Ammonia-induced taurine release from cultured rabbit Müller cells is an osmoresistant process mediated by intracellular accumulation of cyclic AMP.

abstract：:The GTP binding proteins Rhes and AGS1/Dexras1 define a subfamily of the Ras superfamily and have been shown to affect signaling by G-protein-coupled receptors. We tested the effects of both proteins at an early stage of signaling by dopamine receptors, activation of adenylyl cyclase. Rhes decreased dopamine D1 recept...

journal_title：Journal of neuroscience research

authors： Harrison LM,He Y

更新日期：2011-06-01 00:00:00

abstract：:The use of progesterone following brain injury has a controversial history. On one hand, some lab-based models have showed progesterone as being neuroprotective, but on the other, clinical trials have showed quite the opposite. One of many complaints that arose from this discrepancy was the lack of a diverse pool of a...

journal_title：Journal of neuroscience research

authors： Blackshear K,Giessner S,Hayden JP,Duncan KA

更新日期：2018-04-01 00:00:00

abstract：:In many regions of the rat central nervous system, oligodendrocytes develop from migratory A2B5+ precursor cells. In the rat spinal cord, during early embryonic development the capacity for oligodendrogenesis appears to be restricted to ventral regions of the spinal cord, while cultures of postnatal rat spinal cord co...

journal_title：Journal of neuroscience research

authors： Fok-Seang J,Miller RH

更新日期：1994-02-01 00:00:00

abstract：:HAND2 (also known as dHAND) is a basic helix-loop-helix (bHLH) transcription factor essential for development of the heart, limbs, and neural crest-derived lineages. HAND2 expression is observed in a number of tissues derived from the neural crest, including components of the peripheral nervous system, where it has be...

journal_title：Journal of neuroscience research

authors： Dai YS,Hao J,Bonin C,Morikawa Y,Cserjesi P

更新日期：2004-06-01 00:00:00

abstract：:Our previous results support the idea that CREB (cyclic AMP-response element binding protein) may be a mediator of neuroligand and growth factor signals that, coupled to different signal transduction pathways, play different roles at specific stages of oligodendrocyte development. In the early stages, when cells are i...

journal_title：Journal of neuroscience research

authors： Afshari FS,Chu AK,Sato-Bigbee C

更新日期：2001-10-01 00:00:00

abstract：:The neuronal intermediate filaments include not only the neurofilament triplet proteins but also peripherin and alpha-internexin. To determine whether neurite outgrowth is enhanced by alpha-internexin, the cDNA of rat alpha-internexin tagged with enhanced green fluorescent protein (EGFP) was transfected into a rat adr...

journal_title：Journal of neuroscience research

authors： Chien CL,Liu TC,Ho CL,Lu KS

更新日期：2005-06-01 00:00:00

abstract：:Brain metabolism increases during stimulation, but this increase does not affect all energy metabolism equally. Briefly after stimulation, there is a local increase in cerebral blood flow and in glucose uptake, but a smaller increase in oxygen uptake. This indicates that temporarily the rate of glycolysis is faster th...

journal_title：Journal of neuroscience research

authors： Díaz-García CM,Yellen G

更新日期：2019-08-01 00:00:00

abstract：:This study examined the effect of chronic exposure to ethanol and brain-derived neurotrophic factor (BDNF) on the responsiveness of cerebellar granule cells to gamma-aminobutyric acid (GABA). Cerebellar granule cell cultures were chronically exposed to ethanol (100 mM), BDNF (20 ng/ml), or the combination of ethanol a...

journal_title：Journal of neuroscience research

authors： Ericson M,Haythornthwaite AR,Yeh PW,Yeh HH

更新日期：2003-09-01 00:00:00

abstract：:In order to study the voltage-dependent ion channels in microglia, and their possible modulation by pro-inflammatory substances like lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) we employed the patch-clamp technique on purified rat microglial cell subcultures grown for 1 - 5 days in control condition or a...

journal_title：Journal of neuroscience research

authors： Visentin S,Agresti C,Patrizio M,Levi G

更新日期：1995-11-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) acts as a potent survival factor for many neuronal populations, including spinal motoneurons, indicating the therapeutic promise of GDNF for neurological disorders. Injury to spinal cord (SCI) triggers processes destructive to ascending sensory and descending motor co...

journal_title：Journal of neuroscience research

authors： Cheng H,Wu JP,Tzeng SF

更新日期：2002-08-01 00:00:00

abstract：:The neural cell adhesion molecule (NCAM) plays a key role in neural development, regeneration, and synaptic plasticity. The crystal structure of a fragment of NCAM comprising the three N-terminal immunoglobulin (Ig)-like modules indicates that the first and second Ig modules bind to each other, thereby presumably medi...

