Endogenous adult neural stem cells: limits and potential to repair the injured central nervous system.

abstract：:Apolipoprotein E (apo-E), a protein involved in lipid metabolism and cholesterol transport, has been found to be up-regulated in CNS injury and is associated with Alzheimer's disease in humans. In this study, we show that apo-E is also up-regulated after complete spinal cord transection in the C57BL/6 mouse. In the un...

journal_title：Journal of neuroscience research

authors： Seitz A,Kragol M,Aglow E,Showe L,Heber-Katz E

更新日期：2003-02-01 00:00:00

abstract：:Thymocyte differentiation antigen-1 (Thy-1) is a cell surface glycoprotein found on T cells and neurons and is involved in cell-to-cell interactions. In addition, Thy-1 knockouts (KO) are a potential mouse model of restless legs syndrome (RLS) based on clinical observations and the role of dopamine in the disease. In ...

journal_title：Journal of neuroscience research

authors： Carkaci-Salli N,Battula S,Wang X,Connor JR,Vrana KE

更新日期：2012-08-01 00:00:00

abstract：:The iron transport protein, transferrin, and the iron storage protein ferritin were examined immunohistochemically along with iron in a number of brain regions from normal and aged humans. Two age groups were examined: a middle-aged group (28-49 years), and an older group (60-90 years). Transferrin, ferritin, and iron...

journal_title：Journal of neuroscience research

authors： Connor JR,Menzies SL,St Martin SM,Mufson EJ

更新日期：1990-12-01 00:00:00

abstract：:Primary brain tumors, particularly glioblastomas (GB), remain a challenge for oncology. An element of the malignant brain tumors' aggressive behavior is the fact that GB are among the most densely vascularized tumors. To determine some of the molecular regulations occuring at the brain tumor endothelium level during t...

journal_title：Journal of neuroscience research

authors： Régina A,Jodoin J,Khoueir P,Rolland Y,Berthelet F,Moumdjian R,Fenart L,Cecchelli R,Demeule M,Béliveau R

更新日期：2004-01-15 00:00:00

abstract：:A number of cytokines and growth factors may affect astrocyte proliferation and functions. Transforming growth factor-beta 1 (TGF-beta 1) is a pleiotropic cytokine which exerts multiple effects on growth and differentiation of different cell types. TGF-beta 1 is present in low amounts in the normal brain. TGF-beta 1 g...

journal_title：Journal of neuroscience research

authors： Vergeli M,mazzanti B,Ballerini C,Gran B,Amaducci L,Massacesi L

更新日期：1995-01-01 00:00:00

abstract：:Grafting fetal ventral mesencephalon has been utilized to alleviate the symptoms of Parkinson's disease. One obstacle in using this approach is the limited outgrowth from the transplanted dopamine neurons. Thus, it is important to evaluate factors that promote outgrowth from fetal dopamine neurons. Proteoglycans (PGs)...

journal_title：Journal of neuroscience research

authors： Berglöf E,Plantman S,Johansson S,Strömberg I

更新日期：2008-01-01 00:00:00

abstract：:We review three principally different forms of injury-induced synaptic alterations. (1) Displacement of presynaptic terminals from perikarya and dendrites of axotomized neurons, (2) central changes in primary afferent terminals of peripherally axotomized sensory ganglion cells, and (3) anterograde Wallerian-type degen...

journal_title：Journal of neuroscience research

authors： Aldskogius H,Liu L,Svensson M

更新日期：1999-10-01 00:00:00

abstract：:Tungstate treatment increases the phosphorylation of glycogen synthase kinase-3beta (GSK3beta) at serine 9, which triggers its inactivation both in cultured neural cells and in vivo. GSK3 phosphorylation is dependent on the activation of extracellular signal-regulated kinases 1/2 (ERK1/2) induced by tungstate. As a co...

journal_title：Journal of neuroscience research

authors： Gómez-Ramos A,Domínguez J,Zafra D,Corominola H,Gomis R,Guinovart JJ,Avila J

更新日期：2006-02-01 00:00:00

abstract：:The cellular localization of calpain is important in understanding the roles that calpain may play in physiological function. We, therefore, examined calpain expression, activity, and immunofluorescent localization in primary cultures of rat oligodendrocytes. The mRNA expression of m-calpain was 64.8% (P = 0.0033) and...

journal_title：Journal of neuroscience research

authors： Ray SK,Neuberger TJ,Deadwyler G,Wilford G,DeVries GH,Banik NL

更新日期：2002-11-15 00:00:00

abstract：:The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act as a miRNA sponge to repress miRNA function, participate in splicing of target genes, translate genes into protein and interact with RNA bindi...

