Cytokines, chemokines, and cytokine receptors in human microglia.

abstract：:Rapsyn is a protein that interacts with the cytoplasmic face of the nicotinic acetylcholine receptors (AChR) to cluster them within postsynaptic membrane of muscle. Here we show that intracellular AChRs are also affected by rapsyn. When rapsyn was co-transfected with AChR into QT-6 fibroblasts, (125)I-alpha-bungarotox...

journal_title：Journal of neuroscience research

authors： Han H,Yang SH,Phillips WD

更新日期：2000-04-15 00:00:00

abstract：:The regeneration of transected mouse sciatic nerves using semipermeable acrylic copolymer tubes to enclose both stumps has been qualitatively assessed from 1 to 30 weeks post-operative. Quantitative morphometric analysis of electron micrograph montages of complete transverse sections of the segment regenerated between...

journal_title：Journal of neuroscience research

authors： Uzman BG,Villegas GM

更新日期：1983-01-01 00:00:00

abstract：:Accumulation of beta-amyloid protein (Abeta) in the brain is a hallmark of Alzheimer's disease (AD), and Abeta-mediated pathogenesis could result from increased production of Abeta or insufficient Abeta clearance by microglia, astrocytes, or the vascular system. Cell-surface receptors, such as scavenger receptors, mig...

journal_title：Journal of neuroscience research

authors： Nakamura K,Ohya W,Funakoshi H,Sakaguchi G,Kato A,Takeda M,Kudo T,Nakamura T

更新日期：2006-09-01 00:00:00

abstract：:Growth cones are essential for neuronal pathfinding during embryonic development and again after injury, when they aid in neuronal regeneration. This study was aimed at investigating the role of kinases in the earliest events in neuronal regeneration, namely, the formation of new growth cones from injured neuronal pro...

journal_title：Journal of neuroscience research

authors： Geddis MS,Rehder V

更新日期：2003-10-15 00:00:00

abstract：:Brain edema accounts for significant morbidity and mortality in many neurologic conditions such as head trauma, stroke, meningitis, and brain tumor. The water channel aquaporin-4 (AQP4) has been found to be an important determinant of brain water accumulation and clearance of excess brain water. We report the developm...

journal_title：Journal of neuroscience research

authors： Thiagarajah JR,Papadopoulos MC,Verkman AS

更新日期：2005-04-15 00:00:00

abstract：:The effect of two different potassium channel blockers, 4-aminopyridine (4-AP) and quinine, on the alpha 2-adrenoceptor mediated modulation of norepinephrine (NE) release was investigated. Pairs of mouse vasa deferentia were loaded with 3H-norepinephrine (3H-NE), superfused continuously, and stimulated electrically. 4...

journal_title：Journal of neuroscience research

authors： Zimanyi I,Folly G,Vizi ES

更新日期：1988-05-01 00:00:00

abstract：:There is evidence that zinc may be involved in the pathogenesis of Parkinson's disease by an apoptotic pathway. However, the mechanisms underlying zinc-induced apoptosis are unknown. Previous studies showed that 6-hydroxydopamine (6-OHDA)-enhanced potassium channels are involved in apoptosis of dopaminergic neurons. O...

journal_title：Journal of neuroscience research

authors： Shi L,Song N,Jiang H,Wang J,Ma Z,Xie J

更新日期：2009-02-01 00:00:00

abstract：:In this Mini-Review we present a new hypothesis in support of the neurodegenerative theory as a mechanism for the pathogenesis of multiple sclerosis (MS). The pathogenesis of MS results from changes in two distinct CNS compartments. These are the "myelin" and "nonmyelin" compartments. The myelin compartment is where p...

journal_title：Journal of neuroscience research

authors： Mastronardi FG,Moscarello MA

更新日期：2005-05-01 00:00:00

abstract：:The extracellular matrix surrounds different neuronal compartments in the mature nervous system. In a variety of vertebrates, most brain regions are loaded with a distinct type of extracellular matrix around the somatodendritic part of neurons, termed perineuronal nets. The present study reports that chondrotin sulfat...

journal_title：Journal of neuroscience research

authors： Lendvai D,Morawski M,Brückner G,Négyessy L,Baksa G,Glasz T,Patonay L,Matthews RT,Arendt T,Alpár A

更新日期：2012-02-01 00:00:00

abstract：:The brain is both central in orchestrating the response to stress, and, a very sensitive target when such response is not controlled. In fact, stress has long been associated with the onset and/or exacerbation of several neuropsychiatric disorders such as anxiety, depression, and drug addiction. The hippocampus is a k...

