Nerve growth factor induces the Oct-2 transcription factor in sensory neurons with the kinetics of an immediate-early gene.

abstract：:Although protein kinase Cdk5-p35 is important in many aspects of the development and function of the central nervous system, relatively little is known about its regulation. In the present study, we examined the relationship between the association of this kinase with membranes and its activity in perinatal and adult ...

journal_title：Journal of neuroscience research

authors： Sato K,Zhu YS,Saito T,Yotsumoto K,Asada A,Hasegawa M,Hisanaga S

更新日期：2007-11-01 00:00:00

abstract：:The rationale for designing and synthesizing 24 different peptide analogs and subpeptides of residues 69-84 of guinea pig myelin basic protein is presented. The encephalitogenic potential of 19 of these peptides in Lewis rats is also given. ...

journal_title：Journal of neuroscience research

authors： Hashim GA,Day ED

更新日期：1987-01-01 00:00:00

abstract：:Calcium/calmodulin-dependent serine kinase (CASK), a causative gene in X-linked mental retardation, carries out multiple functions in neurons, including vesicle trafficking of ion channels, synapse formation, and gene transcription. From a yeast two-hybrid screen, Krüppel-like zinc finger protein B cell lymphoma/COUP-...

journal_title：Journal of neuroscience research

authors： Kuo TY,Hong CJ,Chien HL,Hsueh YP

更新日期：2010-08-15 00:00:00

abstract：:Nerve growth factor (NGF)-specific signal transduction leads to changes in protein methylation during neuronal differentiation of PC12 cells (Cimato et al. [1997] J. Cell Biol. 138:1089-1103). In the present work, we demonstrate that, among NGF-regulated proteins, arginine methylation is more prevalent than carboxylme...

journal_title：Journal of neuroscience research

authors： Cimato TR,Tang J,Xu Y,Guarnaccia C,Herschman HR,Pongor S,Aletta JM

更新日期：2002-02-15 00:00:00

abstract：:Ferritin is the major iron storage protein and accounts for the majority of the iron in the brain. Thus, ferritin is a key component in protecting the brain from iron induced oxidative damage. The high lipid content, high rate of oxidative metabolism, and high iron content combine to make the brain the organ most susc...

journal_title：Journal of neuroscience research

authors： Connor JR,Boeshore KL,Benkovic SA,Menzies SL

更新日期：1994-03-01 00:00:00

abstract：:A frontal pole cDNA library from monkey (Macaca mulatta) brain was screened to identify mRNAs that are expressed more in frontal pole as compared to primary visual cortex. Three cDNA clones, whose greater expression was confirmed by Northern blot analysis, were identified as cytochrome oxidase (COX) subunits I, II, an...

journal_title：Journal of neuroscience research

authors： Chandrasekaran K,Stoll J,Giordano T,Atack JR,Matocha MF,Brady DR,Rapoport SI

更新日期：1992-07-01 00:00:00

abstract：:Embryonic central nervous system neuroepithelial cells are a transient population of cells that give rise to neuronal and glial progenitors. In the E12-E16 embryonic rat spinal neural tube we have identified neuroepithelial cells as radially oriented cells expressing the GD3 ganglioside as recognized by the monoclonal...

journal_title：Journal of neuroscience research

authors： Bannerman PG,Oliver TM,Xu Z,Shieh A,Pleasure DE

更新日期：1996-09-01 00:00:00

abstract：:As the main input structure of the basal ganglia (BG), the striatum collects and integrates information from several brain areas and funnels them forward to other BG nuclei. The striatal projection neurons are medium-sized spiny neurons classified in two main subpopulations, based on their neurochemical characterizati...

journal_title：Journal of neuroscience research

authors： Ciriachi C,Svane-Petersen D,Rickhag M

更新日期：2019-10-01 00:00:00

abstract：:Anoxia during delivery is a complication that can disturb infant brain development leading to various types of neurological disorders. Our studies have shown that increased body temperature of newborn rats of both sexes intensifies the postanoxic oxidative stress and prevents triggering the endogenous adaptive respons...

journal_title：Journal of neuroscience research

authors： Kletkiewicz H,Maliszewska J,Jaworski K,Jermacz Ł,Smoliński DJ,Rogalska J

更新日期：2019-10-01 00:00:00

abstract：:Several neuronal and non-neuronal cell lines express a Ca(2+)-dependent mechanism of transmitter release that can be demonstrated after loading the cells with acetylcholine during culture. In contrast, a particular cell line, the neuroblastoma N18TG-2, was found to be deficient for release. We transfected N18TG-2 cell...

journal_title：Journal of neuroscience research

authors： Falk-Vairant J,Meunier FM,Lesbats B,Corrèges P,Eder-Colli L,Salem N,Synguelakis M,Dunant Y,Israël M

