Kainate-induced apoptosis correlates with c-Jun activation in cultured cerebellar granule cells.

abstract：:The effect of two different potassium channel blockers, 4-aminopyridine (4-AP) and quinine, on the alpha 2-adrenoceptor mediated modulation of norepinephrine (NE) release was investigated. Pairs of mouse vasa deferentia were loaded with 3H-norepinephrine (3H-NE), superfused continuously, and stimulated electrically. 4...

journal_title：Journal of neuroscience research

authors： Zimanyi I,Folly G,Vizi ES

更新日期：1988-05-01 00:00:00

abstract：:BACE1 initiates processing of the amyloid precursor protein (APP) in the production of amyloid beta (Abeta) peptide. After beta-cleavage by BACE1, the C-terminal stub of the APP fragment is further processed by the gamma-secretase complex to produce Abeta. Because APP, Abeta, the gamma-secretase complex, and BACE1 are...

journal_title：Journal of neuroscience research

authors： Ebina M,Futai E,Tanabe C,Sasagawa N,Kiso Y,Ishiura S

更新日期：2009-02-01 00:00:00

abstract：:The transfer of the adenovirus 5 E1A gene into brain cells from rat embryos led to the establishment of phenotypically untransformed clonal glial cell lines. Some lines displayed properties of oligodendrocyte-astrocyte progenitors. Their differentiation involved several steps that were dependent on culture conditions ...

journal_title：Journal of neuroscience research

authors： Evrard C,Galiana E,Rouget P

更新日期：1988-09-01 00:00:00

abstract：:Motor neurons (MNs) are designated as alpha/gamma and fast/slow based on their target sites and the types of muscle fibers innervated; however, few molecular markers that distinguish between these subtypes are available. Here we report that osteopontin (OPN) is a selective marker of alpha MNs in the mouse spinal cord....

journal_title：Journal of neuroscience research

authors： Misawa H,Hara M,Tanabe S,Niikura M,Moriwaki Y,Okuda T

更新日期：2012-04-01 00:00:00

abstract：:Heat shock protein 60 (HSP60) and HSP10 are mitochondrial chaperonin proteins and are responsible for the folding of newly imported proteins and 13 polypeptides encoded by mitochondrial DNA. The expressions of HSP60 and HSP10 are regulated simultaneously because these genes are localized head to head on chromosome, se...

journal_title：Journal of neuroscience research

authors： Kim SW,Lee JK

更新日期：2007-05-01 00:00:00

abstract：:NG2 chondroitin sulfate proteoglycan is a surface marker of oligodendroglial progenitor cells (OPCs) in various species. In contrast to well-studied rat OPCs, however, we found that purified mouse NG2 surface positive cells (NG2(+) cells) require additional activation of cyclic AMP (cAMP) signaling for survival in a m...

journal_title：Journal of neuroscience research

authors： Horiuchi M,Lindsten T,Pleasure D,Itoh T

更新日期：2010-04-01 00:00:00

abstract：:Insulin-like growth factors, IGF-I and IGF-II, are potent regulators of oligodendrocyte development. Most of the IGF present in vivo is bound to members of a family of six high-affinity IGF-binding proteins (IGFBPs), which can either potentiate or inhibit IGF action, depending on other conditions. Additionally, serum ...

journal_title：Journal of neuroscience research

authors： Mewar R,McMorris FA

更新日期：1997-12-01 00:00:00

abstract：:Human fetal brain is a potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative diseases. We explored whether NSCs isolated from cortex and striatum of human fetuses, aged 6-9 weeks post-conception, maintain their regional identity and differentiate into specific neuron types in c...

journal_title：Journal of neuroscience research

authors： Kallur T,Darsalia V,Lindvall O,Kokaia Z

更新日期：2006-12-01 00:00:00

abstract：:Nociceptive neuronal activation in subcortical regions has not been well investigated in functional magnetic resonance imaging (fMRI) studies. The present report aimed to use the blood oxygenation level-dependent (BOLD) fMRI technique to map nociceptive responses in both subcortical and cortical regions by employing a...

journal_title：Journal of neuroscience research

authors： Shih YY,Chen YY,Chen CC,Chen JC,Chang C,Jaw FS

更新日期：2008-06-01 00:00:00

abstract：:The structures associated with learning and memory have been widely studied for over 100 years. The idea of the famous neuropsychologist K.S. Lashley, that learning and memory are stored diffusely in the brain, dominated neuroscience in the early half of Twentieth Century. Since Scoville reported in 1957 a persistent ...

