Integrin-type signaling has a distinct influence on NMDA-induced cytoskeletal disassembly.

abstract：:The non-receptor protein tyrosine kinase Fyn, which is a member of the Src family of kinases, has been shown to be essential for normal myelination and has been suggested to play a role in oligodendrocyte development. However, oligodendrocyte development has not been studied directly in cells lacking Fyn. Additionally...

journal_title：Journal of neuroscience research

authors： Sperber BR,McMorris FA

更新日期：2001-02-15 00:00:00

abstract：:The BM89 antigen, first identified in porcine brain by means of a monoclonal antibody, is a neuron-specific molecule widely distributed in the mammalian central and peripheral nervous system (Merkouri and Matsas: Neuroscience 50:53-68, 1992). Here we describe the purification of BM89 antigen from porcine and mouse bra...

journal_title：Journal of neuroscience research

authors： Gaitanou M,Mamalaki A,Merkouri E,Matsas R

更新日期：1997-06-15 00:00:00

abstract：:Immunocytochemical studies indicated that Purkinje cells cultured from chick embryonic cerebellum (embryonic day 8) strongly express a glutamate transporter EAAT2 cloned from human brain (GLT-1 in rat brain). At both 7 days and 14 days in culture, Purkinje neurons accumulated 1 microM [3H]L-glutamate via a potent "hig...

journal_title：Journal of neuroscience research

authors： Meaney JA,Balcar VJ,Rothstein JD,Jeffrey PL

更新日期：1998-12-01 00:00:00

abstract：:Acrylamide (ACR) is an environmental toxicant and prototypic tool for studying mechanisms of peripheral neuropathies. Reductions in fast anterograde axonal transport (faAXT) are thought to be a critical step leading to axonal degeneration. Kinesin and microtubules (MT) were evaluated as molecular sites of action using...

journal_title：Journal of neuroscience research

authors： Sickles DW,Brady ST,Testino A,Friedman MA,Wrenn RW

更新日期：1996-10-01 00:00:00

abstract：:PC12 cells can differentiate into neuron-like cells after treatment with either nerve growth factor (NGF) or transduction with a retrovirus which expresses the K-ras oncogene. The concomitant treatment of NGF plus ras differentiates PC12 cells further than either agent alone with respect to neurite outgrowth, acetylch...

journal_title：Journal of neuroscience research

authors： Tao-Cheng JH,Dosemeci A,Bressler JP,Brightman MW,Simpson DL

更新日期：1995-10-15 00:00:00

abstract：:The dentate gyrus is selectively reduced in size in the insulin-like growth factor 1 (IGF1) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of...

journal_title：Journal of neuroscience research

authors： Cheng CM,Cohen M,Tseng V,Bondy CA

更新日期：2001-05-15 00:00:00

abstract：:The extracellular matrix surrounds different neuronal compartments in the mature nervous system. In a variety of vertebrates, most brain regions are loaded with a distinct type of extracellular matrix around the somatodendritic part of neurons, termed perineuronal nets. The present study reports that chondrotin sulfat...

journal_title：Journal of neuroscience research

authors： Lendvai D,Morawski M,Brückner G,Négyessy L,Baksa G,Glasz T,Patonay L,Matthews RT,Arendt T,Alpár A

更新日期：2012-02-01 00:00:00

abstract：:A coordinated up-regulation in the expression of all three neurofilament (NF) proteins occurs during postnatal development in the rat (Schlaepfer and Bruce, J Neurosci Res [in press], 1990a). In the present study, sciatic nerves were transected in neonatal rats in order to determine the effects of axotomy on the postn...

journal_title：Journal of neuroscience research

authors： Schwartz ML,Shneidman PS,Bruce J,Schlaepfer WW

更新日期：1990-10-01 00:00:00

abstract：:The induction of an inflammatory response and release of cytokines such as TNF may be involved in the age-related etiology of Alzheimer disease (AD). In the brain, microglia have been shown to produce a wide variety of immune mediators, including the pro-inflammatory cytokine tumor necrosis factor (TNF). We hypothesiz...

journal_title：Journal of neuroscience research

authors： Viel JJ,McManus DQ,Smith SS,Brewer GJ

更新日期：2001-06-01 00:00:00

abstract：:Low density dissociated cultures of embryonic rat hippocampal cells were used to study the effects of neurotrophin-3 (NT-3) on neuronal morphogenesis. The results obtained indicate that NT-3 enhances neurite outgrowth and branching; this is a dose-dependent effect, detected in approximately 50% of the neurons, and pre...

