Abstract:
:The function of the prion protein is unknown despite suggestions it binds copper. Radioactive copper (Cu(67)) was used to demonstrate that histidine-dependent uptake of copper by cerebellar cells in culture is related to the level of PrP(c) expression. Copper is released by neurones at the synapse. Veratridine-induced release from synapses was proportional to the level of PrP(c) expression. Veratridine-induced release can be abolished only from PrP(c) expressing cells by pretreatment with phosphatidyl-specific phospholipase C, an enzyme that cleaves PrP(c) from the cell surface. These results suggest that PrP(c) aids cellular copper uptake and may have a function at the synapse related to release of copper during transmission.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Brown DRkeywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
717-25issue
5eissn
0360-4012issn
1097-4547pii
10.1002/(SICI)1097-4547(19991201)58:5<717::AID-JNRjournal_volume
58pub_type
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