Differential vascular permeability along the forebrain ventricular neurogenic niche in the adult murine brain.

abstract：:Although it has been well established that the drug efflux pump P-glycoprotein (P-gp) protects the brain against the entry of cytotoxic drugs, its real in situ localization, i.e., at brain capillary endothelial cells or on astrocyte foot processes, is still controversial. The aim of this study was to compare the expre...

journal_title：Journal of neuroscience research

authors： Declèves X,Regina A,Laplanche JL,Roux F,Boval B,Launay JM,Scherrmann JM

更新日期：2000-06-01 00:00:00

abstract：:Ionotropic N-methyl-D-aspartate (NMDA) receptor agonists, L-aspartic acid (L-Asp) and NMDA, have been shown to inhibit histamine-stimulated acid secretion, but their effect on gastric mucosal blood flow (GMBF) is largely unknown. The aim of this study was to investigate whether L-Asp and NMDA inhibit histamine-stimula...

journal_title：Journal of neuroscience research

authors： Tsai LH,Lee YJ,Wu JY

更新日期：2004-09-01 00:00:00

abstract：:Ferritin is the major iron storage protein and accounts for the majority of the iron in the brain. Thus, ferritin is a key component in protecting the brain from iron induced oxidative damage. The high lipid content, high rate of oxidative metabolism, and high iron content combine to make the brain the organ most susc...

journal_title：Journal of neuroscience research

authors： Connor JR,Boeshore KL,Benkovic SA,Menzies SL

更新日期：1994-03-01 00:00:00

abstract：:Glial and glia-derived cells express a variety of receptors for neurotransmitters and hormones, the majority of which evoke both Ca(2+) release from intracellular stores and Ca(2+) entry across the plasma membrane. We investigated the links between histamine H(1) receptor activation, Ca(2+) release from intracellular ...

journal_title：Journal of neuroscience research

authors： Barajas M,Andrade A,Hernandez-Hernandez O,Felix R,Arias-Montaño JA

更新日期：2008-11-15 00:00:00

abstract：:Cultured rat mesencephalic neurons were used to assess the effects of gamma-aminobutyric acid (GABA) transport blockers on toxicity caused by malonate, a reversible, competitive inhibitor of succinate dehydrogenase. Previous studies utilizing an ex vivo chick retinal preparation have shown that GABA release and cell s...

journal_title：Journal of neuroscience research

authors： Stokes AH,Bernard LP,Nicklas WJ,Zeevalk GD

更新日期：2001-04-01 00:00:00

abstract：:This Review describes the current status of poststroke epilepsy (PSE) with an emphasis on poststroke epileptogenesis modeling for testing new therapeutic agents. Stroke is a leading cause of epilepsy in an aging population. Late-onset "epileptic" seizures have been reported in up to 30% cases after stroke. Nevertheles...

journal_title：Journal of neuroscience research

authors： Reddy DS,Bhimani A,Kuruba R,Park MJ,Sohrabji F

更新日期：2017-04-01 00:00:00

abstract：:Antiglycolipid IgM antibodies are known to induce formation of "wide spaced" or "expanded" myelin, a distinctive form of dysmyelination characterized by a repeat period approximately two or three times normal, which is seen also in diseases, including multiple sclerosis. To determine whether an antibody directed again...

journal_title：Journal of neuroscience research

authors： Rosenbluth J,Schiff R

更新日期：2009-03-01 00:00:00

abstract：:Catecholamine-producing cell types are generated from specified neuronal lineages during vertebrate development. The catecholaminergic phenotype is also expressed transiently in some cell types in non-catecholaminergic tissues, including the sensory ganglia, enteric ganglia, and ventral portions of the neural tube dur...

journal_title：Journal of neuroscience research

authors： Matsushita N,Kobayashi K,Miyazaki J,Kobayashi K

更新日期：2004-10-01 00:00:00

abstract：:In this Mini-Review we present a new hypothesis in support of the neurodegenerative theory as a mechanism for the pathogenesis of multiple sclerosis (MS). The pathogenesis of MS results from changes in two distinct CNS compartments. These are the "myelin" and "nonmyelin" compartments. The myelin compartment is where p...

journal_title：Journal of neuroscience research

authors： Mastronardi FG,Moscarello MA

更新日期：2005-05-01 00:00:00

abstract：:In eukaryotes, mitochondria are critical for cellular bioenergetics and mediating apoptosis. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is an important regulator of mitochondrial biogenesis and function. However, the role of PGC-1alpha in neuronal a...

