Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders.

abstract：:The amino acid glutamate plays a key role in brain function. One of the major roles of glutamate is to mediate fast excitatory neurotransmission via activation of ionotropic glutamate receptors (iGluRs). More recently, however, it has become clear that glutamate also serves a regulatory function through activation of ...

journal_title：Journal of neuroscience research

authors： Winder DG,Conn PJ

更新日期：1996-10-15 00:00:00

abstract：:Noradrenalin (NA) regulates the expression of arginine-vasopressin (AVP) and oxytocin (OT) by magnocellular neurons in the supraoptic nucleus (SON) of the hypothamalus. Nitric oxide (NO) may be one of the factors involved in the NA signaling pathway regulating AVP and OT expression. To test this possibility, we used a...

journal_title：Journal of neuroscience research

authors： Maolood N,Grange-Messent V,Raison D,Hardin-Pouzet H

更新日期：2007-10-01 00:00:00

abstract：:Cultured astrocytes from neonatal rat cerebral hemispheres are depolarized by the excitatory neurotransmitter glutamate. In this study we have used selective agonists of different neuronal glutamate receptor subtypes, namely, the N-methyl-D-aspartate (NMDA), kainate, and quisqualate type, to characterize pharmacologic...

journal_title：Journal of neuroscience research

authors： Backus KH,Kettenmann H,Schachner M

更新日期：1989-03-01 00:00:00

abstract：:The discharge behavior of neurons depends on a variable expression and sorting pattern of voltage-dependent potassium (Kv) channels that changes during development. The rodent retina represents a neuronal network whose main functions develop after birth. To obtain information about neuronal maturation we analyzed the ...

journal_title：Journal of neuroscience research

authors： Höltje M,Brunk I,Grosse J,Beyer E,Veh RW,Bergmann M,Grosse G,Ahnert-Hilger G

更新日期：2007-01-01 00:00:00

abstract：:The dentate gyrus is selectively reduced in size in the insulin-like growth factor 1 (IGF1) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of...

journal_title：Journal of neuroscience research

authors： Cheng CM,Cohen M,Tseng V,Bondy CA

更新日期：2001-05-15 00:00:00

abstract：:Molecular and behavioral timekeeping is regulated by the circadian system which includes the brain's suprachiasmatic nucleus (SCN) that translates environmental light information into neuronal and endocrine signals aligning peripheral tissue rhythms to the time of day. Despite the critical role of circadian rhythms in...

journal_title：Journal of neuroscience research

authors： Yaw AM,Duong TV,Nguyen D,Hoffmann HM

更新日期：2021-01-01 00:00:00

abstract：:Previous studies have shown that PC12 cells overexpressing beta/A4 amyloid peptide display altered morphology characterized by pronounced membrane ruffling and extensive intercellular appositions. Having observed other cell types in which these features accompany increased connexin43 (Cx43) production and gap junction...

journal_title：Journal of neuroscience research

authors： Nagy JI,Hossain MZ,Hertzberg EL,Marotta CA

更新日期：1996-04-15 00:00:00

abstract：:Four brain-specific, DNase I hypersensitive sites (HSS) have been mapped to the 5' flanking region of the mouse 68-kDa neurofilament gene. These sites are contained within a 1.7-kb sequence that confers neuronal specificity of expression of this gene in transgenic mice. To identify DNA sequences that might be involved...

journal_title：Journal of neuroscience research

authors： Ivanov TR,Brown IR

更新日期：1992-06-01 00:00:00

abstract：:Recent advances in human induced pluripotent stem cells (hiPSCs) offer new possibilities for biomedical research and clinical applications. Differentiated neurons from hiPSCs are expected to be useful for developing novel methods of treatment for various neurological diseases. However, the detailed process of function...

journal_title：Journal of neuroscience research

authors： Ohara Y,Koganezawa N,Yamazaki H,Roppongi RT,Sato K,Sekino Y,Shirao T

更新日期：2015-12-01 00:00:00

abstract：:Increase of intracellular [Ca(2+)] evoked by action potentials in a cell can induce long-term synaptic plasticity even without concomitant presynaptic stimulation. We used optical recording of the fluorescence of a Ca(2+)-indicator Oregon Green to investigate whether differences in results obtained with modifications ...