journal_title：Journal of neuroscience research

authors： Morfini G,DiTella MC,Feiguin F,Carri N,Cáceres A

更新日期：1994-10-01 00:00:00

abstract：:It has been demonstrated that L-pipecolic acid (L-PA), a major metabolic intermediate of L-lysine (L-Lys) in the mammalian and chicken brain, is involved in the functioning of the GABAergic system. A previous study has shown that intracerebroventricular (i.c.v.) injection of L-PA suppressed feeding and induced sleep-l...

journal_title：Journal of neuroscience research

authors： Takagi T,Bungo T,Tachibana T,Saito ES,Saito S,Yamasaki I,Tomonaga S,Denbow DM,Furuse M

更新日期：2003-07-15 00:00:00

abstract：:This study was undertaken in order to establish the presence of pluripotential neuroblasts in the developing chick CNS. This has been suggested by our previous observations that expression of emerging neuronal phenotypes in the chick embryo CNS is affected by exposure to neurotrophic substances (i.e., GHRH, SRIF, NGF,...

journal_title：Journal of neuroscience research

authors： Kentroti S,Vernadakis A

更新日期：1995-08-01 00:00:00

abstract：:The localization of voltage-gated calcium channel (VGCC) alpha(1) subunits in cultured GABAergic mouse cortical neurons was examined by immunocytochemical methods. Ca(v)1.2 and Ca(v)1.3 subunits of L-type VGCCs were found in cell bodies and dendrites of GABA-immunopositive neurons. Likewise, the Ca(v)2.3 subunit of R-...

journal_title：Journal of neuroscience research

authors： Timmermann DB,Westenbroek RE,Schousboe A,Catterall WA

更新日期：2002-01-01 00:00:00

abstract：:Catecholamine-producing cell types are generated from specified neuronal lineages during vertebrate development. The catecholaminergic phenotype is also expressed transiently in some cell types in non-catecholaminergic tissues, including the sensory ganglia, enteric ganglia, and ventral portions of the neural tube dur...

journal_title：Journal of neuroscience research

authors： Matsushita N,Kobayashi K,Miyazaki J,Kobayashi K

更新日期：2004-10-01 00:00:00

abstract：:The Shaw subfamily of potassium channel genes, including Kv3.1, are highly expressed within the auditory nuclei of the brainstem, where they have been implicated in the characteristic response properties of particular types of neurons. Potassium currents carried by Kv3.1 are voltage-dependent, have a high activation t...

journal_title：Journal of neuroscience research

authors： Hendriks R,Morest DK,Kaczmarek LK

更新日期：1999-12-15 00:00:00

abstract：:The Dale's law postulates that a neuron releases the same neurotransmitter from all its branches. In the case of multiple neurotransmitters it would require all transmitters to be released from all branches. The retinal cholinergic amacrine cells contain and release gamma-aminobutyric (GABA) and, therefore, if GABA an...

journal_title：Journal of neuroscience research

authors： Duarte CB,Santos PF,Carvalho AP

更新日期：1999-11-15 00:00:00

abstract：:A low concentration of transition metal ions Co2+ and Ni2+ increases the inward current density in neurons from the land snail Helix aspersa. The currents were measured using a single electrode voltage-clamp/internal perfusion method under conditions in which the external Na+ was replaced by Tris+, the predominant ext...

journal_title：Journal of neuroscience research

authors： Kim YK,Woodruff ML

更新日期：1991-04-01 00:00:00

abstract：:Preterm birth and associated brain injury are the primary cause of cerebral palsy and developmental disabilities and are among the most serious global health issues that modern society faces. Current therapy for infants suffering from premature brain injury is still mainly supportive, and there are no effective treatm...

journal_title：Journal of neuroscience research

authors： Peng X,Song J,Li B,Zhu C,Wang X

更新日期：2020-05-01 00:00:00

abstract：:Germinal matrix (GM) vasculature is selectively vulnerable to hemorrhage in premature infants during the first 48 hr of life. This is attributed to rapid angiogenesis of this brain region, resulting in formation of nascent vessels that show a paucity of pericytes and immaturity of extracellular matrix. Integrins are k...

journal_title：Journal of neuroscience research

authors： Dummula K,Vinukonda G,Xu H,Hu F,Zia MT,Braun A,Shi Q,Wolk J,Ballabh P

更新日期：2010-05-01 00:00:00

abstract：:Early studies of murine experimental autoimmune encephalomyelitis (EAE) induced with myelin basic protein (MBP) divide various mouse strains into either "susceptible" or "resistant" phenotypes. Resistance is defined as lack of encephalitogenic responses after active immunization or adoptive transfer. It is now becomin...

