Reactive astrogliosis induces astrocytic differentiation of adult neural stem/progenitor cells in vitro.

abstract：:Amyotrophic lateral sclerosis is an age-related neurological disease, characterized by neurofilament (NF) accumulation in primary axons followed by degeneration of motor neurons. To elucidate age-related factors that might lead to pathological NF accumulation, NFs were compared between young and aged rats. Electron mi...

journal_title：Journal of neuroscience research

authors： Uchida A,Yorifuji H,Lee VM,Kishimoto T,Hisanaga S

更新日期：1999-10-15 00:00:00

abstract：:The prenatal and early postnatal stages represent a critical time window for human brain development. Interestingly, this window partly overlaps with the maturation of the intestinal flora (microbiota) that play a critical role in the bidirectional communication between the central and the enteric nervous systems (mic...

journal_title：Journal of neuroscience research

authors： Eltokhi A,Janmaat IE,Genedi M,Haarman BCM,Sommer IEC

更新日期：2020-07-01 00:00:00

abstract：:In contrast to its known anti-apoptotic activity in sympathetic neurons, immortal neuronal cell lines, and primary cultured immature neurons of the central nervous system (CNS), the role of Bcl-2 in CNS neurons in the adult brain is poorly understood. In the present study, we examined effects of overexpression of Bcl-...

journal_title：Journal of neuroscience research

authors： Wang HD,Fukuda T,Suzuki T,Hashimoto K,Liou SY,Momoi T,Kosaka T,Yamamoto K,Nakanishi H

更新日期：1999-07-01 00:00:00

abstract：:Mounting evidence has demonstrated that the microenvironment of stem/progenitor cells plays an important role in their proliferation and commitment to their fate. However, it remains unclear how all elements, such as astrocytes, microglia, extracellular matrix molecules, soluble factors, and their cross-talk interacti...

journal_title：Journal of neuroscience research

authors： Liao H,Huang W,Niu R,Sun L,Zhang L

更新日期：2008-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and disability among young adults and is highly prevalent among recently deployed military personnel. Survivors of TBI often experience cognitive and emotional deficits, suggesting that long-term effects of injury may disrupt neuronal function in critical brain ...

journal_title：Journal of neuroscience research

authors： Klein RC,Acheson SK,Qadri LH,Dawson AA,Rodriguiz RM,Wetsel WC,Moore SD,Laskowitz DT,Dawson HN

更新日期：2016-06-01 00:00:00

abstract：:Asphyxia during delivery produces long-term deficits in brain development, including hippocampus. We investigated hippocampal plasticity after perinatal asphyxia, measuring postnatal apoptosis and neurogenesis. Asphyxia was performed by immersing rat fetuses with uterine horns removed from ready-to-deliver rats into a...

journal_title：Journal of neuroscience research

authors： Morales P,Fiedler JL,Andrés S,Berrios C,Huaiquín P,Bustamante D,Cardenas S,Parra E,Herrera-Marschitz M

更新日期：2008-09-01 00:00:00

abstract：:The large, medium-sized, and small neurons of the dorsal root ganglion (DRG) have different functions in the processing of various senses. Hyperpolarization-activated, cyclic nucleotide-gated channels (HCN) contribute greatly to neuronal excitability. In the present study, which used whole-cell patch clamp techniques ...

journal_title：Journal of neuroscience research

authors： Tu H,Deng L,Sun Q,Yao L,Han JS,Wan Y

更新日期：2004-06-01 00:00:00

abstract：:The production of collagen-degrading proteases by cultured neonatal rat microglia was examined using an immobilized fibronectin-gelatin matrix coupled to a fluorescent marker and by substrate gel analysis. When microglia were plated onto the surface of the matrix and incubated under resting (nonstimulated) conditions,...

journal_title：Journal of neuroscience research

authors： Colton CA,Keri JE,Chen WT,Monsky WL

更新日期：1993-06-15 00:00:00

abstract：:The expression of gangliosides of the lactosylceramide (LC) and of the gangliotetraosylceramide (GTC) series on the surface of cells from rat embryonic cerebellar tissue was investigated by double-color indirect immunofluorescence. GD3 was assumed to be representative of LC and was detected using a specific monoclonal...

journal_title：Journal of neuroscience research

authors： Gravotta D,Ferreira A,Busciglio J,Caceres A,Landa CA,Maccioni HJ

更新日期：1990-02-01 00:00:00

abstract：:We studied the postischemic alterations of second messenger and receptor systems focusing on the strionigral pathway in order to clarify the mechanism of the delayed neuronal changes in remote areas of the rat brain after transient focal ischemia. Chronological changes of [3H]forskolin and [3H]SCH 23390 binding sites ...

