Graph theory analysis of the dopamine D2 receptor network in Parkinson's disease patients with cognitive decline.

Abstract:

:Cognitive decline in Parkinson's disease (PD) is a common sequela of the disorder that has a large impact on patient well-being. Its physiological etiology, however, remains elusive. Our study used graph theory analysis to investigate the large-scale topological patterns of the extrastriatal dopamine D2 receptor network. We used positron emission tomography with [11 C]FLB-457 to measure the binding potential of cortical dopamine D2 receptors in two networks: the meso-cortical dopamine network and the meso-limbic dopamine network. We also investigated the application of partial volume effect correction (PVEC) in conjunction with graph theory analysis. Three groups were investigated in this study divided according to their cognitive status as measured by the Montreal Cognitive Assessment score, with a score ≤25 considered cognitively impaired: (a) healthy controls (n = 13, 11 female), (b) cognitively unimpaired PD patients (PD-CU, n = 13, 5 female), and (c) PD patients with mild cognitive impairment (PD-MCI, n = 17, 4 female). In the meso-cortical network, we observed increased small-worldness, normalized clustering, and local efficiency in the PD-CU group compared to the PD-MCI group, as well as a hub shift in the PD-MCI group. Compensatory reorganization of the meso-cortical dopamine D2 receptor network may be responsible for some of the cognitive preservation observed in PD-CU. These results were found without PVEC applied and PVEC proved detrimental to the graph theory analysis. Overall, our findings demonstrate how graph theory analysis can be used to detect subtle changes in the brain that would otherwise be missed by regional comparisons of receptor density.

journal_name

J Neurosci Res

authors

Mihaescu AS,Kim J,Masellis M,Graff-Guerrero A,Cho SS,Christopher L,Valli M,Díez-Cirarda M,Koshimori Y,Strafella AP

doi

10.1002/jnr.24760

subject

Has Abstract

pub_date

2020-12-03 00:00:00

eissn

0360-4012

issn

1097-4547

pub_type

杂志文章
  • Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzheimer's disease.

    abstract::Accumulation of beta-amyloid protein (Abeta) in the brain is a hallmark of Alzheimer's disease (AD), and Abeta-mediated pathogenesis could result from increased production of Abeta or insufficient Abeta clearance by microglia, astrocytes, or the vascular system. Cell-surface receptors, such as scavenger receptors, mig...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20992

    authors: Nakamura K,Ohya W,Funakoshi H,Sakaguchi G,Kato A,Takeda M,Kudo T,Nakamura T

    更新日期:2006-09-01 00:00:00

  • Targeting of mRNAs within the glial cell cytoplasm: how to hide the message along the journey.

    abstract::The subcellular targeting of mRNAs encoding myelin proteins to the oligodendrocyte processes is an accepted fact in myelin formation. How these messengers are kept silent during their movement to the subcellular domain where they are turned on remains a mystery. This review focuses on aspects of mRNA targeting and spe...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/1097-4547(20001115)62:4<473::AID-JNR1>3.0.

    authors: Boccaccio GL

    更新日期:2000-11-15 00:00:00

  • Current states of endogenous stem cells in adult spinal cord.

    abstract::New neurons are continuously generated throughout life in the subgranular zone in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles. With the aid of new methodologies, significant progress has been made in the characterization of endogenous stem cells (ependymal ce...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.23480

    authors: Qin Y,Zhang W,Yang P

    更新日期:2015-03-01 00:00:00

  • Sprouting inducing activity of human sera: low capacity in sera from patients with cranial polyneuropathy.

    abstract::Cranial idiopathic acute peripheral facial nerve paralysis (Bell palsy) has been used as a model disease in the present study mainly to investigate trophic capacity of serum components. The ability to induce sprouting from chick embryo dorsal root ganglia was used as the bioassay for trophic activity. Sera from normal...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490090411

    authors: Aviel A,Schwartz M

    更新日期:1983-01-01 00:00:00

  • Respiration in rat cerebral astrocytes from primary culture.

    abstract::Respiration was measured polarographically in astrocytes from dissociated neonatal rat cerebra grown in primary culture. Cells grown in a modified Eagle's minimal essential medium containing 20% fetal calf serum for 14 to 21 days respired at a rate of 34.23 n at. equiv 0 mg protein-1 min-1. Cells which were grown in t...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490050605

    authors: Olson JE,Holtzman D

    更新日期:1980-01-01 00:00:00

  • Inflammatory markers in women with postpartum depressive symptoms.