journal_title：Journal of neuroscience research

authors： Liang J,Yang Y,Zhu X,Wang X,Chen R

更新日期：2010-07-01 00:00:00

abstract：:Nicotinates, pantothenates, riboflavin, vitamins B6 and B12' free (acetyl) and total (free and bound) choline, biopterin, thiamin, biotin, methylated and nonmethylated folates in frontal, temporal, precentral, postcentral, and occipital cortex, thalamus, cerebellum, pons, basal ganglia, and substantia nigra were estim...

journal_title：Journal of neuroscience research

authors： Baker H,Frank O,Chen T,Feingold S,DeAngelis B,Baker E

更新日期：1984-01-01 00:00:00

abstract：:Manganese (Mn) is an essential metal and plays an important role in the brain. To evaluate Mn uptake into the brain during development and aging, 54Mn concentrations in the brain of rats aged from 5 days to 95 weeks were measured after injection of 54MnCl2. 54Mn concentration in the brain of 5-day-old rats was the hig...

journal_title：Journal of neuroscience research

authors： Takeda A,Ishiwatari S,Okada S

更新日期：1999-04-01 00:00:00

abstract：:Numerical synaptic density and synaptic vesicle density in rat frontal cortex were examined by electron microscopy as a function of age. The density of axospinous synapses, a major population of synapses, was found to peak at age 1 month, and to gradually decrease with aging. The synaptic vesicle density in axospinous...

journal_title：Journal of neuroscience research

authors： Nakamura H,Kobayashi S,Ohashi Y,Ando S

更新日期：1999-05-01 00:00:00

abstract：:In rodents, oligodendrocytes and myelinating Schwann cells express connexin32 (Cx32) and Cx29, which have different localizations in the two cell types. We show here that, in contrast to Cx32, Cx29 does not form gap junction plaques or functional gap junctions in transfected cells. Furthermore, when expressed together...

journal_title：Journal of neuroscience research

authors： Ahn M,Lee J,Gustafsson A,Enriquez A,Lancaster E,Sul JY,Haydon PG,Paul DL,Huang Y,Abrams CK,Scherer SS

更新日期：2008-04-01 00:00:00

abstract：:We have examined the expression and distribution of the extracellular matrix molecule tenascin-C in and around lesions of the thoracic dorsal columns in adult rats 3 days to 8 weeks after injury, using in situ hybridization, immunofluorescence, electron microscopy and immunoelectron microscopy. Numerous tenascin-C mRN...

journal_title：Journal of neuroscience research

authors： Zhang Y,Winterbottom JK,Schachner M,Lieberman AR,Anderson PN

更新日期：1997-08-15 00:00:00

abstract：:Mitotic activity persists in various regions of the adult mammal CNS. While evidences of neurogenesis appeared, many studies focused on the features of the adult stem cells from germinative areas such as the subventricular zone of the lateral ventricles, the dentate gyrus of the hippocampus, the cortex, the fourth ven...

journal_title：Journal of neuroscience research

authors： Picard-Riera N,Nait-Oumesmar B,Baron-Van Evercooren A

更新日期：2004-04-15 00:00:00

abstract：:Both the adenosine analogue 2-chloro-adenosine (2-CA) and the reducing sugar deoxy-D-ribose (dRib) induce apoptosis of astroglial cells in rat brain primary cultures (Abbracchio et al.: Biochem Biophys Res Commun 213:908-915, 1995). The present study was undertaken to elucidate by both morphological and cytofluorimetr...

journal_title：Journal of neuroscience research

authors： Ceruti S,Barbieri D,Veronese E,Cattabeni F,Cossarizza A,Giammarioli AM,Malorni W,Franceschi C,Abbracchio MP

更新日期：1997-02-15 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-exposed cats develop severe Parkinsonism that spontaneously resolves in 4-6 weeks. The present study examined the extent to which compensatory changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) gene and protein expression may underlie this behaviora...

journal_title：Journal of neuroscience research

authors： Rothblat DS,Schroeder JA,Schneider JS

更新日期：2001-08-01 00:00:00

abstract：:We generated a new cell line, N38, by conditionally immortalizing mouse oligodendrocytes (OLs) at early stages of maturation. The morphology and marker expression pattern suggest N38 cells are similar to immature OLs. N38 cells were sensitive to changes in serum concentrations, and forcing the cells to differentiate i...

journal_title：Journal of neuroscience research

authors： Bongarzone ER,Byravan S,Givogri MI,Schonmann V,Campagnoni AT

更新日期：2000-11-01 00:00:00

abstract：:Using morphological, immunocytochemical, and functional parameters we have previously shown that highly purified adult rat microglial cells undergo a process of "activation" when cultured in a serum-containing medium in the absence of added proinflammatory substances or other factors (Slepko and Levi: Glia 16:241-246,...

