Abstract:
:Data from a study in which 12 chronic mental patients and 12 control subject were given D-[3-14C] glucose intravenously in our arterio-venous technique for determining cerebral metabolism in vivo were reexamined. Previously unpublished whole-blood lactate determinations in these experiments indicated a cerebral production of much higher specific activity of [1-14C]-lactate from the D-[3-14C] glucose by mental patients. Of several possible explanations offered for this difference, the most likely was that involving a small lactate compartment(s) in some specific region(s) in which decarboxylation of the endogenously formed cerebral lactate was partially inhibited. Two other experiments with mental patients (one given [U-14C] glucose and the other, [1-14C] glucose) whose extraordinary results were described, in part, in a previous report, were interpreted as more extreme examples of the production of higher specific activity 14C-lactate from 14C-glucose by mental patients' brains upon their very unusual whole blood lactate data.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Sacks W,Schechter DC,Sacks Sdoi
10.1002/jnr.490060209subject
Has Abstractpub_date
1981-01-01 00:00:00pages
225-36issue
2eissn
0360-4012issn
1097-4547journal_volume
6pub_type
杂志文章abstract::The birth of cells with neurogenic potential in the adult brain is assessed commonly by detection of exogenous S phase markers, such as bromodeoxyuridine (BrdU). Analysis of other phases of the cell cycle, however, can provide insight into how external factors, such as opiates, influence the cycling of newly born cell...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20090
更新日期:2004-06-15 00:00:00
abstract::Ionotropic glutamate receptors, N-methyl-d-aspartate receptors (NMDARs) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs), are densely distributed in the mammalian brain and actively regulate a variety of cellular activities. Expression and function of these receptors are also under a tig...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.21050
更新日期:2006-12-01 00:00:00
abstract::We have studied the effect of induced glial fibrillary acidic protein (GFAP) on motility, cell morphology, and proliferation of two originally GFAP-negative human glioma cell lines. Glioma cell lines U-1242 MG and U-251 MG sp subclone 3A were transfected with a vector system that allows for an inducible GFAP expressio...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000415)60:2<245::AID-JNR
更新日期:2000-04-15 00:00:00
abstract::Vascular smooth muscle (VSM) cells comprise one of the primary targets of the sympathetic nervous system and have been shown to secrete nerve growth factor (NGF). There is increasing evidence that changes in the levels of NGF in the adult may underlie certain pathological conditions. To investigate the potential role ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::Previous studies have shown that PC12 cells overexpressing beta/A4 amyloid peptide display altered morphology characterized by pronounced membrane ruffling and extensive intercellular appositions. Having observed other cell types in which these features accompany increased connexin43 (Cx43) production and gap junction...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960415)44:2<124::AID-JNR
更新日期:1996-04-15 00:00:00
abstract::Trophic factors, such as the neurotrophins, CNTF, and GDNF, represent unique families of proteins that are essential for the development of the vertebrate nervous system. Surprisingly, there is little evidence to date that these proteins exist in Drosophila melanogaster and Caenorhabditis elegans, even though other po...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract::Injury to the central nervous system (CNS) either from trauma or due to demyelinating/degenerating diseases results in a typical response of astrocytes, termed astrogliosis. This reaction is characterized by astrocyte proliferation, extensive hypertrophy of nuclei, cell body, and cytoplasmic processes and an increase ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490380403
更新日期:1994-07-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/1097-4547(20001115)62:4<473::AID-JNR1>3.0.