journal_title：Journal of neuroscience research

authors： Køhler LB,Soroka V,Korshunova I,Berezin V,Bock E

更新日期：2010-08-01 00:00:00

abstract：:A-type K+ channels (IA channels) contribute to learning and memory mechanisms by regulating neuronal excitabilities in the CNS, and their expression level is targeted by Ca2+ influx via synaptic NMDA receptors (NMDARs) during long-term potentiation (LTP). However, it is not clear how local synaptic Ca2+ changes induce...

journal_title：Journal of neuroscience research

authors： Yang YS,Jeon SC,Kang MS,Kim SH,Eun SY,Jin SH,Jung SC

更新日期：2017-12-01 00:00:00

abstract：:Myelin-associated glycoprotein (MAG) is a potent inhibitor of axonal regeneration and also, depending on the age and type of neuron, can promote axonal growth. In addition, MAG influences stability of both myelin and the axon in the intact, mature nervous system. The identity of the neuron/axonal MAG-binding receptor ...

journal_title：Journal of neuroscience research

authors： De Bellard ME,Filbin MT

更新日期：1999-04-15 00:00:00

abstract：:The gene mutated in the mouse open brain (opb) phenotype antagonizes sonic hedgehog-mediated signaling and encodes a small GTPase of the Rab family, Rab23. To date, the brain expression profile and exact mechanism of function of the Rab23 protein has remained unknown. Specific antibodies generated against Rab23 showed...

journal_title：Journal of neuroscience research

authors： Guo A,Wang T,Ng EL,Aulia S,Chong KH,Teng FY,Wang Y,Tang BL

更新日期：2006-05-01 00:00:00

abstract：:In this study, we examined the neuroprotective effect of standardized Bacopa monniera extract (BME: BESEB CDRI-08) against the D-galactose (D-gal)-induced brain aging in rats. Experimental groups were subjected to contextual-associative learning task. We found that the administration of BME in the D-gal-treated group ...

journal_title：Journal of neuroscience research

authors： Prisila Dulcy C,Singh HK,Preethi J,Rajan KE

更新日期：2012-10-01 00:00:00

abstract：:Astrocytes are the predominant cell type in the vicinity of glutamatergic synapses, where they monitor and maintain low levels of glutamate. Synaptic homeostasis of glutamate involves its removal from the synaptic cleft via high-affinity glutamate transporters, glutamate transporter-1 (GLT-1)/excitatory amino acid tra...

journal_title：Journal of neuroscience research

authors： Sandhu JK,Sikorska M,Walker PR

更新日期：2002-06-01 00:00:00

abstract：:The central nervous system (CNS) is considered a nonpermissive environment for axonal regeneration because of the presence of myelin and associated repulsive molecules. However, neural cells transplanted to the CNS preferably migrate and extend their fibers in white matter areas. We previously showed that white matter...

journal_title：Journal of neuroscience research

authors： Fang Z,Forslund N,Takenaga K,Lukanidin E,Kozlova EN

更新日期：2006-03-01 00:00:00

abstract：:To determine whether acute hyperglycemia changes the hyperemic response to functional activation of brain, the area and magnitude of the activation were measured in healthy volunteers maintained at euglycemia and then at hyperglycemia using the hyperglycemic clamp technique. Activation of the visual cortex (8-16 Hz) w...

journal_title：Journal of neuroscience research

authors： Gruetter R,Uğurbil K,Seaquist ER

更新日期：2000-10-15 00:00:00

abstract：:Apoptosis and neuronal atrophy are commonly seen in patients infected with the human immunodeficiency virus type 1 (HIV-1) in the late phase of infection. The HIV-1 envelope glycoprotein gp120 has been suggested to be a causal agent of neuronal loss. Therefore, blocking gp120 neurotoxicity may be an effective way to r...

journal_title：Journal of neuroscience research

authors： Bachis A,Mocchetti I

更新日期：2006-04-01 00:00:00

abstract：:Miniature endplate potentials (MEPPs) with slow rising phase can be attributed either to burst of transmitter releases or to distortion of conduction from remote releasing sites. The spontaneous activity of neuromuscular junctions recorded extracellularly at mouse diaphragms using sharp electrodes was analyzed to test...

journal_title：Journal of neuroscience research

authors： Vautrin J,Kriebel ME

更新日期：1992-03-01 00:00:00

abstract：:Changes in dopamine (DA) D(1), D(2), D(3), and D(4) receptors and serotonin 5-HT(1A) and 5-HT(2A) receptors in rat forebrain regions were autoradiographically quantified after continuous infusion of JL 13 [(5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine fumarate] for 28 days with osmotic minipumps...