    abstract::Postpartum depression (PPD) is a devastating disorder affecting not only more than 10% of all women giving birth, but also the baby, the family, and the society. Compiling evidence suggests the involvement of the immune system in the pathophysiology of major depression; yet, the immune response in perinatal depression...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.24312

    authors: Bränn E,Fransson E,White RA,Papadopoulos FC,Edvinsson Å,Kamali-Moghaddam M,Cunningham JL,Sundström-Poromaa I,Skalkidou A

    更新日期:2020-07-01 00:00:00

  • Re-evaluation of phencyclidine low-affinity or "non-NMDA" binding sites.

    abstract::TCP and its derivative gacyclidine (+/- GK11) are high-affinity non-competitive antagonists of N-methyl-D-aspartate (NMDA) receptors (NMDARs) and as such exhibit significant neuroprotective properties. These compounds also bind with a low affinity to binding sites whose pharmacological profiles are different from that...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.10203

    authors: Hirbec H,Mausset AL,Kamenka JM,Privat A,Vignon J

    更新日期:2002-05-01 00:00:00

  • Responses of young and aged rat CNS to partial cholinergic immunolesions and NGF treatment.

    abstract::The cholinergic neurons of the basal forebrain (CNBF) are the major source of cholinergic innervation of the cortex and hippocampus. In Alzheimer's disease and aged brain, there are severe losses of cholinergic neurons in the nucleus basalis of Meynert, leading to a reduction of cortical cholinergic activity which cor...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19980501)52:3<322::AID-JNR

    authors: Wörtwein G,Yu J,Toliver-Kinsky T,Perez-Polo JR

    更新日期:1998-05-01 00:00:00

  • The involvement of thrombin in the pathogenesis of glioblastoma.

    abstract::Prothrombin and its active derivative thrombin are key members of the coagulation system. The only site of extra-hepatic thrombin expression is the central nervous system (CNS), where it is involved in brain development, protection, and regeneration. Thrombin affects various degenerative and ischemic CNS diseases like...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.24049

    authors: Krenzlin H,Lorenz V,Alessandri B

    更新日期:2017-10-01 00:00:00

  • Pentylenetetrazol seizures increase pro-nerve growth factor-like immunoreactivity in the reticular thalamic nucleus and nerve growth factor mRNA in the dentate gyrus.

    abstract::Neurotrophins may have a neuroprotective role and are probably involved in the control of axonal sprouting and synaptic plasticity. An antibody raised against a pro-sequence of nerve growth factor (NGF) was tested. In control undisturbed rats, a strong immunoreactivity was detected in scattered cells in and around the...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490350409

    authors: Humpel C,Ebendal T,Cao Y,Olson L

    更新日期:1993-07-01 00:00:00

  • Production of tumor necrosis factor-alpha as a result of glia-T-cell interaction correlates with the pathogenic activity of myelin basic protein-reactive T cells in experimental autoimmune encephalomyelitis.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) has attracted the greatest attention as a major factor in experimental autoimmune encephalomyelitis (EAE) pathogenesis. We compared rats undergoing EAE with manipulated but healthy animals by examining TNF-alpha gene expression in cells recovered from the brain. We used reverse ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19960815)45:4<400::AID-JNR

    authors: Sun D,Hu X,Shah R,Zhang L,Coleclough C

    更新日期:1996-08-15 00:00:00

  • Protective effect of a synapsin peptide genetically fused to the B subunit of Escherichia coli heat-labile enterotoxin in rat autoimmune encephalomyelitis.

    abstract::Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease with similarities to multiple sclerosis that requires the activation of auto reactive T cells that infiltrate the central nervous system. In previous studies we have shown that intraperitoneal administration of synaptosomal antige...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22048

    authors: Scerbo MJ,Rupil LL,Bibolini MJ,Roth GA,Monferran CG

    更新日期:2009-08-01 00:00:00

  • K+ channel properties in cultured mouse Schwann cells: dependence on extracellular K+.

    abstract::In cultured Schwann cells, single-channel and whole-cell K+ currents can be activated by depolarizing the membrane to values more negative than -50 mV. In elevated extracellular K+ concentration ([K+]o), however, single-channel activity and whole-cell currents could be recorded at more negative potentials. Thus, the t...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490280208

    authors: Verkhratsky A,Hoppe D,Kettenmann H

    更新日期:1991-02-01 00:00:00

  • Single K channel currents in Schwann cells from normal and neurofibromatosis-affected damselfish.

    abstract::Damselfish neurofibromatosis is a naturally occurring disease of a tropical marine fish species. Affected fish exhibit peripheral nerve sheath tumors which contain morphologically abnormal Schwann cells (SC), similar to tumors encountered in the human disease neurofibromatosis type 1. Unitary A-type K channels in cell...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:

    authors: Fieber LA

    更新日期:1997-05-15 00:00:00

  • Treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor in vitro enhances expression of other neurotrophic factors as well as cytokines and chemokines.

