Genetic elevation of monoamine oxidase levels in dopaminergic PC12 cells results in increased free radical damage and sensitivity to MPTP.

abstract：:The discharge behavior of neurons depends on a variable expression and sorting pattern of voltage-dependent potassium (Kv) channels that changes during development. The rodent retina represents a neuronal network whose main functions develop after birth. To obtain information about neuronal maturation we analyzed the ...

journal_title：Journal of neuroscience research

authors： Höltje M,Brunk I,Grosse J,Beyer E,Veh RW,Bergmann M,Grosse G,Ahnert-Hilger G

更新日期：2007-01-01 00:00:00

abstract：:Recent experiments have shown that Arg, Lys, and Leu can be incorporated posttranslationally into proteins of regenerating sciatic nerves of rats. The present experiments investigate a mixture of 15 radioactive amino acids to determine if additional amino acids can be conjugated posttranslationally to proteins of rege...

journal_title：Journal of neuroscience research

authors： Chakraborty G,Yu M,Luo D,Sturman JA,Ingoglia NA

更新日期：1990-04-01 00:00:00

abstract：:The pathogenic processing of the amyloid precursor protein (APP) into beta-amyloid peptides, which give rise to beta-amyloid plaques in the brains of Alzheimer's disease patients, requires the enzymatic activity of the beta-site APP-cleaving enzyme 1 (BACE1). We report the cloning and sequence of a 1.5-kb DNA fragment...

journal_title：Journal of neuroscience research

authors： Lange-Dohna C,Zeitschel U,Gaunitz F,Perez-Polo JR,Bigl V,Rossner S

更新日期：2003-07-01 00:00:00

abstract：:Metallothionein (MT) belongs to a family of metal-binding cysteine-rich proteins comprising several structurally related proteins implicated in tissue protection and regeneration after injuries and functioning as antiapoptotic antioxidants in neurological disorders. This has been demonstrated in animals receiving MT t...

journal_title：Journal of neuroscience research

authors： Asmussen JW,Von Sperling ML,Penkowa M

更新日期：2009-10-01 00:00:00

abstract：:Astrocytes play a diverse role in central nervous system (CNS) injury. Production of the serine protease inhibitors (serpins) plasminogen activator inhibitor-1 (PAI-1) and protease nexin-1 (PN-1) by astrocytes may counterbalance excessive serine protease activity associated with CNS pathologies such as ischemic stroke...

journal_title：Journal of neuroscience research

authors： Hultman K,Blomstrand F,Nilsson M,Wilhelmsson U,Malmgren K,Pekny M,Kousted T,Jern C,Tjärnlund-Wolf A

更新日期：2010-08-15 00:00:00

abstract：:Retinal microglia play an important role as resident immunocompetent and phagocytic cells in the event of injury and disease. Retinal microglia and microglia precursor transplantation show a rescue effect in ischemic retina and retinal degeneration. However, studies of retinal microglia have been hampered by the diffi...

journal_title：Journal of neuroscience research

authors： Jiang XS,Ni YQ,Liu TJ,Zhang M,Jiang R,Xu GZ

更新日期：2014-04-01 00:00:00

abstract：:Inhibitors of differentiation (Id) play an essential role in the neurogenesis of the central nervous system. However, the expression and function of Id in the development of cochlear sensory epithelial cells have yet to be elucidated. In this study, we demonstrate the Id1 gene was expressed in the rapidly growing otoc...

journal_title：Journal of neuroscience research

authors： Ozeki M,Hamajima Y,Feng L,Ondrey FG,Schlentz E,Lin J

更新日期：2007-02-15 00:00:00

abstract：:Most previous studies on spinal cord injury (SCI) have used rodent models. Direct extrapolation of the results obtained in rodents to clinical cases is difficult, however, because of neurofunctional and anatomic differences between rodents and primates. In the present study, the development of histopathologic changes ...

journal_title：Journal of neuroscience research

authors： Iwanami A,Yamane J,Katoh H,Nakamura M,Momoshima S,Ishii H,Tanioka Y,Tamaoki N,Nomura T,Toyama Y,Okano H

更新日期：2005-04-15 00:00:00

abstract：:Music has a long history of healing or mitigating physical and mental illness in the clinical setting. We aimed to test changes in behavioral cognition and serum proteomics in rats undergoing music intervention (MI). The Morris water maze (MWM) was used to evaluate spatial learning and memory in rats. Serum protein ex...

journal_title：Journal of neuroscience research

authors： Xiong X,Han L,Liu S,Miao J,Luo M,Xue M,Wang X,Ni L,Yang J,Huang C

更新日期：2018-10-01 00:00:00

abstract：:Zinc ion elevation contributes to acute excitotoxic brain injury and correlates with the severity of dementia in chronic neurodegenerative diseases. Downstream control of zinc-triggered signals is believed to be an efficient countermeasure. In the current study, we examined whether the flavonoid luteolin (Lu) could pr...

