Abstract：
:The use of progesterone following brain injury has a controversial history. On one hand, some lab-based models have showed progesterone as being neuroprotective, but on the other, clinical trials have showed quite the opposite. One of many complaints that arose from this discrepancy was the lack of a diverse pool of animal models and paradigms employed during the preclinical phase. However, over the past decade, the zebra finch has emerged as an optimal organism for the study of steroid-mediated neuroprotection. Following an injury, steroid hormones and receptors are upregulated, serving to decrease neuroinflammation and overall damage to the brain. As compared to other vertebrate models, zebra finches can upregulate expression of both estrogens and androgens at a faster and more robust response, suggesting that vertebrates differ in their neuroprotective mechanisms and timing following injury. Therefore, to expand the types organisms studied in pre-clinical trials, we chose to use zebra finches. While the majority of work in the zebra finch brain has focused on estrogens and androgens, we sought to clarify the role of progesterone following injury. Adult male zebra finches were given daily injections of progesterone following a penetrating injury and then were assessed for the size of injury and expression of various genes associated with neuroinflammation and cell survival. Treatment with progesterone decreased the injury size in zebra finches over controls and increased expression of various genes associated with cell survival and neuroinflammation. These data suggest that progesterone does mediate neuroprotection, most likely through the alteration of neuroinflammatory and cell survival pathways.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Blackshear K,Giessner S,Hayden JP,Duncan KAdoi
10.1002/jnr.24060subject
Has Abstractpub_date
2018-04-01 00:00:00pages
545-555issue
4eissn
0360-4012issn
1097-4547journal_volume
96pub_type
杂志文章abstract：:CD200, a type I transmembrane glycoprotein, can interact with its receptor CD200R, which plays an inhibitory role in the activation of microglia-the resident macrophages of the central nervous system. In this study, the rat C6 glioma cell line (C6-1) that was previously characterized with high in vivo tumorigenicity w...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23922
更新日期：2016-12-01 00:00:00
abstract：:Traumatic brain injury (TBI) is the major cause of physical disability and emotional vulnerability. Treatment of TBI is lacking due to its multimechanistic etiology, including derailed mitochondrial and cellular energy metabolism. Previous studies from our laboratory show that an endogenous nitric oxide (NO) metabolit...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24279
更新日期：2018-12-01 00:00:00
abstract：:Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much pe...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20655
更新日期：2005-11-15 00:00:00
abstract：:Using a solution-hybridization assay and specific oligonucleotidic probes, we have studied IGF-I and insulin receptor mRNAs in the rat central nervous system during development. The expression of mRNAs was maximal at embryonic day 15 and 20 for IGF-I receptors, and at embryonic day 20 and the day of birth for insulin ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490280212
更新日期：1991-02-01 00:00:00
abstract：:The role of insulin-like growth factor-1 (IGF-1) in amyotrophic lateral sclerosis (ALS) and its mechanism of action are important from both pathogenic and therapeutic points of view. The present study investigated the changes of IGF-1Rbeta and the key intracellular downstream protein insulin receptor substrate-1 (IRS-...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20668
更新日期：2005-11-15 00:00:00
abstract：:Perinatal hypoxia is a major cause of neurodevelopmental deficits. Neuronal migration patterns are particularly sensitive to perinatal hypoxia/ischemia and are associated with the clinical deficits. The rat model of hypoxia/ischemia at P7 mimics that of perinatal injury in humans. Before assessing the effects of postn...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21607
更新日期：2008-05-15 00:00:00
abstract：:Statins are potent cholesterol biosynthesis inhibitors that exert protective effects in humans and in experimental models of stroke. The mechanisms involved in these protective actions are not completely understood. This study evaluates whether atorvastatin (ATV) treatment affects the GluN1 and GluN2B subunits of the ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23426
更新日期：2014-11-01 00:00:00
