Tyrosine hydroxylase gene expression in human ventral mesencephalon: detection of tyrosine hydroxylase messenger RNA in neurites.

abstract：:Previous animal studies have linked white matter damage to certain schizophrenia-like behaviors in cuprizone (CPZ)-exposed mouse. Mitochondrial dysfunction, oxidative stress, neuroinflammation, and oligodendrocyte loss coexist in the brain of such mice. The aim of this study was to examine effects of the antioxidant N...

journal_title：Journal of neuroscience research

authors： Zhang L,Xu S,Huang Q,Xu H

更新日期：2018-05-01 00:00:00

abstract：:It has been postulated that the pathogenesis of Parkinson's disease (PD) is associated with mitochondrial dysfunction. Rotenone, an inhibitor of mitochondrial complex I, provides models of PD both in vivo and in vitro. We investigated the neuroprotective effect of D-beta-hydroxybutyrate (bHB), a ketone body, against r...

journal_title：Journal of neuroscience research

authors： Imamura K,Takeshima T,Kashiwaya Y,Nakaso K,Nakashima K

更新日期：2006-11-01 00:00:00

abstract：:Statins are potent cholesterol biosynthesis inhibitors that exert protective effects in humans and in experimental models of stroke. The mechanisms involved in these protective actions are not completely understood. This study evaluates whether atorvastatin (ATV) treatment affects the GluN1 and GluN2B subunits of the ...

journal_title：Journal of neuroscience research

authors： Gutierrez-Vargas JA,Muñoz-Manco JI,Garcia-Segura LM,Cardona-Gómez GP

更新日期：2014-11-01 00:00:00

abstract：:The effects of fetal asphyxia on cerebral function and development, involve the transition from fetal to neonatal life. Changes in cerebral glucose metabolism may be an early postnatal indicator of fetal asphyxia. The objective is to develop an experimental lamb model involving the transition from fetal to neonatal li...

journal_title：Journal of neuroscience research

authors： Thorngren-Jerneck K,Ley D,Hellström-Westas L,Hernandez-Andrade E,Lingman G,Ohlsson T,Oskarsson G,Pesonen E,Sandell A,Strand SE,Werner O,Marsal K

更新日期：2001-12-01 00:00:00

abstract：:Early studies of murine experimental autoimmune encephalomyelitis (EAE) induced with myelin basic protein (MBP) divide various mouse strains into either "susceptible" or "resistant" phenotypes. Resistance is defined as lack of encephalitogenic responses after active immunization or adoptive transfer. It is now becomin...

journal_title：Journal of neuroscience research

authors： Shaw MK,Kim C,Hao HW,Chen F,Tse HY

更新日期：1996-09-15 00:00:00

abstract：:The concentration of myelin basic protein (MBP) mRNA in primary cultures of cells dissociated from embryonic mouse cerebra and grown in the presence of varying amounts of thyroid hormone was measured using a 32P-labeled cDNA probe and a dot-blot procedure. The cDNA probe contained 1.85 kilobases of the gene for MBP. T...

journal_title：Journal of neuroscience research

authors： Shanker G,Campagnoni AT,Pieringer RA

更新日期：1987-01-01 00:00:00

abstract：:Systemic osmotic homeostasis is regulated mainly by neuroendocrine system of arginine-vasopressin (AVP) in mammalians. In the present study, we demonstrated that the immunoreactivity of tissue plasminogen activator (tPA) was observed specifically at neurosecretory granules of AVP-positive magnocellular terminals and t...

journal_title：Journal of neuroscience research

authors： Imamura Y,Morita S,Nakatani Y,Okada K,Ueshima S,Matsuo O,Miyata S

更新日期：2010-07-01 00:00:00

abstract：:The amygdala contributes to the generation and propagation of epileptiform activity in temporal lobe epilepsy (TLE). Ictal symptoms such as fear, dreamy states (déjà vu, memory flashbacks, experiential hallucinations), epigastric auras, or sympathetic outflow with cardiovascular changes are often linked to a seizure f...

journal_title：Journal of neuroscience research

authors： Yilmazer-Hanke D,O'Loughlin E,McDermott K

更新日期：2016-06-01 00:00:00

abstract：:The regeneration of transected mouse sciatic nerves using semipermeable acrylic copolymer tubes to enclose both stumps has been qualitatively assessed from 1 to 30 weeks post-operative. Quantitative morphometric analysis of electron micrograph montages of complete transverse sections of the segment regenerated between...

journal_title：Journal of neuroscience research

authors： Uzman BG,Villegas GM

更新日期：1983-01-01 00:00:00

abstract：:The actions of endogenous opioids and nociceptin/orphanin FQ are mediated by four homologous G protein-coupled receptors that constitute the opioid receptor family. However, little is known about opioid systems in cyclostomes (living jawless fish) and how opioid systems might have evolved from invertebrates. Here, we ...

