Nerve growth factor receptor gene expression in human peripheral blood lymphocytes in aging.

abstract：:Axotomy is a powerful stimulus of axon growth and plastic changes. We investigated the potential role of BDNF/trkB signaling in the sprouting of dopaminergic nigral axons in response to axotomy of the medial forebrain bundle. Tyrosine hydroxylase immunohistochemistry revealed the existence of sprouting mechanisms in t...

journal_title：Journal of neuroscience research

authors： García Navia JT,Burguillos MA,Ramón-Cueto A,Machado A,Cano J,Venero JL

更新日期：2008-07-01 00:00:00

abstract：:Scatchard analysis of saturation isotherms of [125I]-iodopindolol was used to characterize beta-adrenoceptor density (Bmax) and affinity constant (Kd) in female and male hamster Harderian glands. Single-point experiments were also completed in intact females, intact males, and castrated or superior cervical ganglionec...

journal_title：Journal of neuroscience research

authors： Pangerl A,Pangerl B,Buzzell GR,Jones DJ,Reiter RJ

更新日期：1989-04-01 00:00:00

abstract：:The expression of gangliosides of the lactosylceramide (LC) and of the gangliotetraosylceramide (GTC) series on the surface of cells from rat embryonic cerebellar tissue was investigated by double-color indirect immunofluorescence. GD3 was assumed to be representative of LC and was detected using a specific monoclonal...

journal_title：Journal of neuroscience research

authors： Gravotta D,Ferreira A,Busciglio J,Caceres A,Landa CA,Maccioni HJ

更新日期：1990-02-01 00:00:00

abstract：:Astrocytes play a diverse role in central nervous system (CNS) injury. Production of the serine protease inhibitors (serpins) plasminogen activator inhibitor-1 (PAI-1) and protease nexin-1 (PN-1) by astrocytes may counterbalance excessive serine protease activity associated with CNS pathologies such as ischemic stroke...

journal_title：Journal of neuroscience research

authors： Hultman K,Blomstrand F,Nilsson M,Wilhelmsson U,Malmgren K,Pekny M,Kousted T,Jern C,Tjärnlund-Wolf A

更新日期：2010-08-15 00:00:00

abstract：:Fast-scan cyclic voltammetry (FSCV) is an established method for measuring dopamine (DA) levels in the brain in real time. However, it is difficult to discriminate DA from other monoamines such as serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE). We report a novel DA-specific biosensor consisting of a car...

journal_title：Journal of neuroscience research

authors： Ishida A,Imamura A,Ueda Y,Shimizu T,Marumoto R,Jung CG,Hida H

更新日期：2018-05-01 00:00:00

abstract：:Chronic lead exposure during development is known to produce learning deficits. In the present study, we investigated the effects of developmental exposure to lead on spatial memory, as shown in the Morris water maze, and on expression of inducible cyclooxygenase-2 protein in the hippocampi of male rats. Rats were sep...

journal_title：Journal of neuroscience research

authors： Soodi M,Sharifzadeh M,Naghdi N,Ostad N,Abdollahi M,Roghani A

更新日期：2007-11-01 00:00:00

abstract：:The type 1 metabotropic glutamate receptor (mGluR1) plays an import role in the synaptic physiology and development of cerebellar Purkinje neurons. mGluR1 expression occurs early in the developmental program of Purkinje neurons, at an age that precedes expression of the dendritic structure. Few studies have investigat...

journal_title：Journal of neuroscience research

authors： Netzeband JG,Gruol DL

更新日期：2008-02-01 00:00:00

abstract：:Growth hormone (GH) appears to play a major role in a reciprocal axis that has been postulated between the thymus and pituitary glands. Our previous studies showed that thymic structure, as well as T-cell proliferation and IL-2 synthesis, could be restored in aged female Wistar-Furth rats by the implantation of GH3 pi...

journal_title：Journal of neuroscience research

authors： Davila DR,Brief S,Simon J,Hammer RE,Brinster RL,Kelley KW

更新日期：1987-01-01 00:00:00

abstract：:Cell transplantation offers a potential new treatment for stroke. Animal studies using models that produce ischemic damage in both the striatum and the frontal cortex have shown beneficial effects when hNT cells (postmitotic immature neurons) were transplanted into the ischemic striatum. In this study, we investigated...

journal_title：Journal of neuroscience research

authors： Bliss TM,Kelly S,Shah AK,Foo WC,Kohli P,Stokes C,Sun GH,Ma M,Masel J,Kleppner SR,Schallert T,Palmer T,Steinberg GK

更新日期：2006-05-01 00:00:00

abstract：:In searching for possible differences in the composition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) forms in dystrophic brain, the distribution of various enzyme molecules in normal (NB) and dystrophic (DB) 129B6F1/J mouse brain has been investigated. The tissue was sequentially extracted with sa...

