Cerebral citric acid cycle enzymes in methionine sulfoximine toxicity.

abstract：:Understanding the pathway for amyloid percursor protein (APP) catabolism has become an important line of investigation. APP is a ubiquitous membrane bound protein that is rapidly cleaved at the membrane, yielding a secreted protein identical to protease nexin II and an internalized 11.5 kDa 100 residue C terminal deri...

journal_title：Journal of neuroscience research

authors： Wolozin B,Bacic M,Merrill MJ,Lesch KP,Chen C,Lebovics RS,Sunderland T

更新日期：1992-09-01 00:00:00

abstract：:The location of glyoxylate-complex molecules has been investigated in several areas of the rat cerebral cortex using the immunohistochemical peroxidase-antiperoxidase (PAP) method. Antibodies against glyoxylate-complex molecules have been developed in the rabbit after immunization with a glyoxylate-bovine serum albumi...

journal_title：Journal of neuroscience research

authors： Martínez-Rodríguez R,Alonso MJ,De Miguel E,Gómez de Segura I,Gómez-Aguado F,Picazo A,Corcuera MT,Alvarez MI,Toledano A

更新日期：1998-01-15 00:00:00

abstract：:Deletion of the tumor suppressor gene p53 has been shown to improve the outcome in experimental models of focal cerebral ischemia and kainate-induced seizures. To evaluate the potential role of p53 in traumatic brain injury, genetically modified mice lacking a functional p53 gene (p53(-/-), n = 9) and their wild-type ...

journal_title：Journal of neuroscience research

authors： Tomasevic G,Raghupathi R,Scherbel U,Wieloch T,McIntosh TK

更新日期：2010-11-15 00:00:00

abstract：:Nerve growth factor (NGF) has a modulating effect on immune function, which may occur as a consequence of binding to the NGF receptor (NGF-R). To determine if mRNA for the gene coding for p75NGFR (low affinity NGF-R) is present in lymphocytes, Northern blot analysis of mRNA from human peripheral blood lymphocytes (PBL...

journal_title：Journal of neuroscience research

authors： Kittur SD,Song L,Endo H,Adler WH

更新日期：1992-07-01 00:00:00

abstract：:Traditionally, the sources of guidance cues for dendritic outgrowth are mainly associated with external bodies (A) rather than with the same neuron from which dendrites originate (B). To quantify the relationship between factors A and B as determinants of the adult dendritic shape, the morphology of 83 intracellularly...

journal_title：Journal of neuroscience research

authors： Samsonovich AV,Ascoli GA

更新日期：2003-01-15 00:00:00

abstract：:To elucidate the biological differences in neural phenotype between malignant rhabdoid tumor (MRT) and neuroblastoma cell lines, we examined the expression of solube N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex proteins in MRT cell lines under differentiation induction with 12-...

journal_title：Journal of neuroscience research

authors： Yoshida S,Narita T,Taga T,Ohta S,Takeuchi Y

更新日期：2002-09-01 00:00:00

abstract：:Astrocytes purified from the neonatal rat brain were cultured for up to 3 weeks prior to being treated with agents that can induce reactive changes in astrocytes. These agents included dibutyryl cAMP, interleukin-1 beta, and macrophage conditioned media. After treating astrocytes for 3 days, the agents were removed an...

journal_title：Journal of neuroscience research

authors： Miller C,Tsatas O,David S

更新日期：1994-05-01 00:00:00

abstract：:Nerve growth factor (NGF) is a protein essential for the survival and normal function of sympathetic neurons. Two-site immunoassays have been developed over the past decade in several laboratories and used to estimate its endogenous concentrations in a variety of effector tissues. However, levels appear restricted to ...

journal_title：Journal of neuroscience research

authors： Zettler C,Bridges DC,Zhou XF,Rush RA

更新日期：1996-12-01 00:00:00

abstract：:In its severe form, X-linked adrenoleukodystrophy (ALD) is a lethal neurologic disease of children, characterized by progressive cerebral demyelination and adrenal insufficiency. Associated with a biochemical defect of peroxisomal beta-oxidation, very long-chain fatty acids (VLCFA) build up in tissues that have a high...

journal_title：Journal of neuroscience research

authors： Forss-Petter S,Werner H,Berger J,Lassmann H,Molzer B,Schwab MH,Bernheimer H,Zimmermann F,Nave KA

更新日期：1997-12-01 00:00:00

abstract：:Despite the accumulating data on the molecular and cell biological characteristics of neural stem/progenitor cells, their electrophysiological properties are not well understood. In the present work, changes in the membrane properties and current profiles were investigated in the course of in vitro-induced neuron form...