journal_title：Journal of neuroscience research

authors： Moran-Gates T,Massari C,Graulich A,Liégeois JF,Tarazi FI

更新日期：2006-08-15 00:00:00

abstract：:GM1 ganglioside has been shown to stimulate recovery of the damaged dopamine system under a number of different circumstances. In addition to rescue of damaged dopamine neurons, the present study assessed the ability of GM1 to enhance the synthesis of dopamine in remaining nigrostriatal neurons following 1-methyl-4-ph...

journal_title：Journal of neuroscience research

authors： Schneider JS,Kean A,DiStefano L

更新日期：1995-09-01 00:00:00

abstract：:An aminopeptidase purified to homogeneity from cytosol of rat brain cleaved dynorphins having 5-17 residues and selected proenkephalins at the Tyr-Gly bond only to release Tyr and the desTyr fragments. The enzyme protein consisted of a single polypeptide chain of Mr 103,000 and was inhibited by puromycin, bestatin, an...

journal_title：Journal of neuroscience research

authors： Berg MJ,Marks N

更新日期：1984-01-01 00:00:00

abstract：:We have proposed that lactate is a "volume transmitter" in the brain and underpinned this by showing that the lactate receptor, G-protein-coupled receptor 81 (GPR81, also known as HCA1 or HCAR1), which promotes lipid storage in adipocytes, is also active in the mammalian brain. This includes the cerebral neocortex and...

journal_title：Journal of neuroscience research

authors： Morland C,Lauritzen KH,Puchades M,Holm-Hansen S,Andersson K,Gjedde A,Attramadal H,Storm-Mathisen J,Bergersen LH

更新日期：2015-07-01 00:00:00

abstract：:The purpose of this study was to determine if calpain-induced proteolysis was associated with retinal degeneration or dysfunction in the rat acute ocular hypertensive model. Acute glaucoma was produced by elevation of IOP to 120 mm Hg for 1 hr. Retinal degeneration was evaluated by H&E staining and apoptosis was deter...

journal_title：Journal of neuroscience research

authors： Oka T,Tamada Y,Nakajima E,Shearer TR,Azuma M

更新日期：2006-05-15 00:00:00

abstract：:In order to better characterize the presynaptic GABA receptors regulating glutamate release in the cerebellum [Levi and Gallo, 1981], a number of GABA agonists and GABA transport inhibitors were tested for their ability to potentiate the depolarization-induced release of the glutamate analog D-[3H]aspartate from super...

journal_title：Journal of neuroscience research

authors： Aloisi F,Gallo V,Levi G

更新日期：1983-01-01 00:00:00

abstract：:The neuroblastoma, N1E-115, was grown for 9 days after subcultivation. The development of acetylcholinestrase (AChE), choline acetyltransferase (CAT), QNB-binding, choline uptake, and acetylcholine release was measured on days 1, 3, 6, and 9. In parallel experiments the irreversible AChE inhibitor soman was added to n...

journal_title：Journal of neuroscience research

authors： Kumar U,Sellström A

更新日期：1990-09-01 00:00:00

abstract：:HEPES inhibited the taurine uptake in glial cells. A different kind of inhibition was observed when HEPES was present in the culture medium or in the incubation medium used for the taurine-uptake measurement. As an example of a possible interference of HEPES in pharmacological experiments, we have studied the effect o...

journal_title：Journal of neuroscience research

authors： Lleu PL,Rebel G

更新日期：1989-05-01 00:00:00

abstract：:Studies have shown that individuals with both a history of traumatic brain injury and inheritance of apolipoprotein E-4 (ApoE4) allele are associated with a poor neurologic outcome and an increased risk for Alzheimer's disease. We assessed the hypothesis that thrombin released during brain injury causes an increase in...

journal_title：Journal of neuroscience research

authors： Mhatre M,Hensley K,Nguyen A,Grammas P

更新日期：2006-08-01 00:00:00

abstract：:The inherited deficiency of galactosylceramide beta-galactosidase (E.C. 3.2.1.46: galactocerebrosidase) activity results in globoid cell leukodystrophy in humans (Krabbe disease) and in mice (twitcher mutant). To determine whether Krabbe patients' cells complement twitcher cells to produce, in hybrid combination, grea...

journal_title：Journal of neuroscience research

authors： Skiba MC,Lyerla TA,Konola JT,Raghavan S

更新日期：1990-12-01 00:00:00