Abstract：
:Four brain-specific, DNase I hypersensitive sites (HSS) have been mapped to the 5' flanking region of the mouse 68-kDa neurofilament gene. These sites are contained within a 1.7-kb sequence that confers neuronal specificity of expression of this gene in transgenic mice. To identify DNA sequences that might be involved in gene regulation, the HSS situated near the promoter region has been analyzed by gel mobility shift assays and DNase I footprinting to investigate protein binding sequences. Of particular interest are two footprints localized to a 9-nucleotide sequence that flanks both the light and medium neurofilament gene in mouse and to a sequence that demonstrates partial homology to several promoter regions, including element-1, a motif required for neuron specificity in Drosophila. A prominent footprint was also detected at a sequence that contains a near-perfect palindrome centered at a PstI restriction site.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Ivanov TR,Brown IRdoi
10.1002/jnr.490320204keywords:
subject
Has Abstractpub_date
1992-06-01 00:00:00pages
149-58issue
2eissn
0360-4012issn
1097-4547journal_volume
32pub_type
杂志文章abstract：:The present study examined the effects of high-altitude exposure on the pineal gland, the main source of production of melatonin. It was surmised that hypoxia experienced at high altitude, caused by decreased oxygen tension in the ambient air, might lead to some structural alterations in the pineal gland and, hence, a...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10136
更新日期：2002-02-15 00:00:00
abstract：:The function of the prion protein is unknown despite suggestions it binds copper. Radioactive copper (Cu(67)) was used to demonstrate that histidine-dependent uptake of copper by cerebellar cells in culture is related to the level of PrP(c) expression. Copper is released by neurones at the synapse. Veratridine-induced...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:The exposure of SY5Y neuroblastoma cells to high concentrations of glucose, fructose, or galactose is an experimental model commonly used for in vitro evaluation of typical neuronal alterations observed in diabetes mellitus. In the present study, we observed that 2 weeks of exposure to high carbohydrate concentrations...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:Polychlorinated biphenyls (PCBs) cause a wide spectrum of toxic effects in the brain through undefined mechanisms. Exposure to the PCB mixture Aroclor-1254 (A1254) increases the repressor element-1 silencing transcription factor (REST) expression, leading to neuronal death. This study sought to understand the sequence...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23464
更新日期：2015-01-01 00:00:00
abstract：:One premise regarding the mechanism of injury-evoked neuroregeneration is that injured cells induce the release of neurotrophic factors to trigger neurogenesis. Extracellular purine nucleotides exert multiple neurotrophic actions in the central nervous system mediated via activation of purinergic receptors. However, w...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21954
更新日期：2009-05-01 00:00:00
abstract：:Light microscopic anterograde tracing studies indicate that neurons in the central nucleus of the amygdala (CNA) project to a region of the dorsal pontine tegmentum ventral to the superior cerebellar peduncle which contains noradrenergic dendrites of the nucleus locus coeruleus (LC). However, it has not been establish...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19960801)45:3<289::AID-JNR
更新日期：1996-08-01 00:00:00
abstract：:Injury to areas of the central nervous system can alter neurotrophin levels, which may influence postlesion neuronal survival and plasticity. To determine if sensorineural hearing loss induces such changes, we used an enzyme-linked immunosorbent assay (ELISA) to measure neurotrophin-3 (NT-3) and brain-derived neurotro...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20457
更新日期：2005-05-01 00:00:00
abstract：:Molecular and behavioral timekeeping is regulated by the circadian system which includes the brain's suprachiasmatic nucleus (SCN) that translates environmental light information into neuronal and endocrine signals aligning peripheral tissue rhythms to the time of day. Despite the critical role of circadian rhythms in...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24606
更新日期：2021-01-01 00:00:00