journal_title：Journal of neuroscience research

authors： Huang AY,Taylor AMW,Ghogha A,Pribadi M,Wang Q,Kim TSJ,Cahill CM,Coppola G,Evans CJ

更新日期：2020-08-23 00:00:00

abstract：:GM1 ganglioside has been shown to stimulate recovery of the damaged dopamine system under a number of different circumstances. In addition to rescue of damaged dopamine neurons, the present study assessed the ability of GM1 to enhance the synthesis of dopamine in remaining nigrostriatal neurons following 1-methyl-4-ph...

journal_title：Journal of neuroscience research

authors： Schneider JS,Kean A,DiStefano L

更新日期：1995-09-01 00:00:00

abstract：:Acetylcholinesterase (AChE) molecular forms were studied in normal (NM) and in dystrophic (DM) 129B6F1/J mouse muscle. Successive extractions of the tissue with saline and saline-Triton X-100 buffers yielded two soluble fractions, S1 and S2. Forty percent of the AChE in NM was measured in S1 and 60% in S2, and 65% and...

journal_title：Journal of neuroscience research

authors： Cabezas-Herrera J,Campoy FJ,Vidal CJ

更新日期：1994-08-01 00:00:00

abstract：:The transforming growth factors beta (TGF-beta), a family of regulatory polypeptides, are involved in numerous vital processes including inflammation and wound healing. Since repair of a peripheral nerve lesion includes a series of well-defined steps of cellular actions possibly controlled by TGF-beta s, and since TGF...

journal_title：Journal of neuroscience research

authors： Rufer M,Flanders K,Unsicker K

更新日期：1994-11-01 00:00:00

abstract：:Factor Xa (FXa) plays a critical role in the coagulation cascade by generation of thrombin. During focal ischemia thrombin levels increase in the brain tissue and cause neural damage. This study examined the hypothesis that administration of the FXa inhibitor, apixaban, following focal ischemic stroke may have therape...

journal_title：Journal of neuroscience research

authors： Bushi D,Chapman J,Wohl A,Stein ES,Feingold E,Tanne D

更新日期：2018-08-01 00:00:00

abstract：:The types of cells contacted by growth cones were examined in chick-quail and vice versa chimeras. Simultaneously, the presence of nonspecific cholinesterase (nChE) was monitored in developing peripheral nerves of these embryos. In all the chimeras studied, the growth cones were in contact with both Schwann cell proge...

journal_title：Journal of neuroscience research

authors： Haninec P,Dubový P

更新日期：1992-02-01 00:00:00

abstract：:NOD-like receptors (NLRs) are critical cytoplasmic pattern-recognition receptors (PRRs) that play an important role in the host innate immune response and immunity homeostasis. There is a growing body of evidence that NLRs are involved in a wide range of inflammatory diseases, including cancer, metabolic diseases, and...

journal_title：Journal of neuroscience research

authors： Kong X,Yuan Z,Cheng J

更新日期：2017-08-01 00:00:00

abstract：:Monocarboxylate transporters (MCTs) are involved in the uptake and release of lactate, pyruvate, and ketone bodies. Studies of their distribution at both the mRNA and protein levels have highlighted the specific expression of MCT1, MCT2, and more recently MCT4 in the central nervous system. MCT1 was found strongly exp...

journal_title：Journal of neuroscience research

authors： Pellerin L,Bergersen LH,Halestrap AP,Pierre K

更新日期：2005-01-01 00:00:00

abstract：:Tauopathies, including Alzheimer's disease (AD), are a group of neurodegenerative disorders characterized by the presence of intraneuronal filamentous inclusions of abnormally phosphorylated tau protein. In AD brains, it has been shown that the level of abnormally phosphorylated tau is higher than in age-matched contr...

journal_title：Journal of neuroscience research

authors： Blard O,Frébourg T,Campion D,Lecourtois M

更新日期：2006-10-01 00:00:00

abstract：:To study the influence of cell surface-associated molecules on intercellular communication, C6 glioma cells were cultured both on plastic and on substrata of paraformaldehyde-fixed B104 neuroblastoma cells. By then comparing the phenotypic expression of these "cocultured" C6 cells with cells cultured on tissue culture...

journal_title：Journal of neuroscience research

authors： Ciment G,de Vellis J

更新日期：1982-01-01 00:00:00

abstract：:Neuron-glia interactions at paranodal junctions play important roles in action potential propagation. Among their many functions, they contribute to the passive electrical properties of myelinated nerve fibers and actively regulate the polarized distribution of ion channels along axons. Despite their importance, relat...