journal_title：Journal of neuroscience research

authors： Jelitai M,Anderová M,Chvátal A,Madarász E

更新日期：2007-06-01 00:00:00

abstract：:A mouse monoclonal antibody (5B9), directed against a carbohydrate epitope of human epidermal growth factor receptor (EGFR), recognized an 81-kDalton glycoprotein in buffer-soluble and detergent-solubilized rat brain extracts (BE). The glycoprotein was more abundant in extracts prepared from injured brain than in thos...

journal_title：Journal of neuroscience research

authors： Río C,Pérez-Cerdá F,Matute C,Nieto-Sampedro M

更新日期：1995-04-15 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is the major constituent of glial filaments and is restricted within the CNS to astrocytes. As with other classes of intermediate filament proteins, the regulation of GFAP expression is poorly understood. Utilizing highly purified cultures of astrocytes and a chemically defined (...

journal_title：Journal of neuroscience research

authors： Morrison RS,De Vellis J,Lee YL,Bradshaw RA,Eng LF

更新日期：1985-01-01 00:00:00

abstract：:Anorexia nervosa (AN) is a severe and complex psychiatric disorder characterized by intense fear about weight gain and finalized to food-related control behaviors. Growing interest has been demonstrated about neurobiological processes subtend to AN physiopathology. The present review aimed to collect neurostructural a...

journal_title：Journal of neuroscience research

authors： Alfano V,Mele G,Cotugno A,Longarzo M

更新日期：2020-11-01 00:00:00

abstract：:A series of major and minor ganglioside species were isolated from a single human adult brain and analyzed for their lipophilic composition. Hematosides, GM3 and GD3, each showing double bands on thin-layer chromatograms, were separated into the upper band and lower band fractions to be analyzed for the heterogeneity ...

journal_title：Journal of neuroscience research

authors： Ando S,Yu RK

更新日期：1984-01-01 00:00:00

abstract：:Gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter of CNS, has been consistently implicated in the pathophysiology of schizophrenia. GABA is synthesized from glutamate by the enzyme glutamic acid decarboxylase (GAD). Two isoforms of GAD have been identified and have been named GAD65 and GAD67 ba...

journal_title：Journal of neuroscience research

authors： Dracheva S,Elhakem SL,McGurk SR,Davis KL,Haroutunian V

更新日期：2004-05-15 00:00:00

abstract：:Green fluorescent protein (GFP) transgenic zebrafish technology has been employed to directly visualize and analyze dynamic developmental processes, such as cell migration and morphogenesis. Stable transgenic zebrafish that express GFP in oligodendrocytes can be a valuable tool to visualize complex myelination process...

journal_title：Journal of neuroscience research

authors： Yoshida M,Macklin WB

更新日期：2005-07-01 00:00:00

abstract：:Glutamate is an important regulator of dendrite development; however, during cerebral ischemia, massive glutamate release can lead to neurodegeneration and death. An early consequence of glutamate excitotoxicity is dendrite injury, which often precedes cell death. We examined the effect of glutamate on dendrite growth...

journal_title：Journal of neuroscience research

authors： Monnerie H,Shashidhara S,Le Roux PD

更新日期：2003-12-01 00:00:00

abstract：:The production of collagen-degrading proteases by cultured neonatal rat microglia was examined using an immobilized fibronectin-gelatin matrix coupled to a fluorescent marker and by substrate gel analysis. When microglia were plated onto the surface of the matrix and incubated under resting (nonstimulated) conditions,...

journal_title：Journal of neuroscience research

authors： Colton CA,Keri JE,Chen WT,Monsky WL

更新日期：1993-06-15 00:00:00

abstract：:The use of trimethadione (TMO) as a protector in hyperbaric oxygen toxicity in the conscious rat has been examined in detail. The oxidation-reduction state of pyridine nucleotides was measured simultaneously with the EEG activity from the surface of the brain cortex. From the data obtained, a few parameters were calcu...

journal_title：Journal of neuroscience research

authors： Mayevsky A

更新日期：1975-01-01 00:00:00

abstract：:Previously, we reported that chelation of intracellular zinc with N, N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN)-induced macromolecule synthesis-dependent apoptosis of cultured cortical neurons. According to the current theory of apoptosis, release of mitochondrial cytochrome C into the cytosol is required...