更新日期：1996-08-01 00:00:00

abstract：:The multifactorial nature of traumatic brain injury (TBI), especially the complex secondary tissue injury involving intertwined networks of molecular pathways that mediate cellular behavior, has confounded attempts to elucidate the pathology underlying the progression of TBI. Here, systems biology strategies are explo...

journal_title：Journal of neuroscience research

authors： Yu C,Boutté A,Yu X,Dutta B,Feala JD,Schmid K,Dave J,Tawa GJ,Wallqvist A,Reifman J

更新日期：2015-02-01 00:00:00

abstract：:We describe here the presence of ubiquitin and its conjugation system in the rat retina. Retinal homogenates and supernatants conjugate [125I]human ubiquitin with either endogenous or exogenous proteins. The conjugating activity is relatively stable over time, requires ATP, and has a pH optimum of approximately 8. The...

journal_title：Journal of neuroscience research

authors： Naash M,Izbicka E,Anderson RE

更新日期：1991-10-01 00:00:00

abstract：:Nerve growth factor (NGF) is the best-characterized neurotrophic substance and has recently been shown to influence cholinergic neurons in the basal forebrain. Hippocampus and neocortex, the primary targets for these central neurons, have further been found to contain high levels of NGF. Using enzyme immunoassay and a...

journal_title：Journal of neuroscience research

authors： Lärkfors L,Strömberg I,Ebendal T,Olson L

更新日期：1987-01-01 00:00:00

abstract：:Acrylamide (ACR) is an environmental toxicant and prototypic tool for studying mechanisms of peripheral neuropathies. Reductions in fast anterograde axonal transport (faAXT) are thought to be a critical step leading to axonal degeneration. Kinesin and microtubules (MT) were evaluated as molecular sites of action using...

journal_title：Journal of neuroscience research

authors： Sickles DW,Brady ST,Testino A,Friedman MA,Wrenn RW

更新日期：1996-10-01 00:00:00

abstract：:Structure and dimension of the dendritic arbor are important determinants of information processing by the nerve cell, but mechanisms and molecules involved in dendritic growth are essentially unknown. We investigated early mechanisms of dendritic growth using mouse fetal hippocampal neurons in primary culture, which ...

journal_title：Journal of neuroscience research

authors： Grosse G,Grosse J,Tapp R,Kuchinke J,Gorsleben M,Fetter I,Höhne-Zell B,Gratzl M,Bergmann M

更新日期：1999-06-01 00:00:00

abstract：:The higher prevalence and risk for Alzheimer's disease in women relative to men has been partially attributed to the precipitous decline in gonadal hormone levels that occurs in women following the menopause. Although considerable attention has been focused on the consequence of estrogen loss, and thus estrogen's neur...

journal_title：Journal of neuroscience research

authors： Kaur P,Jodhka PK,Underwood WA,Bowles CA,de Fiebre NC,de Fiebre CM,Singh M

更新日期：2007-08-15 00:00:00

abstract：:Oligodendrocyte-specific protein (OSP/claudin-11) is a major component of CNS myelin and has been recently added to the claudin family of tight junction proteins. In this study, the developmental expression of OSP/claudin-11 was determined using in situ hybridization, immunohistochemistry (IH), and Western blot analys...

journal_title：Journal of neuroscience research

authors： Bronstein JM,Chen K,Tiwari-Woodruff S,Kornblum HI

更新日期：2000-05-01 00:00:00

abstract：:We have studied the interaction between several growth factors to promote parasympathetic neuronal survival. Neither insulin nor insulin-like growth factor-I (IGF-I) had any effect on the survival of embryonic day 8 chick ciliary neurons in culture. Similarly, the protein kinase C activator phorbol dibutyrate (PdBu) h...

journal_title：Journal of neuroscience research

authors： Crouch MF,Hendry IA

更新日期：1991-01-01 00:00:00

abstract：:The chronic constriction injury (CCI) of the sciatic nerve is a nerve injury-based model of neuropathic pain (NP). Comorbidities of NP such as depression, anxiety, and cognitive deficits are associated with a functional reorganization of the medial prefrontal cortex (mPFC). Here, we have employed an adapted model of C...

journal_title：Journal of neuroscience research

authors： Medeiros P,de Freitas RL,Boccella S,Iannotta M,Belardo C,Mazzitelli M,Romano R,De Gregorio D,Coimbra NC,Palazzo E,Maione S

更新日期：2020-02-01 00:00:00

abstract：:Preterm birth and associated brain injury are the primary cause of cerebral palsy and developmental disabilities and are among the most serious global health issues that modern society faces. Current therapy for infants suffering from premature brain injury is still mainly supportive, and there are no effective treatm...