journal_title：Journal of neuroscience research

authors： Zhou F,Qu L,Lv K,Chen H,Liu J,Liu X,Li Y,Sun X

更新日期：2011-11-01 00:00:00

abstract：:The activation of cellular inflammatory response is tightly linked to induced production of reactive oxygen species (ROS) and nitric oxide (NO), which in turn have been identified as important regulators of cellular iron metabolism. In the present study, we have used the microglia cell line BV-2 and the neuroblastoma ...

journal_title：Journal of neuroscience research

authors： Reis K,Hälldin J,Fernaeus S,Pettersson C,Land T

更新日期：2006-10-01 00:00:00

abstract：:The effects of extracellular acidification on the synaptic function and neuronal excitability were investigated on the hippocampal CA1 neurons. A decrease of extracellular pH from 7.4 to 6.7 did not alter either the resting membrane potential or the neuronal membrane input resistance. Extracellularly recorded field ex...

journal_title：Journal of neuroscience research

authors： Hsu KS,Liang YC,Huang CC

更新日期：2000-11-01 00:00:00

abstract：:Ionotropic N-methyl-D-aspartate (NMDA) receptor agonists, L-aspartic acid (L-Asp) and NMDA, have been shown to inhibit histamine-stimulated acid secretion, but their effect on gastric mucosal blood flow (GMBF) is largely unknown. The aim of this study was to investigate whether L-Asp and NMDA inhibit histamine-stimula...

journal_title：Journal of neuroscience research

authors： Tsai LH,Lee YJ,Wu JY

更新日期：2004-09-01 00:00:00

abstract：:Primary fibroblasts initiated from skin biopsies of Wistar rats were transfected with a plasmid that encodes the human growth hormone and the neomycin resistance genes. Cell clones selected for G418 resistance and expressing high levels of human growth hormone were propagated in vitro and subsequently transplanted int...

journal_title：Journal of neuroscience research

authors： Doering LC,Chang PL

更新日期：1991-07-01 00:00:00

abstract：:We have demonstrated recently that atypical antipsychotics possess neuroprotective actions in H2O2-mediated and serum-withdrawal models of cell death. In the present study, we compared the ability of atypical and typical antipsychotics to protect against an insult mediated by Abeta(25-35), an apoptogenic fragment of t...

journal_title：Journal of neuroscience research

authors： Wei Z,Mousseau DD,Richardson JS,Dyck LE,Li XM

更新日期：2003-12-15 00:00:00

abstract：:Glutamine synthetase (GS) activity was used as a marker to examine differences in astrocyte development in mice selectively bred for ethanol sensitivity: long sleep (LS), short sleep (SS), mild ethanol withdrawal (MEW), severe ethanol withdrawal (SEW) and control ethanol withdrawal (CEW). We found that 1) GS activity ...

journal_title：Journal of neuroscience research

authors： Sakellaridis N,Mangoura D,Masserrano JM,Detsis V,Leoni CJ,Deitrich R,Vernadakis A

更新日期：1989-11-01 00:00:00

abstract：:To determine whether one or more opioid receptor types might be preferentially involved in gliogenesis, primary mixed glial cultures derived from mouse cerebra were continuously treated with varying concentrations of opioid agonists selective for mu (mu), i.e., DAGO ([D-Ala2, MePhe4, Gly(ol)5]enkephalin), delta (delta...

journal_title：Journal of neuroscience research

authors： Stiene-Martin A,Hauser KF

更新日期：1991-08-01 00:00:00

abstract：:Nascent neural crest cells derived from explanted E12 embryonic rat caudal neural tubes were used as an assay system to investigate the effects of fibroblast growth factors on neural crest cell (NCC) survival, proliferation, migration, and differentiation. In vitro and in vivo all NCC express low affinity nerve growth...

journal_title：Journal of neuroscience research

authors： Bannerman PG,Pleasure D

更新日期：1993-09-01 00:00:00

abstract：:It was previously reported that a monoclonal antibody to beta-amyloid precursor protein (mab22C11; Boehringer Mannheim, Indianapolis, IN) labels an intermediate filament-associated protein (beta APP-IFAP) in cultured human skin fibroblasts (Dooley et al.: J Neurosci Res 33:60-67, 1992). The time course of its expressi...

journal_title：Journal of neuroscience research

authors： Durham HD,Minotti S,Dooley NP,Nalbantoglu J

更新日期：1994-08-15 00:00:00

abstract：:Alpha2-adrenergic receptors control norepinephrine (NE) release and tumor necrosis factor-alpha (TNF) production from neurons. TNF regulates NE release, depending on alpha2-adrenergic receptor functioning. The relationship between TNF production in the brain and alpha2-adrenergic receptor activation could have profoun...