journal_title：Journal of neuroscience research

authors： Ahn YH,Koh JY,Hong SH

更新日期：2000-09-01 00:00:00

abstract：:Organotypic slices are used frequently in studies of central nervous system development and function because they provide excellent experimental access with significant preservation of cellular context and relationships. Within a slice, however, a variety of factors may cause individual classes of neurons to respond d...

journal_title：Journal of neuroscience research

authors： Niblock MM,Brunso-Bechtold JK,Riddle DR

更新日期：2001-09-01 00:00:00

abstract：:Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the case of (1)H NMR experiments, originate undesired resonances i...

journal_title：Journal of neuroscience research

authors： Lei H,Duarte JM,Mlynarik V,Python A,Gruetter R

更新日期：2010-02-01 00:00:00

abstract：:Parallel corticostriatonigral circuits have been proposed that separately process motor, cognitive, and emotional-motivational information. Functional integration requires that interactions exist between neurons participating in these circuits. This makes it imperative to study the complex anatomical substrate underly...

journal_title：Journal of neuroscience research

authors： Wouterlood FG,Engel A,Daal M,Houwen G,Meinderts A,Jordà Siquier T,Beliën JAM,van Dongen YC,Scheel-Krüger J,Thierry AM,Groenewegen HJ,Deniau JM

更新日期：2018-09-01 00:00:00

abstract：:We studied the effects of electrical stimulation of the inferior alveolar nerve (IAN) on cardiovascular responses in cats. There was statistical correlation between cardiovascular response and prestimulus mean arterial blood pressure (MABP) and heart rate (HR). A trigeminal depressor response (TDR) was induced when th...

journal_title：Journal of neuroscience research

authors： Ohshita N,Nakajo N,Takemura M

更新日期：2004-06-15 00:00:00

abstract：:Mouse sciatic nerves were transected and 3 hr to 16 days later proximal segments were removed and homogenized. Supernatants of these segments or of normal sciatic nerves were added to Schwann cells maintained in Dulbecco's modified Eagle's medium (DMEM) + 15% fetal calf serum (FCS). After 6 days, Schwann cells were so...

journal_title：Journal of neuroscience research

authors： Zhang QL,Lin PX,Chang Y,Webster HD

更新日期：1994-04-01 00:00:00

abstract：:P0-glycoprotein, the major integral membrane protein of peripheral nerve myelin, is thought to mediate myelination and membrane interactions via its extracellular domain (P0-ED). Molecular modeling of P0-ED has suggested which of its amino acid side-chains may be involved in heterophilic and homophilic adhesions. We p...

journal_title：Journal of neuroscience research

authors： Kirschner DA,Szumowski K,Gabreëls-Festen AA,Hoogendijk JE,Bolhuis PA

更新日期：1996-11-15 00:00:00

abstract：:Motor neurons (MNs) are designated as alpha/gamma and fast/slow based on their target sites and the types of muscle fibers innervated; however, few molecular markers that distinguish between these subtypes are available. Here we report that osteopontin (OPN) is a selective marker of alpha MNs in the mouse spinal cord....

journal_title：Journal of neuroscience research

authors： Misawa H,Hara M,Tanabe S,Niikura M,Moriwaki Y,Okuda T

更新日期：2012-04-01 00:00:00

abstract：:The purpose of this study was to determine how oligodendrocytes die following Fas receptor activation. An immortalized human oligodendrocyte hybrid line (MO3.13) was challenged with Fas ligand (FasL), and cell death was assessed by flow cytometry and DNA gel electrophoresis. Caspase activation was determined by either...

journal_title：Journal of neuroscience research

authors： Li W,Maeda Y,Ming X,Cook S,Chapin J,Husar W,Dowling P

更新日期：2002-07-15 00:00:00

abstract：:The interaction of bovine white matter proteolipid apoproteins with sodium dodecyl sulfate (SDS) was studied. Equilibrium dialysis binding measurements show that the apoprotein binds approximately 1.5 gm SDS per gram protein at high ionic strength (gamma/2 = 0.17). At low ionic strength (gamma/2 = 0.01) the protein bi...

journal_title：Journal of neuroscience research

authors： Sakura JD

更新日期：1981-01-01 00:00:00

abstract：:Four brain-specific, DNase I hypersensitive sites (HSS) have been mapped to the 5' flanking region of the mouse 68-kDa neurofilament gene. These sites are contained within a 1.7-kb sequence that confers neuronal specificity of expression of this gene in transgenic mice. To identify DNA sequences that might be involved...

journal_title：Journal of neuroscience research

authors： Ivanov TR,Brown IR

更新日期：1992-06-01 00:00:00