Oligodendrocyte-specific gene expression in mouse brain: use of a myelin-forming cell type-specific promoter in an adeno-associated virus.

abstract：:Cultured rat mesencephalic neurons were used to assess the effects of gamma-aminobutyric acid (GABA) transport blockers on toxicity caused by malonate, a reversible, competitive inhibitor of succinate dehydrogenase. Previous studies utilizing an ex vivo chick retinal preparation have shown that GABA release and cell s...

journal_title：Journal of neuroscience research

authors： Stokes AH,Bernard LP,Nicklas WJ,Zeevalk GD

更新日期：2001-04-01 00:00:00

abstract：:The activity levels of pyruvate dehydrogenase, enzymes of the citric acid cycle, aspartate and alanine aminotransferases, and NADP+-isocitrate dehydrogenase were determined in the cerebral cortex, cerebellum, brain stem, corpus striatum, hippocampus, and midbrain regions of normal rats and rats injected with acute and...

journal_title：Journal of neuroscience research

authors： Ratnakumari L,Subbalakshmi GY,Murthy CR

更新日期：1985-01-01 00:00:00

abstract：:The olfactory ensheathing cell (OEC) is a unique glial cell able to support neurite outgrowth in the CNS throughout life. The OEC has been described as having both Schwann cell-like and astrocyte-like characteristics. The purpose of this study was to compare gap junctional communication and connexin (Cx) expression in...

journal_title：Journal of neuroscience research

authors： Barnett SC,Thompson RJ,Lakatos A,Pitts J

更新日期：2001-09-15 00:00:00

abstract：:Phencyclidine (PCP) is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Several studies have demonstrated that chronic NMDA receptor antagonist treatment in humans and animals can cause long-term behavioral changes that are reminiscent of negative and cognitive schizophrenia-like symptoms. The muscari...

journal_title：Journal of neuroscience research

authors： Newell KA,Zavitsanou K,Huang XF

更新日期：2007-05-01 00:00:00

abstract：:The production of collagen-degrading proteases by cultured neonatal rat microglia was examined using an immobilized fibronectin-gelatin matrix coupled to a fluorescent marker and by substrate gel analysis. When microglia were plated onto the surface of the matrix and incubated under resting (nonstimulated) conditions,...

journal_title：Journal of neuroscience research

authors： Colton CA,Keri JE,Chen WT,Monsky WL

更新日期：1993-06-15 00:00:00

abstract：:Transplanting neural stem cells (NSC) to the damaged brain has been regarded as a potential treatment for neurodegenerative diseases such as Alzheimer's disease (AD), a condition characterized by memory loss. We hypothesized that transplantation of NSC into the hippocampal regions of APP + PS1 transgenic (Tg) mice, a ...

journal_title：Journal of neuroscience research

authors： Zhang W,Wang GM,Wang PJ,Zhang Q,Sha SH

更新日期：2014-02-01 00:00:00

abstract：:In contrast to its known anti-apoptotic activity in sympathetic neurons, immortal neuronal cell lines, and primary cultured immature neurons of the central nervous system (CNS), the role of Bcl-2 in CNS neurons in the adult brain is poorly understood. In the present study, we examined effects of overexpression of Bcl-...

journal_title：Journal of neuroscience research

authors： Wang HD,Fukuda T,Suzuki T,Hashimoto K,Liou SY,Momoi T,Kosaka T,Yamamoto K,Nakanishi H

更新日期：1999-07-01 00:00:00

abstract：:Embryonic central nervous system neuroepithelial cells are a transient population of cells that give rise to neuronal and glial progenitors. In the E12-E16 embryonic rat spinal neural tube we have identified neuroepithelial cells as radially oriented cells expressing the GD3 ganglioside as recognized by the monoclonal...

journal_title：Journal of neuroscience research

authors： Bannerman PG,Oliver TM,Xu Z,Shieh A,Pleasure DE

更新日期：1996-09-01 00:00:00

abstract：:Hemin, the oxidized form of heme, is released from hemoglobin after CNS hemorrhage and may contribute to injury to surrounding tissue. The heme oxygenase (HO) enzymes catalyze the breakdown of hemin to biliverdin, carbon monoxide, and ferric iron. Although HO-2, the isoform expressed predominantly in neurons, accelera...

journal_title：Journal of neuroscience research

authors： Chen-Roetling J,Benvenisti-Zarom L,Regan RF

更新日期：2005-12-15 00:00:00

abstract：:Toll-like receptors (TLRs) play an essential role in initiating intracellular type I interferon (IFN)-mediated innate immunity against viral infections. We examined whether human neuronal cells (primary human neurons, NT2-N and CHP-212 cells) express TLRs and mount type I IFN-mediated innate immunity against herpes si...

