Abstract:
:Isotonic media containing sodium salts from weak organic acids induce cell swelling in several experimental preparations (Grinstein et al., 1984; Jakubovicz et al., 1987). In vivo perfusion of rat dentate gyrus, using a microdialysis probe, with modified Krebs-Ringer bicarbonate solutions in which 50 mM NaCl was isotonically substituted by the sodium salts from organic acids with a pKa value of greater than 2 (acetate, propionate, or pyruvate), induced a reversible increase in the extracellular taurine concentration. By contrast, similar NaCl substitutions with sodium salts from the stronger organic acids isethionate and methane-sulfonate did not change extracellular taurine levels. Extracellular taurine increases evoked by acetate, propionate, or pyruvate were almost completely abolished when the perfusion liquid was made hypertonic by adding sucrose (50 mM). A 30% reduction of the acetate-induced extracellular taurine increase was observed both when amiloride was present or when the [Na+]0 was lowered. Both conditions are known to inhibit Na+/H+ exchange. These results are compatible with the hypothesis that acid load-induced taurine release is stimulated by an osmotic sensitive mechanism, part of which is dependent on activation of the Na+/H+ exchange.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Solis JM,Herranz AS,Herreras O,Menéndez N,del Rio RMdoi
10.1002/jnr.490260205subject
Has Abstractpub_date
1990-06-01 00:00:00pages
159-67issue
2eissn
0360-4012issn
1097-4547journal_volume
26pub_type
杂志文章abstract::Butyrate produced a biphasic modulation of the thyroid hormone receptor in neuroblastoma N2A cells increasing receptor number by 20-35% at concentrations 0.25-0.75 mM and decreasing receptor levels by 30-55% at 2-4 mM. The half-life of the receptor, as assessed by its disappearance after incubation with 18 microM cycl...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490270102
更新日期:1990-09-01 00:00:00
abstract::Monoclonal antibody J1-31 (MAb J1-31, isotype IgG 2b) was raised against crude homogenate of brain tissue from a multiple sclerosis (MS) patient (autopsy sample; Malhotra et al.: Microbios Letters 26:151-157, 1984). In human brain, MAb J1-31 recognizes an intracellular protein antigen (J1-31 antigen), which bands at a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220106
更新日期:1989-01-01 00:00:00
abstract::The tissue- and cell-specific expression of three neutral glycosphingolipids, gangliotetraosylceramide (GA1), gangliopentaosylceramide (GalNAc-GA1), and the novel 3-O-acetyl-sphingosine-series glycolipid (FMC-5), were examined with monospecific polyclonal antibodies. Immunohistochemical studies of rodent brain cross-s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21419
更新日期:2007-10-01 00:00:00
abstract::Primary cultures of cerebral glia derived from neonatal rat brain were utilized to determine 1) the developmental changes of dolichol-linked oligosaccharide and N-linked glycoprotein biosyntheses, 2) the enzymatic correlates of these developmental changes, and 3) the temporal relations between the biosyntheses of doli...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200409
更新日期:1988-08-01 00:00:00
abstract::In the present study, following previous experience with electrolytic lesion of the rat brain, and subsequent reduction of reactive gliosis with 7 beta-hydroxycholesterol derivatives (Bochelen et al.: Neuroscience 51:827-834, 1992), we have performed a hemisection of the spinal cord in adult rats and investigated the ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410110
更新日期:1995-05-01 00:00:00
abstract::Thymocyte differentiation antigen-1 (Thy-1) is a cell surface glycoprotein found on T cells and neurons and is involved in cell-to-cell interactions. In addition, Thy-1 knockouts (KO) are a potential mouse model of restless legs syndrome (RLS) based on clinical observations and the role of dopamine in the disease. In ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23046
更新日期:2012-08-01 00:00:00
abstract::Adenosine signalling has an important role in cochlear protection from oxidative stress. In most tissues, intracellular adenosine kinase (ADK) is the primary route of adenosine metabolism and the key regulator of intracellular and extracellular adenosine levels. The present study provides the first evidence for ADK di...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22421
更新日期:2010-09-01 00:00:00
abstract::Previously we reported results of an incubation experiment with neurofilaments that supported the existence of a mu-type of Ca2+-activated neutral protease in the rat peripheral nerve; it was active with microM order Ca2+ (mu-CANP). This time, we partially purified the mu-CANP from a crude CANP fraction of rat periphe...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490150206
