：Journal of neuroscience research

authors： Carine K,Schengrund CL

更新日期：1984-01-01 00:00:00

abstract：:Astrocytes are excitable neural cells that contribute to brain information processing via bidirectional communication with neurons. This involves the release of gliosignaling molecules that affect synapses patterning and activity. Mechanisms mediating the release of these molecules likely consist of non-vesicular and ...

journal_title：Journal of neuroscience research

authors： Jorgačevski J,Potokar M,Kreft M,Guček A,Mothet JP,Zorec R

更新日期：2017-11-01 00:00:00

abstract：:The induction of an inflammatory response and release of cytokines such as TNF may be involved in the age-related etiology of Alzheimer disease (AD). In the brain, microglia have been shown to produce a wide variety of immune mediators, including the pro-inflammatory cytokine tumor necrosis factor (TNF). We hypothesiz...

journal_title：Journal of neuroscience research

authors： Viel JJ,McManus DQ,Smith SS,Brewer GJ

更新日期：2001-06-01 00:00:00

abstract：:Amyloid plaques, found in characteristically large numbers in specific brain areas of Alzheimer's disease (AD) and Down's Syndrome (DS) patients, are composed of a 41-43 amino acid peptide, A4, derived from a transmembrane glycoprotein, amyloid precursor protein (APP). In transformed cells APP has been shown to be cle...

journal_title：Journal of neuroscience research

authors： Baskin F,Rosenberg RN,Greenberg BD

更新日期：1991-05-01 00:00:00

abstract：:The neural cell adhesion molecule (NCAM) plays a key role in neural development, regeneration, and synaptic plasticity. The crystal structure of a fragment of NCAM comprising the three N-terminal immunoglobulin (Ig)-like modules indicates that the first and second Ig modules bind to each other, thereby presumably medi...

journal_title：Journal of neuroscience research

authors： Køhler LB,Soroka V,Korshunova I,Berezin V,Bock E

更新日期：2010-08-01 00:00:00

abstract：:The role of the plasmin-generating system, a serum component, in the development of dissociated embryonic chick spinal cord cells in culture was studied. Studies were performed in a defined system where the cells were maintained in a serum-free medium. Under these conditions the cells produce plasminogen activator. It...

journal_title：Journal of neuroscience research

authors： Kalderon N

更新日期：1982-01-01 00:00:00

abstract：:Programmed cell death involving gene regulation and de novo protein synthesis is a major component of both normal development and a number of disease conditions. Hence, knowledge of its mechanisms, especially transcription factors, that regulate expression of the genes involved in neurodegenerative disorders is of gre...

journal_title：Journal of neuroscience research

authors： Mioduszewska B,Jaworski J,Szklarczyk AW,Klejman A,Kaczmarek L

更新日期：2008-01-01 00:00:00

abstract：:Long-duration exposure to weightlessness results in bone demineralization, muscle atrophy, cardiovascular deconditioning, altered sensory-motor control, and central nervous system reorganizations. Exercise countermeasures and body loading methods so far employed have failed to prevent these changes. A human mission to...

journal_title：Journal of neuroscience research

authors： Lackner JR,DiZio P

更新日期：2000-10-15 00:00:00

abstract：:To study the influence of cell surface-associated molecules on intercellular communication, C6 glioma cells were cultured both on plastic and on substrata of paraformaldehyde-fixed B104 neuroblastoma cells. By then comparing the phenotypic expression of these "cocultured" C6 cells with cells cultured on tissue culture...

journal_title：Journal of neuroscience research

authors： Ciment G,de Vellis J

更新日期：1982-01-01 00:00:00

abstract：:Macrophages play critical roles in both degenerative and regenerative processes following peripheral nerve injury. These include phagocytosis of debris, stimulation of Schwann cell dedifferentiation and proliferation, and salvage of myelin lipids for reutilization during regeneration. To better define the role of macr...

journal_title：Journal of neuroscience research

authors： Venezie RD,Toews AD,Morell P

更新日期：1995-01-01 00:00:00