journal_title：Journal of neuroscience research

authors： Nagasawa H,Araki T,Kogure K

更新日期：1992-11-01 00:00:00

abstract：:We have previously shown in rat primary cultured mesencephalic cells that cyanide induces a high level of oxidative stress and necrotic death. To evaluate the mechanism of the cytotoxicity, the effects of cyanide on intracellular glutathione (GSH) pools and inducible nitric oxide synthase (iNOS)-mediated reactive nitr...

journal_title：Journal of neuroscience research

authors： Prabhakaran K,Li L,Borowitz JL,Isom GE

更新日期：2006-10-01 00:00:00

abstract：:Recent advances in human induced pluripotent stem cells (hiPSCs) offer new possibilities for biomedical research and clinical applications. Differentiated neurons from hiPSCs are expected to be useful for developing novel methods of treatment for various neurological diseases. However, the detailed process of function...

journal_title：Journal of neuroscience research

authors： Ohara Y,Koganezawa N,Yamazaki H,Roppongi RT,Sato K,Sekino Y,Shirao T

更新日期：2015-12-01 00:00:00

abstract：:Using a canine model of classical late-infantile neuronal ceroid lipofuscinosis (CLN2 disease), a study was conducted to evaluate the potential pharmacological activity of recombinant human tripeptidyl peptidase-1 (rhTPP1) enzyme replacement therapy administered directly to the cerebrospinal fluid (CSF). CLN2 disease ...

journal_title：Journal of neuroscience research

authors： Katz ML,Coates JR,Sibigtroth CM,Taylor JD,Carpentier M,Young WM,Wininger FA,Kennedy D,Vuillemenot BR,O'Neill CA

更新日期：2014-11-01 00:00:00

abstract：:Neural precursor cells, including neural stem and progenitor cells, in the subventricular zone (SVZ) are the main targets for cytomegalovirus (CMV) infection in developing brains. The neural precursor cells in the SVZ of the adult brain have been reported to respond by proliferating after infusion with epidermal growt...

journal_title：Journal of neuroscience research

authors： Han GP,Li L,Kosugi I,Kawasaki H,Tsuchida T,Miura K,Tsutsui Y

更新日期：2007-10-01 00:00:00

abstract：:CD9 is a tetra-membrane-spanning glycoprotein involved in cell adhesion, migration, and proliferation in both the immune and the immature nervous system. In this study, CD9 expression was detected in myelin of mouse brain, starting at postnatal day 16. The amount of CD9 protein continuously increased with age and pers...

journal_title：Journal of neuroscience research

authors： Kagawa T,Mekada E,Shishido Y,Ikenaka K

更新日期：1997-10-15 00:00:00

abstract：:The role of axons in the expression of the major myelin glycoprotein, P0, has been investigated using neuron/Schwann cell cultures. These cultures were either nonmyelinating or myelinating due to growth in defined medium or in medium containing serum and chick embryo extract, respectively. The neurons and Schwann cell...

journal_title：Journal of neuroscience research

authors： Brunden KR,Windebank AJ,Poduslo JF

更新日期：1990-06-01 00:00:00

abstract：:Cannabinoids bind to two G-protein-coupled receptors, CB1 and CB2, expressed by neurons and cells of the immune system, respectively. Glioma cells (astrocyte-derived brain tumor cells) express cannabinoid receptors, and numerous in vitro and in vivo studies performed in rodents have concluded that apoptosis could be i...

journal_title：Journal of neuroscience research

authors： Widmer M,Hanemann CO,Zajicek J

更新日期：2008-11-01 00:00:00

abstract：:People showing symptoms of attention deficit hyperactivity disorder (ADHD) often present an impairment of reaction time and response inhibition. These executive functions are influenced by nicotinergic acetylcholine receptors (nAchr) as mediators of cholinergic signaling, and show differences between both sexes. We ex...

journal_title：Journal of neuroscience research

authors： Schote AB,A L Sayk C,Pabst K,Meier JK,Frings C,Meyer J

更新日期：2019-02-01 00:00:00

abstract：:Oxidative mechanisms of injury are important in many neurological disorders. Developing oligodendrocytes (pre-OLs) are particularly sensitive to oxidative stress-mediated injury. We previously demonstrated a novel function of phylloquinone (vitamin K(1)) and menaquinone 4 (MK-4; a major form of vitamin K2) in protecti...

journal_title：Journal of neuroscience research

authors： Li J,Wang H,Rosenberg PA

更新日期：2009-07-01 00:00:00

abstract：:The normal innervation of structures in mouse foot pads was investigated with immunohistochemistry and confocal microscopy. Nerves were visualized by incubating Zamboni fixed, thick, frozen sections with antibodies to protein gene product 9.5 (PGP 9.5), vasoactive intestinal peptide, substance P, calcitonin gene-relat...