journal_title：Journal of neuroscience research

authors： Shu SY,Wu YM,Bao XM,Leonard B

更新日期：2003-03-01 00:00:00

abstract：:Our previous study demonstrated that 2-phenylethynyl-butyltellurium (PEBT), an organotellurium compound, enhances memory in mice. In this study, the effects of PEBT on cognitive impairment induced by Aβ25-35 were assessed by Morris water maze and step-down inhibitory avoidance tasks. Mice received a single intracerebr...

journal_title：Journal of neuroscience research

authors： Souza AC,Sari MH,Pinton S,Luchese C,Neto JS,Nogueira CW

更新日期：2013-06-01 00:00:00

abstract：:The response of cells localized in the brain subventricular zone (SVZ) to growth factor stimulation has been largely described for development and adult life, whereas no information on their behavior during aging is available. To address the question of whether the cells in the SVZ of old mice respond to the intracere...

journal_title：Journal of neuroscience research

authors： Tirassa P,Triaca V,Amendola T,Fiore M,Aloe L

更新日期：2003-06-01 00:00:00

abstract：:A previous study demonstrated the release of newly loaded radiolabelled taurine (Tau) from cultured rabbit Müller glia not only following typical cell volume-increasing treatments with high (65 mM) potassium ions or hypotonic media, but also with ammonium chloride (further referred to as ammonia), in a dose-dependent ...

journal_title：Journal of neuroscience research

authors： Faff L,Reichenbach A,Albrecht J

更新日期：1996-10-15 00:00:00

abstract：:The close homologue of L1 (CHL1) is a member of the L1 family of cell recognition molecules. The protein is expressed by a variety of nerve cell types and subpopulations of glial cells in vivo and promotes elongation of neurites and survival of nerve cells in vitro. Here we demonstrate that glial cells up-regulate exp...

journal_title：Journal of neuroscience research

authors： Rolf B,Lang D,Hillenbrand R,Richter M,Schachner M,Bartsch U

更新日期：2003-03-15 00:00:00

abstract：:Alcohol-related events have been proposed to be under neurochemical control. For example, the concentration of methionine enkephalin (Met-enkephalin) in brain has been inversely correlated with ethanol consumption in alcohol-preferring and alcohol-nonpreferring mice. The concentrations of Met-enkephalin are controlled...

journal_title：Journal of neuroscience research

authors： Plotkin SR,Banks WA,Waguespack PJ,Kastin AJ

更新日期：1997-05-01 00:00:00

abstract：:Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke-related disability. Stroke has dropped to the fifth leading cause of death in men,...

journal_title：Journal of neuroscience research

authors： Spychala MS,Honarpisheh P,McCullough LD

更新日期：2017-01-02 00:00:00

abstract：:Previous studies from our laboratory suggest that Alzheimer's disease sera contain a repertoire of antibodies to the heavy neurofilament subunit (NF-H) and that a subpopulation of these antibodies bind specifically to epitopes highly enriched in NF-H isolated from the purely cholinergic electromotor neurons of Torpedo...

journal_title：Journal of neuroscience research

authors： Faigon M,Hadas E,Alroy G,Chapman J,Auerbach JM,Michaelson DM

更新日期：1991-08-01 00:00:00

abstract：:Muscle spindles are sensory receptors composed of specialized muscle fibers, known as intrafusal muscle fibers, along with the endings of sensory neuron axons that innervate these muscle fibers. Formation of muscle spindles requires neuregulin1 (NRG1), which is released by sensory axons, activating ErbB receptors in m...

journal_title：Journal of neuroscience research

authors： Herndon CA,Ankenbruck N,Fromm L

更新日期：2014-02-01 00:00:00

abstract：:Intact synaptosomes prepared from 28-day-old rat brains were incubated with CMP-N-acetyl-(14C) neuraminic acid in Krebs-Henseleit buffer in an atmosphere of 95% O2: 5% CO2, at 37 degrees C. The activity of CMP-NANA:ganglioside sialosyltransferase using endogenous acceptors was 0.84 pmoles NANA transferred/mg synaptoso...

journal_title：Journal of neuroscience research

authors： Durrie R,Saito M,Rosenberg A

更新日期：1987-01-01 00:00:00

abstract：:The effects of the environmental contaminants methylmercury (MeHg) and inorganic mercury (HgCl(2)) on cell viability, intracellular calcium concentration ([Ca(2+)](i)), and reactive oxygen species (ROS) generation were studied in rat cerebellar granule neuron cultures using fluorescent methods. MeHg exhibited an LC(50...

journal_title：Journal of neuroscience research

authors： Gassó S,Cristòfol RM,Selema G,Rosa R,Rodríguez-Farré E,Sanfeliu C

更新日期：2001-10-01 00:00:00

abstract：:As aging population is increasing, new methodologies to apprehend and enhance the mechanisms related to optimal brain function in advancing age become urgent. This review describes how the combined use of non-invasive brain stimulation (NIBS) with functional magnetic resonance imaging (fMRI) provides novel experimenta...