更新日期:2000-11-15 00:00:00
abstract::Ephrins and Eph receptors are a family of molecules that have been implicated in axonal pathfinding. A unique feature of B-class ephrins and Eph receptors is their ability to transmit bidirectional signals in both ephrin- and Eph receptor-expressing cells upon cell-cell contact. These signals can lead to cytoskeletal ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10457
更新日期:2003-01-01 00:00:00
abstract::Preterm birth results in significant cognitive and motor disabilities, but recent evidence suggests that there is variable recovery over time. One possibility that may explain this variable recovery entails variable neurogenic responses in the subventricular zone (SVZ) following the period of chronic hypoxia experienc...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21597
更新日期:2008-05-01 00:00:00
abstract::Fibroblast growth factor 2 (FGF2) exhibits pleiotropic functions during embryogenesis. In neural development, both pro- and antineurogenic activities of FGF2 have been described in the differentiation of neuronal progenitors into postmitotic neurons. We used cultured neural stem cells (NSCs) derived from rat embryonic...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20627
更新日期:2005-10-15 00:00:00
abstract::The applications of neural progenitor cells in clinical therapy for neural degeneration, such as Parkinson's disease, Huntington's disease, and cerebral infarction, have long been explored widely. It had been suggested that these cells may block the apoptosis of ischemia-induced neuronal damage and may themselves resi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10476
更新日期:2003-01-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22694
更新日期:2011-10-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490300127
更新日期:1991-09-01 00:00:00
abstract::The cutaneous electroreceptor "tuberous organs" of the lateral line system of Eigenmannia virescens were studied at light and electron microscopic levels with immunohistochemical and autoradiographic techniques after sectioning of the posterior branch of the lateral line nerve. After deafferentation total degeneration...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490390506
更新日期:1994-12-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20304
更新日期:2004-11-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990301)55:5<578::AID-JNR
更新日期:1999-03-01 00:00:00
abstract::In the non-amyloidogenic pathway, the Alzheimer's amyloid precursor protein (APP) is cleaved within the amyloid-beta domain by alpha-secretase precluding deposition of intact amyloid-beta peptide. The large ectodomain released from the cell surface by the action of alpha-secretase has several neuroprotective propertie...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.10737
更新日期:2003-11-01 00:00:00
abstract::Nerve growth factor (NGF) has a modulating effect on immune function, which may occur as a consequence of binding to the NGF receptor (NGF-R). To determine if mRNA for the gene coding for p75NGFR (low affinity NGF-R) is present in lymphocytes, Northern blot analysis of mRNA from human peripheral blood lymphocytes (PBL...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320316
更新日期:1992-07-01 00:00:00
abstract::The engrailed gene has been identified in Drosophila as an important developmental gene involved in the control of segmentation. Here we describe the embryonic expression of a chicken gene, ChickEn (Darnell et al.: J Cell Biol 103(5):311a, 1986), which contains homology to the Drosophila engrailed gene. Northern blots...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490210234
更新日期:1988-10-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23423
更新日期:2014-11-01 00:00:00
abstract::Using subtype-specific Ca-channel blockers, we have characterised the voltage-sensitive Ca2+ currents as well as neurotransmitter release from cultured mouse cerebellar granule cells. The whole cell version of the patch clamp technique was adapted to monitor the isolated Ca-channel currents. The currents were activate...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(sici)1097-4547(19970401)48:1<43::aid-jnr4
更新日期:1997-04-01 00:00:00
abstract::The vesicular acetylcholine transporter (VAChT) is a transmembrane protein required, in cholinergic neurons, for selective storage of acetylcholine into synaptic vesicles. Although dorsal root ganglion (DRG) neurons utilize neuropeptides and amino acids for neurotransmission, we have previously demonstrated the presen...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10855
更新日期:2004-01-15 00:00:00
abstract::A study was conducted on the adsorption of 14C-ATP to a surface film of a hydrophobic protein derived from synaptic membranes isolated from bovine cerebellum. The adsorption of ATP to the protein film followed a rate law based on diffusion and an energy barrier to adsorption, the rate law being generally applicable to...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490020109
更新日期:1976-01-01 00:00:00
abstract::An inflammatory response involving activated microglia in neuritic beta-amyloid plaques is found in Alzheimer's disease (AD) brain. Because HDL lipoproteins have been shown to carry the beta-amyloid peptide (Abeta) in plasma and CSF, we have investigated the influence of plasma high-density lipoprotein (HDL) and lipid...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1999-08-15 00:00:00
abstract::Recent experiments have shown that Arg, Lys, and Leu can be incorporated posttranslationally into proteins of regenerating sciatic nerves of rats. The present experiments investigate a mixture of 15 radioactive amino acids to determine if additional amino acids can be conjugated posttranslationally to proteins of rege...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250407
更新日期:1990-04-01 00:00:00
abstract::Calcium/calmodulin-dependent serine kinase (CASK), a causative gene in X-linked mental retardation, carries out multiple functions in neurons, including vesicle trafficking of ion channels, synapse formation, and gene transcription. From a yeast two-hybrid screen, Krüppel-like zinc finger protein B cell lymphoma/COUP-...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22407
更新日期:2010-08-15 00:00:00
abstract::Isatin (indole-2,3-dione) is an endogenous indole that has a distinct and discontinuous distribution in the brain and in other mammalian tissues and body fluids. Its output is increased under conditions of stress and anxiety. Its biological targets remain poorly characterized, although [(3)H]isatin binding sites have ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22104
更新日期:2009-09-01 00:00:00
abstract::The expression of the immunoglobulin superfamily member myelin-associated glycoprotein (MAG) and the extracellular matrix glycoprotein tenascin-R (TN-R) by oligodendrocytes overlaps in time and space. The two molecules can be neurite outgrowth-inhibitory or -promoting depending on the neuronal cell type and the enviro...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990315)55:6<687::AID-JNR
更新日期:1999-03-15 00:00:00
abstract::Recent studies have demonstrated that neural stem cell (NSC) culture at physiologically normoxic conditions (2-5% O2) is advantageous in terms of neuronal differentiation and survival. Neuronal differentiation is accompanied by a remarkable shift to mitochondrial oxidative metabolism compared with preferentially glyco...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23615
更新日期:2015-11-01 00:00:00