Abstract:
:Ischemia elicits a variety of stress responses in neuronal cells, which result in cell death. wld(S) Mice bear a mutation that significantly delays Wallerian degeneration. This mutation also protects all neuronal cells against other types of stresses resulting in cell death, including ischemia. To clarify the types of stresses that neuronal cell bodies derived from wld(S) mice are protected from, we exposed primary cultured neurons derived from wld(S) mice to various components of hypoxic stress. We found that wld(S) mouse neurons are protected against cellular injury induced by reoxygenation following hypoxic stress. Furthermore, we found that wld(S) mouse neurons are protected against functional impairment of the mitochondrial electron transport chain. These data suggest that Wld(S) protein expression may provide protection against neuronal cell death caused by mechanisms involving mitochondrial electron transport dysfunction.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Tokunaga S,Araki Tdoi
10.1002/jnr.22792subject
Has Abstractpub_date
2012-03-01 00:00:00pages
664-71issue
3eissn
0360-4012issn
1097-4547journal_volume
90pub_type
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