journal_title：Journal of neuroscience research

authors： Reynolds JL,Ignatowski TA,Spengler RN

更新日期：2005-03-15 00:00:00

abstract：:Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an endogenous ligand for the NOP receptor, ample evidence has revealed unique functional profiles of the N/OFQ-NOP receptor system. NOP receptors are expressed in key neural substrates involved in pain and reward modulation. In nonhuma...

journal_title：Journal of neuroscience research

authors： Kiguchi N,Ding H,Ko MC

更新日期：2020-04-07 00:00:00

abstract：:Mitochondrial dysfunction has been implicated in cell death in many neurodegenerative diseases. Diminished activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), a key and arguably rate-limiting enzyme of the Krebs cycle, occurs in these disorders and may underlie decreased brain metabolism. The present st...

journal_title：Journal of neuroscience research

authors： Huang HM,Ou HC,Xu H,Chen HL,Fowler C,Gibson GE

更新日期：2003-10-15 00:00:00

abstract：:Oligodendrocytes (OLs) and the myelin produced by them are enriched in two glycosphingolipids, galactosylceramide (GalC) and its sulfated form, cerebroside sulfate (CBS). We showed earlier that these two glycolipids in opposed liposomal membranes or in methanol solution can adhere to each other. Here we have examined ...

journal_title：Journal of neuroscience research

authors： Boggs JM,Wang H

更新日期：2001-10-15 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is an extensively studied protein that is evolutionarily conserved and widely distributed in the brain of vertebrates. It acts via its cognate receptors TrkB and p75NTR and plays a central role in the developmental neurogenesis, neuronal survival, proliferation, differentiation...

journal_title：Journal of neuroscience research

authors： Anand SK,Mondal AC

更新日期：2020-05-01 00:00:00

abstract：:Cranial idiopathic acute peripheral facial nerve paralysis (Bell palsy) has been used as a model disease in the present study mainly to investigate trophic capacity of serum components. The ability to induce sprouting from chick embryo dorsal root ganglia was used as the bioassay for trophic activity. Sera from normal...

journal_title：Journal of neuroscience research

authors： Aviel A,Schwartz M

更新日期：1983-01-01 00:00:00

abstract：:The ligand-activated transcription factor peroxisome proliferator-activated receptor beta (PPARbeta) is present in the brain and is implicated in the regulation of genes with potential roles in neurotoxicity. We sought to examine the role of PPARbeta in neuronal cell death by using the PPARbeta ligand GW0742. Primary ...

journal_title：Journal of neuroscience research

authors： Smith SA,Monteith GR,Robinson JA,Venkata NG,May FJ,Roberts-Thomson SJ

更新日期：2004-07-15 00:00:00

abstract：:Parallel corticostriatonigral circuits have been proposed that separately process motor, cognitive, and emotional-motivational information. Functional integration requires that interactions exist between neurons participating in these circuits. This makes it imperative to study the complex anatomical substrate underly...

journal_title：Journal of neuroscience research

authors： Wouterlood FG,Engel A,Daal M,Houwen G,Meinderts A,Jordà Siquier T,Beliën JAM,van Dongen YC,Scheel-Krüger J,Thierry AM,Groenewegen HJ,Deniau JM

更新日期：2018-09-01 00:00:00

abstract：:Larval acetylcholinesterase (acetylcholine acetylhydrolase) EC 3.1.3.7 of the trematode Schistosoma mansoni was characterized and purified by affinity chromatography. The enzyme was solubilized from sonicated cercarial tissue and showed a Km value of 1.83 mM and a Vmax value of 102 U/mg protein. It was characterized a...

journal_title：Journal of neuroscience research

authors： Goldlust A,Arnon R,Silman I,Tarrab-Hazdai R

更新日期：1986-01-01 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated ion channels (HCN) are key determinants of CNS functions. Here we describe an increase in hyperpolarization-activated current (I(h)) at the beginning of whole-cell recordings in rat layer 5 cortical neurons. For a closer investigation of this I(h) increase, we overex...

journal_title：Journal of neuroscience research

authors： Battefeld A,Bierwirth C,Li YC,Barthel L,Velmans T,Strauss U

更新日期：2010-11-01 00:00:00

abstract：:Multi-unit activity was recorded from the diencephalon of unanesthetized, immobilized female rats. Less than 50% of the recording sites in the hypothalamus showed changes in the level of multi-unit activity to changes in the level of glucose utilization induced by injection of 2-deoxy-D-glucose (2-DG). It was also not...

journal_title：Journal of neuroscience research

authors： Rabin BM,Miller DS

更新日期：1980-01-01 00:00:00