journal_title：Journal of neuroscience research

authors： Abellaneda-Pérez K,Vaqué-Alcázar L,Solé-Padullés C,Bartrés-Faz D

更新日期：2019-08-16 00:00:00

abstract：:The induction of heat-shock protein 70 (hsp70) mRNA in the hyperthermic rabbit brain has been examined previously by using Northern blotting and in situ hybridization procedures that measure steady-state levels of mRNA, which may be influenced by transcript stability and transcription rate. In the present investigatio...

journal_title：Journal of neuroscience research

authors： D'Souza CA,Rush SJ,Brown IR

更新日期：1998-06-01 00:00:00

abstract：:P0-glycoprotein, the major integral membrane protein of peripheral nerve myelin, is thought to mediate myelination and membrane interactions via its extracellular domain (P0-ED). Molecular modeling of P0-ED has suggested which of its amino acid side-chains may be involved in heterophilic and homophilic adhesions. We p...

journal_title：Journal of neuroscience research

authors： Kirschner DA,Szumowski K,Gabreëls-Festen AA,Hoogendijk JE,Bolhuis PA

更新日期：1996-11-15 00:00:00

abstract：:Sky (also known as "Tyro3" and "Rse") is a member of the Axl/Sky/Mer receptor tyrosine kinase family and has two immunoglobulin-like repeats and two fibronectin type III-like repeats in the extracellular domain. Gas6 is a ligand for all members of the Axl family, each of which (Axl, Sky, and c-Mer) has different affin...

journal_title：Journal of neuroscience research

authors： Funakoshi H,Yonemasu T,Nakano T,Matumoto K,Nakamura T

更新日期：2002-04-15 00:00:00

abstract：:The effects of KCl-treatment on the survival and proliferation of NE-4C self-renewing neural progenitor cells were investigated during early phases of in vitro induced neurogenesis. NE-4C cells, derived from the anterior brain vesicles of embryonic mouse (E9), divided continuously under non-inducing conditions, but ac...

journal_title：Journal of neuroscience research

authors： Herberth B,Pataki A,Jelitai M,Schlett K,Deák F,Spät A,Madarász E

更新日期：2002-03-01 00:00:00

abstract：:The excitability of the motor cortex is a function of single cell excitability, synaptic strength, and the balance between excitatory cells and inhibitory cells. Sustained periods of sensory stimulation enhance the excitability in the motor cortex. This adaptation, which represents an early change in cortical network ...

journal_title：Journal of neuroscience research

authors： Manto M,Oulad ben Taib N,Luft AR

更新日期：2006-02-01 00:00:00

abstract：:Treatment of chromaffin cells with nitric oxide (NO) donors (SNP and SNAP) and peroxynitrite produces a time- and dose-dependent necrotic and apoptotic cell death. Necrotic cell death was characterized by both an increase in lactate dehydrogenase and ATP release and changes in nuclei and cell morphology (as seen with ...

journal_title：Journal of neuroscience research

authors： Vicente S,Pérez-Rodríguez R,Oliván AM,Martínez Palacián A,González MP,Oset-Gasque MJ

更新日期：2006-07-01 00:00:00

abstract：:Double immunofluorescence studies using antibodies against NF-L and peripherin revealed three distinct subpopulations of neurons in rat dorsal root ganglia (DRG). In the adult rat, 46% of the DRG neurons were small and peripherin-positive (NF-L-negative), and 48% were large and NF-L-positive (peripherin-negative). Abo...

journal_title：Journal of neuroscience research

authors： Goldstein ME,House SB,Gainer H

更新日期：1991-09-01 00:00:00

abstract：:Synaptic vesicles were isolated from adult bovine cortical gray matter by differential centrifugation and membrane filtration of a hypoosmotically lysed crude mitochondrial fraction. Vesicle preparations were analyzed for purity by electron microscopy and enzyme assays. Polyacrylamide gel electrophoresis of SDS-solubi...

journal_title：Journal of neuroscience research

authors： Richter-Landsberg C,Neuhoff V,Waehneldt TV

更新日期：1977-01-01 00:00:00

abstract：:In recent years, several novel types of disorders have been characterized, including what have been termed polyalanine diseases, in which patients have expanded triplet repeats in specific genes, resulting in the translation of aberrantly elongated polyalanine stretches. In this study, we showed that yellow fluorescen...

journal_title：Journal of neuroscience research

authors： Toriumi K,Oma Y,Kino Y,Futai E,Sasagawa N,Ishiura S

更新日期：2008-05-15 00:00:00