Abstract：
:Ephrins and Eph receptors are a family of molecules that have been implicated in axonal pathfinding. A unique feature of B-class ephrins and Eph receptors is their ability to transmit bidirectional signals in both ephrin- and Eph receptor-expressing cells upon cell-cell contact. These signals can lead to cytoskeletal alterations that have been attributed to regulating neuronal growth responses. Examination of gene-target knockout mice has supported this hypothesis, revealing numerous developmental defects in the nervous systems of mice mutant for both B-class ephrins and Eph receptors. To examine the potential scope of action for these genes in the nervous system, we have used in situ hybridization to study the mRNA expression of ephrins (B1, B2, and B3) and Eph receptors (B1, B2, B3, A4) in neonatal and adult mice. We found ephrins and Eph receptors to be expressed throughout the CNS. Expression was observed in the epithelium and migratory regions of the neonate and adult tissues as well as in discrete regions of high plasticity, including the adult olfactory bulb, hippocampus, and cerebellum. These studies suggest additional potential roles for these molecules in the postnatal and adult CNS and will serve as a guide in the detailed evaluation of mutant mice.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Liebl DJ,Morris CJ,Henkemeyer M,Parada LFdoi
10.1002/jnr.10457keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
7-22issue
1eissn
0360-4012issn
1097-4547journal_volume
71pub_type
杂志文章abstract：:The phosphorylative neuromodulation of the regulatory subunit of protein kinase type II (R-II) in cytosolic fractions from denervated and sham-operated, contralateral soleus muscles of the rat was evaluated. The denervation-induced increase in the 32P-phosphorylation of R-II is not related to an increased dephosphoryl...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490140208
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abstract：:In the embryonic and postnatal rat retina a cell surface antigen that is detected by monoclonal antibody JONES is distributed in a dorsoventral gradient. Biochemical analysis has determined that the antigen is a modified ganglioside, 9-O-acetyl GD3. In the present study, the distributions of 9-O-acetyl GD3 and its pos...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490210231
更新日期：1988-10-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.1159
更新日期：2001-08-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.10545
更新日期：2003-03-01 00:00:00
abstract：:Rho-GTPase has been implicated in the apoptosis of many cell types, including neurons, but the mechanism by which it acts is not fully understood. Here, we investigate the roles of Rho and ROCK in apoptosis during transplantation of embryonic stem cell-derived neural precursor cells. We find that dissociation of neura...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21502
更新日期：2008-02-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21173
更新日期：2007-03-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490290210
更新日期：1991-06-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10061
更新日期：2001-12-01 00:00:00
abstract：:The cholinergic neurons of the basal forebrain (CNBF) are the major source of cholinergic innervation of the cortex and hippocampus. In Alzheimer's disease and aged brain, there are severe losses of cholinergic neurons in the nucleus basalis of Meynert, leading to a reduction of cortical cholinergic activity which cor...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19980501)52:3<322::AID-JNR
更新日期：1998-05-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10667
更新日期：2003-08-15 00:00:00
abstract：:The purpose of this study was to determine how oligodendrocytes die following Fas receptor activation. An immortalized human oligodendrocyte hybrid line (MO3.13) was challenged with Fas ligand (FasL), and cell death was assessed by flow cytometry and DNA gel electrophoresis. Caspase activation was determined by either...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10285
更新日期：2002-07-15 00:00:00
abstract：:An experimental model based on kainic acid (KA) injections replicates many phenomenological features of human temporal lobe epilepsy, the most common type of epilepsy in adults. Taurine, 2-aminoethanesulfonic acid, present in high concentrations in many invertebrate and vertebrate systems, is believed to serve several...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21950
更新日期：2009-05-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22241
更新日期：2010-03-01 00:00:00
abstract：:The objective of the present investigation was to answer the following question: Does the visual cortex affect the neuronal firing of retinal ganglion cells in the rat? To test this hypothesis, the visual cortex was inactivated by a reversible cryoblockade. Action potentials of a ganglion cell were recorded from its a...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490100407
更新日期：1983-01-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：
更新日期：1997-02-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24109
更新日期：2020-03-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20104
更新日期：2004-05-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21875
更新日期：2009-02-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21281
更新日期：2007-05-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490360308
更新日期：1993-10-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490360408
更新日期：1993-11-01 00:00:00
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journal_title：Journal of neuroscience research
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更新日期：2015-06-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490220212
更新日期：1989-02-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490320409
更新日期：1992-08-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22288
更新日期：2010-05-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490260415
更新日期：1990-08-01 00:00:00
abstract：:Perceptually similar stimuli, despite not being consciously distinguishable, may result in distinct cortical brain activations. Hypothesizing that perceptually similar tastes are discriminable by electroencephalography (EEG), we recorded 22 human participants' response to equally intense sweet-tasting stimuli: caloric...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10123
更新日期：2002-02-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19981101)54:3<353::AID-JNR
更新日期：1998-11-01 00:00:00
abstract：:In the present study we report self-assembly of individual neurofilament (NF) triplet proteins (70K, 150K, and 200K daltons) isolated by anion exchange chromatography from bovine spinal cord. Formation of smooth 10-nm filaments by both NF 150K and NF 70K is shown. Optimal conditions for NK 150K filament formation were...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490110204
更新日期：1984-01-01 00:00:00