journal_title：Journal of neuroscience research

authors： Moral-Naranjo MT,Cabezas-Herrera J,Vidal CJ

更新日期：1996-01-15 00:00:00

abstract：:Laminin mediates neural adhesion and process formation. A possible signal transduction pathway for laminin was investigated in both NG108-15 and PC12 neuronal cells using radiolabeling studies as well as various stimulators and inhibitors of phosphatases and kinases. Using [32P]-ortho-phosphate, laminin caused a decre...

journal_title：Journal of neuroscience research

authors： Weeks BS,DiSalvo J,Kleinman HK

更新日期：1990-11-01 00:00:00

abstract：:Plexiform layer synaptic and photoreceptor cell components were investigated in retinas of Royal College of Surgeons (RCS) dystrophic rats transplanted with normal retinal pigment epithelial (RPE) cells by immunocytochemistry using previously characterized monoclonal antibodies. In retinas of normal adult rats and RPE...

journal_title：Journal of neuroscience research

authors： Sheedlo HJ,Li L,Barnstable CJ,Turner JE

更新日期：1993-11-01 00:00:00

abstract：:The aim of the present study was to prepare cultures enriched in type-2 astrocytes (AS) and to analyze some of the properties of these cells over relatively long culture periods. Cultures enriched in type-2 AS were obtained by subculturing, at low cell density and in the presence of fetal calf serum, a cell population...

journal_title：Journal of neuroscience research

authors： Aloisi F,Agresti C,Levi G

更新日期：1988-10-01 00:00:00

abstract：:Male gerbils (Meriones unguiculatus) were bred and reared either grouped under enriched environmental conditions or isolated under impoverished environmental conditions. The objective of the present study was to examine the influence of social environment on structural and functional ontogeny of the medial prefrontal ...

journal_title：Journal of neuroscience research

authors： Winterfeld KT,Teuchert-Noodt G,Dawirs RR

更新日期：1998-04-15 00:00:00

abstract：:The chronic constriction injury (CCI) of the sciatic nerve is a nerve injury-based model of neuropathic pain (NP). Comorbidities of NP such as depression, anxiety, and cognitive deficits are associated with a functional reorganization of the medial prefrontal cortex (mPFC). Here, we have employed an adapted model of C...

journal_title：Journal of neuroscience research

authors： Medeiros P,de Freitas RL,Boccella S,Iannotta M,Belardo C,Mazzitelli M,Romano R,De Gregorio D,Coimbra NC,Palazzo E,Maione S

更新日期：2020-02-01 00:00:00

abstract：:The C57BL/6 mice strain is known to be reputedly resistant to induction of experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome in human by bovine peripheral myelin (BPM), and P2 protein or the P2 protein peptide 57-81. The P0 peptide 180-199 is a stronger neuritogenic antigen than the P2...

journal_title：Journal of neuroscience research

authors： Zou LP,Ljunggren HG,Levi M,Nennesmo I,Wahren B,Mix E,Winblad B,Schalling M,Zhu J

更新日期：2000-12-01 00:00:00

abstract：:The high circulating levels of leptin in neonatal rodents do not seem to be regulating energy balance at this age, but rather may play an important role for brain development. We tested the hypothesis that high neonatal leptin levels modify hippocampal function and production of synaptic proteins with possible long-te...

journal_title：Journal of neuroscience research

authors： Walker CD,Long H,Williams S,Richard D

更新日期：2007-03-01 00:00:00

abstract：:CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor-like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues. To date, more than 130 differen...

journal_title：Journal of neuroscience research

authors： Ungaro C,Mazzei R,Conforti FL,Sprovieri T,Servillo P,Liguori M,Citrigno L,Gabriele AL,Magariello A,Patitucci A,Muglia M,Quattrone A

更新日期：2009-04-01 00:00:00

abstract：:Cultures of chicken day 8 embryo retinal cells, essentially free of contaminating non-neuronal elements, were used to examine the neurotoxicity of various excitatory amino acid transmitter receptor agonists. At 7 days in vitro, N-methyl-D-aspartate (NMDA), following 24 hr exposure to 0.1-1.0 mM, destroyed 60-70% of th...

journal_title：Journal of neuroscience research

authors： Facci L,Leon A,Skaper SD

更新日期：1990-10-01 00:00:00

abstract：:Inhibitory luminopsins (iLMO2) integrate opto- and chemo-genetic approaches and allow for cell-type specific inhibition of neuronal activity. When exposed to a Renilla luciferase substrate, Coelenterazine (CTZ), iLMO2 generates bioluminescence-mediated activation of its amino-terminal halorhodopsin, resulting in neuro...