    abstract::Microarray analyses demonstrated that a variety of genes was affected by treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor (PEDF). The genes for neurotrophins, glial cell-derived neurotrophic factor (GDNF), and their receptors were regulated differentially in i...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20196

    authors: Yabe T,Herbert JT,Takanohashi A,Schwartz JP

    更新日期:2004-09-01 00:00:00

  • Development of integrins in the vasculature of germinal matrix, cerebral cortex, and white matter of fetuses and premature infants.

    abstract::Germinal matrix (GM) vasculature is selectively vulnerable to hemorrhage in premature infants during the first 48 hr of life. This is attributed to rapid angiogenesis of this brain region, resulting in formation of nascent vessels that show a paucity of pericytes and immaturity of extracellular matrix. Integrins are k...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22301

    authors: Dummula K,Vinukonda G,Xu H,Hu F,Zia MT,Braun A,Shi Q,Wolk J,Ballabh P

    更新日期:2010-05-01 00:00:00

  • Role for myelin-associated glycoprotein as a functional tenascin-R receptor.

    abstract::The expression of the immunoglobulin superfamily member myelin-associated glycoprotein (MAG) and the extracellular matrix glycoprotein tenascin-R (TN-R) by oligodendrocytes overlaps in time and space. The two molecules can be neurite outgrowth-inhibitory or -promoting depending on the neuronal cell type and the enviro...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19990315)55:6<687::AID-JNR

    authors: Yang H,Xiao ZC,Becker B,Hillenbrand R,Rougon G,Schachner M

    更新日期:1999-03-15 00:00:00

  • Experimental epidural hematoma causes cerebral infarction and activates neocortical glial and neuronal genesis in adult guinea pigs.

    abstract::Epidural hematoma (EDH) is a type of life-threatening traumatic brain injury. Little is known about the extent to which EDH may cause neural damage and regenerative response in the cerebral cortex. Here we attempted to explore these issues by using guinea pigs as an experimental model. Unilateral EDH was induced by in...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.23148

    authors: Pan A,Li M,Gao JY,Xue ZQ,Li Z,Yuan XY,Luo DW,Luo XG,Yan XX

    更新日期:2013-02-01 00:00:00

  • Multimodal neuroimaging in anorexia nervosa.

    abstract::Anorexia nervosa (AN) is a severe and complex psychiatric disorder characterized by intense fear about weight gain and finalized to food-related control behaviors. Growing interest has been demonstrated about neurobiological processes subtend to AN physiopathology. The present review aimed to collect neurostructural a...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.24674

    authors: Alfano V,Mele G,Cotugno A,Longarzo M

    更新日期:2020-11-01 00:00:00

  • Regulation by GD3 of the proinflammatory response of microglia mediated by interleukin-15.

    abstract::The interleukin (IL)-15-dependent immune responses of murine microglia were strongly affected by low concentrations of the ganglioside GD3. The ganglioside binding to IL-15 inhibited the proinflammatory effects of the cytokine, reducing IL-15-dependent T-cell proliferation as well as mRNA expression for IL-15Ralpha, p...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20777

    authors: Gómez-Nicola D,Doncel-Pérez E,Nieto-Sampedro M

    更新日期:2006-04-01 00:00:00

  • Acidic fibroblast growth factor (aFGF) is expressed in the neuronal and glial spinal cord cells of adult mice.

    abstract::Fibroblast growth factors (FGFs) are known to be synthesized in the central nervous system (CNS) and to act on CNS cells in vitro, but less is known about their synthesis, expression, and role in vivo. In this work, using specific anti-acidic fibroblast growth factor (aFGF) antibodies, we have shown for the first time...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490290417

    authors: Tourbah A,Oliver L,Jeanny JC,Gumpel M

    更新日期:1991-08-01 00:00:00

  • Fine structure of long-term changes in the cochlear nucleus after acoustic overstimulation: chronic degeneration and new growth of synaptic endings.

    abstract::The companion study showed that acoustic overstimulation of adult chinchillas, with a noise level sufficient to damage the cochlea, led to cytological changes and degeneration of synaptic endings in the cochlear nucleus within 1-16 weeks. In the present study, the same stimulus was used to study the long-term effects ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20212

    authors: Kim JJ,Gross J,Potashner SJ,Morest DK

    更新日期:2004-09-15 00:00:00

  • Input from central nucleus of the amygdala efferents to pericoerulear dendrites, some of which contain tyrosine hydroxylase immunoreactivity.