更新日期:1986-01-01 00:00:00
abstract::The cholinergic neurons of the basal forebrain (CNBF) are the major source of cholinergic innervation of the cortex and hippocampus. In Alzheimer's disease and aged brain, there are severe losses of cholinergic neurons in the nucleus basalis of Meynert, leading to a reduction of cortical cholinergic activity which cor...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980501)52:3<322::AID-JNR
更新日期:1998-05-01 00:00:00
abstract::The objective of this study was to compare cerebrospinal fluid (CSF) levels of the light subtype of the neurofilament proteins (NFL), tau, and beta-amyloid42 (Abeta42) in individuals with moderate or severe white matter changes (WMC) and in those with mild or no WMC. Twenty-two patients with Alzheimer's disease (AD), ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1242
更新日期:2001-11-01 00:00:00
abstract::The pathogenic processing of the amyloid precursor protein (APP) into beta-amyloid peptides, which give rise to beta-amyloid plaques in the brains of Alzheimer's disease patients, requires the enzymatic activity of the beta-site APP-cleaving enzyme 1 (BACE1). We report the cloning and sequence of a 1.5-kb DNA fragment...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10639
更新日期:2003-07-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Progressive and systemic loss of motor neurons with gliosis in the central nervous system (CNS) is a neuropathological hallmark of ALS. Chondroitin sulfate proteoglycans (CSPGs) are the major components of the extracellular matrix of the mammali...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24127
更新日期:2018-02-01 00:00:00
abstract::The increase in myelin basic protein (MBP) synthesis observed in brain aggregate cultures supplemented with macrophages is reflected in elevated supernatant protein levels of the key promoters of oligodendrocyte proliferation, fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor-AA (PDGF-AA), during t...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10837
更新日期:2003-12-15 00:00:00
abstract::In order to study the voltage-dependent ion channels in microglia, and their possible modulation by pro-inflammatory substances like lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) we employed the patch-clamp technique on purified rat microglial cell subcultures grown for 1 - 5 days in control condition or a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490420402
更新日期:1995-11-01 00:00:00
abstract::Adhesion responses triggered by integrin-class matrix receptors have been implicated in the synaptic reorganization events necessary for certain types of neuronal plasticity. Hippocampal slice cultures were used to test whether the related structural transformations elicited by NMDA receptor stimulation are regulated ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000315)59:6<827::AID-JNR
更新日期:2000-03-15 00:00:00
abstract::Although protein kinase Cdk5-p35 is important in many aspects of the development and function of the central nervous system, relatively little is known about its regulation. In the present study, we examined the relationship between the association of this kinase with membranes and its activity in perinatal and adult ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21438
更新日期:2007-11-01 00:00:00
abstract::Few diseases in clinical medicine cause as much diagnostic consternation as central nervous system (CNS) vasculitis because of its varying modes of presentation and frequently overlapping clinical and pathological features. There are no pathognomonic clinical or laboratory findings. The purpose of the present retrospe...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10180
更新日期:2002-03-15 00:00:00
abstract::Data from a study in which 12 chronic mental patients and 12 control subject were given D-[3-14C] glucose intravenously in our arterio-venous technique for determining cerebral metabolism in vivo were reexamined. Previously unpublished whole-blood lactate determinations in these experiments indicated a cerebral produc...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490060209
更新日期:1981-01-01 00:00:00
abstract::The engrailed gene has been identified in Drosophila as an important developmental gene involved in the control of segmentation. Here we describe the embryonic expression of a chicken gene, ChickEn (Darnell et al.: J Cell Biol 103(5):311a, 1986), which contains homology to the Drosophila engrailed gene. Northern blots...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490210234