journal_title：Journal of neuroscience research

authors： Jaiswal PB,Tung JK,Gross RE,English AW

更新日期：2020-03-01 00:00:00

abstract：:The amino acid glutamate plays a key role in brain function. One of the major roles of glutamate is to mediate fast excitatory neurotransmission via activation of ionotropic glutamate receptors (iGluRs). More recently, however, it has become clear that glutamate also serves a regulatory function through activation of ...

journal_title：Journal of neuroscience research

authors： Winder DG,Conn PJ

更新日期：1996-10-15 00:00:00

abstract：:Hyperglycemia and acidosis are the key factors in diabetic complications. It has been shown that acute or chronic diabetes alters serotonin levels in brain. However, the mechanism of hyperglycemia- or acidosis-induced changes in serotonin levels remains poorly understood. Because Ca2+-dependent protein kinases play a ...

journal_title：Journal of neuroscience research

authors： Ramakrishnan R,Prabhakaran K,Jayakumar AR,Gunasekaran P,Sheeladevi R,Suthanthirarajan N

更新日期：2005-05-15 00:00:00

abstract：:Axonal injury is often characterized by axonal transport defects and abnormal accumulation of intra-axonal components. Nitric oxide (NO) has a key role in mediating inflammatory axonopathy in many neurodegenerative diseases, but little is known about how nitrosative/oxidative stress affects axonal transport or whether...

journal_title：Journal of neuroscience research

authors： Redondo J,Hares K,Wilkins A,Scolding N,Kemp K

更新日期：2015-06-01 00:00:00

abstract：:Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much pe...

journal_title：Journal of neuroscience research

authors： Lee SM,Lee JW,Song YS,Hwang DY,Kim YK,Nam SY,Kim DJ,Yun YW,Yoon DY,Hong JT

更新日期：2005-11-15 00:00:00

abstract：:Using a canine model of classical late-infantile neuronal ceroid lipofuscinosis (CLN2 disease), a study was conducted to evaluate the potential pharmacological activity of recombinant human tripeptidyl peptidase-1 (rhTPP1) enzyme replacement therapy administered directly to the cerebrospinal fluid (CSF). CLN2 disease ...

journal_title：Journal of neuroscience research

authors： Katz ML,Coates JR,Sibigtroth CM,Taylor JD,Carpentier M,Young WM,Wininger FA,Kennedy D,Vuillemenot BR,O'Neill CA

更新日期：2014-11-01 00:00:00

abstract：:The p53 tumor suppressor gene, which is considered the guardian of the genome, encodes a phosphoprotein, which is a sequence-specific transcriptional activator or repressor of target genes. The role of p53 in developmental processes has not been studied extensively, although its expression appears to undergo temporal ...

journal_title：Journal of neuroscience research

authors： Poulaki V,Benekou A,Bozas E,Bolaris S,Stylianopoulou F

更新日期：1999-05-15 00:00:00

abstract：:The potassium-induced stimulation of oxygen consumption in brain slices has a threshold value of 15-20 mM potassium, and it reaches its maximum at 35-50 mM. Although this phenomenon now has been known for almost 50 years, its physiological role remains undetermined. One reason for this may be that the high concentrati...

journal_title：Journal of neuroscience research

authors： Hertz L,Kjeldsen CS

更新日期：1985-01-01 00:00:00

abstract：:GM1 ganglioside has been shown to stimulate recovery of the damaged dopamine system under a number of different circumstances. In addition to rescue of damaged dopamine neurons, the present study assessed the ability of GM1 to enhance the synthesis of dopamine in remaining nigrostriatal neurons following 1-methyl-4-ph...

journal_title：Journal of neuroscience research

authors： Schneider JS,Kean A,DiStefano L

更新日期：1995-09-01 00:00:00

abstract：:Dorsal root ganglia (DRG) neurons connect the spinal cord and uterine cervix, and are activated at parturition with subsequent stimulation of secondary neurons in the spinal dorsal horn and autonomic areas. Neuropeptide neurotransmitters and receptors have been studied in these areas, but amino acid transmitters, e.g....

journal_title：Journal of neuroscience research

authors： Ghosh C,Storey-Workley M,Usip S,Hafemeister J,Miller KE,Papka RE

更新日期：2007-05-01 00:00:00

abstract：:The cytokines ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) signal through a receptor complex formed between two transmembrane proteins, gp130 and LIFRbeta. In addition, CNTF also uses a ligand-binding component which is anchored to the cell membrane. In the case of cardiotrophin-1 (CT-1), LI...

journal_title：Journal of neuroscience research

authors： Arce V,Garces A,de Bovis B,Filippi P,Henderson C,Pettmann B,deLapeyrière O

更新日期：1999-01-01 00:00:00