journal_title：Journal of neuroscience research

authors： Zhou Y,Ye L,Wan Q,Zhou L,Wang X,Li J,Hu S,Zhou D,Ho W

更新日期：2009-10-01 00:00:00

abstract：:It has been demonstrated that L-pipecolic acid (L-PA), a major metabolic intermediate of L-lysine (L-Lys) in the mammalian and chicken brain, is involved in the functioning of the GABAergic system. A previous study has shown that intracerebroventricular (i.c.v.) injection of L-PA suppressed feeding and induced sleep-l...

journal_title：Journal of neuroscience research

authors： Takagi T,Bungo T,Tachibana T,Saito ES,Saito S,Yamasaki I,Tomonaga S,Denbow DM,Furuse M

更新日期：2003-07-15 00:00:00

abstract：:Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system with an autoimmune attack on the components of the myelin sheath and axons. The etiology of the disease remains largely unknown, but it is commonly acknowledged that the development of MS probably results from the interacti...

journal_title：Journal of neuroscience research

authors： Cheng Y,Sun L,Xie Z,Fan X,Cao Q,Han J,Zhu J,Jin T

更新日期：2017-10-01 00:00:00

abstract：:Dissociated embryonic rat ventral mesencephalon containing the developing A8-A10 dopamine (DA) neurons was cultured alone or in the presence of a 10 mm segment of adult rat sciatic nerve that had been explanted and maintained in separate culture for 72 hours prior to introduction to mesencephalic cultures. Nerve segme...

journal_title：Journal of neuroscience research

authors： Collier TJ,Sladek CD,Gallagher MJ,Gereau RW 4th,Springer JE

更新日期：1990-11-01 00:00:00

abstract：:The extension of filopodia from growth cones of regenerating neurites from rat superior cervical ganglion neurons in tissue culture was studied. Cultures were grown on a thin layer of fibrous collagen and maintained in a medium containing serum and nerve growth factor. Time-lapse cinematography and computer-assisted m...

journal_title：Journal of neuroscience research

authors： Argiro V,Bunge MB,Johnson MI

更新日期：1985-01-01 00:00:00

abstract：:The response of cells localized in the brain subventricular zone (SVZ) to growth factor stimulation has been largely described for development and adult life, whereas no information on their behavior during aging is available. To address the question of whether the cells in the SVZ of old mice respond to the intracere...

journal_title：Journal of neuroscience research

authors： Tirassa P,Triaca V,Amendola T,Fiore M,Aloe L

更新日期：2003-06-01 00:00:00

abstract：:PC12 cells can differentiate into neuron-like cells after treatment with either nerve growth factor (NGF) or transduction with a retrovirus which expresses the K-ras oncogene. The concomitant treatment of NGF plus ras differentiates PC12 cells further than either agent alone with respect to neurite outgrowth, acetylch...

journal_title：Journal of neuroscience research

authors： Tao-Cheng JH,Dosemeci A,Bressler JP,Brightman MW,Simpson DL

更新日期：1995-10-15 00:00:00

abstract：:The effect of neonatal hyperthyroidism produced by injection of tri-iodothyronine (T3) on myelination and on the microperoxisomal population of the brain was studied in young rats. Data on the lipid composition of myelin show that myelinogenesis starts earlier in treated animals. In coincidence with the early appearan...

journal_title：Journal of neuroscience research

authors： Adamo AM,Aloise PA,Soto EF,Pasquini JM

更新日期：1990-03-01 00:00:00

abstract：:Neurotrophins may have a neuroprotective role and are probably involved in the control of axonal sprouting and synaptic plasticity. An antibody raised against a pro-sequence of nerve growth factor (NGF) was tested. In control undisturbed rats, a strong immunoreactivity was detected in scattered cells in and around the...

journal_title：Journal of neuroscience research

authors： Humpel C,Ebendal T,Cao Y,Olson L

更新日期：1993-07-01 00:00:00

abstract：:Calpain, an intracellular cysteine protease, has been widely reported to be involved in neuronal cell death. The purpose of this study is to investigate the role of calpain activation in axonal damage-induced retinal ganglion cell (RGC) death. Twelve-week-old male calpstatin (an endogenous calpain inhibitor) knockout ...

journal_title：Journal of neuroscience research

authors： Ryu M,Yasuda M,Shi D,Shanab AY,Watanabe R,Himori N,Omodaka K,Yokoyama Y,Takano J,Saido T,Nakazawa T

更新日期：2012-04-01 00:00:00

abstract：:Recombinant adeno-associated viral (AAV)-mediated therapeutic gene transfer to dorsal root ganglia (DRG) is an effective and safe tool for treating chronic pain. However, AAV with various constitutively active promoters leads to transgene expression predominantly to neurons, while glial cells are refractory to AAV tra...