journal_title：Journal of neuroscience research

authors： Navarro X,Verdú E,Wendelscafer-Crabb G,Kennedy WR

更新日期：1995-05-01 00:00:00

abstract：:Polyglutamine (polyQ) aggregate bodies are a hallmark of dentatorubral-pallidoluysian atrophy and related neurodegenerative disorders, although the relationship between aggregate body formation and cell death is not clear. We analyzed the kinetics of polyQ aggregate formation and the time intervals for cell death, tra...

journal_title：Journal of neuroscience research

authors： Toyoshima I,Sugawara M,Kato K,Wada C,Shimohata T,Koide R,Onodera O,Tsuji S

更新日期：2002-05-15 00:00:00

abstract：:To identify and characterize the lineage potential of rat neural retina progenitor cells (NRPCs) in vitro and engrafted into rats with retinal degeneration, NRPCs were isolated from neural retinas of embryonic day 17 Long Evans rats and cultured in serum-free or serum-containing media with fibroblast growth factor 2 a...

journal_title：Journal of neuroscience research

authors： Yang P,Seiler MJ,Aramant RB,Whittemore SR

更新日期：2002-08-15 00:00:00

abstract：:Astroglial participation in the regional differences of vulnerability to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-induced neurodegeneration was investigated in the rat hippocampus and medial septum using L-alpha-aminoadipate (alpha-AA) as a specific astroglial toxin. alpha-AA was microinjected i...

journal_title：Journal of neuroscience research

authors： Rodríguez MJ,Martínez-Sánchez M,Bernal F,Mahy N

更新日期：2004-08-01 00:00:00

abstract：:Adult neurogenesis is influenced by blood-borne factors. In this context, greater or lesser vascular permeability along neurogenic niches would expose differentially neural stem cells (NSCs), transit amplifying cells (TACs), and neuroblasts to such factors. Here we evaluate endothelial cell morphology and vascular per...

journal_title：Journal of neuroscience research

authors： Colín-Castelán D,Ramírez-Santos J,Gutiérrez-Ospina G

更新日期：2016-02-01 00:00:00

abstract：:The effects of the human immunodeficiency virus type 1 envelope protein gp120 on the release of GABA elicited by N-methyl-D-aspartate (NMDA) from rat hippocampal neurons in primary culture has been investigated. NMDA (1-300 microM) increased in a concentration-dependent manner (EC50 =37.9+/-12 microM) the release of [...

journal_title：Journal of neuroscience research

authors： Fontana G,Valenti L,Raiteri M

更新日期：1997-09-15 00:00:00

abstract：:In cultured Schwann cells, single-channel and whole-cell K+ currents can be activated by depolarizing the membrane to values more negative than -50 mV. In elevated extracellular K+ concentration ([K+]o), however, single-channel activity and whole-cell currents could be recorded at more negative potentials. Thus, the t...

journal_title：Journal of neuroscience research

authors： Verkhratsky A,Hoppe D,Kettenmann H

更新日期：1991-02-01 00:00:00

abstract：:Physiological responses to acute stress proceed with the activation of the hypothalamus-pituitary-adrenal gland (HPA) system. Many brain regions are known to modulate the HPA axis activation in stress responses, but the detailed neural circuits and signaling system in the upstream of the HPA axis have to be explored f...

journal_title：Journal of neuroscience research

authors： Kim KS,Han PL

更新日期：2009-10-01 00:00:00

abstract：:Astroglial cells play an important role in maintaining neuronal function in the adult and in the developing nervous system. Ethanol exposure induces profound alterations in the astrogliogenesis process, affecting important cell functions, including intracellular protein trafficking. Because the actin cytoskeleton play...

journal_title：Journal of neuroscience research

authors： Guasch RM,Tomas M,Miñambres R,Valles S,Renau-Piqueras J,Guerri C

更新日期：2003-05-15 00:00:00

abstract：:Miniature endplate potentials (MEPPs) with slow rising phase can be attributed either to burst of transmitter releases or to distortion of conduction from remote releasing sites. The spontaneous activity of neuromuscular junctions recorded extracellularly at mouse diaphragms using sharp electrodes was analyzed to test...

journal_title：Journal of neuroscience research

authors： Vautrin J,Kriebel ME

更新日期：1992-03-01 00:00:00

abstract：:Data from a study in which 12 chronic mental patients and 12 control subject were given D-[3-14C] glucose intravenously in our arterio-venous technique for determining cerebral metabolism in vivo were reexamined. Previously unpublished whole-blood lactate determinations in these experiments indicated a cerebral produc...

journal_title：Journal of neuroscience research

authors： Sacks W,Schechter DC,Sacks S

更新日期：1981-01-01 00:00:00