Abstract:
:Oxidative stress, neuroinflammation, and excitotoxicity are frequently considered distinct but common hallmarks of several neurological disorders, including Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and Alzheimer's disease. Although neuron degeneration and death are the ultimate consequences of these pathological processes, it is now widely accepted that alterations in the function of surrounding glial cells are key features in the progression of these diseases. In response to alteration in their local environment, microglia, commonly considered the resident immune cells of the nervous parenchyma, become activated and release a variety of soluble factors. Among these, proinflammatory cytokines and free radicals actively participate in the degenerative insults. In addition, excitotoxic neuronal damage resulting from excessive glutamate is frequently associated with impaired handling of extracellular glutamate by gliotic astrocytes. Although several research projects have focused on the biochemical mechanisms of the regulation of glial glutamate transporters, a relationship between activation of microglia and modulation of astrocytic glutamate uptake is now suggested. The aim of this review is to summarize and discuss the data showing an influence of inflammatory mediators and related free radicals on the expression and activity of glial glutamate transporters.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Tilleux S,Hermans Edoi
10.1002/jnr.21325subject
Has Abstractpub_date
2007-08-01 00:00:00pages
2059-70issue
10eissn
0360-4012issn
1097-4547journal_volume
85pub_type
杂志文章,评审abstract::Synaptic circuitry in the upper dorsal horn, disorganized due to transganglionic degenerative atrophy (evoked by blockade of retrograde axoplasmic transport in the related peripheral nerve), begins to be reestablished by a process of regenerative synaptoneogenesis as soon as retrograde transport is resumed. Central ax...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220110
更新日期:1989-01-01 00:00:00
abstract::Neurotrophins may have a neuroprotective role and are probably involved in the control of axonal sprouting and synaptic plasticity. An antibody raised against a pro-sequence of nerve growth factor (NGF) was tested. In control undisturbed rats, a strong immunoreactivity was detected in scattered cells in and around the...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490350409
更新日期:1993-07-01 00:00:00
abstract::The Oct-2 transcription factor has a predominantly inhibitory effect on gene expression in neuronal cell lines. This factor and its corresponding mRNA have previously been shown to be elevated in adult rat dorsal root ganglion (DRG) neurons chronically exposed to nerve growth factor (NGF). Here we show that the Oct-2 ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400205
更新日期:1995-02-01 00:00:00
abstract::Several recently discovered lines of evidence support the involvement of myelin basic protein (BP)-specific T cells in multiple sclerosis (MS). To identify potentially relevant immunodominant T cell epitopes, human BP (Hu-BP)-reactive T cell lines were selected from MS and normal donors and tested for reactivity to cl...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490280215
更新日期:1991-02-01 00:00:00
abstract::The combination of nerve growth factor (NGF) and phorbol 12-myristate 13-acetate (PMA) rapidly induced the locomotion of PC12 cells by sequentially stimulating lamellar spreading, ruffling with pinocytosis, and polarization by retraction from the substratum. During migration, cells acquired long processes as a result ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960515)44:4<308::AID-JNR
更新日期:1996-05-15 00:00:00
abstract::Recent advances in human induced pluripotent stem cells (hiPSCs) offer new possibilities for biomedical research and clinical applications. Differentiated neurons from hiPSCs are expected to be useful for developing novel methods of treatment for various neurological diseases. However, the detailed process of function...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23666
更新日期:2015-12-01 00:00:00
abstract::We investigated the possible mechanisms how interferon (IFN)-beta may control T cell infiltration in the CNS in experimental autoimmune encephalomyelitis (EAE). Adoptive transfer (AT) EAE was induced in groups of six female Lewis rats. Animals were treated with 3 x 10(5) units of recombinant rat IFN-beta s.c. once at ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1128
更新日期:2001-07-01 00:00:00