journal_title：Journal of neuroscience research

authors： Shaw MK,Kim C,Hao HW,Chen F,Tse HY

更新日期：1996-09-15 00:00:00

abstract：:We describe here a novel monoclonal antibody (mab H6) which recognizes CD9, an integral cell surface constituent previously described in cells of the hematopoietic lineage and involved in the aggregation of platelets. Mab H6 was raised against membranes of immature mouse astrocytes and reacted with a protein of 25-27 ...

journal_title：Journal of neuroscience research

authors： Schmidt C,Künemund V,Wintergerst ES,Schmitz B,Schachner M

更新日期：1996-01-01 00:00:00

abstract：:The effects of ischemia (removal of oxygen and glucose for 4 h) and anoxia (removal of oxygen alone) on astrocytes were studied in dissociated cultures of E14 spinal cord containing both neurons and astrocytes. In addition, a group of cultures was treated with a low Na+, low Ca2+, and high K+ medium during the 4-h isc...

journal_title：Journal of neuroscience research

authors： Goldberg WJ,Connor JR,Bernstein JJ

更新日期：1987-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a key role in controlling innate immune responses to a wide variety of pathogen-associated molecules as well as endogenous signals. In addition, TLR expression within nonimmune cells has been recognized as as modulator of cell behavior. In this study we have addressed the question of wh...

journal_title：Journal of neuroscience research

authors： Bsibsi M,Nomden A,van Noort JM,Baron W

更新日期：2012-02-01 00:00:00

abstract：:Studies have shown that individuals with both a history of traumatic brain injury and inheritance of apolipoprotein E-4 (ApoE4) allele are associated with a poor neurologic outcome and an increased risk for Alzheimer's disease. We assessed the hypothesis that thrombin released during brain injury causes an increase in...

journal_title：Journal of neuroscience research

authors： Mhatre M,Hensley K,Nguyen A,Grammas P

更新日期：2006-08-01 00:00:00

abstract：:There is evidence that zinc may be involved in the pathogenesis of Parkinson's disease by an apoptotic pathway. However, the mechanisms underlying zinc-induced apoptosis are unknown. Previous studies showed that 6-hydroxydopamine (6-OHDA)-enhanced potassium channels are involved in apoptosis of dopaminergic neurons. O...

journal_title：Journal of neuroscience research

authors： Shi L,Song N,Jiang H,Wang J,Ma Z,Xie J

更新日期：2009-02-01 00:00:00

abstract：:Two clones encoding human glial fibrillary acidic protein (GFAP) were isolated from a human astrocytoma cDNA library. The clones pHGFAP1 and pHGFAP2 were selected by the combined use of differential colony hybridization and hybridization-selection technique with polyclonal anti GFAP antiserum. The longer one, pHGFAP1,...

journal_title：Journal of neuroscience research

authors： Rataboul P,Faucon Biguet N,Vernier P,De Vitry F,Boularand S,Privat A,Mallet J

更新日期：1988-01-01 00:00:00

abstract：:A link between aluminum (Al) exposure and age-related neurological disorders has long been proposed. Although the exact mechanism by which the metal may influence disease processes is unknown, there is evidence that exposure to Al causes an increase in both oxidative stress and inflammatory events. These processes hav...

journal_title：Journal of neuroscience research

authors： Campbell A,Becaria A,Lahiri DK,Sharman K,Bondy SC

更新日期：2004-02-15 00:00:00

abstract：:We have investigated the involvement of c-Jun in cell death induced by exposure of primary cultures of murine cerebellar granule cells to the glutamate receptor agonist kainate (KA) and evaluated its possible use as a marker for apoptosis. Using cerebellar granule cell neurones from postnatal day 7 mice, we found that...

journal_title：Journal of neuroscience research

authors： Cheung NS,Carroll FY,Larm JA,Beart PM,Giardina SF

更新日期：1998-04-01 00:00:00

abstract：:Ischemic stroke is a leading cause of death and disability in the United States. It is known that males and females respond differently to stroke. Depending on age, the incidence, prevalence, mortality rate, and disability outcome of stroke differ between the sexes. Females generally have strokes at older ages than ma...

journal_title：Journal of neuroscience research

authors： Dotson AL,Offner H

更新日期：2017-01-02 00:00:00

abstract：:Topoisomerase IIβ (top IIβ) is a nuclear enzyme with an essential role in neural development. The regulation of top IIβ gene expression during neural differentiation is poorly understood. Functional analysis of top IIβ gene structure displayed a GC box sequence in its transcription promoter, which binds the nuclear tr...

journal_title：Journal of neuroscience research

authors： Guo H,Cao C,Chi X,Zhao J,Liu X,Zhou N,Han S,Yan Y,Wang Y,Xu Y,Yan Y,Cui H,Sun H

更新日期：2014-10-01 00:00:00