journal_title：Journal of neuroscience research

authors： Balaban P,Chistiakova M,Malyshev A,Volgushev M

更新日期：2004-05-15 00:00:00

abstract：:Previous studies have identified a group of cells in the dorsolateral hypothalamus that project to many different areas in the CNS, such as thalamus, diagonal band of Broca, basal ganglia, cerebral cortex, hippocampus, and olfactory bulb. Their role is presently unknown, but the cells have been reported to stain for a...

journal_title：Journal of neuroscience research

authors： Quinn J,Eckenstein FP,Baughman RW

更新日期：1992-04-01 00:00:00

abstract：:Ex vivo gene therapy is emerging as a promising approach for the treatment of neurodegenerative diseases and central nervous system (CNS) trauma. We have shown previously that human adult astrocytes can be expanded in vitro and can express various therapeutic transgenes (Ridet et al. [1999] Hum. Gene Ther. 10:271-280;...

journal_title：Journal of neuroscience research

authors： Ridet JL,Sarkis C,Serguera C,Zennou V,Charneau P,Mallet J

更新日期：2003-06-15 00:00:00

abstract：:Cannabinoids bind to two G-protein-coupled receptors, CB1 and CB2, expressed by neurons and cells of the immune system, respectively. Glioma cells (astrocyte-derived brain tumor cells) express cannabinoid receptors, and numerous in vitro and in vivo studies performed in rodents have concluded that apoptosis could be i...

journal_title：Journal of neuroscience research

authors： Widmer M,Hanemann CO,Zajicek J

更新日期：2008-11-01 00:00:00

abstract：:The presence of acetylcholinesterase has been detected in the thymus of several species both biochemically and histochemically. In this study we have investigated the molecular forms and the level of this enzyme in separate compartments of the murine thymus and in different thymocyte subpopulations. Similar levels of ...

journal_title：Journal of neuroscience research

authors： Rossi A,Vicini E,Scarsella G,Biagioni S

更新日期：1991-06-01 00:00:00

abstract：:Contacts between horizontal and bipolar cells are described in the retina of the teleost Eugerres plumieri. A single, long expansion observed in the external cone horizontal cells makes contact by means of a terminal button with the cell body of a bipolar. It represents the only contact between this class of horizonta...

journal_title：Journal of neuroscience research

authors： Parthe V

更新日期：1981-01-01 00:00:00

abstract：:Using morphological, immunocytochemical, and functional parameters we have previously shown that highly purified adult rat microglial cells undergo a process of "activation" when cultured in a serum-containing medium in the absence of added proinflammatory substances or other factors (Slepko and Levi: Glia 16:241-246,...

journal_title：Journal of neuroscience research

authors： Slepko N,Minghetti L,Polazzi E,Nicolini A,Levi G

更新日期：1997-08-01 00:00:00

abstract：:The immunohistochemical distribution of microtubule-associated protein 2 (MAP2), being normally restricted to nerve cell bodies and dendrites, became altered in rat dorsal root ganglia and spinal cord neurons in cultures infected with rhesus rotavirus. MAP2 appeared in axons of both sources of neurons as displayed wit...

journal_title：Journal of neuroscience research

authors： Weclewicz K,Svensson L,Billger M,Holmberg K,Wallin M,Kristensson K

更新日期：1993-10-01 00:00:00

abstract：:The combination of nerve growth factor (NGF) and phorbol 12-myristate 13-acetate (PMA) rapidly induced the locomotion of PC12 cells by sequentially stimulating lamellar spreading, ruffling with pinocytosis, and polarization by retraction from the substratum. During migration, cells acquired long processes as a result ...

journal_title：Journal of neuroscience research

authors： Altun-Gultekin ZF,Wagner JA

更新日期：1996-05-15 00:00:00

abstract：:Preterm birth results in significant cognitive and motor disabilities, but recent evidence suggests that there is variable recovery over time. One possibility that may explain this variable recovery entails variable neurogenic responses in the subventricular zone (SVZ) following the period of chronic hypoxia experienc...

journal_title：Journal of neuroscience research

authors： Li Q,Michaud M,Stewart W,Schwartz M,Madri JA

更新日期：2008-05-01 00:00:00

abstract：:The role of axons in the expression of the major myelin glycoprotein, P0, has been investigated using neuron/Schwann cell cultures. These cultures were either nonmyelinating or myelinating due to growth in defined medium or in medium containing serum and chick embryo extract, respectively. The neurons and Schwann cell...