journal_title：Journal of neuroscience research

authors： Xiang H,Xu H,Fan F,Shin SM,Hogan QH,Yu H

更新日期：2018-03-01 00:00:00

abstract：:Parkinson's disease (PD) is a movement disorder characterized by a progressive loss of nigrostriatal dopaminergic neurons. Microglia activation and neuroinflammation have been associated with the pathogenesis of PD. Indeed, cytokines have been proposed as candidates that mediate the apoptotic cell death of dopaminergi...

journal_title：Journal of neuroscience research

authors： Bureau G,Longpré F,Martinoli MG

更新日期：2008-02-01 00:00:00

abstract：:Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder of the central nervous system (CNS) caused by a wide variety of mutations affecting proteolipid protein 1 (PLP1). We assessed the effects of PLP1 mutations on water diffusion in CNS white matter by using diffusion tensor imaging. Twelve patients with different...

journal_title：Journal of neuroscience research

authors： Laukka JJ,Makki MI,Lafleur T,Stanley J,Kamholz J,Garbern JY

更新日期：2014-12-01 00:00:00

abstract：:Butyrate produced a biphasic modulation of the thyroid hormone receptor in neuroblastoma N2A cells increasing receptor number by 20-35% at concentrations 0.25-0.75 mM and decreasing receptor levels by 30-55% at 2-4 mM. The half-life of the receptor, as assessed by its disappearance after incubation with 18 microM cycl...

journal_title：Journal of neuroscience research

authors： Yusta B,Ortiz-Caro J,Bedo G,Pascual A,Aranda A

更新日期：1990-09-01 00:00:00

abstract：:In the non-amyloidogenic pathway, the Alzheimer's amyloid precursor protein (APP) is cleaved within the amyloid-beta domain by alpha-secretase precluding deposition of intact amyloid-beta peptide. The large ectodomain released from the cell surface by the action of alpha-secretase has several neuroprotective propertie...

journal_title：Journal of neuroscience research

authors： Allinson TM,Parkin ET,Turner AJ,Hooper NM

更新日期：2003-11-01 00:00:00

abstract：:The interleukin (IL)-15-dependent immune responses of murine microglia were strongly affected by low concentrations of the ganglioside GD3. The ganglioside binding to IL-15 inhibited the proinflammatory effects of the cytokine, reducing IL-15-dependent T-cell proliferation as well as mRNA expression for IL-15Ralpha, p...

journal_title：Journal of neuroscience research

authors： Gómez-Nicola D,Doncel-Pérez E,Nieto-Sampedro M

更新日期：2006-04-01 00:00:00

abstract：:Previously, we reported the presence of multiple neurotransmitters in subclones of SN6, a septal cholinergic hybrid cell line. To obtain information concerning the functionality of these transmitters, we measured transmitter contents, activities of transmitter-producing enzymes, and the effect of serum-free culture me...

journal_title：Journal of neuroscience research

authors： Gallyas F Jr,Satoh J,Endoh M,Kunishita T,Tabira T

更新日期：1995-12-15 00:00:00

abstract：:Ionotropic N-methyl-D-aspartate (NMDA) receptor agonists, L-aspartic acid (L-Asp) and NMDA, have been shown to inhibit histamine-stimulated acid secretion, but their effect on gastric mucosal blood flow (GMBF) is largely unknown. The aim of this study was to investigate whether L-Asp and NMDA inhibit histamine-stimula...

journal_title：Journal of neuroscience research

authors： Tsai LH,Lee YJ,Wu JY

更新日期：2004-09-01 00:00:00

abstract：:Adhesion responses triggered by integrin-class matrix receptors have been implicated in the synaptic reorganization events necessary for certain types of neuronal plasticity. Hippocampal slice cultures were used to test whether the related structural transformations elicited by NMDA receptor stimulation are regulated ...

journal_title：Journal of neuroscience research

authors： Bahr BA

更新日期：2000-03-15 00:00:00

abstract：:Recent studies have indicated that embryonic stem cells (ESCs) can be a source for the replacement of spiral ganglion neurons (SGNs), auditory primary neurons, and neurite projections from ESC-derived neurons to auditory sensory epithelia. However, the potential of ESC-derived neurons for synapse formation with audito...

journal_title：Journal of neuroscience research

authors： Matsumoto M,Nakagawa T,Kojima K,Sakamoto T,Fujiyama F,Ito J

更新日期：2008-11-01 00:00:00

abstract：:Recent data indicate that molecular mimicry may play a role in the pathogenesis of human-T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), an immune-mediated disease of the central nervous system (CNS). Specifically, HAM/TSP patients developed antibodies that cross-reac...

journal_title：Journal of neuroscience research

authors： Kalume F,Lee SM,Morcos Y,Callaway JC,Levin MC

更新日期：2004-07-01 00:00:00