abstract::The presence of glycosaminoglycans (GAG) has been histochemically demonstrated in the CNS of various mammalian species. They have been related with some nerve functions as neurotransmitters storage and synaptic transmission. In the present paper, the histochemical properties of nerve cell cytoplasmic GAG were studied ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490110103
更新日期:1984-01-01 00:00:00
abstract::Oxidative stress results in protein oxidation and is implicated in cerebral disease, such as Parkinson's disease, Alzheimer's disease, and ischemic stroke. Sulfiredoxin-1 (Srxn1) is an endogenous antioxidant protein that has neuroprotective effects. The mechanisms of Srxn1 in oxidative stress have not been well studie...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23218
更新日期:2013-06-01 00:00:00
abstract::Recent evidence has demonstrated that neural stem cells (NSC) can be expanded from a variety of sources, including embryos, fetuses, and adult bone marrow and brain tissue. We have previously reported the generation of adult rat bone marrow-derived cellular spheres that are morphologically and phenotypically similar t...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21131
更新日期:2007-02-01 00:00:00
abstract::The distribution of both tyrosine hydroxylase (TH) antigen and messenger RNA was investigated in the ventral mesencephalon from human brain using a 35S-labeled human TH cDNA probe and a polyclonal TH antibody. A hybridization signal was detected not only in the perikaryon but also in the neurites, most probably dendri...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250415
更新日期:1990-04-01 00:00:00
abstract::The pathogenic processing of the amyloid precursor protein (APP) into beta-amyloid peptides, which give rise to beta-amyloid plaques in the brains of Alzheimer's disease patients, requires the enzymatic activity of the beta-site APP-cleaving enzyme 1 (BACE1). We report the cloning and sequence of a 1.5-kb DNA fragment...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10639
更新日期:2003-07-01 00:00:00
abstract::Recent studies suggest that heterotypic cell-cell interactions influence gliogenesis in the developing rat central nervous system. CNS neuron-derived factors have been hypothesized to exist, and several have been identified and partially characterized which affect the number of oligodendrocytes in vitro. In order to s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200303
更新日期:1988-07-01 00:00:00
abstract::We sought to establish a mouse model of subcortical ischemic vascular dementia (SIVD) that develops predominant white matter (WM) injury and cognitive dysfunction induced by chronic cerebral hypoperfusion. Adult C57Bl/6 male (n = 48) mice were subjected to bilateral common carotid artery stenosis with external microco...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21925
更新日期:2009-04-01 00:00:00
abstract::Monocyte chemoattractant protein-1 (MCP-1, CCL2) is a well-defined chemokine implicated in the pathology of various neurodegenerative diseases and brain injuries, such as Alzheimer's disease, multiple sclerosis, stroke, and traumatic injury. We investigated the effect of the activation of P2 purinoceptors on MCP-1 pro...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21982
更新日期:2009-05-15 00:00:00
abstract::Oligomeric forms of α-synuclein are believed to cause mitochondrial injury, which may contribute to neurotoxicity in Parkinson's disease (PD). Here oligomers of α-synuclein were prepared using the dopamine metabolite, DOPAL (3,4-dihydroxyphenyl-acetaldehyde), in the presence of guanidinium hydrochloride. Electron micr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24513
更新日期:2019-12-01 00:00:00
abstract::Neuronal degeneration has been shown to be involved in various neurological disorders. Growth/trophic factors and their receptors are known to be important for the regeneration and survival of neurons. We report here the molecular cloning of a receptor-like protein tyrosine kinase, bsk, (for brain specific kinase). Bs...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490370117
更新日期:1994-01-01 00:00:00
abstract::In the present work, we analyzed whether endogenous and/or transplanted bone marrow mononuclear cells (BMMC) migrate spontaneously to the crushed sciatic nerve and whether they transdifferentiate into Schwann cells (SC) in order to help repair the damaged tissue. We also studied both the immunohistochemical evolution ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22645
更新日期:2011-08-01 00:00:00
abstract::Scatchard analysis of saturation isotherms of [125I]-iodopindolol was used to characterize beta-adrenoceptor density (Bmax) and affinity constant (Kd) in female and male hamster Harderian glands. Single-point experiments were also completed in intact females, intact males, and castrated or superior cervical ganglionec...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220411