abstract：:The amygdala contributes to the generation and propagation of epileptiform activity in temporal lobe epilepsy (TLE). Ictal symptoms such as fear, dreamy states (déjà vu, memory flashbacks, experiential hallucinations), epigastric auras, or sympathetic outflow with cardiovascular changes are often linked to a seizure f...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.23689
更新日期：2016-06-01 00:00:00
abstract：:Metabotropic glutamate receptors (mGluRs) and calcium receptors (CaR) are closely related G protein-coupled receptors (GPCRs). The similar structural and functional properties of mGluRs and CaRs include conserved amino acid residues involved in glutamate binding in mGluRs and Ca2+ binding in the CaR. Furthermore, rece...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10853
更新日期：2004-02-15 00:00:00
abstract：:The rewarding effect of opiates is mediated through dissociable neural systems in drug naïve and drug-dependent states. Neuroadaptations associated with chronic drug use are similar to those produced by chronic pain, suggesting that opiate reward could also involve distinct mechanisms in chronic pain and pain-naïve st...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24553
更新日期：2019-11-12 00:00:00
abstract：:Destruction of the ventromedial hypothalamic nuclei (VMN) in the weanling rat without injury to the median eminence results in a series of somatic, endocrine, and metabolic changes that are characterized by normal food and water intake but decreased linear growth, normal body weight but increased carcass fat and reduc...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490020202
更新日期：1976-01-01 00:00:00
abstract：:Microtubule-associated protein (MAP)1B-heterozygous (MAP1B+/-) mice are deficient in the expression of MAP1B in the hippocampus, cerebellum, and olfactory cortex. Although MAP1B+/- mice showed half the normal levels of MAP1B protein, they had no measurable amounts of phosphorylated MAP1B. High-frequency theta burst st...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20624
更新日期：2005-10-01 00:00:00
abstract：:Calcium/calmodulin-dependent serine kinase (CASK), a causative gene in X-linked mental retardation, carries out multiple functions in neurons, including vesicle trafficking of ion channels, synapse formation, and gene transcription. From a yeast two-hybrid screen, Krüppel-like zinc finger protein B cell lymphoma/COUP-...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22407
更新日期：2010-08-15 00:00:00
abstract：:The role of axons in the expression of the major myelin glycoprotein, P0, has been investigated using neuron/Schwann cell cultures. These cultures were either nonmyelinating or myelinating due to growth in defined medium or in medium containing serum and chick embryo extract, respectively. The neurons and Schwann cell...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490260202
更新日期：1990-06-01 00:00:00
abstract：:The mitochondrial permeability transition (mPT) has been implicated in both excitotoxic and apoptotic neuronal cell death, despite the fact that it has not been previously identified in neurons. To study the mPT in hippocampal neurons, cultures were loaded with the mitochondrial dye JC-1 and observed with confocal and...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19980915)53:6<728::AID-JNR
更新日期：1998-09-15 00:00:00
abstract：:The rationale for designing and synthesizing 24 different peptide analogs and subpeptides of residues 69-84 of guinea pig myelin basic protein is presented. The encephalitogenic potential of 19 of these peptides in Lewis rats is also given. ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490180130
更新日期：1987-01-01 00:00:00
abstract：:Pinealocytes of various mammalian species contain abundant synaptic-like microvesicles (SLMVs) which are considered the endocrine equivalent of neuronal synaptic vesicles. Although the pinealocytes may thus be a suitable cellular model for experimental in vitro studies of SLMVs, nothing is known about the presence of ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(sici)1097-4547(19970301)47:5<509::aid-jnr
更新日期：1997-03-01 00:00:00
abstract：:To explore the feasibility of cell type-specific gene expression in oligodendrocytes as a possible therapeutic approach for demyelinating diseases, the cell specificity, tissue specificity, and duration of gene expression were investigated using recombinant adeno-associated viral vectors (rAAV) carrying a green fluore...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19990215)55:4<504::AID-JNR
更新日期：1999-02-15 00:00:00