journal_title：Journal of neuroscience research

authors： Zang J,Lu D,Xu A

更新日期：2020-01-01 00:00:00

abstract：:We sought to establish a mouse model of subcortical ischemic vascular dementia (SIVD) that develops predominant white matter (WM) injury and cognitive dysfunction induced by chronic cerebral hypoperfusion. Adult C57Bl/6 male (n = 48) mice were subjected to bilateral common carotid artery stenosis with external microco...

journal_title：Journal of neuroscience research

authors： Miki K,Ishibashi S,Sun L,Xu H,Ohashi W,Kuroiwa T,Mizusawa H

更新日期：2009-04-01 00:00:00

abstract：:Parkinson's disease (PD) is the most common movement disorder associated with the elderly which, other than symptomatic therapies, has no effective treatment or preventive measures. Sirtuins and their pharmacological activators/inhibitors have been associated with a range of neuroprotective effects, and a large body o...

journal_title：Journal of neuroscience research

authors： Tang BL

更新日期：2017-04-01 00:00:00

abstract：:Fractionation of muscle microsomes rich in sarcoplasmic reticulum (SR) by isopicnic centrifugation yielded three types of membranes. Heavy (HM), intermediate (IM), and light membranes (LM), with isopicnic points of 38, 33, and 25% w/w sucrose, were rich in terminal cisternae/triads, longitudinal SR, and T-tubules, res...

journal_title：Journal of neuroscience research

authors： Campoy FJ,Cabezas-Herrera J,Vidal CJ

更新日期：1992-12-01 00:00:00

abstract：:A-type K+ channels (IA channels) contribute to learning and memory mechanisms by regulating neuronal excitabilities in the CNS, and their expression level is targeted by Ca2+ influx via synaptic NMDA receptors (NMDARs) during long-term potentiation (LTP). However, it is not clear how local synaptic Ca2+ changes induce...

journal_title：Journal of neuroscience research

authors： Yang YS,Jeon SC,Kang MS,Kim SH,Eun SY,Jin SH,Jung SC

更新日期：2017-12-01 00:00:00

abstract：:Mannitol, which is a cell-impermeable and nontoxic polyalcohol, has been shown to be a useful tool for reversible opening of the blood-brain barrier (BBB). Despite successful clinical trials, the molecular mechanism of the mannitol-induced changes in cerebral endothelial cells (CECs) are poorly understood. For our exp...

journal_title：Journal of neuroscience research

authors： Farkas A,Szatmári E,Orbók A,Wilhelm I,Wejksza K,Nagyoszi P,Hutamekalin P,Bauer H,Bauer HC,Traweger A,Krizbai IA

更新日期：2005-06-15 00:00:00

abstract：:The neonatal lesion with 6-hydroxydopamine (6-OHDA) in rodents induces juvenile hyperactivity and paradoxical hypolocomotor response to psychostimulants, in striking contrast to what is observed when similar lesions are carried out in adults. The early disruption of central dopaminergic pathways is followed by increas...

journal_title：Journal of neuroscience research

authors： Avale ME,Nemirovsky SI,Raisman-Vozari R,Rubinstein M

更新日期：2004-10-15 00:00:00

abstract：:Neuronal pathology of the brain with Alzheimer's disease (AD) is characterized by numerous depositions of amyloid-beta peptides (Abeta). Abeta binding to the 75-kDa neurotrophin receptor (p75NTR) causes neuronal cell death. Here we report that Abeta causes cell death in neuronal hybrid cells transfected with p75NTR, b...

journal_title：Journal of neuroscience research

authors： Tsukamoto E,Hashimoto Y,Kanekura K,Niikura T,Aiso S,Nishimoto I

更新日期：2003-09-01 00:00:00

abstract：:A series of major and minor ganglioside species were isolated from a single human adult brain and analyzed for their lipophilic composition. Hematosides, GM3 and GD3, each showing double bands on thin-layer chromatograms, were separated into the upper band and lower band fractions to be analyzed for the heterogeneity ...

journal_title：Journal of neuroscience research

authors： Ando S,Yu RK

更新日期：1984-01-01 00:00:00

abstract：:We previously demonstrated that a synthetic retinoic acid receptor agonist, Am80, attenuated intracerebral hemorrhage (ICH)-induced neuropathological changes and neurological dysfunction. Because inflammatory events are among the prominent features of ICH pathology that are affected by Am80, this study investigated th...

journal_title：Journal of neuroscience research

authors： Matsushita H,Hijioka M,Ishibashi H,Anan J,Kurauchi Y,Hisatsune A,Seki T,Shudo K,Katsuki H

更新日期：2014-08-01 00:00:00

abstract：:Iron deficiency and chronic mild carbon monoxide (CO) exposure are nutritional and environmental problems that can be experienced simultaneously. We examined the effects of chronic mild CO exposure and iron availability on auditory development in the rat. We propose that chronic mild CO exposure creates an oxidative s...