abstract：:Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke-related disability. Stroke has dropped to the fifth leading cause of death in men,...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.23962
更新日期：2017-01-02 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease caused by the selective death of motor neurons. Between 5% and 10% of ALS patients have a genetically inherited form of the disease known as familial ALS (FALS), and approximately 20% of FALS patients have mutations in the SOD1 gene. Although the m...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21902
更新日期：2009-03-01 00:00:00
abstract：:Manganese (Mn) is an essential metal and plays an important role in the brain. To evaluate Mn uptake into the brain during development and aging, 54Mn concentrations in the brain of rats aged from 5 days to 95 weeks were measured after injection of 54MnCl2. 54Mn concentration in the brain of 5-day-old rats was the hig...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19990401)56:1<93::AID-JNR1
更新日期：1999-04-01 00:00:00
abstract：:In eukaryotes, mitochondria are critical for cellular bioenergetics and mediating apoptosis. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is an important regulator of mitochondrial biogenesis and function. However, the role of PGC-1alpha in neuronal a...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22354
更新日期：2010-07-01 00:00:00
abstract：:Changes in gene expression were examined in the brain of mice treated with a drug of abuse, 3,4-methylenedioxymethamphetamine (MDMA, also called Ecstasy). Frontal cortex and midbrain mRNA, analyzed by differential display polymerase chain reaction (DD-PCR) method, showed an altered expression of several cDNAs, 11 of w...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10571
更新日期：2003-04-15 00:00:00
abstract：:It is generally recognized that lipid peroxides play an important role in the pathogenesis of several diseases and that sulfhydryl groups are critically involved in cellular defense against endogenous or exogenous oxidants. Recent evidence indicates that lipid peroxides directly participate in induction of cytoprotect...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10177
更新日期：2002-04-01 00:00:00
abstract：:Cytomegalovirus (CMV) is a major cause of congenital brain disease, and its neuropathogenesis may be related to viral infection of rapidly dividing, susceptible neural precursor cells (NPCs). In the present study, we evaluated the susceptibility of human fetal brain-derived NPCs (nestin(+), A2B5(+), CD133(+)) to infec...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20682
更新日期：2005-12-15 00:00:00
abstract：:HAND2 (also known as dHAND) is a basic helix-loop-helix (bHLH) transcription factor essential for development of the heart, limbs, and neural crest-derived lineages. HAND2 expression is observed in a number of tissues derived from the neural crest, including components of the peripheral nervous system, where it has be...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20105
更新日期：2004-06-01 00:00:00
abstract：:Fractionation of muscle microsomes rich in sarcoplasmic reticulum (SR) by isopicnic centrifugation yielded three types of membranes. Heavy (HM), intermediate (IM), and light membranes (LM), with isopicnic points of 38, 33, and 25% w/w sucrose, were rich in terminal cisternae/triads, longitudinal SR, and T-tubules, res...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490330409
更新日期：1992-12-01 00:00:00
abstract：:Microglia, the resident macrophages of the central nervous system, are the primary cells to respond to injury in the brain, both in inflammation, e.g., in multiple sclerosis, and trauma. Chemokines are potential mediators of microglial cell recruitment to sites of injury; thus, the ability of microglia to migrate in r...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19990101)55:1<17::AID-JNR3
更新日期：1999-01-01 00:00:00
abstract：:The changes in ganglioside composition and metabolism of deafferentiated rat hippocampus were estimated after septal lesion. A significant decrease in total ganglioside concentration was found 7 days after the lesion. The reduced level of total gangliosides persisted at 17 and 25 days. Relative increase in the proport...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490210107
更新日期：1988-09-01 00:00:00
abstract：:Green fluorescent protein (GFP) transgenic zebrafish technology has been employed to directly visualize and analyze dynamic developmental processes, such as cell migration and morphogenesis. Stable transgenic zebrafish that express GFP in oligodendrocytes can be a valuable tool to visualize complex myelination process...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20516