journal_title：Journal of neuroscience research

authors： Alviña K,Jodeiri Farshbaf M,Mondal AK

更新日期：2021-01-01 00:00:00

abstract：:The purpose of this study was to determine how oligodendrocytes die following Fas receptor activation. An immortalized human oligodendrocyte hybrid line (MO3.13) was challenged with Fas ligand (FasL), and cell death was assessed by flow cytometry and DNA gel electrophoresis. Caspase activation was determined by either...

journal_title：Journal of neuroscience research

authors： Li W,Maeda Y,Ming X,Cook S,Chapin J,Husar W,Dowling P

更新日期：2002-07-15 00:00:00

abstract：:The localization of voltage-gated calcium channel (VGCC) alpha(1) subunits in cultured GABAergic mouse cortical neurons was examined by immunocytochemical methods. Ca(v)1.2 and Ca(v)1.3 subunits of L-type VGCCs were found in cell bodies and dendrites of GABA-immunopositive neurons. Likewise, the Ca(v)2.3 subunit of R-...

journal_title：Journal of neuroscience research

authors： Timmermann DB,Westenbroek RE,Schousboe A,Catterall WA

更新日期：2002-01-01 00:00:00

abstract：:Monoclonal antibody J1-31 (MAb J1-31, isotype IgG 2b) was raised against crude homogenate of brain tissue from a multiple sclerosis (MS) patient (autopsy sample; Malhotra et al.: Microbios Letters 26:151-157, 1984). In human brain, MAb J1-31 recognizes an intracellular protein antigen (J1-31 antigen), which bands at a...

journal_title：Journal of neuroscience research

authors： Malhotra SK,Predy R,Johnson ES,Singh R,Leeuw K

更新日期：1989-01-01 00:00:00

abstract：:Zinc ion elevation contributes to acute excitotoxic brain injury and correlates with the severity of dementia in chronic neurodegenerative diseases. Downstream control of zinc-triggered signals is believed to be an efficient countermeasure. In the current study, we examined whether the flavonoid luteolin (Lu) could pr...

journal_title：Journal of neuroscience research

authors： Zhou F,Qu L,Lv K,Chen H,Liu J,Liu X,Li Y,Sun X

更新日期：2011-11-01 00:00:00

abstract：:An aminopeptidase purified to homogeneity from cytosol of rat brain cleaved dynorphins having 5-17 residues and selected proenkephalins at the Tyr-Gly bond only to release Tyr and the desTyr fragments. The enzyme protein consisted of a single polypeptide chain of Mr 103,000 and was inhibited by puromycin, bestatin, an...

journal_title：Journal of neuroscience research

authors： Berg MJ,Marks N

更新日期：1984-01-01 00:00:00

abstract：:The rationale for designing and synthesizing 24 different peptide analogs and subpeptides of residues 69-84 of guinea pig myelin basic protein is presented. The encephalitogenic potential of 19 of these peptides in Lewis rats is also given. ...

journal_title：Journal of neuroscience research

authors： Hashim GA,Day ED

更新日期：1987-01-01 00:00:00

abstract：:Previous studies have shown that treating rat cortical neurons in primary culture with apolipoprotein E (apoE) peptide increased cytoplasmic Ca2+ by 2 mechanisms: 1) an influx of extracellular Ca2+ resulting from the activation of a cell surface Ca2+ channel; and 2) release of Ca2+ from internal Ca2+ stores via a G-pr...

journal_title：Journal of neuroscience research

authors： Wang X,Luebbe P,Gruenstein E,Zemlan F

更新日期：1998-03-01 00:00:00

abstract：:A previous study demonstrated the release of newly loaded radiolabelled taurine (Tau) from cultured rabbit Müller glia not only following typical cell volume-increasing treatments with high (65 mM) potassium ions or hypotonic media, but also with ammonium chloride (further referred to as ammonia), in a dose-dependent ...

journal_title：Journal of neuroscience research

authors： Faff L,Reichenbach A,Albrecht J

更新日期：1996-10-15 00:00:00

abstract：:The present study analyzed the in vitro effects induced by sodium L-lactate on human astrocytes and the SH-SY5Y cell line, when added at concentrations of 5, 10, and 25 mmol/liter. Expression of brain-derived neurotrophic factor (BDNF), inducible nitric oxide synthase (iNOS), and heat shock protein 70 kDa (HSP70) was ...

journal_title：Journal of neuroscience research

authors： Coco M,Caggia S,Musumeci G,Perciavalle V,Graziano AC,Pannuzzo G,Cardile V

更新日期：2013-02-01 00:00:00

abstract：:The amino acid glutamate plays a key role in brain function. One of the major roles of glutamate is to mediate fast excitatory neurotransmission via activation of ionotropic glutamate receptors (iGluRs). More recently, however, it has become clear that glutamate also serves a regulatory function through activation of ...

