Regulation of thyroid hormone receptor and c-erbA mRNA levels by butyrate in neuroblastoma (N2A) and glioma (C6) cells.

abstract：:C6 cells were adapted to proliferate in defined culture medium to allow the study of long-term effects of serum-free growth conditions on their phenotypic antigen expression and production of neurite promoting factors (NPFs). Cultures were grown in either Ham's F-12 or supplemented Opti-MEM-I containing 15% heat-inact...

journal_title：Journal of neuroscience research

authors： Coyle DE

更新日期：1995-06-15 00:00:00

abstract：:We investigated whether a learning impairment after a controlled cortical impact (CCI) injury was associated with alterations in molecules involved in synaptic plasticity and learning and memory. Adult male rats with moderate CCI to the left parietal cortex, tested in a Morris water maze (MWM) beginning at postinjury ...

journal_title：Journal of neuroscience research

authors： Griesbach GS,Sutton RL,Hovda DA,Ying Z,Gomez-Pinilla F

更新日期：2009-02-15 00:00:00

abstract：:Germinal matrix (GM) vasculature is selectively vulnerable to hemorrhage in premature infants during the first 48 hr of life. This is attributed to rapid angiogenesis of this brain region, resulting in formation of nascent vessels that show a paucity of pericytes and immaturity of extracellular matrix. Integrins are k...

journal_title：Journal of neuroscience research

authors： Dummula K,Vinukonda G,Xu H,Hu F,Zia MT,Braun A,Shi Q,Wolk J,Ballabh P

更新日期：2010-05-01 00:00:00

abstract：:Essential to understanding the roles proteins and structural elements play at the synapse is to understand the development, remodeling and reinnervation of peripheral neuromuscular junctions. It has, however, been a challenging task to label and visualize neuromuscular junctions. In this paper we demonstrate how adeno...

journal_title：Journal of neuroscience research

authors： Jacob JM,Zhou Q,Liu Y

更新日期：2000-07-01 00:00:00

abstract：:The twitcher mouse is well known as a naturally occurring authentic mouse model of human globoid cell leukodystrophy (GLD; Krabbe disease) due to genetic deficiency of lysosomal galactosylceramidase. The twitcher mice used most commonly are on the C57BL/6J background. We generated twitcher mice that were on the mixed ...

journal_title：Journal of neuroscience research

authors： Tominaga K,Matsuda J,Kido M,Naito E,Yokota I,Toida K,Ishimura K,Suzuki K,Kuroda Y

更新日期：2004-08-15 00:00:00

abstract：:The five major antioxidant enzymes, glutathione, and in vivo or in vitro stimulated (Fe(++)-ascorbate) peroxidation were similar in old and young Rana perezi frogs. Long-term (2.5 months) treatment with aminotriazole strongly decreased cerebral catalase (CAT) activity and increased in vivo but not in vitro peroxidatio...

journal_title：Journal of neuroscience research

authors： Barja de Quiroga G,Pérez-Campo R,López-Torres M

更新日期：1990-07-01 00:00:00

abstract：:Previous animal studies have linked white matter damage to certain schizophrenia-like behaviors in cuprizone (CPZ)-exposed mouse. Mitochondrial dysfunction, oxidative stress, neuroinflammation, and oligodendrocyte loss coexist in the brain of such mice. The aim of this study was to examine effects of the antioxidant N...

journal_title：Journal of neuroscience research

authors： Zhang L,Xu S,Huang Q,Xu H

更新日期：2018-05-01 00:00:00

abstract：:Brain metabolism increases during stimulation, but this increase does not affect all energy metabolism equally. Briefly after stimulation, there is a local increase in cerebral blood flow and in glucose uptake, but a smaller increase in oxygen uptake. This indicates that temporarily the rate of glycolysis is faster th...

journal_title：Journal of neuroscience research

authors： Díaz-García CM,Yellen G

更新日期：2019-08-01 00:00:00

abstract：:We used intracellular recording to investigate the functional interaction between protein kinase C (PKC) and protein kinase A (PKA) signal transduction cascades in the control of transmitter release in the neuromuscular synapses from adult rats. Our results indicate that: 1) PKA and PKC are independently involved in a...

journal_title：Journal of neuroscience research

authors： Santafé MM,Garcia N,Lanuza MA,Tomàs M,Tomàs J

更新日期：2009-02-15 00:00:00

abstract：:Despite consistent observations of sex differences in depression and related emotional disorders, we do not yet know how these sex differences modulate the effects of genetic polymorphisms implicated in risk for these disorders. This Mini-Review focuses on genetic polymorphisms of the serotonergic system to illustrate...

