Abstract:
:To study the potential role of Alzheimer precursor protein A4 (APP) and beta-amyloid (A/beta) on aging motor neuron survival, expression of APP, A/beta, and choline acetyltransferase (ChaT) were investigated in aged rats after either distal axotomy or root avulsion injury. Approximately 45% in number of total aged spinal motor neuron were normally APP-positive. A/beta-positive neurites were observed normally in the spinal ventral horn of aged rats. After distal axotomy, without apparent neurodegeneration such as cell loss and decreased ChaT-immunoreactivity, increased levels of APP expression were observed in the spinal cords of aged rats post-injury. In contrast, after avulsion, expression of APP and A/beta were downregulated in the spinal ventral horn of aged rats, and marked loss of spinal motor neurons and downregulated ChaT expression were observed. Our data indicate that APP and A/beta might play beneficial roles in neuronal survival of aged spinal motor neurons after axonal injury.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Xie Y,Yao Z,Chai H,Wong WM,Wu Wdoi
10.1002/jnr.10667keywords:
subject
Has Abstractpub_date
2003-08-15 00:00:00pages
557-64issue
4eissn
0360-4012issn
1097-4547journal_volume
73pub_type
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