journal_title：Journal of neuroscience research

authors： Peng X,Song J,Li B,Zhu C,Wang X

更新日期：2020-05-01 00:00:00

abstract：:HAND2 (also known as dHAND) is a basic helix-loop-helix (bHLH) transcription factor essential for development of the heart, limbs, and neural crest-derived lineages. HAND2 expression is observed in a number of tissues derived from the neural crest, including components of the peripheral nervous system, where it has be...

journal_title：Journal of neuroscience research

authors： Dai YS,Hao J,Bonin C,Morikawa Y,Cserjesi P

更新日期：2004-06-01 00:00:00

abstract：:In offspring, an adequate maternal diet is important for neurodevelopment. One mechanism by which maternal diet impacts neurodevelopment is through its dynamic role in the development of the gut microbiota. Communication between the gut, and its associated microbiota, and the brain is facilitated by the vagus nerve, i...

journal_title：Journal of neuroscience research

authors： Al Rubaye H,Adamson CC,Jadavji NM

更新日期：2021-01-01 00:00:00

abstract：:Sky (also known as "Tyro3" and "Rse") is a member of the Axl/Sky/Mer receptor tyrosine kinase family and has two immunoglobulin-like repeats and two fibronectin type III-like repeats in the extracellular domain. Gas6 is a ligand for all members of the Axl family, each of which (Axl, Sky, and c-Mer) has different affin...

journal_title：Journal of neuroscience research

authors： Funakoshi H,Yonemasu T,Nakano T,Matumoto K,Nakamura T

更新日期：2002-04-15 00:00:00

abstract：:It is believed that the impact of stress on interleukin-1β (IL-1β) depends on the ontogenetic age. This study examines the influence of acute or chronic exposure to forced-swim (FS) stress or high-light open-field (HL-OF) stimulation on the expression of IL-1β. Double immunofluorescence staining was used to reveal the...

journal_title：Journal of neuroscience research

authors： Badowska-Szalewska E,Ludkiewicz B,Spodnik JH,Moryś J

更新日期：2014-11-01 00:00:00

abstract：:Increase of intracellular [Ca(2+)] evoked by action potentials in a cell can induce long-term synaptic plasticity even without concomitant presynaptic stimulation. We used optical recording of the fluorescence of a Ca(2+)-indicator Oregon Green to investigate whether differences in results obtained with modifications ...

journal_title：Journal of neuroscience research

authors： Balaban P,Chistiakova M,Malyshev A,Volgushev M

更新日期：2004-05-15 00:00:00

abstract：:The striatum plays an important role in learning, selecting, and executing actions. As a major input hub of the basal ganglia, it receives and processes a diverse array of signals related to sensory, motor, and cognitive information. Aberrant neural activity in this area is implicated in a wide variety of neurological...

journal_title：Journal of neuroscience research

authors： Lee K,Masmanidis SC

更新日期：2019-12-01 00:00:00

abstract：:Adenosine signalling has an important role in cochlear protection from oxidative stress. In most tissues, intracellular adenosine kinase (ADK) is the primary route of adenosine metabolism and the key regulator of intracellular and extracellular adenosine levels. The present study provides the first evidence for ADK di...

journal_title：Journal of neuroscience research

authors： Vlajkovic SM,Guo CX,Dharmawardana N,Wong AC,Boison D,Housley GD,Thorne PR

更新日期：2010-09-01 00:00:00

abstract：:Relationships among different intensities of electroshock treatment (EST), EEG-recordable primary after discharge (PAD), and beta-adrenergic binding in various brain regions were investigated in adult rats. Different intensities of EST (1-2, 6-8, 20-30 mamp) were applied through ear-clip electrodes for 7 consecutive d...

journal_title：Journal of neuroscience research

authors： Perumal AS,Barkai AI

更新日期：1982-01-01 00:00:00

abstract：:Recent studies have indicated that embryonic stem cells (ESCs) can be a source for the replacement of spiral ganglion neurons (SGNs), auditory primary neurons, and neurite projections from ESC-derived neurons to auditory sensory epithelia. However, the potential of ESC-derived neurons for synapse formation with audito...

journal_title：Journal of neuroscience research

authors： Matsumoto M,Nakagawa T,Kojima K,Sakamoto T,Fujiyama F,Ito J

更新日期：2008-11-01 00:00:00

abstract：:Neurotrophic factors regulate the developmental survival and differentiation of specific neuronal populations. Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are members of the nerve growth factor (NGF) protein family, also known as the neurotrophins. Insights into the different roles of neurotroph...

journal_title：Journal of neuroscience research

authors： Escandón E,Burton LE,Szönyi E,Nikolics K

更新日期：1993-04-15 00:00:00