journal_title：Journal of neuroscience research

authors： Perry LM,Goldstein-Piekarski AN,Williams LM

更新日期：2017-01-02 00:00:00

abstract：:Neurodevelopmental disorders (NDDs) such as intellectual disability and autism spectrum disorder consistently show a male bias in prevalence, but it remains unclear why males and females are affected with different frequency. While many behavioral studies of transgenic NDD models have focused only on males, the requir...

journal_title：Journal of neuroscience research

authors： Mossa A,Manzini MC

更新日期：2021-01-01 00:00:00

abstract：:The transport kinetics of the excitatory sulphur-containing amino acid (SAA) transmitter candidates, L-cysteine sulphinate (L-CSA), L-cysteate (L-CA), L-homocysteine sulphinate (L-HCSA), and L-homocysteate (L-HCA), together with their plasma membrane carrier specificity, was studied in cerebrocortical synaptosome frac...

journal_title：Journal of neuroscience research

authors： Grieve A,Butcher SP,Griffiths R

更新日期：1992-05-01 00:00:00

abstract：:Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of cerebral vasospasm remain poorl...

journal_title：Journal of neuroscience research

authors： Kolias AG,Sen J,Belli A

更新日期：2009-01-01 00:00:00

abstract：:Neurofibromatosis type 2 is a hereditary cancer syndrome characterized by the development of bilateral vestibular schwannomas. Underlying the disease are inactivating mutations of the NF2 tumor suppressor gene, located on chromosome 22, encoding a 595-amino-acid protein. The NF2 protein, also known as merlin or schwan...

journal_title：Journal of neuroscience research

authors： den Bakker MA,Riegman PH,Suurmeijer AP,Vissers CJ,Sainio M,Carpen O,Zwarthoff EC

更新日期：2000-12-15 00:00:00

abstract：:Early studies of murine experimental autoimmune encephalomyelitis (EAE) induced with myelin basic protein (MBP) divide various mouse strains into either "susceptible" or "resistant" phenotypes. Resistance is defined as lack of encephalitogenic responses after active immunization or adoptive transfer. It is now becomin...

journal_title：Journal of neuroscience research

authors： Shaw MK,Kim C,Hao HW,Chen F,Tse HY

更新日期：1996-09-15 00:00:00

abstract：:Histology, immunohistochemistry, and Western blotting were used to characterize the changes in morphology, distribution pattern, and marker protein expression of striatal interneurons in the transition zone of striatal injury induced by 3-NP. The 3-NP treatment in rats yielded movement, motor coordination, and cogniti...

journal_title：Journal of neuroscience research

authors： Mu S,OuYang L,Liu B,Zhu Y,Li K,Zhan M,Liu Z,Jia Y,Lei W,Reiner A

更新日期：2011-05-01 00:00:00

abstract：:Production of hydrogen peroxide as a by-product of the breakdown of catecholamines by the enzyme monoamine oxidase (MAO) has been hypothesized to contribute to the increased proclivity of dopaminergic neurons for oxidative injury. We established clonal dopaminergic PC12 cell lines which have elevated MAO activity leve...

journal_title：Journal of neuroscience research

authors： Wei Q,Yeung M,Jurma OP,Andersen JK

更新日期：1996-12-15 00:00:00

abstract：:In this report, we address the molecular mechanisms that regulate axonal growth by focusing on the gene for one of the major axonal cytoskeletal proteins, T alpha1 alpha-tubulin. During the developmental growth of sympathetic neurons, transcription of a beta-galactosidase transgene driven by the T alpha1 promoter (T a...

journal_title：Journal of neuroscience research

authors： Wu W,Gloster A,Miller FD

更新日期：1997-06-01 00:00:00

abstract：:Cross-linking of alpha-synuclein and Lewy body formation have been implicated in the dopaminergic neuronal cell death observed in Parkinson's disease (PD); the mechanisms responsible, however, are not clear. Reactive oxygen species and advanced glycation end products (AGEs) have been found in the intracellular, alpha-...

journal_title：Journal of neuroscience research

authors： Shaikh S,Nicholson LF

更新日期：2008-07-01 00:00:00

abstract：:We have studied the effect of induced glial fibrillary acidic protein (GFAP) on motility, cell morphology, and proliferation of two originally GFAP-negative human glioma cell lines. Glioma cell lines U-1242 MG and U-251 MG sp subclone 3A were transfected with a vector system that allows for an inducible GFAP expressio...

journal_title：Journal of neuroscience research

authors： Elobeid A,Bongcam-Rudloff E,Westermark B,Nistér M

更新日期：2000-04-15 00:00:00

abstract：:Previous observations have demonstrated decreased in vivo and in vitro protein synthesis by brain ribosomal systems following long-term ethanol ingestion. For further investigation of the properties of brain ribosomes, the 40S and 60S ribosomal subunits were successfully isolated from control and chronic 10% ethanol-d...

