Abstract:
:Immature and mature rat astroglia in culture were assayed for glutamine synthetase (GS) activity after a single exposure to the epileptogen FeCl2. Cells were cultured with both standard and elevated extracellular potassium or glutamate (Glu) concentrations. FeCl2 reduced GS activity below control levels, whereas high Glu increased GS activity. However, stimulation by high Glu was significantly attenuated in cultures given both FeCl2 and high Glu, indicating that cells treated with FeCl2 were not able to respond as effectively to increased extracellular glutamate by increasing their GS activity. The significance of these findings is that glial regulation of the neuronal environment may be impaired, based on the proposed importance of GS in ammonia detoxification in the brain.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Tiffany-Castiglioni E,Roberts JA,Sheeler-Gough LVdoi
10.1002/jnr.490240408subject
Has Abstractpub_date
1989-12-01 00:00:00pages
508-16issue
4eissn
0360-4012issn
1097-4547journal_volume
24pub_type
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