journal_title：Journal of neuroscience research

authors： Slepko N,Minghetti L,Polazzi E,Nicolini A,Levi G

更新日期：1997-08-01 00:00:00

abstract：:Damage to the lateral nucleus of the septum in the rat resulted in atypical learning to a previously meaningless stimulus. Nonreinforced preexposure to a stimulus normally makes more difficult subsequent use of that stimulus for learning. The effect of this preexposure on learning is termed latent inhibition and was d...

journal_title：Journal of neuroscience research

authors： Toga AW,Burton HA

更新日期：1979-01-01 00:00:00

abstract：:The neonatal lesion with 6-hydroxydopamine (6-OHDA) in rodents induces juvenile hyperactivity and paradoxical hypolocomotor response to psychostimulants, in striking contrast to what is observed when similar lesions are carried out in adults. The early disruption of central dopaminergic pathways is followed by increas...

journal_title：Journal of neuroscience research

authors： Avale ME,Nemirovsky SI,Raisman-Vozari R,Rubinstein M

更新日期：2004-10-15 00:00:00

abstract：:Given the ubiquitous nature of opioids in the treatment of pain, it is an interesting paradox that this class of medications also represents one of the least understood components of clinical pain medicine. For many years, there has been intense interest in the mechanisms of opioid activity, but this has not resulted ...

journal_title：Journal of neuroscience research

authors： Montgomery LS

更新日期：2020-08-07 00:00:00

abstract：:Ischemia elicits a variety of stress responses in neuronal cells, which result in cell death. wld(S) Mice bear a mutation that significantly delays Wallerian degeneration. This mutation also protects all neuronal cells against other types of stresses resulting in cell death, including ischemia. To clarify the types of...

journal_title：Journal of neuroscience research

authors： Tokunaga S,Araki T

更新日期：2012-03-01 00:00:00

abstract：:We studied the electrophysiological, hemodynamic, and cytomorphological consequences of microhemorrhagic brain injury induced by a nanoscale iron injection. Of particular interest were the etiology, development, and treatment of epilepsy associated with this injury. We developed an animal model of chronic epilepsy usi...

journal_title：Journal of neuroscience research

authors： Jo A,Heo C,Schwartz TH,Suh M

更新日期：2014-03-01 00:00:00

abstract：:Fibroblast growth factor 2 (FGF2) exhibits pleiotropic functions during embryogenesis. In neural development, both pro- and antineurogenic activities of FGF2 have been described in the differentiation of neuronal progenitors into postmitotic neurons. We used cultured neural stem cells (NSCs) derived from rat embryonic...

journal_title：Journal of neuroscience research

authors： Tsai RY,Kim S

更新日期：2005-10-15 00:00:00

abstract：:Neurofibromatosis type 2 is a hereditary cancer syndrome characterized by the development of bilateral vestibular schwannomas. Underlying the disease are inactivating mutations of the NF2 tumor suppressor gene, located on chromosome 22, encoding a 595-amino-acid protein. The NF2 protein, also known as merlin or schwan...

journal_title：Journal of neuroscience research

authors： den Bakker MA,Riegman PH,Suurmeijer AP,Vissers CJ,Sainio M,Carpen O,Zwarthoff EC

更新日期：2000-12-15 00:00:00

abstract：:Asphyxia during delivery produces long-term deficits in brain development, including hippocampus. We investigated hippocampal plasticity after perinatal asphyxia, measuring postnatal apoptosis and neurogenesis. Asphyxia was performed by immersing rat fetuses with uterine horns removed from ready-to-deliver rats into a...

journal_title：Journal of neuroscience research

authors： Morales P,Fiedler JL,Andrés S,Berrios C,Huaiquín P,Bustamante D,Cardenas S,Parra E,Herrera-Marschitz M

更新日期：2008-09-01 00:00:00

abstract：:Grafting fetal ventral mesencephalon has been utilized to alleviate the symptoms of Parkinson's disease. One obstacle in using this approach is the limited outgrowth from the transplanted dopamine neurons. Thus, it is important to evaluate factors that promote outgrowth from fetal dopamine neurons. Proteoglycans (PGs)...

journal_title：Journal of neuroscience research

authors： Berglöf E,Plantman S,Johansson S,Strömberg I

更新日期：2008-01-01 00:00:00

abstract：:Transient global ischemia causes delayed white matter injury to the brain with oligodendrocyte (OLG) death and myelin breakdown. There is increasing evidence that hypoxia may be involved in several diseases of the white matter, including multiple sclerosis, vascular dementia, and ischemia. Matrix metalloproteinases (M...

journal_title：Journal of neuroscience research

authors： Walker EJ,Rosenberg GA

更新日期：2010-03-01 00:00:00