abstract：:There is evidence that zinc may be involved in the pathogenesis of Parkinson's disease by an apoptotic pathway. However, the mechanisms underlying zinc-induced apoptosis are unknown. Previous studies showed that 6-hydroxydopamine (6-OHDA)-enhanced potassium channels are involved in apoptosis of dopaminergic neurons. O...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21854
更新日期：2009-02-01 00:00:00
abstract：:The brain acid-soluble protein BASP1 (CAP-23, NAP-22) belongs to the family of growth-associated proteins, which also includes GAP-43, a protein recently shown to regulate neural cell adhesion molecule (NCAM)-mediated neurite outgrowth. Here, the effects of BASP1 overexpression were investigated in PC12E2 cells and pr...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21678
更新日期：2008-08-01 00:00:00
abstract：:We have used adult mouse superior cervical ganglia (SCG) to study the role of mitogen activated protein (MAP) kinase activity during axonal outgrowth in vitro. An initial peak in activity within the first hours of culture was followed by a substantially higher activity after 1 to 2 days, a time when axons were activel...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19980515)52:4<453::AID-JNR
更新日期：1998-05-15 00:00:00
abstract：:Histology, immunohistochemistry, and Western blotting were used to characterize the changes in morphology, distribution pattern, and marker protein expression of striatal interneurons in the transition zone of striatal injury induced by 3-NP. The 3-NP treatment in rats yielded movement, motor coordination, and cogniti...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22591
更新日期：2011-05-01 00:00:00
abstract：:This experiment was directed toward determining the relative effectiveness of discrete and diffuse pain stimuli in influencing perception and behavior. Shocks to the footpads were used to activate the discrete pain pathways and shocks to the upper canine teeth to activate the diffuse pain pathways. In the first phase ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490020405
更新日期：1976-01-01 00:00:00
abstract：:We generated a new cell line, N38, by conditionally immortalizing mouse oligodendrocytes (OLs) at early stages of maturation. The morphology and marker expression pattern suggest N38 cells are similar to immature OLs. N38 cells were sensitive to changes in serum concentrations, and forcing the cells to differentiate i...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/1097-4547(20001101)62:3<319::AID-JNR1>3.0.
更新日期：2000-11-01 00:00:00
abstract：:Enriched populations of human microglial cells were isolated from mixed cell cultures prepared from embryonic human telencephalon tissues. Human microglial cells exhibited cell type-specific antigens for macrophage-microglia lineage cells including CD11b (Mac-1), CD68, B7-2 (CD86), HLA-ABC, HLA-DR and ricinus communis...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10253
更新日期：2002-07-01 00:00:00
abstract：:A new subdivision with distinctive morphological and functional attributes has been identified at the caudomedial margin of the neostriatum and surrounding the rostrolateral border of the globus pallidus in the brains of the rat, cat, monkey, and human. The subdivision is termed marginal division (MrD) based on its lo...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：
更新日期：1999-10-15 00:00:00
abstract：:Previously, we showed that in rat cortical neurons, chronic donepezil treatment (10 microM, 4 days) up-regulates nicotinic receptors (nAChR) and makes neurons more sensitive to the neuroprotective effect of donepezil. Here we examined the mechanism of donepezil-induced neuroprotection in neurons chronically treated wi...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21798
更新日期：2008-12-01 00:00:00
abstract：:Iron deficiency and chronic mild carbon monoxide (CO) exposure are nutritional and environmental problems that can be experienced simultaneously. We examined the effects of chronic mild CO exposure and iron availability on auditory development in the rat. We propose that chronic mild CO exposure creates an oxidative s...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20495
更新日期：2005-06-01 00:00:00
abstract：:Amyotrophic lateral sclerosis is an age-related neurological disease, characterized by neurofilament (NF) accumulation in primary axons followed by degeneration of motor neurons. To elucidate age-related factors that might lead to pathological NF accumulation, NFs were compared between young and aged rats. Electron mi...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：
更新日期：1999-10-15 00:00:00