journal_title：Journal of neuroscience research

authors： Winder DG,Conn PJ

更新日期：1996-10-15 00:00:00

abstract：:The metabolism of glutamate, the most likely neurotransmitter of vestibular ganglion cells, includes synthesis from glutamine by the enzyme glutaminase. We used microdissection combined with a fluorometric assay to measure glutaminase activity in the vestibular nerve root and nuclei of rats with unilateral vestibular ...

journal_title：Journal of neuroscience research

authors： Godfrey DA,Xu J,Godfrey MA,Li H,Rubin AM

更新日期：2004-08-15 00:00:00

abstract：:The response of cells localized in the brain subventricular zone (SVZ) to growth factor stimulation has been largely described for development and adult life, whereas no information on their behavior during aging is available. To address the question of whether the cells in the SVZ of old mice respond to the intracere...

journal_title：Journal of neuroscience research

authors： Tirassa P,Triaca V,Amendola T,Fiore M,Aloe L

更新日期：2003-06-01 00:00:00

abstract：:Mononuclear cell infiltration into the CNS and induction of inflammatory cytokines and iNOS in diseases like multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE) have been implicated in subsequent disease pathogenesis and progression. We report that Lovastatin treatment blocks the clinical disease...

journal_title：Journal of neuroscience research

authors： Stanislaus R,Singh AK,Singh I

更新日期：2001-10-15 00:00:00

abstract：:Neural stem cells can be propagated in culture as neurospheres, yielding neurons and glial cells upon differentiation. Although the neurosphere model is widely used, the functional properties of the neurosphere-derived neurons have been only partially characterized, and it is unclear whether repeated passaging alters ...

journal_title：Journal of neuroscience research

authors： Pagani F,Lauro C,Fucile S,Catalano M,Limatola C,Eusebi F,Grassi F

更新日期：2006-06-01 00:00:00

abstract：:The effects of glutamate on intracellular free Ca2+, [Ca2+]i, and neurotoxicity were compared in cerebellar granule neurons in vitro. [Ca2+]i was measured with fura-2 and digital fluorescence imaging microscopy; neurotoxicity was monitored using a vital dye and colorimetric analysis. Glutamate produced dose-dependent ...

journal_title：Journal of neuroscience research

authors： Milani D,Guidolin D,Facci L,Pozzan T,Buso M,Leon A,Skaper SD

更新日期：1991-03-01 00:00:00

abstract：:In the present work, we analyzed whether endogenous and/or transplanted bone marrow mononuclear cells (BMMC) migrate spontaneously to the crushed sciatic nerve and whether they transdifferentiate into Schwann cells (SC) in order to help repair the damaged tissue. We also studied both the immunohistochemical evolution ...

journal_title：Journal of neuroscience research

authors： Usach V,Goitia B,Lavalle L,Martinez Vivot R,Setton-Avruj P

更新日期：2011-08-01 00:00:00

abstract：:Neuron-glia interactions at paranodal junctions play important roles in action potential propagation. Among their many functions, they contribute to the passive electrical properties of myelinated nerve fibers and actively regulate the polarized distribution of ion channels along axons. Despite their importance, relat...

journal_title：Journal of neuroscience research

authors： Ogawa Y,Rasband MN

更新日期：2009-11-15 00:00:00

abstract：:The large, medium-sized, and small neurons of the dorsal root ganglion (DRG) have different functions in the processing of various senses. Hyperpolarization-activated, cyclic nucleotide-gated channels (HCN) contribute greatly to neuronal excitability. In the present study, which used whole-cell patch clamp techniques ...

journal_title：Journal of neuroscience research

authors： Tu H,Deng L,Sun Q,Yao L,Han JS,Wan Y

更新日期：2004-06-01 00:00:00

abstract：:To further our understanding of the functions of the major myelin proteins, myelin basic protein (MBP) and proteolipid protein (PLP), and other myelin proteins, such as 2'3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and myelin-associated glycoprotein (MAG), bovine brain myelin was extracted with Triton X-100, and p...

journal_title：Journal of neuroscience research

authors： Arvanitis DN,Yang W,Boggs JM

更新日期：2002-10-01 00:00:00

abstract：:The neuron-glia cell adhesion molecule (Ng-CAM) mediates neuron-neuron adhesion by a homophilic mechanism and neuron-astrocyte adhesion by a heterophilic mechanism. The protein is expressed on neurons and Schwann cells but not on astrocytes. It is most prevalent during development on cell bodies of migrating neurons a...

journal_title：Journal of neuroscience research

authors： Grumet M

更新日期：1992-01-01 00:00:00