journal_title：Journal of neuroscience research

authors： Webber DS,Lopez I,Korsak RA,Hirota S,Acuna D,Edmond J

更新日期：2005-06-01 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), is a demyelinating autoimmune disease of the central nervous system (CNS). The proinflammatory cytokine TNF alpha, as an endogenous mediator of inflammation, plays an important role in the pathogenesis of EAE disease. In this s...

journal_title：Journal of neuroscience research

authors： Villarroya H,Marie Y,Ouallet JC,Le Saux F,Tchélingérian JL,Baumann N

更新日期：1997-09-01 00:00:00

abstract：:Treatment of chromaffin cells with nitric oxide (NO) donors (SNP and SNAP) and peroxynitrite produces a time- and dose-dependent necrotic and apoptotic cell death. Necrotic cell death was characterized by both an increase in lactate dehydrogenase and ATP release and changes in nuclei and cell morphology (as seen with ...

journal_title：Journal of neuroscience research

authors： Vicente S,Pérez-Rodríguez R,Oliván AM,Martínez Palacián A,González MP,Oset-Gasque MJ

更新日期：2006-07-01 00:00:00

abstract：:L-deprenyl protects neurons in a number of in vivo and in vitro models and it has been postulated that it ameliorates some neurodegenerative disorders. Superoxide dismutase (SOD) is one of the enzymes responsible for the inactivation of oxygen free radicals, and one of the mechanisms of the effect of L-deprenyl is tho...

journal_title：Journal of neuroscience research

authors： Li XM,Juorio AV,Qi J,Boulton AA

更新日期：1998-07-15 00:00:00

abstract：:The effects of bilateral lesions of the ventral noradrenergic bundle (VNA) were studied in male rats. In contrast to data reported by others, hyperphagia and obesity were not observed following VNA lesions. Indeed, except for a depression during the first three postoperative days, food intake (FI) of the VNA lesioned ...

journal_title：Journal of neuroscience research

authors： Bellinger LL,Bernardis LL,Goldman JK

更新日期：1976-01-01 00:00:00

abstract：:Green fluorescent protein (GFP) transgenic zebrafish technology has been employed to directly visualize and analyze dynamic developmental processes, such as cell migration and morphogenesis. Stable transgenic zebrafish that express GFP in oligodendrocytes can be a valuable tool to visualize complex myelination process...

journal_title：Journal of neuroscience research

authors： Yoshida M,Macklin WB

更新日期：2005-07-01 00:00:00

abstract：:In offspring, an adequate maternal diet is important for neurodevelopment. One mechanism by which maternal diet impacts neurodevelopment is through its dynamic role in the development of the gut microbiota. Communication between the gut, and its associated microbiota, and the brain is facilitated by the vagus nerve, i...

journal_title：Journal of neuroscience research

authors： Al Rubaye H,Adamson CC,Jadavji NM

更新日期：2021-01-01 00:00:00

abstract：:Lead is putatively regarded as an environmental neurotoxicant. Long-term low-level lead exposure causes cognitive deficits, but the mechanism remains to be elucidated. In the present study, the excitatory effects of low-level lead exposure on action potential (AP) firing of pyramidal neurons in CA1 region of rat hippo...

journal_title：Journal of neuroscience research

authors： Yan D,Xiao C,Ma FL,Wang L,Luo YY,Liu J,Wang HL,Chen JT,Ruan DY

更新日期：2008-12-01 00:00:00

abstract：:Ionotropic N-methyl-D-aspartate (NMDA) receptor agonists, L-aspartic acid (L-Asp) and NMDA, have been shown to inhibit histamine-stimulated acid secretion, but their effect on gastric mucosal blood flow (GMBF) is largely unknown. The aim of this study was to investigate whether L-Asp and NMDA inhibit histamine-stimula...

journal_title：Journal of neuroscience research

authors： Tsai LH,Lee YJ,Wu JY

更新日期：2004-09-01 00:00:00

abstract：:The Oct-2 transcription factor has a predominantly inhibitory effect on gene expression in neuronal cell lines. This factor and its corresponding mRNA have previously been shown to be elevated in adult rat dorsal root ganglion (DRG) neurons chronically exposed to nerve growth factor (NGF). Here we show that the Oct-2 ...

journal_title：Journal of neuroscience research

authors： Kendall G,Brar-Rai A,Ensor E,Winter J,Wood JN,Latchman DS

更新日期：1995-02-01 00:00:00

abstract：:The expression of gangliosides of the lactosylceramide (LC) and of the gangliotetraosylceramide (GTC) series on the surface of cells from rat embryonic cerebellar tissue was investigated by double-color indirect immunofluorescence. GD3 was assumed to be representative of LC and was detected using a specific monoclonal...

journal_title：Journal of neuroscience research

authors： Gravotta D,Ferreira A,Busciglio J,Caceres A,Landa CA,Maccioni HJ

更新日期：1990-02-01 00:00:00