更新日期:1988-10-01 00:00:00
abstract::The effects of the environmental contaminants methylmercury (MeHg) and inorganic mercury (HgCl(2)) on cell viability, intracellular calcium concentration ([Ca(2+)](i)), and reactive oxygen species (ROS) generation were studied in rat cerebellar granule neuron cultures using fluorescent methods. MeHg exhibited an LC(50...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1205
更新日期:2001-10-01 00:00:00
abstract::Astrocytes are excitable neural cells that contribute to brain information processing via bidirectional communication with neurons. This involves the release of gliosignaling molecules that affect synapses patterning and activity. Mechanisms mediating the release of these molecules likely consist of non-vesicular and ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24051
更新日期:2017-11-01 00:00:00
abstract::Neurofibromatosis type 2 is a hereditary cancer syndrome characterized by the development of bilateral vestibular schwannomas. Underlying the disease are inactivating mutations of the NF2 tumor suppressor gene, located on chromosome 22, encoding a 595-amino-acid protein. The NF2 protein, also known as merlin or schwan...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/1097-4547(20001215)62:6<764::AID-JNR2>3.0.
更新日期:2000-12-15 00:00:00
abstract::The effects of fetal asphyxia on cerebral function and development, involve the transition from fetal to neonatal life. Changes in cerebral glucose metabolism may be an early postnatal indicator of fetal asphyxia. The objective is to develop an experimental lamb model involving the transition from fetal to neonatal li...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10051
更新日期:2001-12-01 00:00:00
abstract::Organotypic slices are used frequently in studies of central nervous system development and function because they provide excellent experimental access with significant preservation of cellular context and relationships. Within a slice, however, a variety of factors may cause individual classes of neurons to respond d...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1174
更新日期:2001-09-01 00:00:00
abstract::Nerve growth factor (NGF) has been purified from the guinea pig prostate using a modification of the Bocchini-Angeletti method for isolating 2.5S NGF from mouse submaxillary glands. As with the mouse preparation, guinea pig prostate NGF appears to migrate as a high molecular weight entity at physiological pH. Followin...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490060403
更新日期:1981-01-01 00:00:00
abstract::This study tested the hypothesis that sensitivity to the Ca(2+) -induced loss of mitochondrial membrane potential (ΔΨ(m)) and the sensitivity of the loss of ΔΨ to mitochondrial permeability transition pore (PTP) inhibitors are different for neurons and astrocytes. Primary cultures of rat cortical neurons and astrocyte...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22709
更新日期:2011-12-01 00:00:00
abstract::Experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), is a demyelinating autoimmune disease of the central nervous system (CNS). The proinflammatory cytokine TNF alpha, as an endogenous mediator of inflammation, plays an important role in the pathogenesis of EAE disease. In this s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19970901)49:5<592::AID-JNR
更新日期:1997-09-01 00:00:00
abstract::Germinal matrix (GM) vasculature is selectively vulnerable to hemorrhage in premature infants during the first 48 hr of life. This is attributed to rapid angiogenesis of this brain region, resulting in formation of nascent vessels that show a paucity of pericytes and immaturity of extracellular matrix. Integrins are k...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22301
更新日期:2010-05-01 00:00:00
abstract::The properties of neuronal plasma membranes are highly specialized, since they include the receptors by which many hormones, neurotransmitters, drugs, and toxins initiate their actions, as well as the components necessary for receiving synaptic input from a variety of sources and for generating the appropriate pattern...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490150412
更新日期:1986-01-01 00:00:00
abstract::Contrary to widely held beliefs, the gene encoding proteolipid protein (PLP), the major structural protein of central nervous system myelin, is expressed in Schwann cells and their tumors. Proteolipid mRNA was identified in human acoustic neuromas and in rat and rabbit sciatic nerves using a human PLP cDNA as a probe....
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180402
更新日期:1987-01-01 00:00:00