更新日期：2005-07-01 00:00:00
abstract：:In the present work, we analyzed whether endogenous and/or transplanted bone marrow mononuclear cells (BMMC) migrate spontaneously to the crushed sciatic nerve and whether they transdifferentiate into Schwann cells (SC) in order to help repair the damaged tissue. We also studied both the immunohistochemical evolution ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22645
更新日期：2011-08-01 00:00:00
abstract：:Myelin gene expression in normal oligodendrocytes (OLG) depends on developmentally regulated protein kinase C (PKC) enzyme activity (Asotra and Macklin: J Neurosci Res 34:571-588, 1993). We studied the developmental expression of the Ca(++)-dependent PKC-alpha, -beta 1, -beta II and -gamma isozymes, and the Ca(++)-ind...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490390305
更新日期：1994-10-15 00:00:00
abstract：:Growing evidence suggests that decreased brain-derived neurotrophic factor (BDNF) levels are associated with Alzheimer's disease (AD) pathogenesis. Therefore, BDNF gene therapy is considered to be a promising therapeutic strategy for treating AD. Sendai virus (SeV) is a type I parainfluenza virus that does not interac...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22830
更新日期：2012-05-01 00:00:00
abstract：:The rewarding effect of opiates is mediated through dissociable neural systems in drug naïve and drug-dependent states. Neuroadaptations associated with chronic drug use are similar to those produced by chronic pain, suggesting that opiate reward could also involve distinct mechanisms in chronic pain and pain-naïve st...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24553
更新日期：2019-11-12 00:00:00
abstract：:By using two different approaches, ubiquitin C-terminal hydrolase 1 (UCHL1) was identified as a potential cerebrospinal fluid (CSF) biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage (ASAH) and presumably other CNS damage and disease states. Appropriate antibodies and a sensitive ELISA were generated, an...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22323
更新日期：2010-05-15 00:00:00
abstract：:Ephrins and Eph receptors are a family of molecules that have been implicated in axonal pathfinding. A unique feature of B-class ephrins and Eph receptors is their ability to transmit bidirectional signals in both ephrin- and Eph receptor-expressing cells upon cell-cell contact. These signals can lead to cytoskeletal ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10457
更新日期：2003-01-01 00:00:00
abstract：:Anorexia nervosa (AN) is a severe and complex psychiatric disorder characterized by intense fear about weight gain and finalized to food-related control behaviors. Growing interest has been demonstrated about neurobiological processes subtend to AN physiopathology. The present review aimed to collect neurostructural a...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.24674
更新日期：2020-11-01 00:00:00
abstract：:The cerebral neocortex is known to modulate asymmetrically certain components of the immune system. It was previously shown that large ablation of the left cortex reduces B and T cell-mediated responses, whereas symmetrical right lesions enhance these responses. We have studied the immunomodulatory role of the brain c...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490220212
更新日期：1989-02-01 00:00:00
abstract：:Encephalitogenic T cells from Lewis rats use a restricted T cell receptor (TCR) gene combination, Vbeta8.2 and Valpha2. The oral administration of myelin basic protein (MBP) to Lewis rats prior to encephalitogenic challenge results in a marked inhibition of clinical neurologic signs of encephalitis, reduced central ne...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19980101)51:1<67::AID-JNR7
更新日期：1998-01-01 00:00:00
abstract：:Niemann-Pick C (NPC) disease is an autosomal recessive lipidosis characterized by lysosomal accumulations of unesterified cholesterol. Cultured NPC cells exhibit a defect in the intracellular trafficking of LDL-derived cholesterol that leads to lysosomal accumulations of unesterified cholesterol. We found in a prelimi...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(sici)1097-4547(19970801)49:3<389::aid-jnr
更新日期：1997-08-01 00:00:00
abstract：:The effects of KCl-treatment on the survival and proliferation of NE-4C self-renewing neural progenitor cells were investigated during early phases of in vitro induced neurogenesis. NE-4C cells, derived from the anterior brain vesicles of embryonic mouse (E9), divided continuously under non-inducing conditions, but ac...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10155
更新日期：2002-03-01 00:00:00