更新日期:1989-04-01 00:00:00
abstract::In culture, cerebellar granule neurons die of apoptosis in serum-free media containing a physiologic level of K(+) but survive in a depolarizing concentration of K(+) or when insulin-like growth factor 1 (IGF-1) is added. Both Akt/PKB activation and caspase-3 inhibition were implicated as the underlying neuroprotectiv...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20024
更新日期:2004-03-15 00:00:00
abstract::We investigated whether a learning impairment after a controlled cortical impact (CCI) injury was associated with alterations in molecules involved in synaptic plasticity and learning and memory. Adult male rats with moderate CCI to the left parietal cortex, tested in a Morris water maze (MWM) beginning at postinjury ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21893
更新日期:2009-02-15 00:00:00
abstract::Brain injury and neuroinflammation are pathophysiologic contributors to acute and chronic neurologic disorders, which are progressive diseases not fully understood. Mammalian metallothioneins I and II (MT-I&II) have significant neuroprotective functions, but the precise mechanisms underlying these effects are still un...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20790
更新日期:2006-05-01 00:00:00
abstract::Recent studies have revealed a significant decrease in white matter volume, including loss of myelin, with age but minimal decrease in gray matter volume (Guttmann et al., [1998] Neurology 50:972-978). Myelin is necessary for the rapid conduction of impulses along axons. Myelinated nerve includes various domains, the ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10386
更新日期:2002-11-01 00:00:00
abstract::Peroxides are generated continuously in cells that consume oxygen. Among the different peroxides, hydrogen peroxide is the molecule that is formed in highest quantities. In addition, organic hydroperoxides are synthesized as products of cellular metabolism. Generation and disposal of peroxides is a very important proc...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.20280
更新日期:2005-01-01 00:00:00
abstract::Glial fibrillary acidic protein (GFAP) is the major constituent of glial filaments and is restricted within the CNS to astrocytes. As with other classes of intermediate filament proteins, the regulation of GFAP expression is poorly understood. Utilizing highly purified cultures of astrocytes and a chemically defined (...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490140202
更新日期:1985-01-01 00:00:00
abstract::The osteoinductive capacity of biological noncellular material has been widely recognized. Studies using bone morphogenetic proteins and acellular bone matrix demonstrate that host mesenchymal cells can be readily transformed into osteoprogenitor cells. The current study sought to determine whether another biological ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23505
更新日期:2015-03-01 00:00:00
abstract::We have examined the expression and distribution of the extracellular matrix molecule tenascin-C in and around lesions of the thoracic dorsal columns in adult rats 3 days to 8 weeks after injury, using in situ hybridization, immunofluorescence, electron microscopy and immunoelectron microscopy. Numerous tenascin-C mRN...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1997-08-15 00:00:00
abstract::Migraine is a common neurological disorder with significantly higher incidence and prevalence in women than men. The presentation of the disease in women is modulated by changes in sex hormones from adolescence to pregnancy and menopause. Yet, the effect of sex influences has often been neglected in both basic and cli...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23903
更新日期:2017-01-02 00:00:00
abstract::SH-SY5Y cells differentiate into neuronal-like cells and express marker proteins like growth-associated protein (GAP-43) and neuropeptide tyrosine when treated with a low concentration (16 nM) of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in the presence of growth factors or serum. Both control and d...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410609
更新日期:1995-08-15 00:00:00
abstract::In recent years, several novel types of disorders have been characterized, including what have been termed polyalanine diseases, in which patients have expanded triplet repeats in specific genes, resulting in the translation of aberrantly elongated polyalanine stretches. In this study, we showed that yellow fluorescen...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21619
更新日期:2008-05-15 00:00:00