Abstract:
:Embryonic central nervous system neuroepithelial cells are a transient population of cells that give rise to neuronal and glial progenitors. In the E12-E16 embryonic rat spinal neural tube we have identified neuroepithelial cells as radially oriented cells expressing the GD3 ganglioside as recognized by the monoclonal anti-GD3 ganglioside antibodies, R24 and LB1. In vitro, neuroepithelial cells, which migrate from the ventral aspect of E12 rat lumbosacral neural tube explants, also express GD3 ganglioside immunoreactivity, thus permitting their distinction from neural crest cells (NCC) which migrate from the dorsal aspect of such explants. Fibroblast growth factor-1 (FGF-1, acidic FGF) and FGF-2 (basic FGF) increase the migration of neuroepithelial cells and the extent to which they incorporate the thymidine analogue bromodeoxyuridine (BrdU). They do not, however, alter the rate at which these migrating neuroepithelial cells undergo cell death. Previous observations established the actions of FGF-1 and FGF-2 on neuronal and glial cells. The present study indicates that these growth factors also influence the motility and proliferation of progenitor cells at a developmental stage which precedes their divergence into neuronal and glial lineages.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Bannerman PG,Oliver TM,Xu Z,Shieh A,Pleasure DEdoi
10.1002/(SICI)1097-4547(19960901)45:5<549::AID-JNRsubject
Has Abstractpub_date
1996-09-01 00:00:00pages
549-57issue
5eissn
0360-4012issn
1097-4547pii
10.1002/(SICI)1097-4547(19960901)45:5<549::AID-JNRjournal_volume
45pub_type
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