journal_title：Journal of neuroscience research

authors： Brunden KR,Windebank AJ,Poduslo JF

更新日期：1990-06-01 00:00:00

abstract：:This study tested the hypothesis that sensitivity to the Ca(2+) -induced loss of mitochondrial membrane potential (ΔΨ(m)) and the sensitivity of the loss of ΔΨ to mitochondrial permeability transition pore (PTP) inhibitors are different for neurons and astrocytes. Primary cultures of rat cortical neurons and astrocyte...

journal_title：Journal of neuroscience research

authors： Kahraman S,Bambrick LL,Fiskum G

更新日期：2011-12-01 00:00:00

abstract：:The expression of many myelin-specific molecules in Schwann cells is profoundly decreased following denervation. This study examines the early reexpression of myelin protein genes associated with reinnervation. Following sciatic nerve crush, the distal, regenerated nerve was divided into appropriate (2.5 or 5 mm) cons...

journal_title：Journal of neuroscience research

authors： Mitchell LS,Griffiths IR,Morrison S,Barrie JA,Kirkham D,McPhilemy K

更新日期：1990-10-01 00:00:00

abstract：:A morphogenic role of neurotransmitters during cellular differentiation in vitro has been demonstrated in recent years. Using in situ hybridization, we confirm the presence of the D1 receptor at E16 and show additionally that the transcript is relatively widespread and present in both proliferative and differentiating...

journal_title：Journal of neuroscience research

authors： Reinoso BS,Undie AS,Levitt P

更新日期：1996-02-15 00:00:00

abstract：:The effects of blinding with or without pineal ablation on brain monoamine levels were studied in male rats. Brain dopamine (DA), norepinephrine (NE), epinephrine (E), and serotonin (5-HT) were measured by radioenzymatic assays. Four weeks following pinealectomy, E levels were significantly enhanced in the frontal cor...

journal_title：Journal of neuroscience research

authors： Niles LP,Brown GM,Mishra RK

更新日期：1983-01-01 00:00:00

abstract：:Functional MRI (fMRI) on spinal cord-injured rodents at 4 and 8 weeks post injury (PI) is described. The paradigm for fMRI, based on electrical stimulation of rat paws, was automated using an in-house designed microprocessor-based controller that was interfaced to a stimulator. The MR images were spatially normalized ...

journal_title：Journal of neuroscience research

authors： Ramu J,Bockhorst KH,Mogatadakala KV,Narayana PA

更新日期：2006-11-01 00:00:00

abstract：:Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis...

journal_title：Journal of neuroscience research

authors： Kane DJ,Ord T,Anton R,Bredesen DE

更新日期：1995-02-01 00:00:00

abstract：:Six different types of spectral responses were recorded from horizontal cells under mesopic conditions in perfused retina, isolated from the dark-adapted mojarra (Eugerres plumieri). They were tentatively termed photopic Lr-, Lg1-, Lg2-, Lb-, and C-type, and scotopic L-type. The Lr-, Lg-, and Lb-type responses showed ...

journal_title：Journal of neuroscience research

authors： Negishi K,Salas R,Parthe V,Drujan BD

更新日期：1988-01-01 00:00:00

abstract：:The neuronal intermediate filaments include not only the neurofilament triplet proteins but also peripherin and alpha-internexin. To determine whether neurite outgrowth is enhanced by alpha-internexin, the cDNA of rat alpha-internexin tagged with enhanced green fluorescent protein (EGFP) was transfected into a rat adr...

journal_title：Journal of neuroscience research

authors： Chien CL,Liu TC,Ho CL,Lu KS

更新日期：2005-06-01 00:00:00

abstract：:Destruction of the ventromedial hypothalamic nuclei (VMN) in the weanling rat without injury to the median eminence results in a series of somatic, endocrine, and metabolic changes that are characterized by normal food and water intake but decreased linear growth, normal body weight but increased carcass fat and reduc...

journal_title：Journal of neuroscience research

authors： Bernardis LL,Goldman JK

更新日期：1976-01-01 00:00:00

abstract：:Data from a study in which 12 chronic mental patients and 12 control subject were given D-[3-14C] glucose intravenously in our arterio-venous technique for determining cerebral metabolism in vivo were reexamined. Previously unpublished whole-blood lactate determinations in these experiments indicated a cerebral produc...

journal_title：Journal of neuroscience research

authors： Sacks W,Schechter DC,Sacks S

更新日期：1981-01-01 00:00:00