    abstract::Light microscopic anterograde tracing studies indicate that neurons in the central nucleus of the amygdala (CNA) project to a region of the dorsal pontine tegmentum ventral to the superior cerebellar peduncle which contains noradrenergic dendrites of the nucleus locus coeruleus (LC). However, it has not been establish...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19960801)45:3<289::AID-JNR

    authors: Van Bockstaele EJ,Chan J,Pickel VM

    更新日期:1996-08-01 00:00:00

  • Histone acetylation inhibitors promote axon growth in adult dorsal root ganglia neurons.

    abstract::Intrinsic mechanisms that guide damaged axons to regenerate following spinal cord injury remain poorly understood. Manipulation of posttranslational modifications of key proteins in mature neurons could reinvigorate growth machinery after injury. One such modification is acetylation, a reversible process controlled by...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.23573

    authors: Lin S,Nazif K,Smith A,Baas PW,Smith GM

    更新日期:2015-08-01 00:00:00

  • N-methyl-D-aspartate but not glutamate induces the release of hydroxyl radicals in the neonatal rat: modulation by group I metabotropic glutamate receptors.

    abstract::Although they likely involve activation of N-methyl-D-aspartate (NMDA) receptors, the mechanisms giving rise to perinatal hypoxic-ischemic-induced damages remained unclear. The purpose of the present study was to investigate in vivo the mechanisms regulating the glutamate-induced release of toxic hydroxyl radicals (.O...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/1097-4547(20001001)62:1<84::AID-JNR9>3.0.C

    authors: Cambonie G,Laplanche L,Kamenka JM,Barbanel G

    更新日期:2000-10-01 00:00:00

  • Pituitary adenylate cyclase-activating polypeptide counteracts the impaired adult neural stem cell viability induced by palmitate.

    abstract::Diabetes and obesity are characterized by hyperlipidemia and represent risk factors for premature neurological disorders. Diabetic/obese animals have impaired adult neurogenesis. We hypothesize that lipotoxicity leading to neurogenesis impairment plays a role in the development of neurological complications. If so, no...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22803

    authors: Mansouri S,Ortsäter H,Pintor Gallego O,Darsalia V,Sjöholm A,Patrone C

    更新日期:2012-04-01 00:00:00

  • Neurogenesis and glial proliferation are stimulated following diffuse traumatic brain injury in adult rats.

    abstract::Although increased neurogenesis has been described in rodent models of focal traumatic brain injury (TBI), the neurogenic response occurring after diffuse TBI uncomplicated by focal injury has not been examined to date, despite the pervasiveness of this distinct type of brain injury in the TBI patient population. Here...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22635

    authors: Bye N,Carron S,Han X,Agyapomaa D,Ng SY,Yan E,Rosenfeld JV,Morganti-Kossmann MC

    更新日期:2011-07-01 00:00:00

  • Role of N-methyl-D-aspartate receptors in gastric mucosal blood flow induced by histamine.

    abstract::Ionotropic N-methyl-D-aspartate (NMDA) receptor agonists, L-aspartic acid (L-Asp) and NMDA, have been shown to inhibit histamine-stimulated acid secretion, but their effect on gastric mucosal blood flow (GMBF) is largely unknown. The aim of this study was to investigate whether L-Asp and NMDA inhibit histamine-stimula...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20202

    authors: Tsai LH,Lee YJ,Wu JY

    更新日期:2004-09-01 00:00:00

  • Inhibition of proteoglycan synthesis affects neuronal outgrowth and astrocytic migration in organotypic cultures of fetal ventral mesencephalon.

    abstract::Grafting fetal ventral mesencephalon has been utilized to alleviate the symptoms of Parkinson's disease. One obstacle in using this approach is the limited outgrowth from the transplanted dopamine neurons. Thus, it is important to evaluate factors that promote outgrowth from fetal dopamine neurons. Proteoglycans (PGs)...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21465

    authors: Berglöf E,Plantman S,Johansson S,Strömberg I

    更新日期:2008-01-01 00:00:00

  • Endogenous aFGF expression and cellular changes after a demyelinating lesion in the spinal cord of adult normal mice: immunohistochemical study.

    abstract::Fibroblast growth factors (FGFs) are known to act on glial cells in vitro. At the present time, their involvement in the remyelinating process of the adult central nervous system (CNS) is still unknown. In the present study, using immunohistochemistry (IHC), we investigated the evolution in time and space of acidic FG...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490330107

    authors: Tourbah A,Baron-Van Evercooren A,Oliver L,Raulais D,Jeanny JC,Gumpel M

    更新日期:1992-09-01 00:00:00