journal_title：Journal of neuroscience research

authors： Tewari S,Murray S,Noble EP

更新日期：1978-01-01 00:00:00

abstract：:In rodents, oligodendrocytes and myelinating Schwann cells express connexin32 (Cx32) and Cx29, which have different localizations in the two cell types. We show here that, in contrast to Cx32, Cx29 does not form gap junction plaques or functional gap junctions in transfected cells. Furthermore, when expressed together...

journal_title：Journal of neuroscience research

authors： Ahn M,Lee J,Gustafsson A,Enriquez A,Lancaster E,Sul JY,Haydon PG,Paul DL,Huang Y,Abrams CK,Scherer SS

更新日期：2008-04-01 00:00:00

abstract：:Spinocerebellar ataxia type 17 (SCA17) is a type of autosomal dominant cerebellar ataxia (ADCA) characterized by variable manifestations, including cerebellar ataxia, dementia, and psychiatric symptoms. Since the identification of a CAG repeat expansion in the TATA-box binding protein (TBP) gene in a patient with atax...

journal_title：Journal of neuroscience research

authors： Cui Y,Yang S,Li XJ,Li S

更新日期：2017-08-01 00:00:00

abstract：:Niemann-Pick C (NPC) disease is an autosomal recessive lipidosis characterized by lysosomal accumulations of unesterified cholesterol. Cultured NPC cells exhibit a defect in the intracellular trafficking of LDL-derived cholesterol that leads to lysosomal accumulations of unesterified cholesterol. We found in a prelimi...

journal_title：Journal of neuroscience research

authors： Goodrum JF,Pentchev PG

更新日期：1997-08-01 00:00:00

abstract：:In order to quantify the changes that occur in the cholinergic central nervous system with aging, we have compared acetylcholine (Ach) formation in brain cortex slice preparations from 2-year-old aged CBF-1 mouse brains and compared the findings with those in 2-4-month-old young adult mouse brain slices. Incorporation...

journal_title：Journal of neuroscience research

authors： Saito M,Kindel G,Karczmar AG,Rosenberg A

更新日期：1986-01-01 00:00:00

abstract：:Detergent-resistant lipid microdomains (Rafts) were isolated from human oligodendroglioma (HOG), human neuroblastoma (LA-N-5), and immortalized dorsal root ganglion (F-11) cell lines by sucrose-density gradient ultracentrifugation and shown to be enriched in cholesterol, sphingomyelin, and ceramide. [(3)H]palmitate la...

journal_title：Journal of neuroscience research

authors： Kilkus J,Goswami R,Testai FD,Dawson G

更新日期：2003-04-01 00:00:00

abstract：:Grafting fetal ventral mesencephalon has been utilized to alleviate the symptoms of Parkinson's disease. One obstacle in using this approach is the limited outgrowth from the transplanted dopamine neurons. Thus, it is important to evaluate factors that promote outgrowth from fetal dopamine neurons. Proteoglycans (PGs)...

journal_title：Journal of neuroscience research

authors： Berglöf E,Plantman S,Johansson S,Strömberg I

更新日期：2008-01-01 00:00:00

abstract：:The cell line PC12, derived from a rat pheochromocytoma, has served as a model for studies on the mechanism of action of nerve growth factor, as well as for the exploration of neuronal differentiation in general. When treated with nanomolar concentrations of nerve growth factor, these neoplastic chromaffin-like cells ...

journal_title：Journal of neuroscience research

authors： Simpson DL,Dickens G,Doll S,Koizumi S,Tocco M,Okuda O,Oshima M,Rudkin BB,Brightman M,Guroff G

更新日期：1991-04-01 00:00:00

abstract：:Cortical or total brain cultures of microglia are commonly used as a model to study the inflammatory processes in Parkinson's disease. Here we characterize microglia cultures from rat ventral midbrain and evaluate their response to zymosan A. We used specific markers of microglia and evaluated the morphology, the phag...

journal_title：Journal of neuroscience research

authors： Cristóvão AC,Saavedra A,Fonseca CP,Campos F,Duarte EP,Baltazar G

更新日期：2010-02-15 00:00:00

abstract：:The interleukin (IL)-15-dependent immune responses of murine microglia were strongly affected by low concentrations of the ganglioside GD3. The ganglioside binding to IL-15 inhibited the proinflammatory effects of the cytokine, reducing IL-15-dependent T-cell proliferation as well as mRNA expression for IL-15Ralpha, p...

journal_title：Journal of neuroscience research

authors： Gómez-Nicola D,Doncel-Pérez E,Nieto-Sampedro M

更新日期：2006-04-01 00:00:00