journal_title：Journal of neuroscience research

authors： Ogawa Y,Rasband MN

更新日期：2009-11-15 00:00:00

abstract：:Transplanting neural stem cells (NSC) to the damaged brain has been regarded as a potential treatment for neurodegenerative diseases such as Alzheimer's disease (AD), a condition characterized by memory loss. We hypothesized that transplantation of NSC into the hippocampal regions of APP + PS1 transgenic (Tg) mice, a ...

journal_title：Journal of neuroscience research

authors： Zhang W,Wang GM,Wang PJ,Zhang Q,Sha SH

更新日期：2014-02-01 00:00:00

abstract：:Multi-unit activity was recorded from the diencephalon of unanesthetized, immobilized female rats. Less than 50% of the recording sites in the hypothalamus showed changes in the level of multi-unit activity to changes in the level of glucose utilization induced by injection of 2-deoxy-D-glucose (2-DG). It was also not...

journal_title：Journal of neuroscience research

authors： Rabin BM,Miller DS

更新日期：1980-01-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is an extensively studied protein that is evolutionarily conserved and widely distributed in the brain of vertebrates. It acts via its cognate receptors TrkB and p75NTR and plays a central role in the developmental neurogenesis, neuronal survival, proliferation, differentiation...

journal_title：Journal of neuroscience research

authors： Anand SK,Mondal AC

更新日期：2020-05-01 00:00:00

abstract：:High-affinity uptake, potassium-stimulated release and receptor binding of gamma-aminobutyric acid (GABA) and taurine were studied in retinas of rats treated with monosodium glutamate (MSG) or iodoacetate-malate (IAM). Such treatments produce a selective damage of the inner retinal layers (MSG) or of the photoreceptor...

journal_title：Journal of neuroscience research

authors： Salceda R,Pasantes-Morales H

更新日期：1982-01-01 00:00:00

abstract：:The neurotrophins are important for their long-term effects on the survival and differentiation of many types of neurons during development. They also appear to protect mature neurons from injury caused by nutrient or oxygen deprivation. More recently, the neurotrophins have been implicated in such short-term processe...

journal_title：Journal of neuroscience research

authors： Jiang H,Guroff G

更新日期：1997-11-01 00:00:00

abstract：:Epidural hematoma (EDH) is a type of life-threatening traumatic brain injury. Little is known about the extent to which EDH may cause neural damage and regenerative response in the cerebral cortex. Here we attempted to explore these issues by using guinea pigs as an experimental model. Unilateral EDH was induced by in...

journal_title：Journal of neuroscience research

authors： Pan A,Li M,Gao JY,Xue ZQ,Li Z,Yuan XY,Luo DW,Luo XG,Yan XX

更新日期：2013-02-01 00:00:00

abstract：:Zinc is an endogenous N-methyl-D-aspartate (NMDA) receptor blocker. It is possible that zinc-mediated modification of hippocampal CA1 long-term potentiation (LTP) is linked to the expression of NMDA receptor subunits, which varies with postnatal development. In the present study, the effect of ZnCl(2) and CaEDTA, a me...

journal_title：Journal of neuroscience research

authors： Takeda A,Itagaki K,Ando M,Oku N

更新日期：2012-03-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) plays an important role in the differentiation, development, and survival of neural stem cells. In this study, we analyzed its effects on the stimulation of human umbilical cord blood-derived mesenchymal stem cells in terms of their potential to differentiate into neuron-like c...

journal_title：Journal of neuroscience research

authors： Lim JY,Park SI,Oh JH,Kim SM,Jeong CH,Jun JA,Lee KS,Oh W,Lee JK,Jeun SS

更新日期：2008-08-01 00:00:00

abstract：:Structure and dimension of the dendritic arbor are important determinants of information processing by the nerve cell, but mechanisms and molecules involved in dendritic growth are essentially unknown. We investigated early mechanisms of dendritic growth using mouse fetal hippocampal neurons in primary culture, which ...

journal_title：Journal of neuroscience research

authors： Grosse G,Grosse J,Tapp R,Kuchinke J,Gorsleben M,Fetter I,Höhne-Zell B,Gratzl M,Bergmann M

更新日期：1999-06-01 00:00:00

abstract：:Calpains and cathepsins are two families of proteases that play an important role in ischemic cell death. In this study, we investigated the effect of E64d, a mu-calpain and cathepsin B inhibitor, in the prevention of neuronal and endothelial apoptotic cell death after focal cerebral ischemia in rats. Rats underwent 2...

journal_title：Journal of neuroscience research

authors： Tsubokawa T,Yamaguchi-Okada M,Calvert JW,Solaroglu I,Shimamura N,Yata K,Zhang JH

更新日期：2006-09-01 00:00:00